Publications 2014

Project Hiltunen:

Autio K J, Schmitz W, Nair RR,  Selkälä EM, Sormunen RT, Miinalainen IJ, Crick PJ, Wang Y, Griffiths WJ, Reddy JK, Baes M, Hiltunen JK. Role of AMACR (α-methylacyl-CoA racemase) and MFE-1 (peroxisomal multifunctional enzyme-1) in bile acid synthesis in mice. Biochem J 461(1):125-35, 2014.

Ding H, Li H, Liu P, Hiltunen JK, Wu Y, Chen Z, Shen J. Templated in-situ synthesis of gold nanoclusters conjugated to drug target bacterial enoyl-ACP reductase, and their application to the detection of mercury ions using a test stripe. Microchim Acta 181:1029-1034, 2014

Ding H, Liang C, Sun K, Wang H, Hiltunen J K, Chen Z, Shen J. Dithiothreitol-capped fluorescent gold nanoclusters: an efficient probe for detection of copper(II) ions in aqueous solution. Biosens Bioelectron, 59:216-220, 2014

Liu PC, Shang L, Li HW, Cui YX, Qin YM, Wu YQ, Hiltunen JK, Chen ZJ, Shen J. Synthesis of fluorescent alpha-chymotrypsin A-functionalized gold nanoclusters and their application to blot-based technology for Hg2+ detection. RSC Adv,  31536-31543, 2014. 

Suomi F, Menger KE, Monteuuis G, Naumann U, Kursu VA, Shvetsova A, Kastaniotis AJ. Expression and Evolution of the Non-Canonically Translated Yeast Mitochondrial Acetyl-CoA Carboxylase Hfa1p. PLoS One 2014 Dec 11;9(12):e114738, 2014

Vapola MH, Rokka A, Sormunen RT, Alhonen L, Schmitz W, Conzelmann E, Wärri A, Grunau S, Antonenkov VD, Hiltunen JK. Peroxisomal membrane channel Pxmp2 in the mammary gland fat pad is essential for stromal lipid homeostasis and development of mammary gland epithelium in mice. Dev Biol 391(1): 66-80, 2014

Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z.  Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase. Nat Commun 5:4805, 2014

Biocomputing Coordinator Juffer:

Beis I, Weckström M, Juffer AH, Hyvönen M. Effects of Diacylglycerols (DAGS) and Arachidonic Acid (AA) on the Physical Properties of Model Lipid Bilayers: A Molecular Dynamics Simulations Study. Biophys J 106:, 802A-802A, 2014.

Anbazhagan P, Harijan RK, Kiema TR, Janardan N, Murthy MR, Michels PA, Juffer AH, Wierenga RK. Phylogenetic relationships and classification of thiolases and thiolase-like proteins of Mycobacterium tuberculosis and Mycobacterium smegmatis. Tuberculosis 94:405-412, 2014.

Ruskamo S, Yadav R, Sharma S, Lehtimaki M, Laulumaa S, Aggarwal S, Simons M, Burck J, Ulrich A, Juffer AH, Kursula I, Kursula P. Atomic-resolution view into structure-function relationships of the human myelin peripheral membrane protein P2, Acta Crystallogr D 70:165-76, 2014.

Sharma S, Lensink MF, Juffer AH. The Structure of the CD3ςς Transmembrane Dimer in Lipid Bilayers. BBA - Biomembranes 1838:739–746, 2014.

Shinya S, Urasaki A, Ohnuma T,Taira T, Suzuki A, Ogata M, Usui T, Lampela O, Juffer AH, Fukamizo T. Interaction of di-N-acetylchitobiosyl moranoline with a family GH19 chitinase from moss, Bryum coronatum. Glycobiology 24:945-55, 2014.

Horbach T, Chi TF, Gotz C, Sharma S, Juffer AH, Dimova EY, Kietzmann T. GSK3β-Dependent phosphorylation alters DNA binding, transactivity and half-life of the transcription factor USF2. PLoS One 9(9):e107914, 2014.

Project Kietzmann:

Chi FT, Jensen JK, Kozlova N, Samoylenko A, Kietzmann T. PAI-1 modulates cell migration in a LRP1-dependent manner via β-catenin and ERK1/2. Thromb Haemost. in press.

Horbach T, Chi TF, Götz C, Sharma S, Juffer AH, Dimova EY, Kietzmann T. GSK3β-Dependent phosphorylation alters DNA binding, transactivity and half-life of the transcription factor USF2. PLoS One 9(9):e107914, 2014.

Horbach T, Goetz C, Kietzmann T, Dimova, EY. Protein kinases as switches for the function of upstream stimulatory factors (USFs) in cancer? Front Pharm. in press.

Kinnunen M, Karmenyanb, Särkeläa A, Dimova EY, Kietzmann T. Low-intensity light detection methods for selected biophotonic applications. Proc. SPIE 9421, Eighth International Conference on Advanced Optical Materials and Devices (AOMD-8), doi:10.1117/12.2084915; 2014

Konzack A, Kietzmann T. Manganese superoxide dismutase in carcinogenesis: friend or foe? Biochem Soc Trans. 42(4): 1012-1016, 2014.

Kozlova N, Samoylenko A, Drobot L, Kietzmann T. Urokinase is a negative modulator of Egf-dependent proliferation and motility in the two breast cancer cell lines MCF-7 and MDA-MB-231. Mol Cancerogenesis, in press.

Lupp S, Khadouma S, Horbach T, Dimova EY, Bohrer AM, Kietzmann T, Montenarh M, Götz C. The upstream stimulatory factor USF1 is regulated by protein kinase CK2 phosphorylation. Cell Signal 26(12):2809-2817, 2014.

Project Kursula:

Han H, Kursula P. Expression, purification, crystallization, and preliminary X-ray crystallographic analysis of the extracellular olfactomedin domain from gliomedin. Acta Crystallogr F 70(Pt11): 1536-1539, 2014. 

Han H, Kursula P. Periaxin and AHNAK nucleoprotein 2 form intertwined homodimers through domain swapping. J Biol Chem 289(20): 14121-14131, 2014.


Han H, Kursula P. The olfactomedin domain from gliomedin is a β-propeller with unique structural properties. J Biol Chem, in press.

Knoll W, Peters J, Kursula P, Gerelli Y, Natali F.Influence of myelin proteins on the structure and dynamics of a model membrane with emphasis on the low temperature regime. J Chem Phys 141(20): 205101, 2014. 

Knoll W, Peters J, Kursula P, Gerelli Y, Ollivier J, Demé B, Telling M, Kemner E, Natali F. Structural and dynamical properties of reconstituted myelin sheaths by myelin proteins MBP and P2 studied by neutron scattering. Soft Matter 10(3): 519-529, 2014.

Kursula P. Crystallographic snapshots of initial steps in the collapse of the calmodulin central helix. Acta Crystallogr D 70(Pt1): 24-30, 2014.


Kursula P. The many structural faces of calmodulin - a multitasking molecular jackknife. Amino Acids 46(10): 2295-2304, 2014.


Laulumaa S, Kursula P, Natali F. Neutron scattering studies on protein dynamics using the human myelin peripheral membrane protein P2. EPJ Web of Conferences, in press.

Onwukwe GU, Kursula P, Koski MK, Schmitz W, Wierenga RK. Human Δ3, Δ2-enoyl-CoA isomerase, type-2: a structural enzymology study on the catalytic role of its ACBP-domain and helix-10. FEBS J, in press.

Piirainen H, Hellman M, Tossavainen H, Permi P, Kursula P, Jaakola VP. Human adenosine A2A receptor binds calmodulin with high affinity in a calcium-dependent manner. Biophys J, in press.

Raasakka A, Kursula P. The myelin membrane-associated enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase: on a highway to structure and function. Neurosci Bull 30(6): 956-966, 2014.


Ruskamo S, Yadav R, Sharma S, Lehtimaki M, Laulumaa S, Aggarwal S, Simons M, Burck J, Ulrich A, Juffer AH, Kursula I, Kursula P. Atomic-resolution view into structure-function relationships of the human myelin peripheral membrane protein P2, Acta Crystallogr D 70:165-76, 2014.

Szambowska A, Tessmer I, Kursula P, Usskilat C, Prus P, Pospiech H,Grosse F. DNA binding properties of human Cdc45 suggest a function as a molecular wedge for DNA unwinding. Nucleic Acids Res 42(4): 2308-2319, 2014.


Zenker J, Stettner M, Ruskamo S, Domènech-Estévez E, Baloui H, Médard JJ, Verheijen MH, Brouwers JF, Kursula P, Kieseier BC, Chrast R. A role of peripheral myelin protein 2 in lipid homeostasis of myelinating Schwann cells. Glia 62(9): 1502-1512, 2014

Junior Investigator Lehtiö:

Haikarainen T, Krauss, S, Lehtiö L. Tankyrases: Structure, Function and Therapeutic Implications in Cancer. Curr Pharm Des 20(41):6472-6488, 2014.

Haikarainen T, Narwal M, Joensuu P, Lehtiö L. Evaluation and Structural Basis for the inhibition of Tankyrases by PARP Inhibitors. ACS Med Chem Lett 5(1):18-22, 2014

Haikarainen T, Frioux C, Zhnag LQ, Li DC, Papageorgiou AC. Crystal structure and biochemical characterization of a manganese superoxide dismutase from Chaetomium thermophilum. Biochim Biophys Acta 1844(2):422-429, 2014

Swarbrick CM, Roman N, Cowieson N, Patterson EI, Nanson J, Siponen MI, Berglund H, Lehtiö L, Forwood JK. Structural Basis for Regulation of the Human Acetyl-CoA Thioesterase 12 and Interactions with the Steroidogenic Acute Regulatory Protein-related Lipid Transfer (START) Domain. J Biol Chem 289(35):24263-24274, 2014

Project Manninen:

Huang Q, Whitington T, Gao P, Lindberg JF, Yang Y, Sun J, Väisänen MR, Szulkin R, Annala M, Yan J, Egevad LA, Zhang K, Lin R, Jolma A, Nykter M, Manninen A, Wiklund F, Vaarala MH, Visakorpi T, Xu J, Taipale J, Wei GH. A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding. Nat Genet 46(2):126-135, 2014.

Junttila S, Saarela U, Halt K, Manninen A, Pärssinen H, Lecca RM, Brandli AW, Sims-Lucas S, Skovorodkin I, Vainio SJ. Functional genetic targeting of the embryonic kidney progenitor cells ex vivo. J Am Soc Nephrol, in press.

Manninen A. Epithelial polarity - generating and integrating signals from the ECM with integrins. Exp Cell Res, in press.

Project Myllyharju:

Jokinen E, Laurila N, Koivunen P, Koivunen JP. Combining targeted drugs to overcome and prevent resistance of solid cancers with some stem-like cell features. Oncotarget 5(19):9295-9307, 2014.

Kaasinen E, Rahikkala E, Koivunen P, Miettinen S, Wamelink MM, Aavikko M, Palin K, Myllyharju J, Moilanen JS, Pajunen L, Karhu A, Aaltonen LA. Clinical characterization, genetic mapping and whole-genome sequence analysis of a novel autosomal recessive intellectual disability syndrome. Eur J Med Genet 57:543-551, 2014.

Kutchuk L*, Laitala A*, Soueid-Bomgarten S, Shentzer P, Rosendahl A-H, Eilot S, Grossman M, Sagi I, Sormunen R, Myllyharju J, Mäki JM, Hasson P. Muscle composition is regulated by a lysyl oxidase-transforming growth factor beta feedback loop. Development 2015, in press. (*Equal contribution).

Lorenzo FR*, Huff C*, Myllymäki M*, Olenchock B, Swierczek S, Tashi T, Gordeuk V, Wuren T, Ri-Li G, McClain DA, Khan TM, Koul PA, Guchhait P, Salama ME, Xing J, Semenza GL, Liberzon E, Wilson A, Simonson TS, Jorde LB, Kaelin WG Jr, Koivunen P#, Prchal JT#. A genetic mechanism for Tibetan high-altitude adaptation. Nat Genet 46:951-956, 2014. (* and #, equal contributions).

Loukovaara S, Koivunen P, Inglés M, Escobar J, Vento M, Andersson S. Elevated protein carbonyl and HIF-1α levels in eyes with proliferative diabetic retinopathy. Acta Ophthalmol 92:323-327, 2014.

Myllyharju J. Collagen Hydroxylases. In: 2-Oxoglutarate-Dependent Dioxygenases. RSC Metallobiology Series No. 3., p. 149-168. Editors Hausinger RP , Schofield CJ. The Royal Society of Chemistry 2015, in press.

Myllyharju J. Extracellular matrix and developing growth plate. Curr Osteoporos Rep 12:439-445, 2014. (Invited review).

Rahtu-Korpela L, Karsikas S, Hörkkö S, Blanco Sequeiros R, Lammentausta E, Mäkelä KA, Herzig KH, Walkinshaw G, Kivirikko KI, Myllyharju J, Serpi R, Koivunen P. HIF prolyl 4-hydroxylase-2 inhibition improves glucose and lipid metabolism and protects against obesity and metabolic dysfunction. Diabetes 63:3324-3333, 2014.

Zheng X, Zhai B, Koivunen P, Shin SJ, Lu G, Liu J, Geisen C, Chakraborty AA, Moslehi JJ, Smalley DM, Wei X, Chen X, Chen Z, Beres JM, Zhang J, Tsao JL, Brenner MC, Zhang Y, Fan C, DePinho RA, Paik J, Gygi SP, Kaelin WG Jr, Zhang Q. Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase. Genes Dev 28:1429-1444, 2014.

Project MÄNNIKKÖ:

Eskola P, Männikkö M, Samartzis D, Karppinen J. Genome-wide association studies of lumbar disc degeneration -are we there yet? Spine J 14:479-482, 2014.

Hietikko E, Sorri M, Männikkö M, Kotimäki J. Higher prevalence of autoimmune diseases and longer spells of vertigo in patients affected with familial Meniere's disease: A clinical comparison of familial and sporadic Meniere's disease. Am J Audiol 23:232-7, 2014.

Project Pihlajaniemi:

Aikio M, Elamaa H, Vicente D, Izzi V, Kaur I, Seppinen L, Speedy HE, Kaminska D, Kuusisto S, Sormunen R, Heljasvaara R, Jones EL, Muilu M, Jauhiainen M, Pihlajamäki J, Savolainen MJ, Shoulders CC, Pihlajaniemi T. Specific collagen XVIII isoforms promote adipose tissue accrual via mechanisms determining adipocyte number and affect fat deposition. Proc Natl Acad Sci USA 111:E3043-52, 2014

Bayramoglu N, Kaakinen M, Eklund L, Åkerfelt M, Nees M, Kannala J, and Heikkilä J. Detection of tumor cell spheroids from co-cultures using phase contrast images and machine learning approach, International Conference on Pattern Recognition (ICPR 2014), 2014

Rygh BC, Løkka G, Heljasvaara R, Pavlin T, Taxt T, Sormunen R, Pihlajaniemi T, Curry F-R.E, Tenstad O, and Reed RK. Image-based assessment of microvascular function and structure in collagen XV and XVIII deficient mice. J Physiol 592:325-336, 2014

D’Amico G, Korhonen EA, Anisimov A, Zarkada G, Holopainen T, Hägerling R, Kiefer F, Elamaa H, Eklund L, Sormunen R, Brekken RA, Adams RH, Koh GY, Saharinen P, and Alitalo K. Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy. J Clin Invest 124:824-834, 2014

Heikkinen A, Pihlajaniemi T, Faissner A, Yuzaki M. Neural ECM and synaptogenesis. Prog Brain Res 214:29-51, 2014

Kaakinen M*, Huttunen S*, Paavolainen L, Marjomäki V, Heikkilä J, and Eklund L. Automatic detection and analysis of cell motility in phase-contrast time-lapse images using a combination of maximally stable extremal regions and Kalman filter approaches. J Microscopy 253:65-78, 2014*Equal contribution.

Kantola T, Väyrynen JP, Klintrup K, Mäkelä J, Karppinen SM, Pihlajaniemi T, Autio-Harmainen H, Karttunen TJ, Mäkinen MJ, Tuomisto A. Serum endostatin levels are elevated in colorectal cancer and correlate with invasion and systemic inflammatory markers. Br J Cancer 111:1605-1613, 2014

Kivelä R, Bry M, Taavitsainen M, Robciuc M, Silvola J, Saraste A, Hulmi J, Anisimov A, Eklund L, Hellberg S, Hlushchuk R, Zhuang Z, Simons M, Djonov V, Knuuti J, Mervaala E, Alitalo K. VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart. EMBO Molecular Medicine 6:307-321, 2014

Ullah Akram S, Kannala J, Kaakinen M, Eklund L, and Heikkilä J. Segmentation of cells from spinning disk confocal images using a multi-stage approach, Asian Conference on Computer Vision (ACCV 2014), 2014

Zaferani A, Talsma DT, Yazdani S, Celie JW, Aikio M, Heljasvaara R, Navis GJ, Pihlajaniemi T, van den Born J. Basement membrane zone collagens XV and XVIII/proteoglycans mediate leukocyte influx in renal ischemia/reperfusion. PLoS One, 9:e106732, 2014

Zainul Z. Terminal schwann cells lead synapse remodelling following injury. (Commentary article), eNeuro 1(1), 2014

Buler M, Aatsinki SM, Izzi V, Uusimaa J, Hakkola J. SIRT5 is under the control of PGC-1α and AMPK and is involved in regulation of mitochondrial energy metabolism. FASEB J 28:3225-3237, 2014

Zainul Z. Positive regulatory genes in peripheral axon regeneration and functional recovery following injury. Am J Neuroprotec Neuroregen 6:4–9, 2014. (Review article)

Project Ruddock:

Alanen HI, Walker KL, Lourdes Velez Suberbie M, Matos CF, Bönisch S, Freedman RB, Keshavarz-Moore E, Ruddock LW,Robinson C. Efficient export of human growth hormone, interferon a2b and antibody fragments to the periplasm be the Escherichia coli Tat pathway in the absence of prior disulfide bond formation. Biochim Biophys Acta 1854:(3):756-63, 2015

Irvine AG, Wallis AK, Sanghera N, Rowe ML, Ruddock LW, Howard MJ, Williamson RA, Blindauer CA, Freedman RB. Protein disulfide-isomerase interacts with a substrate protein at all stages along its folding pathway. PLoS One 9:e82511, 2014

Kummu O, Turunen SP, Prus P, Lehtimäki J, Veneskoski M, Wang C, Hörkkö S. Human monoclonal Fab and human plasma antibodies to carbamyl epitopes cross-react with malondialdehyde-adducts. Immunology 141: 416-430, 2014

Matos CF, Robinson C, Alanen HI, Prus P, Uchida Y, Ruddock LW, Freedman RB, Keshavarz-Moore E. Efficient export of prefolded, disulfide-bonded recombinant proteins to the periplasm by the Tat pathway in Escherichia coli CyDisCo strains. Biotechnol Prog 30:281-290, 2014.

Szambowska A, Tessmer I, Kursula P, Usskilat C, Prus P, Pospiech H,Grosse F. DNA binding properties of human Cdc45 suggest a function as a molecular wedge for DNA unwinding. Nucleic Acids Res 42(4): 2308-2319, 2014.


Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z.  Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase. Nat Commun 5:4805, 2014

Project Savolainen/Herzig/Järvelin:

Albrecht E*, Sillanpää E*, Karrasch S*, Alves AC*, Järvelin MR*, Schultz H*,et al . Telomere length in circulating leukocytes is associated with lung function and disease. Eur Respir J 43, 983-992, 2014 (*Equal contribution).

Bolton JL, et al (encl. Järvelin MR). Genome wide association identifies common variants at the SERPINA6/SERPINA1 locus influencing plasma cortisol and corticosteroid binding globulin. PLoS Genet 10: e1004474, 2014.

Brader L, Reinmark L, Carlberg C, Schwab U, Kolehmainen M, Rosqvist F, Cloetens L, Johansson-Persson A, Gunnarsdottir I, Poutanen K, Herzig KH, Risérus U, Savolainen MJ, Thorsdottir I, Uusitupa M, Hermansen K. Effects of a healthy Nordic diet on plasma 25-hydroxyvitamin D in subjects with metabolic syndrome: a randomized, place-controlled  trial (SYSDIET). Eur J Nutr 53(4):1123-34, 2014.

Buxton JL, Das S, Rodriguez A, Kaakinen M, Couto Alves A, Sebert S, Millwood IY, Laitinen J, O'Reilly PF, Jarvelin MR, Blakemore AI. Multiple measures of adiposity are associated with mean leukocyte telomere length in the northern Finland birth cohort 1966. PLoS One 9(6):e99133, 2014.

Canoy D, Barber TM, Pouta A, Hartikainen AL, McCarthy MI, Franks S, Jarvelin MR, Tapanainen JS, Ruokonen A, Huhtaniemi IT, Martikainen H. Serum sex hormone-binding globulin and testosterone in relation to cardiovascular disease risk factors in young men: a population-based study. Eur J Endocrinol 170:863-872, 2014.

Dellschaft NS, Alexandre-Gouabau MC, Gardner DS, Antignac JP, Keisler DH, Budge H, Symonds ME, Sebert SP. Effect of pre- and postnatal growth and post-weaning activity on glucose metabolism in the offspring. J Endocrinol 224:171-182, 2015.

Gagnon DD, Gagnon SS, Rintamäki H, Törmäkangas T, Puukka K, Herzig KH, Kyröläinen H. The effects of cold exposure on leukocytes, hormones and cytokines during acute exercise in humans. PloS One 9(10):e110774, 2014.

Gagnon DD, Rintamäki H, Gagnon SS, Oksa J, Porvari K, Cheung SS, Herzig KH, Kyröläinen H. Fuel selection during short-term submaximal treadmill exercise in the cold is not affected by pre-exercise low-intensity shivering. Appl Physiol Nutr Metab 39: 282-91, 2014.

Graversen L, Sorensen TI, Gerds TA, Petersen L, Sovio U, Kaakinen M, Sandbaek A, Laitinen J, Taanila A, Pouta A, Jarvelin MR, Obel C. Prediction of adolescent and adult adiposity outcomes from early life anthropometrics. Obesity 23:162-169, 2015.

Graversen L, Sorensen TI, Petersen L, Sovio U, Kaakinen M, Sandbaek A, Laitinen J, Taanila A, Pouta A, Jarvelin MR, Obel C. Preschool weight and body mass index in relation to central obesity and metabolic syndrome in adulthood. PLoS One 9:e89986, 2014

Graversen L, Sorensen TI, Petersen L, Sovio U, Kaakinen M, Sandbaek A, Laitinen J, Taanila A, Pouta A, Jarvelin MR, Obel C. Stability of the associations between early life risk indicators and adolescent overweight over the evolving obesity epidemic. PLoS One 9:e95314, 2014.

Herzig KH, Ahola R, Leppäluoto J, Jokelainen J, Jämsä T, Keinänen-Kiukaanniemi S. Light physical activity determined by a motion sensor decreases insulin resistance, improves lipid homeostasis and reduces visceral fat in high risk subjects: PreDiabEx study RCT. Int J Obes 38(8):1089-96, 2014.

Hintsala H, Kandelberg A, Herzig KH, Rintamäki H, Mäntysaari M, Rantala A, Keinnänen-Kiukaanniemi S, Jaakkola JJ, Ikäheimo TM. Central aortic blood pressure of hypertensive men during short-term cold exposure. Am J Hypertens 27: 656-64, 2014.

Hintsala H, Kentta TV, Tulppo M, Kiviniemi A, Hukkuri HV, Mäntysaari M, Keinnänen-Kiukaanniemi S, Bloigu R, Herzig KH, Antikainen R, Jaakkola JJK, Rintamäki H, Ikäheimo TM. Cardic repolarization and autonomic regulation during short-term cold exposue in hypertensive men: An experimental study. PloS One 9(7):e99973, 2014.

Hoggart CJ, et al. Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index. PLoS Genet 10, e1004508.

Jääskelainen A, Nevanperä N, Remes J, Rahkonen F, Järvelin MR, Laitinen J. Stress-related eating, obesity and associated behavioural traits in adolescents: a prospective population-based cohort study. BMC Public Health 14.321, 2014.

Kaakinen M, Sovio U, Hartikainen AL, Pouta A, Savolainen MJ, Herzig KH, Elliott P, De Stavola B, Läärä E, Järvelin MR. Life course structural equation model of the effects of prenatal and postnatal growth on adult blood pressure. J Epidemiol Community Health 68:1161-1167, 2014.

Kaminska D, Hämäläinen M, Cederberg H, Käkelä P, Venesmaa S, Miettinen P, Ilves I, Herzig KH, Kolehmainen M, Karhunen L, Kuusisto J, Gylling H, Laakso M, Pihlajamäki J. Adipose tissue INSR splicing in humans associates with fasting insulin level and is regulated by weight loss. Diabetologia 57:347-51, 2014.

Khalife N, Kantomaa M, Glover V, Tammelin T, Laitinen J, Ebeling H, Hurtig T, Jarvelin MR, Rodriguez A. Childhood attention-deficit/hyperactivity disorder symptoms are risk factors for obesity and physical inactivity in adolescence. J Am Acad Child Adolesc Psychiatry 53:425-436, 2014.

Kinnunen S, Mänttäri S, Herzig KH, Nieminen P, Mustonen AM, Saarela S. Maintenance of skeletal muscle energy homeostasis during prolonged wintertime fasting in the raccoon dog (Nyctereutes procynoides). J Comp Physiol B. in press.

Kobayashi H, Isohanni M, Jääskelainen E, Miettunen J, Veijola J, Haapea M, Järvelin MR, Jones PB, Murray GK. Linking the developmental and degenerative theories of schizophrenia: association between infant development and adult cognitive decline. Schizophr Bull 40:1319-1327, 2014.

Kolehmainen M, Ulven SM, Paananen J, Laaksonen de Mello V, Schwab U, Carlberg C, Myhrstad M, Pihlajamäki J, Dungner E, Gunnarsdottir I, Cloetens L, Landi-Olsson M, Åkesson B, Rosqvist F, Hukkanen J, Herzig KH, Dragsted LO, Savolainen MJ, Brader L, Hermansen K, Risérus U, Thorsdottir I, Poutanen K, Uusitupa M, Arner P, Dahlman I. A healthy Nordic diet down-regulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome. Am J Clin Nutr 101:228-39, 2015.

Lotfipour S, Ferguson E, Leonard G, Miettunen J, Perron M, Pike GB, Richer L, Seguin JR, Veillette S, Järvelin MR, Moilanen I, Mäki P, Nordström T, Pausova Z, Veijola J, Paus T. Maternal cigarette smoking during pregnancy predicts drug use via externalizing behavior in two community-based samples of adolescents. Addiction 109:1718-1729, 2014.

Loth DW, et al (incl Järvelin MR). Genome-wide association analysis identifies six new loci associated with forced vital capacity. Nat Genet 46:669-677, 2014.

Magnusdottir OK, Landberg R, Gunnarsdottir I, Cloetens L, Åkesson B, Landin-Olsson M, Rosqvist F, Iggman D, Schwab U, Herzig KH, Hukkanen K, Savolainen MJ, Brader L, Hermansen K, Kolehmainen M, Poutanen K, Uusitupa M, Risérus U, Thorsdottir I. Whole grain rye intake, reflected by a biomarker, is associated with favorable blood lipid outcomes in subjects with the metabolic syndrome - a randomized study. PloS One 9(10):e110827, 2014.

Magnusdottir OK, Landberg R, Gunnarsdóttir I, Cloetens L, Åkesson B, Landin-Olsson M, Rosqvist F, Iggman D, Schwab U, Herzig KH, Savolainen MJ, Brader L, Hermansen K, Kolehmainen M, Poutanen K, Uusitupa M, Thorsdottir I, Risérus U. Plasma alkylresorcinols C17:0/C21:0 ratio, a biomarker of relative whole-grain rye intake, is associated to insulin sensitivity: a randomized study. Eur J Clin Nutr 68: 453-8, 2014.

Marklund M, Magnusdottir OK, Rosqvist F, Cloetens L, Landberg R, Kolehmainen M, Brader L, Hermansen K, Poutanen KS, Herzig KH, Savolainen MJ, Dragsted LO, Schwab U, Paananen J, Uusitupa M, Åkesson B, Thorsdottir I, Risérus U. A dietary biomarker approach captures compliance and cardiometabolic effects of a prudent Nordic diet in subjects with metabolic syndrome. J Nutr 144(10):1642-9, 2014.

Marttinen P, Pirinen M, Sarin AP, Gillberg J, Kettunen J, Surakka I, Kangas AJ, Soininen P, O'Reilly P, Kaakinen M, Kähönen M, Lehtimäki T, Ala-Korpela M, Raitakari OT, Salomaa V, Jarvelin MR, Ripatti S, Kaski S. Assessing multivariate gene-metabolome associations with rare variants using Bayesian reduced rank regression. Bioinformatics 30:2026-2034, 2014.

Miettunen J, Murray GK, Jones PB, Mäki P, Ebeling H, Taanila A, Joukamaa M, Savolainen J, Törmänen S, Järvelin MR, Veijola J, Moilanen I. Longitudinal associations between childhood and adulthood externalizing and internalizing psychopathology and adolescent substance use. Psychol Med 44:1727-1738, 2014.

Mutt, S.J., Hypponen, E., Saarnio, J., Jarvelin, M.R. & Herzig, K.H. 2014. Vitamin D and adipose tissue-more than storage. Front Physiol 5:228, 2014.

Mykkänen OT, Huotari A, Herzig KH, Dunlop T, Mykkänen H, Törrönen R, Kirjavainen PV. Wild Blueberries (Vaccinium myrtillus) alleviate inflammation and hypertension associated with developing obesity in mice fed with a high-fat diet. PloS One 9(12):e114790, 2014.

Nyholt DR for the International Headache Genetics Consortium et al (incl Järvelin MR). Concordance of genetic risk across migraine subgroups: Impact on current and future genetic association studies. Cephalalgia, in press.

Päkkilä F, Männistö T, Pouta A, Hartikainen AL, Ruokonen A, Surcel HM, Bloigu A, Vääräsmäki M, Järvelin MR, Moilanen I, Suvanto E. The impact of gestational thyroid hormone concentrations on ADHD symptoms of the child. J Clin Endocrinol Metab 99:E1-8, 2014.

Perry JR et al (incl Järvelin MR). Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature 514: 92-97, 2014.

Pillas D, Kaakinen M, Tzoulaki I, Netuveli G, Rodriguez A, Fung E, Tammelin TH, Blane D, Millwood IY, Hardy R, Sovio U, Pouta A, Hopstock LA, Hartikainen AL, Laitinen J, Vaara S, Khan AA, Chong R, Elliott P, Järvelin MR. Infant locomotive development and its association with adult blood pressure. Eur J Pediatr 173:1309-1317, 2014.

Pinola P, Morin-Papunen LC, Bloigu A, Puukka K, Ruokonen A, Jarvelin MR, Franks S, Tapanainen JS, Lashen H. Anti-Müllerian hormone: correlation with testosterone and oligo- or amenorrhoea in female adolescence in a population-based cohort study. Hum Reprod 29:2317-2325, 2014.

Rahtu-Korpela L, Karsikas S, Hörkkö S, Blanco Sequeiros R, Lammentausta E, Mäkelä KA, Herzig KH, Walkinshaw G, Kivirikko KI, Myllyharju J, Serpi R, Koivunen P. HIF prolyl 4-hydroxylase-2 inhibition improves glucose and lipid metabolism and protects against obesity and metabolic dysfunction. Diabetes 63:3324-3333, 2014.

Ramos A, Rodriguez-Seoane C, Rosa I, Trossbach SV, Ortega-Alonso A, Tomppo L, Ekelund J, Veijola J, Järvelin MR, Alonso J, Veiga S, Sawa A, Hennah W, Garcia A, Korth C, Requena JR. Neuropeptide precursor VGF is genetically associated with social anhedonia and underrepresented in the brain of major mental illness: its downregulation by DISC1. Hum Mol Genet 23:5859-5865, 2014.

Sebert S, Salonurmi T, Keinänen-Kiukaanniemi S, Savolainen M, Herzig KH, Symonds ME, Järvelin MR. Programming effects of FTO in the development of obesity. Acta Physiol 210:58-69, 2014.

Service SK et al (incl Järvelin MR). Re-sequencing expands our understanding of the phenotypic impact of variants at GWAS loci. PLoS Genet 10: e1004147, 2014.

Sipola-Leppänen M, Vääräsmäki M, Tikanmäki M, Hovi P, Miettola S, Ruokonen A, Pouta A, Järvelin MR, Kajantie E. Cardiovascular risk factors in adolescents born preterm. Pediatrics 134:e1072-81, 2014.

Solmi F, Sonneville KR, Easter A, Horton NJ, Crosby RD, Treasure J, Rodriguez A, Järvelin MR, Field AE, Micali N. Prevalence of purging at age 16 and associations with negative outcomes among girls in three community-based cohorts. J Child Psychol Psychiatry 56:87-96, 2015.

Sovio U, Kaakinen M, Tzoulaki I, Das S, Ruokonen A, Pouta A, Hartikainen AL, Molitor J, Järvelin MR. How do changes in body mass index in infancy and childhood associate with cardiometabolic profile in adulthood? Findings from the Northern Finland Birth Cohort 1966 Study. Int J Obes 38:53-59, 2014.

St Pourcain B et al (incl Järvelin MR). Common variation near ROBO2 is associated with expressive vocabulary in infancy. Nat Commun 5:4831, 2014.

Tanner T, Kämppi A, Päkkilä J, Järvelin MR, Patinen P, Tjäderhane L, Anttonen V. Association of smoking and snuffing with dental caries occurrence in a young male population in Finland: a cross-sectional study. Acta Odontol Scand 72:1017-1024, 2014.

Taylor AE et al (incl Järvelin MR). Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium. BMJ Open 4:e006141, 2014.

Taylor AE et al (incl Järvelin MR). Stratification by Smoking Status Reveals an Association of CHRNA5-A3-B4 Genotype with Body Mass Index in Never Smokers. PLoS Genet 10:e1004799, 2014.

The Coffee and Caffeine Genetics Consortium et al (incl Järvelin MR). Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Mol Psychiatry, in press.

Tukiainen T, Pirinen M, Sarin AP, Ladenvall C, Kettunen J, Lehtimaki T, Lokki ML, Perola M, Sinisalo J, Vlachopoulou E, Eriksson JG, Groop L, Jula A, Järvelin MR, Raitakari OT, Salomaa V, Ripatti S. Chromosome X-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage compensation. PLoS Genet 10:e1004127, 2014.

Valcarcel B, Ebbels TM, Kangas AJ, Soininen P, Elliot P, Ala-Korpela M, Järvelin MR, de Iorio M. Genome metabolome integrated network analysis to uncover connections between genetic variants and complex traits: an application to obesity. J R Soc Interface 11:20130908, 2014.

van der Valk RJ et al (incl Järvelin MR). A novel common variant in DCST2 is associated with length in early life and height in adulthood. Hum Mol Genet 24(4):1155-68, 2015.

van Leeuwen EM et al (incl Järvelin MR). The challenges of genome-wide interaction studies: lessons to learn from the analysis of HDL blood levels. PLoS One 9:e109290, 2014.

Verweij KJ, Abdellaoui A, Veijola J, Sebert S, Koiranen M, Keller MC, Järvelin MR, Zietsch BP. The association of genotype-based inbreeding coefficient with a range of physical and psychological human traits. PLoS One 9:e103102, 2014.

West S, Lashen H, Bloigu A, Franks S, Puukka K, Ruokonen A, Järvelin MR, Tapanainen JS, Morin-Papunen L.  Irregular menstruation and hyperandrogenaemia in adolescence are associated with polycystic ovary syndrome and infertility in later life: Northern Finland Birth Cohort 1986 study. Hum Reprod 29:2339-2351, 2014.

West S, Vähäsarja M, Bloigu A, Pouta A, Franks S, Hartikainen AL, Järvelin MR, Corbett S, Vääräsmäki M, Morin-Papunen L. The impact of self-reported oligo-amenorrhea and hirsutism on fertility and lifetime reproductive success: results from the Northern Finland Birth Cohort 1966. Hum Reprod 29:628-633, 2014.

Vimaleswaran KS et al (incl Järvelin MR).  Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study. Lancet Diabetes Endocrinol 2:719-729, 2014.

Vimaleswaran KS, Cavadino A, Berry DJ, Mangino M, Andrews P, Moore JH, Spector TD, Power C, Järvelin MR, Hyppönen E. Interaction between allelic variations in vitamin D receptor and retinoid X receptor genes on metabolic traits. BMC Genet 15: 37, 2014.

Wood AR et al (incl Järvelin MR). Defining the role of common variation in the genomic and biological architecture of adult human height. Nat Genet 46:1173-1186, 2014.

Wurtz P et al (incl Järvelin MR). Metabolic signatures of adiposity in young adults: mendelian randomization analysis and effects of weight change. PLoS Med 11:e1001765, 2014.

Vähätalo LH, Ruohonen ST, Mäkelä S, Kovalainen M, Huotari A, Mäkelä KA, Määttä JA, Miinalainen I, Gilsbach R, Hein L, Ailanen L, Mattila M, Eerola K, Röyttä M, Ruohonen S, Herzig KH, Savontaus E. Neuropeptide Y in the noradrenergic neurones induces obesity and inhibits sympathetic tone in mice. Acta Physiol, in press.

Project Savolainen / Sillanpää:

Avia K, Kärkkäinen K, Lagercrantz U, Savolainen O. Association of FLOWERING LOCUS T/TERMINAL FLOWER 1-like gene FTL2 expression with growth rhythm in Scots pine (Pinus sylvestris). New Phytol 204:159-170, 2014.

Castaings L, Bergonzi S, Albani MC, Kemi U, Savolainen O, Coupland G. Evolutionary conservation of cold-induced antisense RNAs of FLOWERING LOCUS C in Arabidopsis thaliana perennial relatives. Nat Commun 5:4457, 2014.

He L, Pitkäniemi J, Sarin A-P, Salomaa V, Sillanpää MJ, Ripatti S. Hierarchical Bayesian model for rare variant association analysis integrating genotype uncertainty in human sequence data. Genet Epidemiol 39:89-100, 2015.

He L, Sillanpää MJ, Ripatti S, Pitkäniemi J. Bayesian latent variable collapsing model for detecting rare variant interaction effect in twin study. Genet Epidemiol 38:310-324, 2014.

Khazaei H, O'Sullivan DM, Jones H, Sillanpää MJ, Pärssinen P, Manninen O, Stoddard FL. Flanking SNP markers for vicine-convicine concentration in faba bean (Vicia faba L.). Mol Breed 35:38, 2015.

Khazaei H, O'Sullivan DM, Sillanpää MJ, Stoddard FL. Genetic analysis reveals a novel locus in Vicia faba L. decoupling pigmentation in the flower from that in the extra-floral nectaries. Mol Breed 34: 1507-1513, 2014.

Khazaei H, O'Sullivan DM, Sillanpää MJ, Stoddard FL. Use of synteny to identify candidate genes underlying QTL controlling stomatal traits in faba bean (Vicia faba L.). Theor Appl Genet 127: 2371-2385, 2014.

Li Z, Hallingbäck HR, Abrahamsson S, Fries A, Andersson Gull B, Sillanpää MJ, Garcia-Gil MR. Functional multi-locus QTL mapping of temporal trends in Scots pine wood traits. G3 4:2365-2379, 2014.

Makgahlela ML, Strandén I, Nielsen US, Sillanpää MJ, Mäntysaari EA. Using the unified relationship matrix adjusted by breed-wise allele frequencies in genomic evaluation of a multibreed population. J Dairy Sci 97:1117-1127, 2014.

Mathew B, Leon J, Sillanpää MJ. INLA inference and cross-validation to learn variance components in breeding value estimation. Molecular Breeding, in press.

Pasanen L, Holmström L, Sillanpää MJ. Bayesian LASSO, scale space and decision making in association genetics. PLoS ONE, in press.

Pikkuhookana P and Sillanpää MJ. Combined linkage disequilibrium and linkage mapping: Bayesian multilocus approach. Heredity 112:351-360, 2014.

Toivainen T, Pyhäjärvi T, Niittyvuopio A, Savolainen O. A recent local sweep at the PHYA locus in the Northern European Spiterstulen population of Arabidopsis lyrata. Mol Ecol 23:1040-1052, 2014.

Zhou Y, Zhang L, Liu J, Wu G, Savolainen O. Climatic adaptation and ecological divergence between two closely related pine species in Southeast China. Mol Ecol 23:3504-3522, 2014.

Transgenic Facility Coordinator Soininen:

Hurskainen T, Kokkonen N, Sormunen R, Jackow J, Löffek S, Soininen R, Franzke CW, Bruckner-Tuderman L, Tasanen K. Deletion of the Major Bullous Pemphigoid Epitope Region of Collagen XVII Induces Blistering, Autoimmunization, and Itching in Mice. J Invest Dermatol, in press.

INFRAFRONTIER Consortium. INFRAFRONTIER - providing mutant mouse resources as research tools for the international scientific community. Nucleic Acids Res 43:D1171-5, 2015

Colombelli C, Palmisano M, Eshed-Eisenbach Y, Zambroni D, Pavoni E, Ferri C, Saccucci S, Nicole S, Soininen R, McKee KK, Yurchenco PD, Peles E, Wrabetz L, Feltri ML. Perlecan is recruited by dystroglycan to nodes of Ranvier and binds the clustering molecule gliomedin.  J Cell Biol 208:313-329, 2015

Yeung CY, Taylor SH, Garva R, Holmes DF, Zeef LA, Soininen R, Boot-Handford RP, Kadler KE. Arhgap28 is a RhoGAP that inactivates RhoA and downregulates stress fibers. PLoS One 9(9):e107036, 2014

Vaicik MK, Thyboll Kortesmaa J, Movérare-Skrtic S, Kortesmaa J, Soininen R, Bergström G, Ohlsson C, Chong LY, Rozell B, Emont M, Cohen RN, Brey EM, Tryggvason K. Laminin α4 deficient mice exhibit decreased capacity for adipose tissue expansion and weight gain. PLoS One 9(10):e109854, 2014.

EM Microscopy Coordinator Sormunen:

Aikio M, Elamaa H, Vicente D, Izzi V, Kaur I, Seppinen L, Speedy HE, Kaminska D, Kuusisto S, Sormunen R, Heljasvaara R, Jones EL, Muilu M, Jauhiainen M, Pihlajamäki J, Savolainen MJ, Shoulders CC, Pihlajaniemi T. Specific collagen XVIII isoforms promote adipose tissue accrual via mechanisms determining adipocyte number and affect fat deposition. Proc Natl Acad Sci USA 111:E3043-52, 2014

Autio K J, Schmitz W, Nair RR,  Selkälä EM, Sormunen RT, Miinalainen IJ, Crick PJ, Wang Y, Griffiths WJ, Reddy JK, Baes M, Hiltunen JK. Role of AMACR (α-methylacyl-CoA racemase) and MFE-1 (peroxisomal multifunctional enzyme-1) in bile acid synthesis in mice. Biochem J 461(1):125-35, 2014.

Bur H, Haapasaari KM, Turpeenniemi-Hujanen T, Kuittinen O, Auvinen P, Marin K, Koivunen P, Sormunen R, Soini Y, Karihtala P. Oxidative stress markers and mitochondrial antioxidant enzyme expression are increased in aggressive Hodgkin lymphomas. Histopathology 65(3):319-27, 2014.

D’Amico G, Korhonen EA, Anisimov A, Zarkada G, Holopainen T, Hägerling R, Kiefer F, Elamaa H, Eklund L, Sormunen R, Brekken RA, Adams RH, Koh GY, Saharinen P, and Alitalo K. Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy. J Clin Invest 124:824-834, 2014

Hurskainen T, Kokkonen N, Sormunen R, Jackow J, Löffek S, Soininen R, Franzke CW, Bruckner-Tuderman L, Tasanen K. Deletion of the Major Bullous Pemphigoid Epitope Region of Collagen XVII Induces Blistering, Autoimmunization, and Itching in Mice. J Invest Dermatol, in press.

Ihermann-Hella A, Lume M, Miinalainen IJ, Pirttiniemi A, Gui Y, Peränen J, Charron J, Saarma M, Costantini F, Kuure S. Mitogen-activated protein kinase (MAPK) pathway regulates branching by remodeling epithelial cell adhesion. PLoS Genet 10(3):e1004193, 2014

Van Deun J, Mestdagh P, Sormunen R, Cocquyt V, Vermaelen K, Vandesompele J, Bracke M, De Wever O, Hendrix A. The impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling.  J Extracell Vesicles 3:10.3402/jev.v3.24858., 2014.

Karvonen HM, Lehtonen ST, Sormunen RT, Lappi-Blanco E, Sköld CM, Kaarteenaho RL. Lung cancer-associated myofibroblasts reveal distinctive ultrastructure and function. J Thorac Oncol 9(5):664-74, 2014

Lehtonen ST, Karvonen HM, Harju T, Sormunen R, Lappi-Blanco E, Hilli M, Risteli J, Merikallio H, Kaarteenaho R. Stromal cells can be cultured and characterized from diagnostic bronchoalveolar fluid samples obtained from patients with various types of interstitial lung diseases. APMIS 122(4):301-316, 2014.

Naillat F, Veikkolainen V, Miinalainen I, Sipilä P, Poutanen M, Elenius K, Vainio SJ. ErbB4, a receptor tyrosine kinase, coordinates organization of the seminiferous tubules in the developing testis. Mol Endocrinol 28(9):1534-46, 2014

Prunskaite-Hyyryläinen R, Shan J, Railo A, Heinonen KM, Miinalainen I, Yan W, Shen B, Perreault C, Vainio SJ. Wnt4, a pleiotropic signal for controlling cell polarity, basement membrane integrity, and antimüllerian hormone expression during oocyte maturation in the female follicle. FASEB J 28(4):1568-81, 2014.

Rygh BC, Løkka G, Heljasvaara R, Pavlin T, Taxt T, Sormunen R, Pihlajaniemi T, Curry F-R.E, Tenstad O, and Reed RK. Image-based assessment of microvascular function and structure in collagen XV and XVIII deficient mice. J Physiol 592:325-336, 2014

Vapola MH, Rokka A, Sormunen RT, Alhonen L, Schmitz W, Conzelmann E, Wärri A, Grunau S, Antonenkov VD, Hiltunen JK. Peroxisomal membrane channel Pxmp2 in the mammary gland fat pad is essential for stromal lipid homeostasis and development of mammary gland epithelium in mice. Dev Biol 391(1): 66-80, 2014

Yannopoulos FS, Arvola O, Haapanen H, Herajärvi J, Miinalainen I, Jensen H, Kiviluoma K, Juvonen T. Leg ischaemia before circulatory arrest alters brain leucocyte count and respiratory chain redox state. Interact Cardiovasc Thorac Surg 18(3):272-7, 2014.

Project Vainio:

Halt K, Vainio S. Coordination of kidney organogenesis by Wnt signaling. Pediatr Nephrol 29(4):737-44, 2014

Junttila S, Saarela U, Halt K, Manninen A, Pärssinen H, Lecca MR, Brändli AW,  Sims-Lucas S, Skovorodkin I, Vainio SJ. Functional Genetic Targeting of Embryonic Kidney Progenitor Cells Ex Vivo. J Am Soc Nephrol, in press.

Maezawa Y, Onay T, Scott RP, Keir LS, Dimke H, Li C, Eremina V, Maezawa Y, Jeansson M, Shan J, Binnie M, Lewin M, Ghosh A, Miner JH, Vainio SJ, Quaggin SE.  Loss of the podocyte-expressed transcription factor Tcf21/Pod1 results in podocyte differentiation defects and FSGS. J Am Soc Nephrol 25(11):2459-70, 2014.

Naillat F, Veikkolainen V, Miinalainen I, Sipilä P, Poutanen M, Elenius K, Vainio SJ. ErbB4, a receptor tyrosine kinase, coordinates organization of the seminiferous tubules in the developing testis. Mol Endocrinol 28(9):1534-46, 2014

Pietilä I, Vainio SJ. Kidney development: an overview. Nephron Exp Nephrol 126(2):40, 2014

Prunskaite-Hyyryläinen R, Shan J, Railo A, Heinonen KM, Miinalainen I, Yan W, Shen B, Perreault C, Vainio SJ. Wnt4, a pleiotropic signal for controlling cell polarity, basement membrane integrity, and antimüllerian hormone expression during oocyte maturation in the female follicle. FASEB J 28(4):1568-81, 2014.

Rymer C, Paredes J, Halt K, Schaefer C, Wiersch J, Zhang G, Potoka D, Vainio S, Gittes GK, Bates CM, Sims-Lucas S. Renal blood flow and oxygenation drive nephron progenitor differentiation. Am J Physiol Renal Physiol 307(3):F337-45, 2014.

Junior Investigator Wei:

Huang Q, Whitington T, Gao P, Lindberg JF, Yang Y, Sun J, Väisänen MR, Szulkin R, Annala M, Yan J, Egevad LA, Zhang K, Lin R, Jolma A, Nykter M, Manninen A, Wiklund F, Vaarala MH, Visakorpi T, Xu J, Taipale J, Wei GH. A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding. Nat Genet 46(2):126-135, 2014.

Munne PM, Gu Y, Tumiati M, Gao P, Koopal S, Uusivirta S, Sawicki J, Wei GH, Kuznetsov SG. TP53 supports basal-like differentiation of mammary epithelial cells by preventing translocation of deltaNp63 into nucleoli. Sci Rep 4:4663, 2014

Project Wierenga:

Anbazhagan P, Harijan RK, Kiema TR, Janardan N, Murthy MR, Michels PA, Juffer AH, Wierenga RK. Phylogenetic relationships and classification of thiolases and thiolase-like proteins of Mycobacterium tuberculosis and Mycobacterium smegmatis. Tuberculosis 94:405-412, 2014.

Fukao T, Akiba K , Goto M, Kuwayama N, Morita M, Hori T, Aoyama Y, Venkatesan R, Wierenga R, Moriyama Y, Hashimoto T, Usuda N, Murayama K, Ohtake A, Hasegawa Y, Shigematsu Y, Hasegawa,Y. The first case in Asia of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (HSD10 disease) with atypical presentation. J Hum Genet 59:609-614, 2014.

Kiema TR,  Harijan RK,  Strozyk M,  Fukao T,  Alexson S, Wierenga RK. The crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activities. Acta Crystallogr D 70:3212-3225, 2014.

Krause M, Wierenga RK. Towards new non-natural TIM-barrel enzymes using computational design and directed evolution approaches. In “Understanding enzymes; Function, Design, Engineering and Analysis”, Editor: Svendsen AS, Pan Stanford Publishing Pte. Ltd, Singapore  (in press).

Meriläinen G, Wierenga RK. Crystallization and preliminary X-ray diffraction studies of the C-terminal domain of Chlamidia trachomatis CdsD. Acta Crystallogr F 70:1431-1433, 2014.

Onwukwe GU, Kursula P, Koski MK, Schmitz W, Wierenga RK. Human Δ3, Δ2-enoyl-CoA isomerase, type-2: a structural enzymology study on the catalytic role of its ACBP-domain and helix-10. FEBS J, in press.

Peterhoff D, Beer B, Rajendra C, Kumpula EP, Kapetaniou E, Guldan H, Wierenga RK, Sterner R, Babinger P. A comprehensive analysis of the geranylgeranyglyceryl phosphate synthase enzyme family identifies  novel members and reveals mechanisms of substrate specificity and quaternary structure organization.  Mol Microbiol 92:885-899, 2014.

Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z.  Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase. Nat Commun 5:4805, 2014

Project Winqvist:

Agarwal D et al (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M of OBCS, Oulu). FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium. Br J Cancer 110:1088-1100, 2014.

Antoniou AC, Casadei S, Heikkinen T, Barrowdale D, Pylkäs K, Roberts J, Lee A, Subramanian D, De Leeneer K, Fostira F, Tomiak E, Neuhausen SL, Teo ZL, Khan S, Aittomäki K, Moilanen JS, Turnbull C, Seal S, Mannermaa A, Kallioniemi A, Lindeman GJ, Buys SS, Andrulis IL, Radice P, Tondini C, Manoukian S, Toland AE, Miron P, Weitzel JN, Domchek SM, Poppe B, Claes KB, Yannoukakos D, Concannon P, Bernstein JL, James PA, Easton DF, Goldgar DE, Hopper JL, Rahman N, Peterlongo P, Nevanlinna H, King MC, Couch FJ, Southey MC, Winqvist R, Foulkes WD, Tischkowitz M. Breast-cancer risk in families with mutations in PALB2. N Engl J Med 371:497-506, 2014.

Glubb DM et al (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Kauppila S of OBCS, Oulu). Fine scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1 Am J Hum Genet 96:5-20, 2015.

Ghoussaini M, et al (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A of OBCS, Oulu). Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation. Nat Commun 4:4999, 2014.

Johnson N et al (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M of OBCS, Oulu). Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study. Breast Cancer Res, in press.

Kiuru A, Kämäräinen M, Heinävaara S, Pylkäs K, Chapman K, Koivistoinen A, Parviainen T, Winqvist R, Kadhim M, Launonen V, Lindholm C. Assessment of targeted and non-targeted responses in cells deficient in ATM function following exposure to low and high dose X-rays. PLoS One 9:e93211, 2014.

Li J et al (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M of OBCS, Oulu). 2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy. Nat Commun 5:4051, 2014.

Lin WY et al (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Kauppila S of OBCS, Oulu). Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk. Hum Mol Genet 24:285-298, 2015.

Mantere T, Haanpää M, Hanenberg H, Schleutker J, Kallioniemi A, Kähkönen M, Parto K, Avela K, Aittomäki K, von Koskull H, Hartikainen JM, Kosma VM, Laasanen SL, Mannermaa A, Pylkäs K, Winqvist R. Finnish Fanconi anemia mutations and hereditary predisposition to breast and prostate cancer. Clin Genet, in press.

Milne RL et al (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M of OBCS, Oulu). Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium. Hum Mol Genet 23:6096-6111, 2014.

Milne RL et al (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M of OBCS, Oulu). A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46,450 cases and 42,461 controls from the breast cancer association consortium. Hum Mol Genet 23:1934-1946, 2014.

Perry JR et al (incl. Winqvist R, Pylkäs K of OBCS, Oulu). Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature 514:92-97, 2014.

Purrington KS et al (incl. Winqvist R, Jukkola-Vuorinen A, Pylkäs K, Kauppila S of OBCS, Oulu). Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade. Hum Mol Genet 23:6034-6046, 2014.

Sawyer E (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Kauppila S of OBCS, Oulu). Genetic predisposition to in situ and invasive lobular carcinoma of the breast. PLoS Genet 10:e1004285, 2014.

Tervasmäki A, Winqvist R, Jukkola-Vuorinen A, Pylkäs K. Recurrent CYP2C19 deletion allele is associated with triple-negative breast cancer. BMC Cancer 14:902, 2014.

Last updated: 18/11/2016