BCO project leader Doc. Lauri Eklund is a partner in a consortium receiving 1,1 mill. € from the Academy of Finland Health from Science (TERVA) 2017 funding instrument. The project is titled Treating dementia by blood brain barrier opening to increase glymphatic clearance. Principal Investigator of the consortium is Adj. professor, radiologist Vesa Kiviniemi (Department of Radiology, Oulu University Hospital, University of Oulu) and other partners are Dr. Teemu Myllylä (Optoelectronics and Measurement Techniques Unit, Faculty of Information Technology and Electrical Engineering, University of Oulu), and Academy Professor Kari Alitalo (Institute of Biomedicine, University of Helsinki).
Dementia results in tremendous socio economic costs and loss of humane life years. Recent findings indicate that it is caused by inability of the brain to remove waste products due to a failure of glymphatic clearance system. OPEN consortium joins world leading researchers excelled in vascular biology, tissue sensing and neuroimaging to develop an effective treatment for dementia. Recent findings indicate that lost memory can be recovered by momentary opening of blood brain barrier. Our objective is to optimize the opening to boost insufficient brain clearance such that waste products become more effectively removed to stop brain degeneration. We aim to solve the full picture of the brain clearance system and find out the best way to increase the clearance for clinical use to treat demented patients. As an outcome of the project, we expect breakthroughs in the understanding how brain functionality can be maintained, thus delivering great scientific, clinical and societal values.
Last updated: 17.11.2017