Publications 2015

Project Hiltunen:

Antonenkov VD, Isomursu A, Mennerich D, Vapola MH, Weiher H, Kietzmann T, Hiltunen JK. The Human Mitochondrial DNA Depletion Syndrome Gene MPV17 Encodes a Non-selective Channel That Modulates Membrane Potential. J Biol Chem 290(22):13840-61, 2015.

Jokinen R, Lahtinen T, Marttinen P, Myöhänen M, Ruotsalainen P, Yeung N, Shvetsova A.,  Kastaniotis AJ, Hiltunen JK, Öhman T, Nyman TA, Weiler H, Battersby B J. Quantitative changes in Gimap3 and Gimap5 expression modify mitochondrial DNA segregation in mice. Genetics 200: 221-235, 2015.

Liu P, Wang X, Hiltunen K, Chen Z. Controllable drug release system in living cells triggered by enzyme-substrate recognition. ACS Appl Mater Interfaces 7:26811-26818, 2015.

Liu PC, Wang H, Hiltunen JK, Chen ZJ, Shen JC. Cross-linked proteins with gold nanoclusters: A dual-purpose pH-responsive material for controllable cell imaging and antibiotic delivery. Part Part Syst Char 32:749-755, 2015.

Selkälä EM, Nair RR, Schmitz W, Kvist A-P, Baes  M,  Hiltunen JK, Autio KJ. Phytol is lethal for Amacr-deficient mice. Biochim Biophys Acta 1851: 1394-13405, 2015.

Biocomputing Coordinator Juffer:

Garma L and Juffer AH. Comparison of non-sequential sets of protein residues. Comput Biol Chem 61:23-38, 2015.

Project Kietzmann:

Antonenkov VD, Isomursu A, Mennerich D, Vapola MH, Weiher H, Kietzmann T, Hiltunen JK. The Human Mitochondrial DNA Depletion Syndrome Gene MPV17 Encodes a Non-selective Channel That Modulates Membrane Potential. J Biol Chem 290(22):13840-61, 2015.

Deschoemaeker S, Di Conza G, Lilla S, Martín-Pérez R, Mennerich D, Boon L, Hendrikx S, Maddocks OD, Marx C, Radhakrishnan P, Prenen H, Schneider M, Myllyharju J, Kietzmann T, Vousden KH, Zanivan S, Mazzone M. PHD1 regulates p53-mediated colorectal cancer chemoresistance. EMBO Mol Med 7(10):1350-65, 2015.

Espinosa-Diez C, Miguel V, Mennerich D, Kietzmann T, Sánchez-Pérez P, Cadenas S, Lamas S. Antioxidant responses and cellular adjustments to oxidative stress. Redox Biol 6:183-97, 2015.

Ganjam GK, Chi TF, Kietzmann T, Dimova EY. Resveratrol: beneficial or not? Opposite effects of resveratrol on hypoxia-dependent PAI-1 expression in tumour and primary cells. Thromb Haemost 115(1), 2015.

Görlach A, Dimova EY, Petry A, Martínez-Ruiz A, Hernansanz-Agustín P, Rolo AP, Palmeira CM, Kietzmann T. Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved? Redox Biol 6:372-85, 2015.

Horbach T, Götz C, Kietzmann T, Dimova EY. Protein kinases as switches for the function of upstream stimulatory factors: implications for tissue injury and cancer. Front Pharmacol 6:3, 2015.

Kietzmann T. Myocardial infarction in elderly patients: How to assess their bleeding risk? Thromb Haemost 114(5):869-71, 2015.

Konzack A, Jakupovic M, Kubaichuk K, Görlach A, Dombrowski F, Miinalainen I, Sormunen R, Kietzmann T. Mitochondrial Dysfunction Due to Lack of Manganese Superoxide Dismutase Promotes Hepatocarcinogenesis. Antioxid Redox Signal 23(14):1059-75, 2015.

Kozlova N, Jensen JK, Chi TF, Samoylenko A, Kietzmann T. PAI-1 modulates cell migration in a LRP1-dependent manner via β-catenin and ERK1/2. Thromb Haemost 113(5):988-98, 2015.

Kozlova N, Samoylenko A, Drobot L, Kietzmann T. Urokinase is a negative modulator of Egf-dependent proliferation and motility in the two breast cancer cell lines MCF-7 and MDA-MB-231. Mol Carcinog 55(2):170-81, 2015.

Richter K, Konzack A, Pihlajaniemi T, Heljasvaara R, and Kietzmann T. Redox-fibrosis: Impact of TGFβ1 on ROS generators, mediators and functional consequences. Redox Biol 28:344-352, 2015.

Spohrer S, Dimova EY, Kietzmann T, Montenarh M, Götz C. The nuclear fraction of protein kinase CK2 binds to the upstream stimulatory factors (USFs) in the absence of DNA. Cell Signal 28(2):23-31, 2015.

Zagotta I, Dimova EY, Debatin KM, Wabitsch M, Kietzmann T, Fischer-Posovszky P. Obesity and inflammation: reduced cytokine expression due to resveratrol in a  human in vitro model of inflamed adipose tissue. Front Pharmacol 6:79, 2015.

Project Kursula:

Bhargav SP, Vahokoski J, Kallio JP, Torda A, Kursula P, Kursula I. Two independently folding units of Plasmodium profilin suggest evolution via gene fusion. Cell Mol Life Sci 72:4193-4203, 2015.

Chukhlieb M, Raasakka A, Ruskamo S, Kursula P. The N-terminal cytoplasmic domain of neuregulin 1 type III is intrinsically disordered. Amino Acids 47:1567-1577, 2015.

Freischmidt A, Wieland T, Richter B, Ruf W, Schaeffer V, Müller K, Marroquin N, Nordin F, Hübers A, Weydt P, Pinto S, Press R, Millecamps S, Molko N, Bernard E, Desnuelle C, Soriani MH, Dorst J, Graf E, Nordström U, Feiler MS, Putz S, Böckers TM, Meyer T, Winkler AS, Winkelman J, de Carvalho M, Thal DR, Otto M, Brännström T, Volk AE, Kursula P, Danzer KM, Lichtner P, Dikic I, Meitinger T, Ludolph AC, Strom TM, Andersen PM, Weishaupt JH. Haploinsufficiency of TBK1 causes familial amyotrophic lateral sclerosis and fronto-temporal dementia. Nat Neurosci 18:631-636, 2015.

Han H, Kursula P. The olfactomedin domain from gliomedin is a beta-propeller with unique structural properties. J Biol Chem 290:3612-3621, 2015.

Laulumaa S, Blakeley MP, Raasakka A, Moulin M, Härtlein M, Kursula P. Production, crystallization, and neutron diffraction of fully deuterated human myelin peripheral membrane protein P2. Acta Cryst F Struct Biol Commun 71:1391-1395, 2015.

Laulumaa S, Kursula P, Natali F. Neutron scattering studies on protein dynamics using the human myelin peripheral membrane protein P2. EPJ Web of Conferences 83:02010, 2015.

Laulumaa S, Nieminen T, Lehtimäki M, Aggarwal S, Simons M, Koza MM, Vattulainen I, Kursula P*, Natali F* (*joint senior authors). Dynamics of the peripheral membrane protein P2 from human myelin measured by neutron scattering - a comparison between wild-type protein and a hinge mutant. PLoS ONE 10:e0128954, 2015.

Onwukwe GU, Kursula P, Koski MK, Schmitz W, Wierenga RK. Human Δ3, Δ2-enoyl-CoA isomerase, type-2: a structural enzymology study on the catalytic role of its ACBP-domain and helix-10. FEBS J 282:746-768, 2015.

Piirainen H, Hellman M, Tossavainen H, Permi P, Kursula P, Jaakola VP. Human adenosine A2A receptor binds calmodulin with high affinity in a calcium-dependent manner. Biophys J 108:903-917, 2015.

Raasakka A, Myllykoski M, Laulumaa S, Lehtimäki M, Härtlein M, Moulin M, Kursula I, Kursula P. Determinants of ligand binding and catalytic activity in the myelin enzyme 2',3'-cyclic nucleotide 3'-phosphodiesterase. Sci Rep 5:16520, 2015. 

Junior Investigator Lehtiö:

Kumpan K, Nathubhai A, Zhang C, Wood PJ, Lloyd MD, Thompson AS, Haikarainen T, Lehtiö L, Threadgill MD. Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases. Bioorg Med Chem 23:3013-32, 2015

Nkizinkiko Y, Suneel Kumar BV, Jeankumar VU, Haikarainen T, Koivunen J, Madhuri C, Yogeeswari P, Venkannagari H, Obaji E, Pihlajaniemi T, Sriram D, Lehtiö L. Discovery of potent and selective nonplanar tankyrase inhibiting nicotinamide mimics. Bioorg Med Chem 23:4139-4149, 2015.

Paine HA, Nathubhai A, Woon EC, Sunderland PT, Wood PJ, Mahon MF, Lloyd MD, Thompson AS, Haikarainen T, Narwal M, Lehtiö L, Threadgill MD. Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro. Bioorg Med Chem 23:5891-908, 2015

Project Manninen:

Carrera M, Bitu CC, de Oliveira CE, Cervigne NK, Graner E, Manninen A, Salo T, Coletta RD. HOXA10 controls proliferation, migration and invasion in oral squamous cell carcinoma. Int J Clin Exp Pathol 8(4):3613-23, 2015.

Cattavarayane S, Palovuori R, Jayendrakishore TR, Manninen A. α6β1- and αV-integrins are required for long-term self-renewal of murine embryonic stem cells in the absence of LIF. BMC Cell Biol 16:3, 2015.

Junttila S, Saarela U, Halt K, Manninen A, Pärssinen H, Lecca RM, Brandli AW, Sims-Lucas S, Skovorodkin I, Vainio SJ. Functional genetic targeting of the embryonic kidney progenitor cells ex vivo. J Am Soc Nephrol 26(5):1126-37, 2015.

Manninen A. Epithelial polarity - Generating and integrating signals from the ECM with integrins. Exp Cell Res 334(2): 337-349, 2015.

Project Myllyharju:

Aro E, Salo AM, Khatri R, Finnilä M, Miinalainen I, Sormunen R, Pakkanen O,Holster T, Soininen R, Prein C, Clausen-Schaumann H, Aszódi A, Tuukkanen J, Kivirikko KI, Schipani E, Myllyharju J. Severe Extracellular Matrix Abnormalitiesand Chondrodysplasia in Mice Lacking Collagen Prolyl 4-Hydroxylase Isoenzyme IIin Combination with a Reduced Amount of Isoenzyme I. J Biol Chem 290(27):16964-78, 2015.

Deschoemaeker S, Di Conza G, Lilla S, Martín-Pérez R, Mennerich D, Boon L, Hendrikx S, Maddocks OD, Marx C, Radhakrishnan P, Prenen H, Schneider M, Myllyharju J, Kietzmann T, Vousden KH, Zanivan S, Mazzone M. PHD1 regulates p53-mediated colorectal cancer chemoresistance. EMBO Mol Med 7(10):1350-65, 2015.

Komulainen T, Lodge T, Hinttala R, Bolszak M, Pietilä M, Koivunen P, Hakkola J, Poulton J, Morten KJ, Uusimaa J. Sodium valproate induces mitochondrial respiration dysfunction in HepG2 in vitro cell model. Toxicology 331:47-56, 2015.

Kutchuk L, Laitala A, Soueid-Bomgarten S, Shentzer P, Rosendahl AH, Eilot S, Grossman M, Sagi I, Sormunen R, Myllyharju J, Mäki JM, Hasson P. Muscle composition is regulated by a Lox-TGFβ feedback loop. Development 142(5):983-93, 2015.

Myllyharju J. Collagen Hydroxylases. In: 2-Oxoglutarate-Dependent Dioxygenases. RSC Metallobiology Series No. 3., p. 149-168. Editors Hausinger RP , Schofield CJ. The Royal Society of Chemistry, 2015.

Siegert I, Schödel J, Nairz M, Schatz V, Dettmer K, Dick C, Kalucka J, Franke K, Ehrenschwender M, Schley G, Beneke A, Sutter J, Moll M, Hellerbrand C, Wielockx B, Katschinski DM, Lang R, Galy B, Hentze MW, Koivunen P, Oefner PJ, Bogdan C, Weiss G, Willam C, Jantsch J. Ferritin-mediated iron sequestration stabilizes hypoxia-inducible factor-1α upon LPS activation in the presence of ample oxygen. Cell Rep 13:2048-2055, 2015.

Project Pihlajaniemi:

Alahuhta I, Aikio M, Väyrynen O, Nurmenniemi S, Suojanen J, Pihlajaniemi T, Heljasvaara R, Salo T, Nyberg P. Endostatin induces proliferation of oral carcinoma cells but its effect on invasion is modified by the tumor microenvironment. Exp Cell Res 336:130-140, 2015.

Bayramoglu N, Kannala J, Åkerfelt M, Kaakinen M, Eklund L, Nees M, Heikkilä J. A novel feature descriptor based on image statistics. IEEE International Conference on Image Processing (ICIP) 2015.

Boscolo E, Limaye N, Huang L, Kang KT, Soblet J, Uebelhoer M, Mendola A, Nätynki M, Seront E, Dupont S, Hammer J, Legrand C, Brugnara C, Eklund L, Vikkula M, Bischoff J, Boon LM. Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects. J Clin Invest 125:3491-3504, 2015.

Farshchian M, Nissinen L, Siljamäki E, Riihilä P, Toriseva M, Kivisaari A, Ala-aho R, Kallajoki M, Veräjänkorva E, Honkanen HK, Heljasvaara R, Pihlajaniemi T, Grénman R, Peltonen J, Peltonen S, Kähäri VM. EphB2 promotes progression of cutaneous squamous cell carcinoma. J Invest Dermatol 135:1882-1892, 2015.

Fuoco C, Rizzi R, Biondo A, Longa E, Mascaro A, Shapira-Schweitzer K, Kossovar O, Benedetti S, Salvatori ML, Santoleri S , Testa S, Bernardini S, Bottinelli R, Bearzi C, Cannata SM, Seliktar D, Cossu G, Gargioli C. In vivo generation of a mature and functional artificial skeletal muscle. EMBO Mol Med 7:411-22, 2015.

Hakanpää L, Sipilä T, Leppänen VM, Gautam P, Nurmi H, Jacquemet G, Eklund L, Ivaska J, Alitalo K, Saharinen P. Endothelial destabilization by angiopoietin-2 via integrin β1 activation. Nat Commun 6:5962, 2015.

Limaye N, Kangas J, Mendola A, Godfraind C, Schlögel MJ, Helaers R, Eklund L,  Boon ML, Vikkula M. Somatic activating PIK3CA mutations cause venous malformation. Am J Hum Genet 97:914-921, 2015.

Nkizinkiko Y, Suneel Kumar BV, Jeankumar VU, Haikarainen T, Koivunen J, Madhuri C, Yogeeswari P, Venkannagari H, Obaji E, Pihlajaniemi T, Sriram D, Lehtiö L. Discovery of potent and selective nonplanar tankyrase inhibiting nicotinamide mimics. Bioorg Med Chem 23:4139-4149, 2015.

Nätynki M, Kangas J, Miinalainen I, Sormunen R, Pietilä R, Soblet J, Boon LM, Vikkula M, Limaye N, Eklund L. Common and specific effects of TIE2 mutations causing venous malformations. Hum Mol Genet 24:6374-6389, 2015.

Richter K, Konzack A, Pihlajaniemi T, Heljasvaara R, Kietzmann T. Redox-fibrosis: Impact of TGFβ1 on ROS generators, mediators and functional consequences. Redox Biol 28:344-352, 2015.

Salo T, Sutinen M, Sundquist E, Cervigne NK, de Oliveira CE, Akram SU, Ohlmeier S, Apu HE, Suomi F, Eklund L, Juusela P, Åström P, Bitu CC, Korvala J, Coletta RD. A Novel Human Leiomyoma Tissue Derived Matrix for Cell Culture Studies. BMC Cancer 15:981, 2015.

Tu H, Huhtala P, Lee H-M, Adams JC, Pihlajaniemi T. Membrane-associated collagens with interrupted triple-helices (MACITs): evolution from a bilaterian common ancestor and functional conservation in C. elegans. BMC Evol Biol 15:281, 2015.

Åkerfelt M, Bayramoglu N, Robinson S, Toriseva M, Schukov H-P, Härmä V, Virtanen J, Sormunen R, Kaakinen M, Kannala J, Eklund L, Heikkilä J, Nees M. Automated tracking of tumor-stroma morphology in microtissues identifies functional targets within the tumor microenvironment for therapeutic intervention. Oncotarget 6:30035-30056, 2015.

Project Ruddock:

Alanen HI, Walker KL, Lourdes Velez Suberbie M, Matos CF, Bönisch S, Freedman RB, et al. Efficient export of human growth hormone, interferon a2b and antibody fragments to the periplasm by the Escherichia coli Tat pathway in the absence of prior disulfide bond formation. Biochim Biophys Acta 1854:756-63, 2015.

Psioni GB, Ruddock LW, Bulleid N and Mollinari M. Division of labor among oxidoreductases: TMX1 acts preferentially on transmembrane polypeptides. Mol Biol Cell 26:3390-400, 2015.

Project Savolainen/Herzig/Järvelin:

Aarlt A, Ilves I, Aloji L, Miettinen P, Paajanen H, Brunke G, Häsler R, Ellrichmann M, Schreiber S, Rosenstiel R, Ott S, Herzig KH. Characteristic changes in microbial community composition and expression of innate immune genes in acute appendicitis. Innate Immun 21(1):30-41, 2015.

Artigas MS, et al (incl Järvelin MR). Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. Nat Commun 6:8658. doi: 10.1038/ncomms9658, 2015.

Cartwright R, Kirby AC, Tikkinen KA, Mangera A, Thiagamoorthy G, Rajan P, Pesonen JS, Ambrose C, Gonzalez-Maffe J, Bennett P, Palmer T, Walley A, Järvelin M-R, Chapple C, Khullar V. Systematic review and meta-analysis of genetic association studies of urinary symptoms and prolapse in women. Am J Obstet Gynecol 212:199.e1-24, 2015.

Chambers JC, et al (incl Järvelin MR). Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study. Lancet Diabetes Endocrinol 3(7):526-34, 2015.

EArly Genetics and Lifecourse Epidemiology (EAGLE) Eczema Consortium; Australian Asthma Genetics Consortium(AAGC), et al (incl Järvelin MR). Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nat Genet 47(12):1449-56, 2015.

Eskola PJ, Jokelainen J, Järvelin MR, Keinänen-Kiukaanniemi S, Ruokonen A, Puukka K, Timonen M, Auvinen JP. Depression and Insulin Resistance: Additional Support for the Novel Heuristic Model in Perimenopausal Depression. Am J Psychiatry 172(8):796-7, 2015.

Fall T, et al (incl Järvelin MR), on behalf of the ENGAGE Consortium: Age- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors. Diabetes 64(5):1841-52, 2015.

Fung E, Järvelin MR, Doshi RN, Shinbane JS, Carlson SK, Grazette LP, Chang PM, Sangha RS, Huikuri HV, Peters NS. Electrocardiographic patch devices and contemporary wireless cardiac monitoring. Front Physiol 6:149. doi: 10.3389/fphys.2015.00149, eCollection 2015.

Gharib SA, et al (incl Järvelin MR), CHARGE Consortium, SpiroMeta Consortium. Integrative pathway genomics of lung function and airflow obstruction. Hum Mol Genet 24(23):6836-48, 2015.

Graversen L, Sørensen TI, Gerds TA, Petersen L, Sovio U, Kaakinen M, Sandbaek A, Laitinen J, Taanila A, Pouta A, Järvelin M-R, Obel C. Prediction of adolescent and adult adiposity outcomes from early life anthropometrics. Obesity 23(1):162-9, 2015.

Hukkanen J, Puurunen J, Hyötyläinen T, Savolainen MJ, Ruokonen A, Morin-Papunen L, Orešič M, Piltonen T, Tapanainen JS. The effect of atorvastatin treatment on serum oxysterol levels and cytochrome P450 activity. Br J Clin Pharmacol 80: 473-479, 2015.

Hukkanen J, Rysä J, Mäkelä K, Herzig K-H, Hakkola J, Savolainen MJ. The effect of pregnane X receptor agonists on postprandial incretin hormone secretion in rats and humans. J Physiol Pharmacol 66(6):821-39, 2015.

Hägg S, et al (incl Järvelin MR), for the European Network for Genetic and Genomic Epidemiology (ENGAGE) consortium. Adiposity as a Cause of Cardiovascular Disease: A Mendelian Randomization Study, Int J Epidemiol 44(2):578-86, 2015.

Junno JA, Paananen M, Karppinen J, Niinimäki J, Niskanen M, Maijanen H, Väre T, Järvelin MR, Nieminen MT, Tuukkanen J, Ruff C. Age-related trends in vertebral dimensions. J Anat 226(5):434-9, 2015.

Juvonen KR, Macierzanka A, Lille ME, Laaksonen DE, Mykkänen HM, Niskanen LK, Pihlajamäki J, Mäkelä K, Mills C, Mackie A, Mclcome P, Herzig KH, Poutanen KS, Karhunen LJ. Cross-linking of sodium caseinate structured emulsion with transglutaminase alters the postprandial metabolism and appetite responses in healthy young individuals. Br J Nutr 114(3):418-26, 2015.

Jääskeläinen A, Kaila-Kangas L, Leino-Arjas P, Lindbohm ML, Nevanperä N, Remes J, Järvelin MR, Laitinen J. Association between occupational psychosocial factors and waist circumference is modified by diet among men.  Eur J Clin Nutr 69(9):1053-9, 2015.

Jääskeläinen A, Kaila-Kangas L, Leino-Arjas P, Lindbohm ML, Nevanperä N, Remes J, Järvelin MR, Laitinen J. Psychosocial Factors at Work and Obesity Among Young Finnish Adults: A Cohort Study. J Occup Environ Med 57(5):485-92, 2015.

Kato N, et al (incl Järvelin MR). Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. Nat Genet 47(11):1282-93, 2015.

Kinnunen S, Mänttäri S, Herzig KH, Nieminen P, Mustonen AM, Saarela S. Maintenance of skeletal muscle energy homeostasis during prolonged wintertime fasting in the raccoon dog (Nyctereutes procynoides). J Comp Physiol B 185(4):435-45, 2015.

Kolehmainen M, Ulven SM, Paananen J, de Mello V, Schwab U, Carlberg C, Myhrstad M, Pihlajamäki J, Dungner E, Sjölin E, Gunnarsdottir I, Cloetens L, Landin-Olsson M, Åkesson B, Rosqvist F, Hukkanen J, Herzig K-H, Dragsted LO, Savolainen MJ, Brader L, Hermansen K, Risérus U, Thorsdottir I, Poutanen KS, Uusitupa M, Arner P, Dahlman I. Healthy Nordic diet down-regulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome. Am J Clin Nutr 101: 228-239, 2015.

Kovalainen M, Mönkäre J, Riikonen, Pesonen U, Vlasova M, Salonen J, Lehto VP, Järvinen K, Herzig KH. Novel Delivery Systems for Improving the Clinical Use of Peptides. Pharmacol Rev 67(3):541-561, 2015.

Käräjämäki AJ, Pätsi OP, Savolainen MJ, Kesäniemi YA, Huikuri H, Ukkola O. Non-Alcoholic Fatty Liver Disease as a Predictor of Atrial Fibrillation in Middle-Aged Population (OPERA study). PLoS One 16; 10(11): e0142937, 2015.

Lampi J, Koskela H, Hartikainen AL, Ramasamy A, Couto Alves A, Järvelin MR, Pekkanen J. Farm environment during infancy and lung function at the age of 31: a prospective birth cohort study in Finland. BMJ Open 22;5(7):e007350, 2015.

Lehne B, Drong AW, Loh M, Zhang W, Scott WR, Tan ST, Afzal U, Scott J, Jarvelin MR, Elliott P, McCarthy MI, Kooner JS, Chambers JC. A coherent approach for analysis of the Illumina HumanMethylation450 BeadChip improves data quality and performance in epigenome-wide association studies. Genome Biol 16(1):37, 2015

Linneberg A, et al (incl Järvelin MR). Effect of Smoking on Blood Pressure and Resting Heart Rate: A Mendelian Randomisation Meta-Analysis in the CARTA Consortium. Circ Cardiovasc Genet 8(6):832-41, 2015.

Locke AE, et al (incl Järvelin MR). Genetic studies of body mass index yield new insights for obesity biology. Nature 518(7538):197-206, 2015.

Morris RW, et al (incl Järvelin MR). Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium. BMJ Open 5(8):e008808, 2015.

Männistö T, Vääräsmäki M, Sipola-Leppänen M, Tikanmäki M, Matinolli HM, Pesonen AK, Räikkönen K, Järvelin MR, Hovi P, Kajantie E. Independent living and romantic relations among young adults born preterm. Pediatrics 135(2):290-7, 2015.

Nevanperä N, Ala-Mursula L, Seitsamo J, Remes J, Auvinen J, Hopsu L, Husman P, Karppinen J, Järvelin MR, Laitinen J. Long-Lasting Obesity Predicts Poor Work Ability at Midlife: A 15-Year Follow-Up of the Northern Finland 1966 Birth Cohort Study. J Occup Environ Med 57(12):1262-8, 2015.

Obeidat M, et al (incl Järvelin MR). Molecular mechanisms underlying variations in lung function: a systems genetics analysis. Lancet Respir Med 3(10):782-95, 2015.

Ojelade SA, et al (incl Järvelin MR). Rsu1 regulates ethanol consumption in Drosophila and humans. Proc Natl Acad Sci U S A 112(30):E4085-93, 2015.

Peet ED, McCoy DC, Danaei G, Ezzati M, Fawzi W, Järvelin MR, Pillas D, Fink G. Early Childhood Development and Schooling Attainment: Longitudinal Evidence from British, Finnish and Philippine Birth Cohorts. PLoS One 10(9):e0137219, 2015.

Pers TH, Karjalainen JM, Chan Y, Westra HJ, Wood AR, Yang J, Lui JC, Vedantam S, Gustafsson S, Esko T, Frayling T, Speliotes EK. Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Boehnke M, Raychaudhuri S, Fehrmann RS, Hirschhorn JN, Franke L. Biological interpretation of genome-wide association studies using predicted gene functions. Nat Commun 6:5890, 2015.

Puroila A, Paananen M, Taimela S, Järvelin MR, Karppinen J. Lifestyle-Factors in Adolescence as Predictors of Number of Musculoskeletal Pain Sites in Adulthood: A 17-Year Follow-Up Study of a Birth Cohort. Pain Med 16(6):1177-85, 2015.

Rodriguez A, Wang Y, Khan AA, Gissler M, Cartwright R, Järvelin MR. Exposure to antenatal corticosteroid therapy is associated with reduced size at birth: Evidence from Finnish Medical Birth Register of 278,508 births. Psychoneuroendocrinology 61:37, 2015.

Ronkainen J, Huusko TJ, Soininen R, Mondini E, Cinti F, Mäkelä KA, Kovalainen M, Herzig KH, Järvelin MR, Sebert S, Savolainen MJ, Salonurmi T. Fat mass- and obesity-associated gene Fto affects the dietary response in mouse white adipose tissue. Sci Rep 18, 5:9233, 2015.

Ruiz M, Goldblatt P, Morrison J, Kukla L, Švancara J, Järvelin M-R, Taanila A, Saurel-Cubizolles M-J, Lioret S, Bakoula C, Veltsista A, Porta D, Forastiere F, van Eijsden M, Vrijkotte TGM, Eggesbø M, White RA, Barros H, Correia S, Vrijheid M, Torrent M, Rebagliato M, Larrañaga I, Ludvigsson J, Olsen Faresjö Å, Hryhorczuk D, Antipkin Y, Marmot M, Pikhart H. Mother’s education and the risk of preterm and small for gestational age birth: a DRIVERSQ1 meta-analysis of 12 European cohorts. J Epidemiol Community Health 69(9):826-833, 2015.

Savolainen MJ. Epidemiology: Disease Associations and Modulators of HDL-Related Biomarkers. Handb Exp Pharmacol 224: 259-83, 2015.

Shungin D, et al (incl Herzig KH, Järvelin MR). New genetic loci link adipose and insulin biology to body fat distribution. Nature 518(7538):187-96, 2015.

Sipola-Leppänen M, Karvonen R, Tikanmäki M, Matinolli HM, Martikainen S, Pesonen AK, Räikkönen K, Järvelin MR, Hovi P, Eriksson JG, Vääräsmäki M, Kajantie E. Ambulatory Blood Pressure and Its Variability in Adults Born Preterm. Hypertension 65(3):615-21, 2015.

Sipola-Leppänen M, Vääräsmäki M, Tikanmäki M, Matinolli HM, Miettola S, Hovi P, Wehkalampi K, Ruokonen A, Sundvall J, Pouta A, Eriksson JG, Järvelin MR, Kajantie E. Cardiometabolic risk factors in young adults who were born preterm. Am J Epidemiol 181(11):861-73, 2015.

Solmi F, Sonneville KR, Easter A, Horton NJ, Crosby RD, Treasure J, Rodriguez A, Järvelin M-R, Field AE, Micali N. Prevalence of purging at age 16 and associations with negative outcomes among girls in three community-based cohorts. J Child Psychol Psychiatry 56(1):87-96, 2015.

Surakka I, et al (incl Järvelin MR). The impact of low-frequency and rare variants on lipid levels. Nat Genet 47(6):589-97, 2015.

Tanner T, Päkkilä J, Karjalainen K, Kämppi A, Järvelin MR, Patinen P, Tjäderhane L, Anttonen V. Smoking, alcohol use, socioeconomic background and oral health among young Finnish adults. Community Dent Oral Epidemiol 43(5):406-14, 2015.

The Coffee and Caffeine Genetics Consortium, et al (incl Järvelin MR). Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Mol Psychiatry 20(5):647-56, 2015.

van der Valk RJ, et al (incl Järvelin MR). A novel common variant in DCST2 is associated with length in early life and height in adulthood. Hum Mol Genet 24(4):1155-68, 2015.

Wang Q, Kangas AJ, Soininen P, Tiainen M, Tynkkynen T, Puukka K, Ruokonen A, Viikari J, Kähönen M, Lehtimäki T, Salomaa V, Perola M, Davey Smith G, Raitakari OT, Järvelin MR, Würtz P, Kettunen J, Ala-Korpela M. Sex hormone-binding globulin associations with circulating lipids and metabolites and the risk for type 2 diabetes: observational and causal effect estimates. Int J Epidemiol 44(2):623-37, 2015.

Warrington NM, Howe LD, Paternoster L, Kaakinen M, Herrala S, Huikari V, Wu YY, Kemp JP, Timpson NJ, Pourcain BS, Davey Smith G, Tilling K, Jarvelin MR, Pennell CE, Evans DM, Lawlor DA, Briollais L, PalmerLJ. A genome-wide association study of body mass index across early life and childhood. Int J Epidemiol 44(2):700-12, 2015.

Vimaleswaran KS, Cavadino A, Verweij N, Nolte IM, Mateo Leach I; LifeLines Cohort Study, Auvinen J, Veijola J, Elliott P, Penninx BW, Snieder H, Järvelin MR, van der Harst P, Cohen RD, Boucher BJ, Hyppönen E. Interactions between uncoupling protein 2 gene polymorphisms, obesity and alcohol intake on liver function: a large meta-analysed population-based study. Eur J Endocrinol 173(6):863-72, 2015.

Vähätalo LH, Ruohonen ST, Kovalainen M, Huotari A, Mäkelä K, Määttä JA, Mäkelä S, Liisa Ailanen L, Ruohonen S, Röyttä M, Herzig KH, Savontaus E. Neuropeptide Y in the noradrenergic neurons induces obesity and inhibits sympathetic tone. Acta Physiol (Oxf) 213(4):902-19, 2015.

Äijälä M, Ronkainen J, Huusko T, Malo E, Savolainen ER, Savolainen MJ, Salonurmi T, Bloigu R, Antero Kesäniemi Y, Ukkola O. The fat mass and obesity-associated (FTO) gene variant rs9939609 predicts long-term incidence of cardiovascular disease and related death independent of the traditional risk factors. Ann Med  47(8):655-63, 2015.

Project Savolainen/Sillanpää:

Bhattacharjee M, Rajeevan MS, Sillanpää MJ. Prediction of complex human diseases from pathway-focused candidate markers by joint estimation of marker effects: case of chronic fatigue syndrome. Human Genomics 9: 8, 2015.

He L, Pitkäniemi J, Sarin A-P, Salomaa V, Sillanpää MJ, Ripatti S. Hierarchical Bayesian model for rare variant association analysis integrating genotype uncertainty in human sequence data. Genet Epidemiol 39: 89-100, 2015.

Heikkinen M, Ruokonen M, Alexander M, Aspi J, Pyhäjärvi T, Searle JB. Relationship between wild greylag and European domestic geese based on mitochondrial DNA. Anim Genet 46: 485-497, 2015.

Khazaei H, O'Sullivan DM, Jones H, Pitts N, Sillanpää MJ, Pärssinen P, Manninen O, Stoddard FL. Flanking SNP markers for vicine-convicine concentration in faba bean (Vicia faba L.). Molecular Breeding 35: 38, 2015.

Kärkkäinen HP, Li Z, Sillanpää MJ. An efficient genome-wide multilocus epistasis search. Genetics 201:865-870, 2015.

Li Z, Möttönen J, Sillanpää MJ. A robust multiple-locus method for quantitative trait locus analysis of non-normally distributed multiple traits. Heredity 115:556-564, 2015.

Li Z, Sillanpää MJ. Dynamic quantitative trait locus analysis of plant phenomic data. Trends in Plant Sci 20:822-833, 2015.

Li Z, Sillanpää MJ. Efficient use of systems mapping without expert knowledge: Comment on "Mapping complex traits as a dynamic system" by L. Sun and R. Wu. Phys Life Rev 13:192-193, 2015.

Mathew B, Holand AM, Koistinen P, Leon J, Sillanpää MJ. Reparametrization-based estimation of genetic parameters in multi-trait animal model using Integrated Nested Laplace Approximation. Theor Appl Gen, 2015.

Mathew B, Leon J, Sillanpää MJ. Integrated Nested Laplace Approximation inference and cross-validation to tune variance components in breeding value estimation. Molecular Breeding 35: 99, 2015.

Mattila T M,  Aalto E A, Toivainen T , Niittyvuopio A, Piltonen S, Kuittinen H, Savolainen O. Selection for population specific adaptation has shaped patterns of variation in the photoperiod pathway genes in Arabidopsis lyrata during post glacial colonization. Mol Ecol doi:10.1111/mec.13489, 2015.

Möttönen J, Sillanpää MJ. Robust variable selection and coefficient estimation in multivariate multiple regression using LAD-Lasso, pp 235-247, Springer International Publishing, Switzerland, 2015.

Pasanen L, Holmström L, Sillanpää MJ. Bayesian LASSO, scale space and decision making in association genetics. PLoS ONE 10:e0120017, 2015.

Transgenic Facility Coordinator Soininen:

Aro E, Salo AM, Khatri R, Finnilä M, Miinalainen I, Sormunen R, Pakkanen O,Holster T, Soininen R, Prein C, Clausen-Schaumann H, Aszódi A, Tuukkanen J, Kivirikko KI, Schipani E, Myllyharju J. Severe extracellular matrix abnormalitiesand chondrodysplasia in mice lacking collagen prolyl 4-hydroxylase isoenzyme II in combination with a reduced amount of isoenzyme I. J Biol Chem 290(27):16964-78, 2015.

Colombelli C, Palmisano M, Eshed-Eisenbach Y, Zambroni D, Pavoni E, Ferri C, Saccucci S, Nicole S, Soininen R, McKee KK, Yurchenco PD, Peles E, Wrabetz L, Feltri ML. Perlecan is recruited by dystroglycan to nodes of Ranvier and binds the clustering molecule gliomedin. J Cell Biol 208(3):313-29, 2015.

Hurskainen T, Kokkonen N, Sormunen R, Jackow J, Löffek S, Soininen R, Franzke CW, Bruckner-Tuderman L, Tasanen K. Deletion of the major bullous pemphigoid epitope region of collagen XVII induces blistering, autoimmunization, and itching in mice. J Invest Dermatol 135(5):1303-10, 2015.

INFRAFRONTIER Consortium. INFRAFRONTIER--providing mutant mouse resources as research tools for the international scientific community. Nucleic Acids Res 43 (Database issue):D1171-5. 20, 2015.

Ronkainen J, Huusko TJ, Soininen R, Mondini E, Cinti F, Mäkelä KA, Kovalainen M, Herzig KH, Järvelin MR, Sebert S, Savolainen MJ, Salonurmi T. Fat mass- and obesity-associated gene Fto affects the dietary response in mouse white adipose tissue. Sci Rep 18, 5:9233, 2015.

Scavizzi F, Ryder E, Newman S, Raspa M, Gleeson D, Wardle-Jones H, Montoliu L, Fernandez A, Dessain ML, Larrigaldie V, Khorshidi Z, Vuolteenaho R, Soininen R, André P, Jacquot S, Hong Y, de Angelis MH, Ramirez-Solis R, Doe B. Blastocyst genotyping for quality control of mouse mutant archives: an ethical and economical approach. Transgenic Res 24(5):921-927, 2015.

EM Microscopy Coordinator Sormunen:

Aro E, Salo AM, Khatri R, Finnilä M, Miinalainen I, Sormunen R, Pakkanen O,Holster T, Soininen R, Prein C, Clausen-Schaumann H, Aszódi A, Tuukkanen J, Kivirikko KI, Schipani E, Myllyharju J. Severe Extracellular Matrix Abnormalitiesand Chondrodysplasia in Mice Lacking Collagen Prolyl 4-Hydroxylase Isoenzyme II in Combination with a Reduced Amount of Isoenzyme I. J Biol Chem 290(27):16964-78, 2015.

Konzack A, Jakupovic M, Kubaichuk K, Görlach A, Dombrowski F, Miinalainen I, Sormunen R, Kietzmann T. Mitochondrial Dysfunction Due to Lack of Manganese Superoxide Dismutase Promotes Hepatocarcinogenesis. Antioxid Redox Signal 23(14):1059-75, 2015.

Kutchuk L, Laitala A, Soueid-Bomgarten S, Shentzer P, Rosendahl AH, Eilot S, Grossman M, Sagi I, Sormunen R, Myllyharju J, Mäki JM, Hasson P. Muscle composition is regulated by a Lox-TGFβ feedback loop. Development 142(5):983-93, 2015.

Lemma SA, Pasanen AK, Haapasaari KM, Sippola A, Sormunen R, Soini Y, Jantunen E, Koivunen P, Salokorpi N, Bloigu R, Turpeenniemi-Hujanen T, Kuittinen O. Similar chemokine receptor profiles in lymphomas with central nervous systeminvolvement - possible biomarkers for patient selection for central nervoussystem prophylaxis, a retrospective study. Eur J Haematol doi: 10.1111/ejh.12626, 2015.

Moilanen JM, Kokkonen N, Löffek S, Väyrynen JP, Syväniemi E, Hurskainen T,Mäkinen M, Klintrup K, Mäkelä J, Sormunen R, Bruckner-Tuderman L, Autio-Harmainen H, Tasanen K. Collagen XVII expression correlates with the invasion and metastasis of colorectal cancer. Hum Pathol 46(3):434-42, 2015.

Nätynki M, Kangas J, Miinalainen I, Sormunen R, Pietilä R, Soblet J, Boon LM, Vikkula M, Limaye N, Eklund L. Common and specific effects of TIE2 mutations causing venous malformations. Hum Mol Genet 24:6374-6389, 2015.

Sokka M, Rilla K, Miinalainen I, Pospiech H, Syväoja JE. High levels of TopBP1 induce ATR-dependent shut down of rRNA transcription and nucleolar segregation. Nucleic Acids Res 43(10):4975-89, 2015.

Vered M, Lehtonen M, Hotakainen L, Pirilä E, Teppo S, Nyberg P, Sormunen R, Zlotogorski-Hurvitz A, Salo T, Dayan D. Caveolin-1 accumulation in the tongue cancer  tumor microenvironment is significantly associated with poor prognosis: an in-vivo and in-vitro study. BMC Cancer 15:25, 2015.

Vähätalo LH, Ruohonen ST, Mäkelä S, Kovalainen M, Huotari A, Mäkelä KA, Määttä JA, Miinalainen I, Gilsbach R, Hein L, Ailanen L, Mattila M, Eerola K, Röyttä M, Ruohonen S, Herzig KH, Savontaus E. Neuropeptide Y in the noradrenergic neurones induces obesity and inhibits sympathetic tone in mice. Acta Physiol (Oxf) 213(4):902-15, 2015.

Zlotogorski-Hurvitz A, Dayan D, Chaushu G, Korvala J, Salo T, Sormunen R, Vered M. Human saliva-derived exosomes: comparing methods of isolation. J Histochem Cytochem 63(3):181-9, 2015.

Åkerfelt M, Bayramoglu N, Robinson S, Toriseva M, Schukov H-P, Härmä V, Virtanen J, Sormunen R, Kaakinen M, Kannala J, Eklund L, Heikkilä J, Nees M. Automated tracking of tumor-stroma morphology in microtissues identifies functional targets within the tumor microenvironment for therapeutic intervention. Oncotarget 6:30035-30056, 2015.

Project Vainio:

Ali N, Hosseini M, Vainio S, Taïeb A, Cario-André M, Rezvani HR. Skin equivalents: skin from reconstructions as models to study skin development and diseases. Br J Dermatol 173:391-403, 2015.

Berry RL, Ozdemir DD, Aronow B, Lindström NO, Dudnakova T, Thornburn A, Perry P, Baldock R, Armit C, Joshi A, Jeanpierre C, Shan J, Vainio S, Baily J, Brownstein D, Davies J, Hastie ND, Hohenstein P. Deducing the stage of origin of Wilms' tumours from a developmental series of Wt1-mutant mice. Dis Model Mech 8:903-17, 2015.

Bibikova O, Popov A, Bykov A, Prilepskii A, Kinnunen M, Kordas K, Bogatyrev V, Khlebtsov N, Vainio S, Tuchin V. Optical properties of plasmon-resonant bare and  silica-coated nanostars used for cell imaging. J Biomed Opt 20:76017, 2015.

Daniel E, Onwukwe GU, Wierenga RK, Quaggin S E, Vainio S, Krause M. ATGme: Open-source web application for rare codon identification and custom DNA sequence optimization. BMC Bioinformatics 16:303, 2015.

Junttila S, Saarela U, Halt K, Manninen A, Pärssinen H, Lecca RM, Brandli AW, Sims-Lucas S, Skovorodkin I, Vainio SJ. Functional genetic targeting of the embryonic kidney progenitor cells ex vivo. J Am Soc Nephrol 26(5):1126-37, 2015.

Krause M, Rak-Raszewska A, Pietilä I, Quaggin SE, Vainio S. Signaling during Kidney Development. Cells 4(2):112-32. doi: 10.3390/cells4020112, 2015.

Krause M, Samoylenko A, Vainio SJ. Exosomes as renal inductive signals in health and disease, and their application as diagnostic markers and therapeutic agents. Front Cell Dev Biol 3:65, 2015.

Naillat F, Yan W, Karjalainen R, Liakhovitskaia A, Samoylenko A, Xu Q, Sun Z,  Shen B, Medvinsky A, Quaggin S, Vainio SJ. Identification of the genes regulated  by Wnt-4, a critical signal for commitment of the ovary. Exp Cell Res 332:163-78, 2015.

Rajaram RD, Buric D, Caikovski M, Ayyanan A, Rougemont J, Shan J, Vainio SJ, Yalcin-Ozuysal O, Brisken C. Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk. EMBO J 34:641-52, 2015.

Rak-Raszewska A, Hauser PV, Vainio S. Organ In Vitro Culture: What Have We Learned about Early Kidney Development? Stem Cells Int doi: 10.1155/2015/959807, 2015.

Junior Investigator Wei:

Chen H, Yu H, Wang J, Zhang Z, Gao Z, Chen Z, Lu Y, Liu W, Jiang D, Zheng SL, Wei GH, Issacs WB, Feng J, Xu J. Systematic enrichment analysis of potentially functional regions for 103 prostate cancer risk-associated loci. Prostate. 75:1264-1276, 2015.

Heinonen H, Lepikhova T, Sahu B, Pehkonen H, Pihlajamaa P, Louhimo R, Gao P, Wei GH, Hautaniemi S, Jänne OA, Monni O. Identification of several potential chromatin binding sites of HOXB7 and its downstream target genes in breast cancer. Int J Cancer. 137:2374-2383, 2015.

Project Wierenga:

Daniel E, Onwukwe GU, Wierenga RK, Quaggin S E, Vainio S, Krause M. ATGme: Open-source web application for rare codon identification and custom DNA sequence optimization. BMC Bioinformatics 16:303, 2015.

Janardan N, Harijan RK, Kiema TR, Wierenga R K, Murthy MR. Structural characterization of a mitochondrial 3-ketoacyl-CoA (T1)-like thiolase from Mycobacterium smegmatis. Acta Crystallogr D Biol Crystallogr 71:2479-2493, 2015.

Krause M, Neubauer P, Wierenga RK. Structure based directed evolution of a monomeric triosephosphate isomerase: towards a pentose sugar isomerase. Protein Eng Des Sel 28:187-197, 2015.

Onwukwe GU, Koski MK, Pihko P, Schmitz W, Wierenga RK. Structures of yeast peroxisomal Δ3,Δ2- enoyl-CoA isomerase  complexed with acyl-CoA  substrate analogues: the importance of hydrogen bond networks for the reactivity of the catalytic base and the oxyanion hole. Acta Crystallogr D Biol Crystallogr 71:2178-2191, 2015.

Onwukwe GU, Kursula P, Koski MK, Schmitz W, Wierenga RK. Human Δ3, Δ2-enoyl-CoA isomerase, type-2: a structural enzymology study on the catalytic role of its ACBP-domain and helix-10. FEBS J 282:746-768, 2015.

Project Winqvist:

Darabi H, McCue K, Beesley J, Michailidou K, Nord S, Kar S et al (Winqvist R, Jukkola-Vuorinen A of Oulu Breast Cancer Study). Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression. Am J Hum Genet 97:22-34, 2015.

Day FR, Ruth KS, Thompson DJ, Lunetta KL, Pervjakova N, Chasman DI et al (incl. Winqvist R, Pylkäs K of Oulu Breast Cancer Study).  Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nat Genet 2015 47:1294-303, 2015.

Glubb DM, Maranian MJ, Michailidou K, Pooley KA, Meyer KB, Kar S et al (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Kauppila S of Oulu Breast Cancer Study). Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1. Am J Hum Genet 96:5-20, 2015.

Guo Q, Schmidt MK, Kraft P, Canisius S, Chen C, Khan S et al (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M of Oulu Breast Cancer Study). Identification of novel genetic markers of breast cancer survival. J Natl Cancer Inst 107 pii: djv081, 2015.

Guo X, Long J, Zeng C, Michailidou K, Ghoussaini M, Bolla MK et al (incl. Winqvist R of Oulu Breast Cancer Study). Fine-Scale Mapping of the 4q24 Locus Identifies Two Independent Loci Associated with Breast Cancer Risk. Cancer Epidemiol Biomarkers Prev 24:1680-1691, 2015.

Hartikainen JM, Tengström M, Winqvist R, Jukkola-Vuorinen A, Pylkäs K, Kosma VM, Soini Y, Mannermaa A. KEAP1 Genetic Polymorphisms Associate with Breast Cancer Risk and Survival Outcomes. Clin Cancer Res 21:1591-1601, 2015.

Jamshidi M, Fagerholm R, Khan S, Aittomäki K, Czene K, Darabi H et al (incl. Winqvist R, Pylkäs K of Oulu Breast Cancer Study). SNP-SNP interaction analysis of  NF-κB signaling pathway on breast cancer survival. Oncotarget 6:37979-37994, 2015.

Kabisch M, Lorenzo Bermejo J, Dünnebier T, Ying S, Michailidou K, Bolla MK et al (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M of Oulu Breast Cancer Study). Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer. Carcinogenesis 36:256-271, 2015.

Lin WY, Camp NJ, Ghoussaini M, Beesley J, Michailidou K, Hopper JL et al (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Kauppila S of Oulu Breast Cancer Study). Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk. Hum Mol Genet 24:285-298, 2015.

Mantere T, Haanpää M, Hanenberg H, Schleutker J, Kallioniemi A, Kähkönen M, Parto K, Avela K, Aittomäki K, von Koskull H, Hartikainen JM, Kosma VM, Laasanen SL, Mannermaa A, Pylkäs K, Winqvist R. Finnish Fanconi anemia mutations and hereditary predisposition to breast and prostate cancer. Clin Genet 88:68-73, 2015.

Mavaddat N, Pharoah PD, Michailidou K, Tyrer J, Brook MN, Bolla MK et al (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M of Oulu Breast Cancer Study). Prediction of breast cancer risk based on profiling with common genetic variants. J Natl Cancer Inst 107 pii: djv036, 2015.

Meeks HD, Song H, Michailidou K, Bolla MK, Dennis J, Wang Q, Barrowdale D et al (incl. Winqvist R, Pylkäs K of Oulu Breast Cancer Study). BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers. J Natl Cancer Inst 108 pii: djv315, 2015.

Michailidou K, Beesley J, Lindström S, Canisius S, Dennis J, Lush MJ et al (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M of Oulu Breast Cancer Study). Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. Nat Genet 47:373-380, 2015.

Orr N, Dudbridge F, Dryden N, Maguire S, Novo D, Perrakis E et al (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M of Oulu Breast Cancer Study). Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2. Hum Mol Genet 24:2966-2984, 2015.

Pirie A, Guo Q, Kraft P, Canisius S, Eccles DM, Rahman N, (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M of Oulu Breast Cancer Study). Common germline polymorphisms associated with breast cancer-specific survival. Breast Cancer Res 17:58, 2015.

Zhang B, Shu XO, Delahanty RJ, Zeng C, Michailidou K, Bolla MK et al (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M of Oulu Breast Cancer Study). Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization. J Natl Cancer Inst 107 pii: djv219, 2015.

Last updated: 18/11/2016