An article by Kettunen and collaborators in Human Molecular Genetics

Sliz E, Sebert S, Würtz P, Kangas AJ, Soininen P, Lehtimäki T, Kähönen M, Viikari J, Männikkö M, Ala-Korpela M, Raitakari OT, Kettunen J. have published an article with a title “NAFLD risk alleles in PNPLA3, TM6SF2, GCKR and LYPLAL1 show divergent metabolic effects”.

Despite the robust cross-sectional associations on population level, the present results showing neutral or cardioprotective metabolic effects for some of the non-alcoholic fatty liver disease (NAFLD) risk alleles advocate that hepatic lipid accumulation by itself may not increase the level of circulating lipids or other metabolites.

For more information: https://www.ncbi.nlm.nih.gov/pubmed/29648650

Last updated: 10.8.2018