Publications 2013

Project Hiltunen:

Strand E, Pedersen ER, Svingen GFT, Schartum-Hansen H, Rebnord EW, Bjørndal B, Seifert R, Bohov P, Meyer K, Hiltunen JK, Nordrehaug JE, Nilsen DWT, Berge RK, Nygård O. Dietary intake of n-3 long-chain polyunsaturated fatty acids and risk of myocardial infarction in coronary artery disease patients with or without diabetes mellitus: a prospective cohort study. BMC Med 11:216-226, 2013.

Samoylenko A, Hossain JA, Mennerich D, Kellokumpu S, Hiltunen JK, Kietzmann T. Nutritional countermeasures targeting reactive oxygen species in cancer: from mechanisms to biomarkers and clinical evidence. Antioxid Redox Signal 19:2157-2196, 2013.

Kursu SVA, Pietikäinen LP, Fontanesi F, Aaltonen MJ, Suomi F, Raghavan Nair R, Schonauer MS, Dieckmann CL, Barrientos A, Hiltunen JK, Kastaniotis AJ. Defects in mitochondrial fatty acid synthesis result in failure of multiple aspects of mitochondrial biogenesis in Saccharomyces cerevisiae. Mol Microbiol 90:824-840, 2013.

Selkälä EM, Kuusisto SM, Salonurmi T, Savolainen MJ, Jauhiainen M, Pirilä PL, Kvist A-P, Conzelmann E, Schmitz W, Alexson SE, Kotti TJ, Hiltunen JK, Autio KJ. Metabolic adaptation allows Amacr-deficient mice to remain symptom-free despite low levels of mature bile acids.  Biochim Biophys Acta 1831:1335-1343, 2013.

Kasaragod P, Schmitz W, Hiltunen JK, Wierenga RK. The isomerase and hydratase reaction mechanism of the crotonase active site of the multifunctional enzyme (type-1), as deduced from structures of complexes with 3S-hydroxy-acyl-CoA. FEBS J 280:3160-3175, 2013.

Mehtälä ML, Lensink MF, Pietikäinen LP, Hiltunen JK, Glumoff T. On the molecular basis of D-bifunctional protein deficiency type III. PLoS One 8:e53688, 2013.

Mehtälä ML, Haataja TJ, Blanchet CE, Hiltunen JK, Svergun DI, Glumoff T. Quaternary structure of human, Drosophila melanogaster and Caenorhabditis elegans MFE-2 in solution from synchrotron small-angle X-ray scattering. FEBS Lett 587:305-310, 2013.

Junior Investigator Jaakola:

Ashok Y, Nanekar R, Jaakola V-P. Crystallogenesis of adenosine A2A receptor – T4 lysozyme fusion protein: A practical route for the structure. Methods Enzymol 520:175-198, 2013.

Biocomputing Coordinator Juffer:

Sharma S and Juffer AH. An atomistic model for assembly of transmembrane domain of T cell receptor complex. J Am Chem Soc 135:2188-2197, 2013.

Shinya S, Ohnuma T, Yamashiro R, Kimoto H, Kusaoke H, Anbazhagan P, Juffer AH, Fukamizo T. The first identification of carbohydrate binding modules specific to chitosan. J Biol Chem 288:30042-30053, 2013.

Beis I, Juffer AH, Weckström M, Hyvönen M. Physical properties of model phosphatidylcholine bilayers containing diacylglycerol (DAG): A molecular dynamics simulations study. Biophys J 104:663a, 2013.

Project Kietzmann:

Samoylenko A, Hossain JA, Mennerich D, Kellokumpu S, Hiltunen JK, Kietzmann T. Nutritional countermeasures targeting reactive oxygen species in cancer: from mechanisms to biomarkers and clinical evidence. Antiox Redox Signal 19:2157-2196, 2013.

Zagotta I, Dimova EY, Funcke JB, Wabitsch M, Kietzmann T, Fischer-Posovszky P. Resveratrol suppresses PAI-1 gene expression in a human in vitro model of inflamed adipose tissue. Oxid Med Cell Longe 2013, 793525, 2013.

Project Kursula:

Biocenter Publications:

Han H, Myllykoski M, Ruskamo S, Wang C, Kursula P. Myelin-specific proteins: a structurally diverse group of membrane-interacting molecules. Biofactors 39:233-241, 2013.

Forst AH, Karlberg T, Herzog N, Thorsell A-G, Gross A, Feijs KL, Verheugd P, Kursula P, Nijmeijer B, Kremmer E, Kleine H, Ladurner A, Schüler H, Lüscher B. Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains. Structure 21:462-475, 2013.

Myllykoski M, Raasakka A, Lehtimäki M, Han H, Kursula I, Kursula P. Crystallographic analysis of the reaction cycle of 2’,3’-cyclic nucleotide 3’-phosphodiesterase, a unique member of the 2H phosphoesterase family. J Mol Biol 425:4307-4322, 2013.

Han H and Kursula P. Preliminary crystallographic analysis of the N-terminal PDZ-like domain of periaxin, an abundant peripheral nerve protein linked to human neuropathies. Acta Cryst F69:804-808, 2013.

Anantharajan J, Koski MK, Kursula P, Hieta R, Bergmann U, Myllyharju J, Wierenga RK. The structural motifs for substrate binding and dimerisation of the alpha subunit of collagen prolyl 4-hydroxylase. Structure 21:2107-2118, 2013.

Vervaet N, Kallio JP, Meier S, Salmivaara E, Eberhardt M, Zhang S, Sun X, Wu Z, Kursula P, Kursula I. Recombinant production, crystallization and preliminary structural characterization of Schistosoma japonicum profilin. Acta Cryst F69:1264-1267, 2013.

Muruganandam G, Bürck J, Ulrich AS, Kursula I, Kursula P. Lipid membrane association of myelin proteins and peptide segments studied by oriented and synchrotron radiation circular dichroism spectroscopy. J Phys Chem B 117:14983-14993, 2013.

Other Publications from the Biocenter Project:

Knoll W, Peters J, Gerelli Y, Kursula P, Natali F. The influence of the myelin basic protein C8 mutant on the dynamics of myelin membranes. J Phys Soc Jpn 82:SA018, 2013.

Junior Investigator Lehtiö:

Narwal M, Koivunen J, Haikarainen T, Obaji E, Legala O, Venkannagari H, Joensuu P, Pihlajaniemi T, Lehtiö L. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem 56:7880-7889, 2013.

Haikarainen T, Koivunen J, Narwal M, Venkannagari H, Obaji E, Joensuu P, Pihlajaniemi T, Lehtiö L. para-substituted 2-phenyl-3,4-dihydroquinazolin-4-ones as potent and selective tankyrase inhibitors. ChemMedChem 8:1978-1985, 2013.

Haikarainen T, Venkannagari H, Narwal M, Obaji E, Lee HW, Nkizinkiko Y, Lehtiö L. Structural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4. PloS One 8:e65404, 2013.

Lehtiö L, Chi NW, Krauss S. Tankyrases as drug targets. FEBS J 280:3576-3593, 2013.

Narwal M, Haikarainen T, Fallarero A, Vuorela PM, Lehtiö L. Screening and structural analysis of flavones inhibiting tankyrases. J Med Chem 56:3507-3517, 2013.

Venkannagari H, Fallarero A, Feijs KL, Lüscher B, Lehtiö L. Activity-based assay for human mono-ADP-ribosyltransferases ARTD7/PARP15 and ARTD10/PARP10 aimed at screening and profiling inhibitors. Eur J Pharm Sci 49:148-156, 2013.

Project Manninen:

Teräväinen TP, Myllymäki SM, Friedrichs J, Strohmeyer N, Moyano JV, Wu C, Matlin KS, Muller DJ, Manninen A. αV-integrins are required for mechanotransduction in MDCK epithelial cells. PLoS One 8:e71485, 2013.

Projet Männikkö:

Hietikko E, Kotimäki J, Sorri M, Männikkö M. High incidence of Meniere-like symptoms in relatives of Meniere patients in the areas of Oulu University Hospital and Kainuu Central Hospital in Finland. Eur J Med Genet 56:279-285, 2013.

Karjalainen U, Paananen M, Okuloff A, Taimela S, Auvinen J, Männikkö M, Karppinen J. Role of environmental factors and history of low back pain in sciatica symptoms among Finnish adolescents. Spine 38:1105-1111, 2013.

Song Y-Q, Karasugi T, Cheung KMC, Chiba K, Ho DWH, Miyake A, Kao PYP (Kelempisioti A, Eskola P, Männikkö M, Mäkelä P, Karppinen J, Järvelin M-R). Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant. J Clin Invest 123:4909-4917, 2013.

Project Myllyharju:

Biocenter Publications:

Myllyharju J and Koivunen P. Hypoxia-inducible factor prolyl 4-hydroxylases: common and specific roles. Biol Chem 394:435-448, 2013. (Invited review).

Myllyharju J. Prolyl 4-hydroxylases, master regulators of the hypoxia response. Acta Physiol 208:148-165, 2013. (Invited review).

Losman JA, Looper R, Koivunen P, Lee S, Schneider RK, McMahon C, Cowley G, Root D, Ebert BL, Kaelin WG Jr. (R)-2-Hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science 339:1621-1625, 2013.

Kerkelä R, Karsikas S, Szabo Z, Serpi R, Magga J, Gao E, Alitalo K, Anisimov A, Sormunen R, Pietilä I, Vainio L, Koch WJ, Kivirikko KI, Myllyharju J, Koivunen P. Activation of hypoxia response in endothelial cells contributes to ischemic cardioprotection. Mol Cell Biol 33:3321-3329, 2013.

Winter AD, McCormack G, Myllyharju J, Page AP. Prolyl 4-hydroxylase activity is essential for development and cuticle formation in the human infective parasitic nematode Brugia malayi. J Biol Chem 288:1750-1761, 2013.

Tjäderhane L, Vered M, Pääkkönen V, Peteri A, Mäki JM, Myllyharju J, Dayan D, Salo T. The expression and role of lysyl oxidase (LOX) in dentinogenesis. Int Endod J 46:581-589, 2013.

Anantharajan J, Koski MK, Kursula P, Hieta R, Bergmann U, Myllyharju J, Wierenga RK. The structural motifs for substrate binding and dimerization of the alpha subunit of collagen prolyl 4-hydroxylase. Structure 21:2107-2118, 2013.

Palomäki S, Pietilä M, Laitinen S, Pesälä J, Sormunen R, Lehenkari P, Koivunen P. HIF-1alpha is upregulated in human mesenchymal stem cells. Stem Cells 31:1902-1909, 2013.

Other Publications from the Biocenter Project:

Peurala E, Koivunen P, Haapasaari K-M, Bloigu R, Jukkola-Vuorinen A. The prognostic significance and value of cyclin D1, CDK4 and p16 in human breast cancer. Breast Cancer Res 15:R5, 2013.

Project Pihlajaniemi:

Biocenter Publications:

Uebelhoer M, Nätynki M, Kangas J, Mendola A, Nguyen HL, Soblet J, Godfraind C, Boon LM, Eklund L, Limaye N, Vikkula M. Venous malformation-causative TIE2 mutations mediate an AKT-dependent decrease in PDGFB. Hum Mol Genet 22:3438-3448, 2013.

Eklund L, Bry M, Alitalo K. Mouse models for studying angiogenesis and lymphangiogenesis in cancer. Mol Oncol 7:259-282, 2013.

Aikio M, Hurskainen M, Brideau G, Hägg P, Sormunen R, Heljasvaara R, Gould DB, Pihlajaniemi T. Collagen XVIII short isoform is critical for retinal vascularization, and overexpression of the Tsp-1 domain affects eye growth and cataract formation. Invest Ophthalmol Vis Sci 54:7450-7462, 2013.

Izzi V, Chiurchiù V, Doldo E, Palumbo C, Tresoldi I, Bei R, Albonici L, Modesti A. Interleukin-17 produced by malignant mesothelioma-polarized immune cells promotes tumor growth and invasiveness. Eur J Inflamm 11: 203-214, 2013.

Salokorpi N, Yrjänä S, Tuominen H, Karttunen A, Heljasvaara R, Pihlajaniemi T, Heikkinen E, Koivukangas J. Expression of VEGF and collagen XVIII in meningiomas: correlations with histopathological and MRI characteristics. Acta Neurochir (Wien) 155:989-996, 2013.

Haikarainen T, Koivunen J, Narwal M, Venkannagari H, Obaji E, Joensuu P, Pihlajaniemi T, Lehtiö L. para-substituted 2-phenyl-3,4-dihydroquinazolin-4-ones as potent and selective tankyrase inhibitors. ChemMedChem 8:1978-1985, 2013.

Narwal M, Koivunen J, Haikarainen T, Obaji E, Legala OE, Venkannagari H, Joensuu P, Pihlajaniemi T, Lehtiö L. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem 56:7880-7889, 2013.

Eklund L and Saharinen P. Angiopoietin signaling in the vasculature. Exp Cell Res 319:1271-1280, 2013.

Other Publications from the Biocenter Project

Field-Ridley A, Heljasvaara R, Pihlajaniemi T, Adatia I, Sun C, Keller RL, Gong WH, Datar S, Oishi P, Fineman JR. Endostatin, an inhibitor of angiogenesis, decreases after bidirectional superior cavopulmonary anastamosis. Pediatr Cardiol 34:291-295, 2013.

Pihlajaniemi T. Soluväliaineen tutkimuksen monet ulottuvuudet (Äyräpää-lecture). Duodecim 129:2262-2272, 2013.

Zainul Z. Delete genes to repair nerves: Knockouts and axon regeneration in peripheral and central nervous system. Am J Neuroprotec Neuroregen 5:25-31, 2013.

Project Ruddock:

Other Publications from the Biocenter Project:

Saaranen MJ and Ruddock LW. Disulfide bond formation in the cytoplasm. Antioxid Redox Signal 19:46-53, 2013.

Hatahet F and Ruddock LW. Topological plasticity of enzymes involved in disulfide bond formation allows catalysis in either the periplasm or the cytoplasm. J Mol Biol 425:3268-3276, 2013.

Project Savolainen/Herzig/Järvelin:

Biocenter Publications:

Ala-Mursula L, Buxton JL, Ek E, Koiranen M, Taanila A, Blakemore AI, Järvelin M-R. Long-term unemployment is associated with short telomeres in 31-year-old men: an observational study in the Northern Finland birth cohort 1966. PLoS One 8:e80094, 2013.

Anttila V et al. (including Järvelin M-R). Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nat Genet 45:912-917, 2013.

Berndt SI et al. (including Järvelin M-R). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet 45:501-512, 2013.

Bonnelykke K et al. (including Järvelin M-R). Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization. Nat Genet 45:902-906, 2013.

Christensen KL, Hedemann MS, Lærke H, Jørgensen H, Mutt SJ, Herzig KH, Bach Knudsen KE. Concentrated arabinoxylan but not concentrated beta-glucan in wheat bread has similar effects on postprandial insulin as whole-grain rye in porto-arterial catheterized pigs. J Agric Food Chem 61:7760-7768, 2013.

Codd V et al. (including Järvelin M-R). Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet 45:422-427, 2013.

Cousminer DL et al. (including Järvelin M-R). Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Hum Mol Genet 22:2735-2747, 2013.

Couto Alves A et al. (including Järvelin M-R). Dysregulation of complement system and CD4+ T cell activation pathways implicated in allergic response. PLoS One 8:e74821, 2013.

den Hoed M et al. (including Järvelin M-R). Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet 45:621-631, 2013.

Do R et al. (including Järvelin M-R). Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet 45:1345-1352, 2013.

Elomaa AP et al. (including Herzig KH). Self-reported sleep disturbance is associated with elevated levels of PAI-1 in individuals with a recorded history of depressive symptoms. Prog Neuropsychopharmacol Biol Psychiatry 47:46-51, 2013.

Fall T et al. (including Järvelin M-R, Herzig KH, Savolainen MJ). The role of adiposity in cardiometabolic traits: a mendelian randomization analysis. PLoS Med 10:e1001474, 2013.

Fatemifar G et al. (including Järvelin M-R). Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances. Hum Mol Genet 22:3807-3817, 2013.

Global Lipids Genetics Consortium et al. (including Järvelin M-R). Discovery and refinement of loci associated with lipid levels. Nat Genet 45:1274-1283, 2013.

Hautamäki A, Kivioja J, Vavuli S, Kakko S, Savolainen E-R, Savolainen MJ et al. Interleukin 8 promoter polymorphism predicts the initial response to bevacizumab treatment for exudative age-related macular degeneration. Retina 33:1815-1827, 2013.

Huotari A, Xu W, Mönkäre J, Kovalainen M, Herzig KH, Lehto VP, Järvinen K. Effect of surface chemistry of porous silicon microparticles on glucagon-like peptide-1 (GLP-1) loading, release and biological activity. Int J Pharm 454:67-73, 2013.

Huusko T, Salonurmi T, Taskinen P, Liinamaa J, Juvonen T, Pääkkö P, Savolainen M, Kakko S. Elevated messenger RNA expression and plasma protein levels of osteopontin and matrix metalloproteinase types 2 and 9 in patients with ascending aortic aneurysms. J Thorac Cardiovasc Surg 145:1117-1123, 2013.

Junttila E, Ala-Kokko T, Ohtonen P, Vaarala A, Karttunen A, Vuolteenaho O, Salo T, Sutinen M, Karhu T, Herzig KH, Koskenkari J. Neurogenic pulmonary edema in patients with nontraumatic intracerebral hemorrhage: predictors and association with outcome. Anesth Analg 116:855-861, 2013.

Jääskeläinen A, Schwab U, Kolehmainen M, Kaakinen M, Savolainen MJ, Froguel P, Cauchi S, Järvelin M-R, Laitinen J. Meal frequencies modify the effect of common genetic variants on body mass index in adolescents of the Northern Finland birth cohort 1986. PLoS One 8:e73802, 2013.

Khalife N, Glover V, Taanila A, Ebeling H, Järvelin M-R, Rodriguez A. Prenatal glucocorticoid treatment and later mental health in children and adolescents. PLoS One 8:e81394, 2013.

Koskela UE, Kuusisto SM, Nissinen AE, Savolainen MJ, Liinamaa MJ. High vitreous concentration of IL-6 and IL-8, but not of adhesion molecules in relation to plasma concentrations in proliferative diabetic retinopathy. Ophthalmic Res 49:108-114, 2013.

Kovalainen M, Mönkäre J, Kaasalainen M, Riikonen J, Lehto VP, Salonen J, Herzig KH, Järvinen K. Development of porous silicon nanocarriers for parenteral peptide delivery. Mol Pharmaceutics 10:353-359, 2013.

Kujala UM et al. (including Savolainen MJ and Järvelin M-R). Long-term leisure-time physical activity and serum metabolome. Circulation 127:340-348, 2013.

Kupari J, Rossi J, Herzig KH, Airaksinen MS. Lack of cholinergic innervation in gastric mucosa does not affect gastrin secretion or basal acid output in neurturin receptor GFRalpha2 deficient mice. J Physiol 591:2175-2188, 2013.

Laurila PP et al. (including Järvelin M-R). Genomic, transcriptomic, and lipidomic profiling highlights the role of inflammation in individuals with low high-density lipoprotein cholesterol. Arterioscler Thromb Vasc Biol 33:847-857, 2013.

Liu D, Bimbo LM, Mäkilä E, Villanova F, Kaasalainen M, Herranz-Blanco B et al. (including Herzig KH). Co-delivery of a hydrophobic small molecule and a hydrophilic peptide by porous silicon nanoparticles. J Control Release 170:268-278, 2013.

Magnusdottir OK, Landberg R, Gunnarsdottir I, Cloetens L, Åkesson B, Önning G et al. (including Herzig KH and Savolainen MJ). Plasma alkylresorcinols reflect important whole-grain components of a healthy Nordic diet. J Nutr 143:1383-1390, 2013.

Mäkinen VP et al. (including Savolainen M). Triglyceride-cholesterol imbalance across lipoprotein subclasses predicts diabetic kidney disease and mortality in type 1 diabetes: the FinnDiane Study. J Intern Med 273:383-395, 2013.

Miettunen J et al. (including Järvelin M-R). Longitudinal associations between childhood and adulthood externalizing and internalizing psychopathology and adolescent substance use. Psychol Med pp. 1-12, 2013.

Papacleovoulou G et al. (including Järvelin M-R). Maternal cholestasis during pregnancy programs metabolic disease in offspring. J Clin Invest 123:3172-3181, 2013.

Pekkala S, Wiklund P, Hulmi JJ, Ahtiainen J, Horttanainen M, Pöllänen E et al. (including Mäkelä K and Herzig KH). Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health? J Physiol 591:5393-5400, 2013.

Puurunen J, Piltonen T, Puukka K, Ruokonen A, Savolainen MJ, Bloigu R, Morin-Papunen L, Tapanainen JS. Statin therapy worsens insulin sensitivity in women with polycystic ovary syndrome (PCOS): a prospective, randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab 98:4798-4807, 2013.

Raitakari OT, Mäkinen V-P, McQueen MJ, Niemi J, Juonala M, Jauhiainen M et al. (including Hannuksela M and Savolainen MJ). Computationally estimated apolipoproteins B and A1 in predicting cardiovascular risk. Atherosclerosis 226:245-251, 2013.

Randall JC et al. (including Järvelin M-R). Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet 9:e1003500, 2013.

Rietveld CA et al. (including Järvelin M-R). GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science 340:1467-1471, 2013.

Rysä J, Buler M, Savolainen MJ, Ruskoaho H, Hakkola J, Hukkanen J. Pregnane X receptor agonists impair postprandial glucose tolerance. Clin Pharmacol Ther 93:556-563, 2013.

Selkälä EM, Kuusisto SM, Salonurmi T, Savolainen MJ, Jauhiainen M, Pirilä PL, Kvist A-P, Conzelmann E, Schmitz W, Alexson SE, Kotti TJ, Hiltunen JK, Autio KJ. Metabolic adaptation allows Amacr-deficient mice to remain symptom-free despite low levels of mature bile acids. Biochim Biophys Acta 1831:1335-1343, 2013.

Song YQ et al. (including Järvelin M-R). Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant. J Clin Invest 123:4909-4917, 2013.

Stephens SH et al. (including Järvelin M-R). Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking. Genet Epidemiol 37:846-859, 2013.

Thun GA et al. (including Järvelin M-R). Causal and synthetic associations of variants in the SERPINA gene cluster with alpha1-antitrypsin serum levels. PLoS Genet 9:e1003585, 2013.

Uusitupa M et al. (including Savolainen MJ, Herzig KH, Hukkanen J). Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome – a randomized study (SYSDIET). J Intern Med 274:52-66, 2013.

van der Loos MJ et al. (including Järvelin M-R). The molecular genetic architecture of self-employment. PLoS One 8:e60542, 2013.

Vimaleswaran KS et al. (including Herzig KH and Järvelin M-R). Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med 10:e1001383, 2013.

Walters RG et al. (including Järvelin M-R). Rare genomic structural variants in complex disease: lessons from the replication of associations with obesity. PLoS One 8:e58048, 2013.

Würtz P et al. (including Järvelin M-R). Lipoprotein subclass profiling reveals pleiotropy in the genetic variants of lipid risk factors for coronary heart disease: a note on Mendelian randomization studies. J Am Coll Cardiol 62:1906-1908, 2013.

Other Publications from the Biocenter Project:

Bloor ID et al. (including Sebert S). Sex differences in metabolic and adipose tissue responses to juvenile-onset obesity in sheep. Endocrinology 154:3622-3631, 2013.

Fainberg HP, Sharkey D, Sebert S, Wilson V, Pope M, Budge H, Symonds ME. Suboptimal maternal nutrition during early fetal kidney development specifically promotes renal lipid accumulation following juvenile obesity in the offspring. Reprod Fertil Dev 25:728-736, 2013.

Gagnon D, Rintamäki H, Gagnon SS, Cheung SS, Herzig KH, Porvari K, Kyröläinen H. Cold exposure enhances fat utilization but not non-esterified fatty acids, glycerol or catecholamines availability during submaximal walking and running. Front Physiol 4:99, 2013.

Kämppi A, Tanner T, Päkkilä J, Patinen P, Järvelin M-R, Tjäderhane L, Anttonen V. Geographical distribution of dental caries prevalence and associated factors in young adults in Finland. Caries Res 47:346-354, 2013.

Männistö T, Mendola P, Vääräsmäki M, Järvelin M-R, Hartikainen A-L, Pouta A, Suvanto E. Elevated blood pressure in pregnancy and subsequent chronic disease risk. Circulation 127:681-690, 2013.

Männistö T et al. (including Järvelin M-R). Preeclampsia, gestational hypertension and subsequent hypothyroidism. Pregnancy Hypertens 3:21-27, 2013.

Päkkilä F, Männistö T, Surcel H-M, Ruokonen A, Bloigu A, Pouta A, Hartikainen A-L, Vääräsmäki M, Järvelin M-R, Suvanto E. Maternal thyroid dysfunction during pregnancy and thyroid function of her child in adolescence. J Clin Endocrinol Metab 98:965-972, 2013.

Stoll G et al. (including Järvelin M-R). Deletion of TOP3beta, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders. Nat Neurosci 16:1228-1237, 2013.

Suija K, Timonen M, Suviola M, Jokelainen J, Järvelin M-R, Tammelin T. The association between physical fitness and depressive symptoms among young adults: results of the Northern Finland 1966 birth cohort study. BMC Public Health 13:535, 2013.

Tanner T et al. (including Järvelin M-R). Prevalence and polarization of dental caries among young, healthy adults: Cross-sectional epidemiological study. Acta Odontol Scand 71:1436-1442, 2013.

Project Savolainen / Sillanpää:

Biocenter Publications:

Leinonen PH, Remington DL, Leppälä J, Savolainen O. Genetic basis of local adaptation and flowering time variation in Arabidopsis lyrata. Mol Ecol 22:709-723, 2013.

Kemi U, Niittyvuopio A, Toivainen T, Pasanen A, Quilot-Turion B, Holm K, Lagercrantz U, Savolainen O, Kuittinen H. Role of vernalization and of duplicated FLOWERING LOCUS C in the perennial Arabidopsis lyrata. New Phytol 197:323-335, 2013.

Quilot-Turion B, Leppälä J, Leinonen PH, Waldmann P, Savolainen O, Kuittinen H. Genetic changes in flowering and morphology in response to adaptation to a high-latitude environment in Arabidopsis lyrata. Ann Bot 111:957-968, 2013.

Alberto F, Aitken SN, Alia R, González-Martínez SC, Hänninen H, Kremer A, Lefèvre F, Lenormand T, Yeaman S, Whetten R, Savolainen O. Potential for evolutionary responses to climate change - evidence from tree populations. Glob Change Biol 19:1645-1661, 2013.

Leppälä J, Bokma F, Savolainen O. Investigating incipient speciation in Arabidopsis lyrata from patterns of transmission ratio distortion. Genetics 194:697-708, 2013.

Aalto EA, Koelewijn HP, Savolainen O. Cytoplasmic male sterility contributes to hybrid incompatibility between subspecies of Arabidopsis lyrata. G3: Genes, Genomes, Genetics 3:1727-1740, 2013.

Remington DL, Leinonen PH, Leppälä J, Savolainen O. Complex genetic effects on early vegetative development shape resource allocation differences between Arabidopsis
lyrata populations. Genetics 195:1087-1102, 2013.

Savolainen O, Lascoux M, Merilä J. Ecological genomics of local adaptation. Nat Rev Genet 14:807-820, 2013.

Ahlinder J and Sillanpää MJ. Rapid Bayesian inference of heritability in animal models without convergence problems. Methods Ecol Evol 4:1037-1046, 2013.

Kärkkäinen HP and Sillanpää MJ. Fast genomic predictions via Bayesian G-BLUP and multilocus models of threshold traits including censored Gaussian data. G3: Genes, Genomes, Genetics 3:1511-1523, 2013.

Knürr T, Läärä E, Sillanpää MJ. Impact of prior specifications in a shrinkage-inducing Bayesian model for quantitative trait mapping and genomic prediction. Genet Sel Evol 45:24, 2013.

Li Z and Sillanpää MJ. A Bayesian non-parametric approach for mapping dynamic quantitative traits. Genetics 194:997-1016, 2013.

Makgahlela ML, Strandén I, Nielsen US, Sillanpää MJ, Mäntysaari EA. The estimation of genomic relationships using breedwise allele frequencies among animals in multibreed populations. J Dairy Sci 96:5364-5375, 2013.

Meyer P, Siwo G, Zeevi D, Sharon E, Norel R, DREAM6 Promoter Prediction Consortium (including Sillanpää MJ). Inferring gene expression from ribosomal promoter sequences, a crowdsourcing approach. Genome Res 23:1928-1937, 2013.

Other Publications from the Biocenter Project:

Häggman J, Juga J, Sillanpää MJ, Thompson R. Genetic parameters for claw health and feet and leg conformation traits in Finnish Ayrshire cows. J Anim Breed Genet 130:89-97, 2013.

Makgahlela ML, Mäntysaari EA, Strandén I, Koivula M, Nielsen US, Sillanpää MJ, Juga J. Across breed multi-trait random regression genomic predictions in the Nordic Red dairy cattle. J Anim Breed Genet 130:10-19, 2013.

EM Microscopy Coordinator Sormunen:

Huilaja L, Mäkikallo K, Sormunen R, Lohi J, Hurskainen T, Tasanen K. Gestational pemphigoid: placental morphology and function. Acta Derm Venereol 93:33-38, 2013.

Lappi-Blanco E, Lehtonen ST, Sormunen R, Merikallio HM, Soini Y, Kaarteenaho RL. Divergence of tight and adherens junction factors in alveolar epithelium in pulmonary fibrosis. Hum Pathol 44:895-907, 2013.

Quintero IB, Herrala AM, Araujo CL, Pulkka AE, Hautaniemi S, Ovaska K, Pryazhnikov E, Kulesskiy E, Ruuth MK, Soini Y, Sormunen RT, Khirug L, Vihko PT. Transmembrane prostatic acid phosphatase (TMPAP) interacts with snapin and deficient mice develop prostate adenocarcinoma. PLoS One 8:e73072, 2013.

Karvonen HM, Lehtonen ST, Harju T, Sormunen RT, Lappi-Blanco E, Mäkinen JM, Laitakari K, Johnson S, Kaarteenaho RL. Myofibroblast expression in airways and alveoli is affected by smoking and COPD. Respir Res 14:84-96, 2013.

Kerkelä R, Karsikas S, Szabo Z, Serpi R, Magga J, Gao E, Alitalo K, Anisimov A, Sormunen R, Pietilä I, Vainio L, Koch WJ, Kivirikko KI, Myllyharju J, Koivunen P. Activation of hypoxia response in endothelial cells contributes to ischemic cardioprotection. Mol Cell Biol 33:3321-3329, 2013.

Palomäki S, Pietilä M, Laitinen S, Pesälä J, Sormunen R, Lehenkari P, Koivunen P. HIF-1alpha is upregulated in human mesenchymal stem cells. Stem Cells 31:1902-1909, 2013.

Meriläinen S, Mäkelä J, Sormunen R, Alaoja Jensen H, Rimpiläinen R, Vakkala M, Rimpiläinen J, Ohtonen P, Koskenkari J, Koivukangas V, Karttunen T, Lehenkari P, Hassinen I, Juvonen T. Effect of acute pancreatitis on porcine intestine: a morphological study. Ultrastruct Pathol 37:127-138, 2013.

Hendrix A, Sormunen R, Westbroek W, Lambein K, Denys H, Sys G, Braems G, Van den Broecke R, Cocquyt V, Gespach C, Bracke M, De Wever O. Vacuolar H+ ATPase expression and activity is required for Rab27B-dependent invasive growth and metastasis of breast cancer. Int J Cancer 133:843-854, 2013.

Aikio M, Hurskainen M, Brideau G, Hägg P, Sormunen R, Heljasvaara R, Gould D, Pihlajaniemi T. Collagen XVIII short isoform is critical for retinal vascularization, and overexpression of the Tsp-1 domain affects eye growth and cataract formation. Invest Ophthalmol Vis Sci 54:7450-7462, 2013.

Project Vainio:

Cheddad A, Nord C, Hörnblad A, Prunskaite-Hyyryläinen R, Eriksson M, Georgsson F, Vainio SJ, Ahlgren U. Improving signal detection in emission optical projection tomography via single source multi-exposure image fusion. Opt Express 21:16584-16604, 2013.

Parviainen H, Schrade A, Kiiveri S, Prunskaite-Hyyryläinen R, Haglund C, Vainio S, Wilson DB, Arola J, Heikinheimo M. Expression of Wnt and TGF-beta pathway components and key adrenal transcription factors in adrenocortical tumors: association to carcinoma aggressiveness. Pathol Res Pract 209:503-509, 2013.

Heliot C, Desgrange A, Buisson I, Prunskaite-Hyyryläinen R, Shan J, Vainio S, Umbhauer M, Cereghini S. HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2. Development 140:873-885, 2013.

Andersson ER, Saltó C, Villaescusa JC, Cajanek L, Yang S, Bryjova L, Nagy II, Vainio SJ, Ramirez C, Bryja V, Arenas E. Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells. Proc Natl Acad Sci USA 12:110:E602-E610, 2013.

Chapters in Books:

Vainio S. “Kuoleman ja kuolemattomuuden biologia” (Caudeamus), 2013.

Junior Investigator Wei:

Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-binding specificities of human transcription factors. Cell 152:327-339, 2013.

Project Wierenga:

Biocenter Publications:

Kasaragod P, Schmitz W, Hiltunen JK, Wierenga RK. The isomerase and hydratase reaction mechanism of the crotonase active site of the multifunctional enzyme (type-1), as deduced from structures of complexes with 3S-hydroxy-acyl-CoA. FEBS J 280:3160-3175, 2013.

Venkatesan R and Wierenga RK. Structure of mycobacterial beta-oxidation trifunctional enzyme reveals its altered assembly and putative substrate channeling pathway. ACS Chem Biol 8:1063-1073, 2013.

Zhai X, Amyes TL, Wierenga RK, Loria JP, Richard JP. Structural mutations that probe the interactions between the catalytic and dianion activation sites at triosephosphate isomerase. Biochemistry 52:5928-5940, 2013.

Harijan RK, Kiema TR, Karjalainen MP, Janardan N, Murthy MR, Weiss MS, Michels PA, Wierenga RK. Crystal structures of SCP2-thiolases of Trypanosomatidae, human pathogens causing widespread tropical diseases: the importance for catalysis of the cysteine of the unique HDCF loop. Biochem J 455:119-130, 2013.

Anantharajan J, Koski MK, Kursula P, Hieta R, Bergmann U, Myllyharju J, Wierenga RK. The structural motifs for substrate binding and dimerization of the alpha subunit of collagen prolyl 4-hydroxylase. Structure 21:2107-2118, 2013.

Other Publications from the Biocenter Project:

Fukao T, Aoyama Y, Murase K, Hori T, Harijan RK, Wierenga RK, Boneh A, Kondo N. Development of MLPA for human ACAT1 gene and identification of a heterozygous Alu-mediated deletion of exons 3 and 4 in a patient with mitochondrial acetoacetyl-CoA thiolase (T2) deficiency. Mol Genet Metab 110:184-187, 2013.

Project Winqvist:

Meyer KB, O'Reilly M, Michailidou K, Carlebur S, Edwards SL, French JD et al. (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Kauppila S). Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1. Am J Hum Genet 93:1046-1060, 2013.

Nikkilä J, Parplys AC, Pylkäs K, Bose M, Huo Y, Borgmann K, Rapakko K, Nieminen P, Xia B, Pospiech H, Winqvist R. Heterozygous mutations in PALB2 cause DNA replication and damage response defects. Nat Commun 4:2578, 2013.

Haanpää M, Pylkäs K, Moilanen JS, Winqvist R. Evaluation of the need for routine clinical testing of PALB2 c.1592delT mutation in BRCA negative Northern Finnish breast cancer families. BMC Med Genet 14:82, 2013.

Justenhoven C, Obazee O, Winter S, Rabstein S, Lotz A, Harth V et al. (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M). The UGT1A6_19_GG genotype is a breast cancer risk factor. Front Genet 4:104, 2013.

Gaudet MM, Kuchenbaecker KB, Vijai J, Klein RJ, Kirchhoff T, McGuffog L et al. (incl. Winqvist R). Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. PLoS Genet 9:e1003173, 2013.

French JD, Ghoussaini M, Edwards SL, Meyer KB, Michailidou K, Ahmed S at al. (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M). Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers. Am J Hum Genet 92:489-503, 2013.

Garcia-Closas M, Couch FJ, Lindström S, Michailidou K, Schmidt MK, Brook MN et al. (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Kauppila S). Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet 45:392-398, 2013.

Bojesen SE, Pooley KA, Johnatty SE, Beesley J, Michailidou K, Tyrer JP et al. (incl. Winqvist R, Jukkola-Vuorinen A, Pylkäs K, Kauppila S). Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet 45:371-384, 2013.

Michailidou K, Hall P, Gonzalez-Neira A, Ghoussaini M, Dennis J, Milne RL et al. (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M). Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet 45:353-361, 2013.

Last updated: 18/11/2016