Publications 2016

Project Ala-Korpela & Kettunen

Aho V, Ollila HM, Kronholm E, Bondia-Pons I, Soininen P, Kangas AJ, et al (incl Ala-Korpela M). Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses. Sci Rep 22;6:24828, 2016.

Ala-Korpela M, Davey Smith G. Metabolic profiling-multitude of technologies with great research potential, but (when) will translation emerge? Int J Epidemiol 45(5):1311–8, 2016.

Ala-Korpela M. Metabolomics in cardiovascular medicine: Not personalised, not diagnostic. Eur J Prev Cardiol 23(17):1821–2, 2016.

Beaney KE, Cooper JA, McLachlan S, Wannamethee SG, Jefferis BJ, Whincup P, et al (incl Ala-Korpela M). Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids. Cardiovasc Diabetol 15(1):115, 2016.

Bogl LH, Kaye SM, Rämö JT, Kangas AJ, Soininen P, Hakkarainen A, et al (incl Ala-Korpela M). Abdominal obesity and circulating metabolites: A twin study approach. Metabolism 65(3):111–21, 2016.

Drenos F, Davey Smith G, Ala-Korpela M, Kettunen J, Würtz P, Soininen P, et al. Metabolic Characterization of a Rare Genetic Variation Within APOC3 and Its Lipoprotein Lipase-Independent Effects. Circ Cardiovasc Genet 9(3):231–9, 2016.

Gillberg J, Marttinen P, Pirinen M, Kangas AJ, Soininen P, Ali M, et al (incl Ala-Korpela M). Multiple Output Regression with Latent Noise. J Mach Learn Res 17:1–35, 2016.

Kaikkonen JE, Kresanov P, Ahotupa M, Jula A, Mikkilä V, Viikari JSA, et al (incl Ala-Korpela M, Soininen P). Longitudinal study of circulating oxidized LDL and HDL and fatty liver: the Cardiovascular Risk in Young Finns Study. Free Radic Res 50(4):396–404, 2016.

Kyttälä A, Moraghebi R, Valensisi C, Kettunen J, Andrus C, Pasumarthy KK, et al. Genetic Variability Overrides the Impact of Parental Cell Type and Determines iPSC Differentiation Potential. Stem cell reports 6(2):200–12, 2016.

Laurila P-P, Soronen J, Kooijman S, Forsström S, Boon MR, Surakka I, et al (incl Kettunen J). USF1 deficiency activates brown adipose tissue and improves cardiometabolic health. Sci Transl Med 8(323):323ra13, 2016.

Lemmelä S, Solovieva S, Shiri R, Benner C, Heliövaara M, Kettunen J, et al. Genome-Wide Meta-Analysis of Sciatica in Finnish Population. PLoS One 11(10):e0163877, 2016.

Mäkinen V-P, Ala-Korpela M. Metabolomics of aging requires large-scale longitudinal studies with replication. Proc Natl Acad Sci U S A 113(25):E3470, 2016.

Ollila HM, Kronholm E, Kettunen J, Silander K, Perola M, Porkka-Heiskanen T, et al. Insomnia does not mediate or modify the association between MTNR1B risk variant rs10830963 and glucose levels. Diabetologia 59(5):1070–2, 2016.

Preiss D, Rankin N, Welsh P, Holman RR, Kangas AJ, Soininen P, et al (incl Ala-Korpela M). Effect of metformin therapy on circulating amino acids in a randomized trial: the CAMERA study. Diabet Med 33(11):1569–74, 2016.

Raitoharju E, Seppälä I, Lyytikäinen L-P, Viikari J, Ala-Korpela M, Soininen P, et al. Blood hsa-miR-122-5p and hsa-miR-885-5p levels associate with fatty liver and related lipoprotein metabolism-The Young Finns Study. Sci Rep 6:38262, 2016.

Shu L, Zhao Y, Kurt Z, Byars SG, Tukiainen T, Kettunen J, et al. Mergeomics: multidimensional data integration to identify pathogenic perturbations to biological systems. BMC Genomics 17(1):874, 2016.

Vogt S, Wahl S, Kettunen J, Breitner S, Kastenmüller G, Gieger C, et al (incl Ala-Korpela M). Characterization of the metabolic profile associated with serum 25-hydroxyvitamin D: a cross-sectional analysis in population-based data. Int J Epidemiol 45(5):1469–81, 2016.

Würtz P, Cook S, Wang Q, Tiainen M, Tynkkynen T, Kangas AJ, et al (incl Ala-Korpela M). Metabolic profiling of alcohol consumption in 9778 young adults. Int J Epidemiol 45(5):1493–506, 2016.

Cichonska A, Rousu J, Marttinen P, Kangas AJ, Soininen P, Lehtimäki T, et al (incl Ala-Korpela M). metaCCA: summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis. Bioinformatics 32(13):1981–9, 2016.

Kettunen J, Demirkan A, Würtz P, Draisma HHM, Haller T, Rawal R, et al (incl Ala-Korpela M) . Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA. Nat Commun 23;7:11122, 2016.

Wang Q, Würtz P, Auro K, Morin-Papunen L, Kangas AJ, Soininen P, et al (incl Kettunen J, Ala-Korpela M). Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence. Int J Epidemiol 45(5):1445–57, 2016.

Wang Q, Würtz P, Auro K, Mäkinen V-P, Kangas AJ, Soininen P, et al (incl Kettunen J, Ala-Korpela M). Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence. BMC Med 14(1):205, 2016.

Würtz P, Wang Q, Niironen M, Tynkkynen T, Tiainen M, Drenos F, et al (incl Ala-Korpela M). Metabolic signatures of birthweight in 18 288 adolescents and adults. Int J Epidemiol 45(5):1539–50, 2016.

Würtz P, Wang Q, Soininen P, Kangas AJ, Fatemifar G, Tynkkynen T, et al (incl Kettunen J, Ala-Korpela M). Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase. J Am Coll Cardiol 67(10):1200–10, 2016.

Project Hiltunen

Heimer G, Kerätär JM, Riley LG, Balasubramaniam S, Eyal E, Pietikäinen LP, Hiltunen JK, et al. MECR Mutations Cause Childhood-Onset Dystonia and Optic Atrophy, a Mitochondrial Fatty Acid Synthesis Disorder. Am J Hum Genet 99:1229-1224, 2016.

Jokipii-Lukkari S, Kastaniotis AJ, Parkash V, Sundström R, Leiva-Eriksson N, Nymalm Y, Blokhina O, Kukkola E, Fagerstedt KV, Salminen TA, Läärä E, Bülow L, Ohlmeier S, Hiltunen JK, Kallio PT, Häggman H. Dual targeted poplar ferredoxin NADP(+) oxidoreductase interacts with hemoglobin 1. Plant Sci 247:138-149, 2016.

Kettunen KM, Karikoski R, Hämäläinen RH, Toivonen TT, Antonenkov VD, et al (incl Hiltunen JK). Trim37-deficient Mice Recapitulate Several Features of the Multi-organ Disorder Mulibrey Nanism. BiolOpen 5:584-595, 2016

Mindthoff S, Grunau S, Steinfort L, Girzalsky W, Hiltunen JK, Erdmann, R, Antonenkov VD. Peroxisomal Pex11 is a pore-forming protein homologous to TRPM channels. Biochim Biophys Acta 1863:271-283, 2016.

Weiher H,  Pircher H, Dürr J, Hegenbarth S, Knolle P, Grunau S, Vapola M, Hiltunen JK, Zwacka R M, Schmelzer E, Reumann R, Will H. A monoclonal antibody raised against bacterially expressed MPV17 sequences shows peroxisomal, endosomal and lysosomal localisation in U2OS cells. BMC Res Notes 9:128, 2016.

Biocomputing Coordinator Juffer

Garma L, Juffer AH. Comparison of non-sequential sets of protein residues. Comput Biol Chem 61:23-39, 2016.

Garma L, Medina M, Juffer AH. Structure-based classification of FAD binding sites: a comparative study of structural alignment tools. Proteins 4:1728–1747, 2016.

Pietilä I, Prunskaite-Hyyryläinen R, Kaisto S, Tika E, van Eerde AM, Salo AM, Garma L, Miinalainen I, Feitz WF, Bongers EMHF, Juffer AH, Knoers NVAM, Renkema KY, Myllyharju J, Vainio SJ. Wnt5a Deficiency Leads to Anomalies in Ureteric Tree Development, Tubular Epithelial Cell Organization and Basement Membrane Integrity Pointing to a Role in Kidney Collecting Duct Patterning. PLoS ONE 11:e0147171, 2016.

Project Kursula

Jacot D, Tosetti N, Pires IP, Stock J, Graindorge A, Hung YF, Han H, Tewari R, Kursula I, Soldati-Favre D. An apicomplexan actin-binding protein serves as a connector and lipid sensor to coordinate motility and invasion. Cell Host Microbe 20:731-743, 2016.

Mueller C, Samoo A, Hammoudi PM, Klages N, Kallio JP, Kursula I, Soldati-Favre D. Structural and functional dissection of Toxoplasma gondii armadillo repeats only protein. J Cell Sci 129:1031-1045, 2016.

Project Lehtiö

Haikarainen T, Lehtiö L. Proximal ADP-ribose Hydrolysis in Trypanosomatids is Catalyzed by a Macrodomain. Sci Rep 6:24213, 2016.

Haikarainen T, Waaler J, Ignatev A, Nkizinkiko Y, Venkannagari H, Obaji E, Krauss S, Lehtiö L. Development and structural analysis of adenosine site binding tankyrase inhibitors. Bioorg Med Chem Lett 26:(2):328-33, 2016.

Nathubhai A, Wood PJ, Haikarainen T, Hayward PC, Muñoz-Descalzo S, Thompson AS, Lloyd MD, Lehtiö L, Threadgill MD. Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases. Eur J Med Chem 118:316-327, 2016.

Obaji E, Haikarainen T, Lehtiö L. Characterization of the DNA dependent activation of human ARTD2/PARP2. Sci Rep 6:34487, 2016.

Schlesinger M, Vilchez Larrea SC, Haikarainen T, Narwal M, Venkannagari H, Flawiá MM, Lehtiö L, Fernández Villamil SH. Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei.  Parasit Vectors 9:173, 2016.

Venkannagari H, Verheugd P, Koivunen J, Haikarainen T, Obaji E, Narwal M, Pihlajaniemi T, Lüscher B, Lehtiö L. Chemical probe rescues cells from ARTD10/PARP10 induced apoptosis and sensitizes cancer cells to DNA damage. Cell Chem Biol 23:1251-1260, 2016.

Project Manninen

Zhang K, Lee HM, Wei GH, Manninen A . Meta-analysis of gene expression and integrin-associated signaling pathways in papillary renal cell carcinoma subtypes. Oncotarget, 7: 84178-84189, 2016.

EM Microscopy Coordinator Miinalainen

Diggle CP, Sukoff Rizzo SJ, Popiolek M, Hinttala R, Schülke JP, Kurian MA, Carr IM, Markham AF, Bonthron DT, Watson C, Sharif SM, Reinhart V, James LC, Vanase-Frawley MA, Charych E, Allen M, Harms J, Schmidt CJ, Ng J, Pysden K, Strick C, Vieira P, Mankinen K, Kokkonen H, Kallioinen M, Sormunen R, Rinne JO, Johansson J, Alakurtti K, Huilaja L, Hurskainen T, Tasanen K, Anttila E, Marques TR, Howes O, Politis M, Fahiminiya S, Nguyen KQ, Majewski J, Uusimaa J, Sheridan E, Brandon NJ. Biallelic Mutations in PDE10A Lead to Loss of Striatal PDE10A and a Hyperkinetic Movement Disorder with Onset in Infancy. Am J Hum Genet 98:735-43, 2016.

Jacków J, Schlosser A, Sormunen R, Nyström A, Sitaru C, Tasanen K, Bruckner-Tuderman L, Franzke CW. Generation of a Functional Non-Shedding Collagen XVII Mouse Model: Relevance of Collagen XVII Shedding in Wound Healing. J Invest  Dermatol 136(2):516-25, 2016.

Kangas SM, Ohlmeier S, Sormunen R, Jouhilahti EM, Peltonen S, Peltonen J, Heape AM. An approach to comprehensive genome and proteome expression analyses in Schwann cells and neurons during peripheral nerve myelin formation. J Neurochem 138(6):830-44, 2016.

Karppinen SM, Honkanen HK, Heljasvaara R, Riihilä P, Autio-Harmainen H, Sormunen R, Harjunen V, Väisänen MR, Väisänen T, Hurskainen T, Tasanen K, Kähäri VM, Pihlajaniemi T. Collagens XV and XVIII show different expression and localisation in cutaneous squamous cell carcinoma: type XV appears in tumor stroma, while XVIII becomes upregulated in tumor cells and lost from microvessels. Exp Dermatol 25: 348-354, 2016.

Karsikas S, Myllymäki M, Heikkilä M, Sormunen R, Kivirikko KI, Myllyharju J, Serpi R, Koivunen P. HIF-P4H-2 deficiency protects against skeletal muscle ischemia-reperfusion injury.  J Mol Med 94:301-310, 2016.

Lappi-Blanco E, Mäkinen JM, Lehtonen S, Karvonen H, Sormunen R, Laitakari K, Johnson S, Mäkitaro R, Bloigu R, Kaarteenaho R. Mucin-1 correlates with survival, smoking status, and growth patterns in lung adenocarcinoma. Tumour Biol 37(10):13811-13820, 2016.

Lehtonen ST, Veijola A, Karvonen H, Lappi-Blanco E, Sormunen R, Korpela S, Zagai U, Sköld MC, Kaarteenaho R. Pirfenidone and nintedanib modulate properties of fibroblasts and myofibroblasts in idiopathic pulmonary fibrosis. Respir Res 17:14, 2016.

Leinonen H, Rossi M, Salo AM, Tiainen P, Hyvärinen J, Pitkänen M, Sormunen R, Miinalainen I, Zhang C, Soininen R, Kivirikko KI, Koskelainen A, Tanila H, Myllyharju J, Koivunen P. Lack of P4H-TM in mice results in age-related retinal and renal alterations. Hum Mol Genet 25(17):3810-3823, 2016.

Lemma SA, Pasanen AK, Haapasaari KM, Sippola A, Sormunen R, Soini Y, Jantunen E, Koivunen P, Salokorpi N, Bloigu R, Turpeenniemi-Hujanen T, Kuittinen O. Similar chemokine receptor profiles in lymphomas with central nervous system involvement - possible biomarkers for patient selection for central nervous system prophylaxis, a retrospective study. Eur J Haematol 96(5):492-501, 2016.

Leppänen J, Helminen O, Huhta H, Kauppila JH, Miinalainen I, Ronkainen VP, Saarnio J, Lehenkari PP, Karttunen TJ. Doublecortin-like kinase 1-positive enterocyte - a new cell type in human intestine. APMIS 124(11):958-965, 2016.

Meyer-Rochow VB, Miinalainen I. Nanoporous Structures Similar to Those Reported from Squid Sucker Teeth are also Present in Egg Shells of a Terrestrial Flatworm (Platyhelminthes; Rhabditophora; Geoplanidae) from Hachijojima (Izu Islands, Japan). Chem Biodivers 13(7):821-5, 2016.

Nagy II, Xu Q, Naillat F, Ali N, Miinalainen I, Samoylenko A, Vainio SJ. Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis. BMC Dev Biol 16(1):30, 2016.

Pasanen I, Lehtonen S, Sormunen R, Skarp S, Lehtilahti E, Pietilä M, Sequeiros RB, Lehenkari P, Kuvaja P. Breast cancer carcinoma-associated fibroblasts differ from breast fibroblasts in immunological and extracellular matrix regulating pathways. Exp Cell Res 344(1):53-66, 2016.

Peroja P, Haapasaari KM, Mannisto S, Miinalainen I, Koivunen P, Leppä S, Karjalainen-Lindsberg ML, Kuusisto ME, Turpeenniemi-Hujanen T, Kuittinen O, Karihtala P. Total peroxiredoxin expression is associated with survival in patients with follicular lymphoma. Virchows Arch 468(5):623-30, 2016.

Pietilä I, Prunskaite-Hyyryläinen R, Kaisto S, Tika E, van Eerde AM, Salo AM, Garma L, Miinalainen I, Feitz WF, Bongers EM, Juffer A, Knoers NV, Renkema KY, Myllyharju J, Vainio SJ. Wnt5a Deficiency Leads to Anomalies in Ureteric Tree Development, Tubular Epithelial Cell Organization and Basement Membrane Integrity Pointing to a Role in Kidney Collecting Duct Patterning. PLOS One 11:e0147171, 2016.

Prunskaite-Hyyryläinen R, Skovorodkin I, Xu Q, Miinalainen I, Shan J, Vainio SJ. Wnt4 coordinates directional cell migration and extension of the Müllerian duct essential for ontogenesis of the female reproductive tract. Hum Mol Genet 25(6):1059-73, 2016.

Räsänen M, Degerman J, Nissinen TA, Miinalainen I, Kerkelä R, Siltanen A, Backman JT, Mervaala E, Hulmi JJ, Kivelä R, Alitalo K. VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection. Proc Natl  Acad Sci U S A 113(46):13144-13149, 2016.

Sundquist E, Renko O, Salo S, Magga J, Cervigne NK, Nyberg P, Risteli J, Sormunen R, Vuolteenaho O, Zandonadi F, Paes Leme AF, Coletta RD, Ruskoaho H, Salo T. Neoplastic extracellular matrix environment promotes cancer invasion in vitro. Exp Cell Res 344(2):229-40, 2016.

Tervaniemi MH, Katayama S, Skoog T, Siitonen HA, Vuola J, Nuutila K, Sormunen R, Johnsson A, Linnarsson S, Suomela S, Kankuri E, Kere J, Elomaa O. NOD-like receptor signaling and inflammasome-related pathways are highlighted in psoriatic epidermis. Sci Rep 6:22745, 2016.

Project Myllyharju & Karppinen

Briggs KJ, Koivunen P, Cao S, Backus KM, Olenchock BA, Patel H, Zhang Q, Signoretti S, Gerfen GJ, Richardson AL, Witkiewicz AK, Cravatt BF, Clardy J, Kaelin WG Jr. Paracrine induction of HIF by glutamate in triple-negative breast cancer:  EglN1 senses cysteine. Cell 166:126-139, 2016.

Halt K, Pärssinen H, Junttila S, Saarela U, Sims-Lucas S, Koivunen P, Myllyharju J, Quaggin S, Skovorodkin I, Vainio SJ. CD146+ cells are essential for kidney vasculature development. Kidney Int 90: 311-324, 2016.

Karsikas S, Myllymäki M, Heikkilä M, Sormunen R, Kivirikko KI, Myllyharju J, Serpi R, Koivunen P. HIF-P4H-2 deficiency protects against skeletal muscle ischemia-reperfusion injury. J Mol Med 94:301-310, 2016.

Koivunen P, Fell SM, Lu W, Rabinowitz JD, Kung AL, Schlisio S. The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth. Hypoxia 4: 15-27, 2016.

Koivunen P, Serpi R, Dimova EY. Hypoxia-inducible factor prolyl 4-hydroxylase inhibition in cardiometabolic diseases. Pharmacol Res 114:265-273, 2016.

Laukka T, Mariani CJ, Ihantola T, Cao JZ, Kaelin WG Jr, Godley LA, Koivunen P. Fumarate and succinate regulate expression of hypoxia-inducible genes via TETs. J Biol Chem 291: 4256-4265, 2016.

Leinonen H*, Rossi M*, Salo AM, Tiainen P, Hyvärinen J, Sormunen R, Miinalainen I, Zhang C, Soininen R, Kivirikko KI, Pitkänen M, Koskelainen A, Tanila H, Myllyharju J#, Koivunen P#. Lack of P4H-TM results in age-related retinal and renal alterations in mice. Hum Mol Genet 25: 3810-3823, 2016. * and # Equal contributions.

Pietilä I, Prunskaite-Hyyryläinen R, Kaisto S, Nicolaou N, van Eerde AM, Salo AM, Garma L, Miinalainen I, Feitz WF, Bongers EMHF, Juffer A, Knoers NVAM, Renkema KY, Myllyharju J, Vainio SJ. Wnt5a deficiency leads to anomalies in ureteric tree development, tubular epithelial cell organization and basement membrane integrity pointing to a role in kidney collecting duct patterning. PLOS One 11:e0147171, 2016.

Rahtu-Korpela L, Määttä J, Dimova EY, Hörkkö S, Gylling H, Walkinshaw G, Hakkola J, Kivirikko KI, Myllyharju J, Serpi R, Koivunen P. Hypoxia-inducible factor prolyl 4-hydroxylase-2 inhibition protects against development of atherosclerosis. Arterioscler Thromb Vasc Biol 36: 608-617, 2016.

Project Pihlajaniemi & Eklund

Akram SA, Kannala J, Eklund L, Heikkilä J. Joint cell segmentation and tracking using cell proposals. Proc IEEE International Symposium on Biomedical Imaging (ISBI) 920-924, 2016.

Gullberg D, Kletsas D, Pihlajaniemi T. Editorial: Wound healing and fibrosis-two sides of the same coin. Cell Tissue Res 365: 449-451, 2016.

Honkanen H-K, Izzi V, Petäistö T, Holopainen T, Harjunen V, Pihlajaniemi T, Alitalo K, Heljasvaara R. Elevated VEGF-D modulates tumor inflammation and reduces the growth of carcinogen-induced skin tumors. Neoplasia 18(7): 436-446, 2016.

Karppinen SM, Honkanen H-K, Heljasvaara R, Riihilä P, Autio-Harmainen H, Sormunen R, Harjunen V, Väisänen M-R, Väisänen T, Hurskainen T, Tasanen-Määttä K, Kähäri V-M, Pihlajaniemi T. Collagens XV and XVIII show different expression and localization in cutaneous squamous cell carcinoma: type XV appears in tumour stroma while XVIII becomes upregulated in tumour cells and lost from microvessels. Exp Dermatol 25: 348-354, 2016.

Kivinen N, Felszeghy S, Kinnunen AI, Setälä N, Aikio M, Kinnunen K, Sironen R, Pihlajaniemi T, Kauppinen A, Kaarniranta K. Absence of collagen XVIII in mice causes age-related insufficiency in retinal pigment epithelium proteostasis. Biogerontology 17:749-761, 2016.

Lin CH, Chen J, Zhang Z, Johnson GV, Cooper AJ, Feola J, Bank A, Shein J, Ruotsalainen HJ, Pihlajaniemi TA, Goligorsky MS. Endostatin and transglutaminase 2 are involved in fibrosis of aging kidney. Kidney Int 89: 1281–1292, 2016.

Pirhonen J, Arola J, Sädevirta S, Luukkonen P, Karppinen SM, Pihlajaniemi T, Isomäki A, Hukkanen M, Yki-Järvinen H, and Ikonen E. Continuous grading of early fibrosis in NAFLD using label-free imaging: a proof-of-concept study. PLoS One 11: e0147804, 2016.

Robciuc MR, Kivelä R, Williams IM, de Boer JF, van Dijk TH, Elamaa H, Tigistu-Sahle F, Molotkov D, Leppänen VM, Käkelä R, Eklund L, Wasserman DH, Groen AK, Alitalo K. VEGF-B/VEGFR1-Induced expansion of adipose microvasculature counteracts obesity and related metabolic complications. Cell Metab 23:712-724, 2016.

Venkannagari H, Verheugd P, Koivunen J, Haikarainen T, Obaji E, Yashwanth A, Narwal M, Pihlajaniemi T, Lüscher B, and Lehtiö L. Chemical probe rescues cells from ARTD10/PARP10 induced apoptosis and sensitizes cancer cells to DNA damage. Cell Chem Biol 23: 1251-1260, 2016.

Project Savolainen & Herzig & Järvelin

Ala-Kokko T, Mutt SJ, Nisula S, Koskenkari J, Liisanantti J, Ohtonen P, Poukkanen M, Pettilä V, Herzig KH and the FINNAKI study group. Vitamin D deficiency on admission is not associated with 90 day mortality in patients with severe sepsis or septic shock. Ann Med 48(1-2):67-75, 2016.

Cichonska A, Rousu J, Marttinen P, Kangas AJ, Soininen P, Lehtimäki T, Raitakari OT, Järvelin MR, Salomaa V, Ala-Korpela M, Ripatti S, Pirinen M. metaCCA: summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis. Bioinformatics 32(13):1981-9, 2016.

Ehret GB, Ferreira T, Chasman DI, Jackson AU, Schmidt EM, et al (incl Herzig KH, Järvelin MR). The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nat Genet 48(10):1171-84, 2016.

Eising E, Huisman SM, Mahfouz A, Vijfhuizen LS, Anttila V, et al (incl Järvelin MR). Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas. Hum Genet 135(4):425-39, 2016.

Gormley P, Anttila V, Winsvold BS, Palta P, Esko T, et al (incl Järvelin MR). Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nat Genet 48(8):856-66, 2016.

Gormley P, Anttila V, Winsvold BS, Palta P, et al (incl Järvelin MR). Corrigendum: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nat Genet 48(10):1296, 2016.

Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, et al (incl Järvelin MR). Genome-wide associations for birth weight and correlations with adult disease. Nature 538(7624):248-252, 2016.

Kamakura R, Kovalainen M, Leppäluoto J, Herzig KH, Mäkelä KA. The effects of group and single housing and measuring physiological and behavioral parameters using automated monitoring system on stress levels in male mice. Physiol Reports 4(3), 2016.

Kaminska D, Käkelä P, Venesmaa S, Ilves I, Herzig KH, Kolehmainen M, Karhunen L, Kuusisto J, Gylling H, Laakso M, Pihlajamäki J. Regulation of alternative splicing in human obesity loci. Obesity 24(10):2033-7, 2016.

Kanoni S, Masca NG, Stirrups KE, Varga TV, Warren HR, et al (incl Järvelin MR). Analysis with the exome array identifies multiple new independent variants in lipid loci. Hum Mol Genet 25(18):4094-4106, 2016.

Kantomaa MT, Tikanmäki M, Kankaanpää A, Vääräsmäki M, Sipola-Leppänen M, Ekelund U, Hakonen H, Järvelin MR, Kajantie E, Tammelin TH. Accelerometer-Measured Physical Activity and Sedentary Time Differ According to Education Level in Young Adults. PLoS One 11(7):e0158902, 2016.

Karppinen P, Oinas-Kukkonen H, Alahäivälä T, Jokelainen T, Keränen AM, Salonurmi T, Savolainen M. Persuasive user experiences of a Health Behavior Change Support System: A 12-month study for prevention of metabolic syndrome. Int J Med Inform 96:51-61, 2016.

Kettunen J, Demirkan A, Würtz P, Draisma HHM, Haller T, Rawal R, et al (incl Järvelin MR) . Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA. Nat Commun 23;7:11122, 2016.

Kiviniemi AM, Perkiömäki N, Auvinen J, Herrala S, Hautala AJ, Ahola R, Tammelin T, Tulppo MP, Järvelin MR, Korpelainen R, Huikuri HV. Lifelong Physical Activity and Cardiovascular Autonomic Function in Midlife. Med Sci Sports Exerc 48(8):1506-13, 2016.

Larsen SC, Ängquist L, Moldovan M, Huikari V, Sebert S, Cavadino A, Ahluwalia TS, Skaaby T, Linneberg A, Husemoen LLN, Toft U, Pedersen O, Hansen T, Herzig KH, Jarvelin MR, Power C, Hyppönen E, Heitmann BL, Sørensen TIA. Serum 25-hydroxyvitamin D status and longitudinal changes in weight and waist circumference: influence of genetic predisposition to adiposity. PloS One 11(4):e0153611, 2016..

Leder L, Kolehmainen M, Narverud I, Dahlman I, Myhrstad M, et al (incl Herzig KH, Savolainen MJ). Effects of a healthy Nordic diet on gene expression changes in peripheral blood mononuclear cells in response to an oral glucose tolerance test in subjects with metabolic syndrome: a SYSDIET sub-study. Genes Nutr 11:3, 2016.

Lehne B, Drong AW, Loh M, Zhang W, Scott WR, Tan ST, Afzal U, Schulz R, Scott J, Järvelin MR, Elliott P, McCarthy MI, Kooner JS, Chambers JC. Erratum to: A coherent approach for analysis of the Illumina HumanMethylation450 BeadChip improves data quality and performance in epigenome-wide association studies. Genome Biol 17(1):73, 2016.

Linna H, Suija K, Rajala U, Herzig KH, Karhu T, Jokelainen J, Keinänen-Kiukaanniemi S, Timonen M. The association between impaired glucose tolerance and soluble CD40 ligand: a 15-year prospective cohort study. Aging Clin Exp Res 28(6):1243-1249, 2016.

Marioni RE, Ritchie SJ, Joshi PK, Hagenaars SP, Okbay A, Fischer K, Adams MJ, Hill WD, Davies G; Social Science Genetic Association Consortium., Nagy R, Amador C, Läll K, Metspalu A, Liewald DC, Campbell A, Wilson JF, Hayward C, Esko T, Porteous DJ, Gale CR, Deary IJ. Genetic variants linked to education predict longevity. Proc Natl Acad Sci U S A 113(47):13366-13371, 2016.

Mason WA, January SA, Chmelka MB, Parra GR, Savolainen J, Miettunen J, Järvelin MR, Taanila A, Moilanen I. Cumulative contextual risk at birth in relation to adolescent substance use, conduct problems, and risky sex: General and specific predictive associations in a Finnish birth cohort. Addict Behav 58:161-6, 2016.

Minelli C, Dean CH, Hind M, Couto Alves A, Amara AFS, et al (incl Järvelin MR). Association of Forced Vital Capacity with the Developmental Gene NCOR2. PlosOne 11(2): e0147388, 2016.

Narverud I, Myhrstad MCW, Herzig KH, Karhu T, Dahl TB, Halvorsen B, Ulven SM, Holven KB. Lack of Effects of a Single High-Fat Meal Enriched with Vegetable n-3 or a Combination of Vegetable and Marine n-3 Fatty Acids on Intestinal Peptide Release and Adipokines in Healthy Female Subjects. Front Nutr 3:38, 2016.

Okbay A, Baselmans BM, De Neve JE, Turley P, Nivard MG, et al (incl Järvelin MR). Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nat Genet 48(6):624-33, 2016. Corrigendum: 48(8):970 and 48(12):1591, 2016.

Okbay A, Beauchamp JP, Fontana MA, Lee JJ, Pers TH, et al (incl Järvelin MR). Genome-wide association study identifies 74 loci associated with educational attainment. Nature 533(7604):539-42, 2016.

Olli K, Saarinen M, Forssten S, Madetoja M, Herzig KH, Tiihonen K. Independent and combined effects of lactitol, polydextrose and Bacteroides thetaiotaomicron on postprandial metabolism and body weight in rats fed a high-fat diet. Front Nutr 3:15, 2016.

Palaniswamy S, Williams D, Järvelin MR, Sebert S. Vitamin D and the Promotion of Long-Term Metabolic Health from a Programming Perspective. Nutr Metab Insights 8(Suppl 1):11-21, 2016.

Parmar PG, Taal HR, Timpson NJ, Thiering E, Lehtimäki T, et al (incl Järvelin MR). International GWAS Consortium Identifies Novel Loci Associated with Blood Pressure in Children and Adolescents. Circ Cardiovasc Genet 9(3):266-78, 2016.

Perkiömäki N, Auvinen J, Tulppo MP, Hautala AJ, Perkiömäki J, Karhunen V, Keinänen-Kiukaanniemi S, Puukka K, Ruokonen A, Järvelin MR, Huikuri HV, Kiviniemi AM. Association between Birth Characteristics and Cardiovascular Autonomic Function at Mid-Life. PLoS One 11(8):e0161604, 2016.

Rannikko I, Jääskeläinen E, Miettunen J, Ahmed AO, Veijola J, Remes AM, Murray GK, Husa AP, Järvelin MR, Isohanni M, Haapea M. Predictors of Long-Term Change in Adult Cognitive Performance: Systematic Review and Data from the Northern Finland Birth Cohort 1966. Clin Neuropsychol 30(1):17-50, 2016.

Ried JS, Jeff M J, Chu AY, Bragg-Gresham JL, van Dongen J, et al (incl Järvelin MR). A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. Nat Commun 7:13357, 2016.

Ronkainen J, Mondini E, Cinti F, Cinti S, Sebért S, Savolainen MJ, Salonurmi T. Fto-Deficiency Affects the Gene and MicroRNA Expression Involved in Brown Adipogenesis and Browning of White Adipose Tissue in Mice. Int J Mol Sci 17(11), 2016.

Ruiz M, Goldblatt P, Morrison J, Porta D, Forastiere F, Hryhorczuk D, Antipkin Y, Saurel-Cubizolles MJ, Lioret S, Vrijheid M, Torrent M, Iñiguez C, Larrañaga I, Bakoula C, Veltsista A, van Eijsden M, Vrijkotte TG, Andrýsková L, Dušek L, Barros H, Correia S, Järvelin MR, Taanila A, Ludvigsson J, Faresjö T, Marmot M, Pikhart H. Impact of Low Maternal Education on Early Childhood Overweight and Obesity in Europe. Paediatr Perinat Epidemiol 30(3):274-84, 2016.

Schumann G, Liu C, O'Reilly P, Gao H, Song P, et al (incl Herzig KH, Järvelin MR). KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference. Proc Natl Acad Sci U S A 113(50):14372-14377, 2016.

Surendran P, Drenos F, Young R, Warren H, Cook JP, et al (incl Järvelin MR). Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nat Genet 48(10):1151-61, 2016.

Tikanmäki M, Tammelin T, Sipola-Leppänen M, Kaseva N, Matinolli HM, Miettola S, Eriksson JG, Järvelin MR, Vääräsmäki M, Kajantie E. Physical Fitness in Young Adults Born Preterm. Pediatrics 137(1):1-10, 2016.

Uimari O, Auvinen J, Jokelainen J, Puukka K, Ruokonen A, Järvelin MR, Piltonen T, Keinänen-Kiukaanniemi S, Zondervan K, Järvelä I, Ryynänen M, Martikainen H. Uterine fibroids and cardiovascular risk. Hum Reprod 31(12):2689-2703, 2016.

Wang Q, Würtz P, Auro K, Morin-Papunen L, Kangas AJ, Soininen P, Tiainen M, Tynkkynen T, Joensuu A, Havulinna AS, Aalto K, Salmi M, Blankenberg S, Zeller T, Viikari J, Kähönen M, Lehtimäki T, Salomaa V, Jalkanen S, Järvelin MR, Perola M, Raitakari OT, Lawlor DA, Kettunen J, Ala-Korpela M. Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence. Int J Epidemiol 45(5):1445-1457, 2016.

Wang Q, Würtz P, Auro K, Mäkinen VP, Kangas AJ, Soininen P, Tiainen M, Tynkkynen T, Jokelainen J, Santalahti K, Salmi M, Blankenberg S, Zeller T, Viikari J, Kähönen M, Lehtimäki T, Salomaa V, Perola M, Jalkanen S, Järvelin MR, Raitakari OT, Kettunen J, Lawlor DA, Ala-Korpela M. Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence. BMC Med 14(1):205, 2016.

Vavuli S, Salonurmi T, Loukovaara S, Nissinen A, Savolainen MJ, Liinamaa MJ. Elevated levels of plasma IgA autoantibodies against oxidized LDL found in proliferative diabetic retinopathy but not in nonproliferative retinopathy. J Diabetes Res, 2016:2614153, 2016.

Williams DM, Palaniswamy S, Sebert S, Buxton JL, Blakemore AI, Hyppönen E, Järvelin MR. 25-Hydroxyvitamin D Concentration and Leukocyte Telomere Length in Young Adults: Findings From the Northern Finland Birth Cohort 1966. Am J Epidemiol 183(3):191-198, 2016.

Würtz P, Cook S, Wang Q, Tiainen M, Tynkkynen T, Kangas AJ, Soininen P, Laitinen J, Viikari J, Kähönen M, Lehtimäki T, Perola M, Blankenberg S, Zeller T, Männistö S, Salomaa V, Järvelin MR, Raitakari OT, Ala-Korpela M, Leon DA. Metabolic profiling of alcohol consumption in 9778 young adults. Int J Epidemiol 45(5):1493-1506, 2016.

Würtz P, Wang Q, Niironen M, Tynkkynen T, Tiainen M, Drenos F, Kangas AJ, Soininen P, Skilton MR, Heikkilä K, Pouta A, Kähönen M, Lehtimäki T, Rose RJ, Kajantie E, Perola M, Kaprio J, Eriksson JG, Raitakari OT, Lawlor DA, Davey Smith G, Järvelin MR, Ala-Korpela M, Auro K. Metabolic signatures of birthweight in 18 288 adolescents and adults. Int J Epidemiol 45(5):1539-1550, 2016.

Würtz P, Wang Q, Soininen P, Kangas AJ, Fatemifar G, Tynkkynen T, Tiainen M, Perola M, Tillin T, Hughes AD, Mäntyselkä P, Kähönen M, Lehtimäki T, Sattar N, Hingorani AD, Casas JP, Salomaa V, Kivimäki M, Järvelin MR, Davey Smith G, Vanhala M, Lawlor DA, Raitakari OT, Chaturvedi N, Kettunen J, Ala-Korpela M. Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase. J Am Coll Cardiol 67(10):1200-10, 2016.

Väyrynen JP, Jagalur Mutt S, Herzig KH, Klintrup K, Mäkelä J, Markus J Mäkinen MJ, Tuomisto A. Decreased preoperative serum 25-Hydroxyvitamin D levels in colorectal cancer are associated with systemic inflammation and serrated morphology. Sci Rep 6:36519, 2016.

Väyrynen JP, Kantola T, Väyrynen SA, Klintrup K, Bloigu R, Mäkelä J, Karhu T, Herzig KH, Karttunen TK, Tuomisto A, Mäkinen MJ. The relationships between serum cytokine levels and tumor infiltrating immune cells and their clinical significance in colorectal cancer. Int J Cancer 139(1):112-21, 2016.

Project Savolainen & Sillanpää & Pyhäjärvi

Bari A, Chaubey YP, Sillanpää MJ, Stoddard FL, Damania AB, Alaoui SB, Mackay M. "Applied mathematics in genetic resources: Toward a synergistic approach combining innovations with theoretical aspects." in Applied Mathematics and Omics to Assess Crop Genetic Resources for Climate Change Adaptive Traits. Bari A, Damania A B, Mackay M, Dayanandan S. (editors). Oxford: CRC Press, Taylor & Francis Group, 2016

Bari A, Khazaei H, Stoddard FL, Street K, Sillanpää MJ, Chaubey YP, Dayanandan S, Endresen DTF, De Pauw E, Damania AB. In silico evaluation of plant genetic resources to search for traits for adaptation to climate change. Climatic Change 134: 667-680, 2016.

He L, Sillanpää MJ, Silventoinen K, Kaprio J, and Pitkäniemi J. Estimating modifying effect of age on genetic and environmental variance components in twin models. Genetics 202(4): 1313-28, 2016.

Kuismin M, Sillanpää MJ. Use of Wishart prior and simple extensions for sparse precision matrix estimation. PLoS ONE 11: e0148171, 2016.

Lascoux M, Glémin S, Savolainen O.Local adaptation in plants. eLS DOI: 10.1002/9780470015902.a0025270, 2016.

Mathew B, Holand AM, Koistinen P, Leon J, Sillanpää MJ. Reparametrization-based estimation of genetic parameters in multi-trait animal model using Integrated Nested Laplace Approximation. Theor Appl Genet 129: 215-225, 2016.

Mattila T M, Aalto E A, Toivainen T , Niittyvuopio A, Piltonen S, Kuittinen H,  Savolainen O. Selection for population specific adaptation has shaped patterns of variation in the photoperiod pathway genes in Arabidopsis lyrata during post glacial colonization. Molecular Ecology 25: 581-597, 2016.

Savolainen O, Lascoux M. Genomics: Geography matters for Arabidopsis. Nature 537:314-315, 2016.

Transgenic Facility Coordinator Soininen

Ataca D, Caikovski M, Piersigilli A, Moulin A, Benarafa C, Earp SE, Guri Y, Kostic C, Arsenivic Y, Soininen R, Apte SS, Brisken C. Adamts18 deletion results in distinct developmental defects and provides a model for congenital disorders of lens, lung, and female reproductive tract development. Biol Open. 5(11):1585-1594, 2016.

Leinonen H, Rossi M, Salo AM, Tiainen P, Hyvärinen J, Pitkänen M, Sormunen R, Miinalainen I, Zhang C, Soininen R, Kivirikko KI, Koskelainen A, Tanila H, Myllyharju J, Koivunen P. Lack of P4H-TM in mice results in age-related retinal and renal alterations. Hum Mol Genet. 25(17):3810-3823, 2016.

Raess M, Ambrosio de Castro A, Gailus-Durner V, Fessele S, Hrabe de Angelis M, the INFRAFRONTIER Consortium. INFRAFRONTIER: a European resource for studying the functional basis of human disease. Mamm Genome 27(7-8):445-50, 2016.

Project Uusimaa & Hinttala

Carrozzo R, Verrigni D, Rasmussen M, de Coo R, Amartino H, Bianchi M, Buhas D, Mesli S, Naess K, Born AP, Woldseth B, Prontera P, Batbayli M, Ravn K, Joensen F, Cordelli DM, Santorelli FM, Tulinius M, Darin N, Duno M, Jouvencel P, Burlina A, Stangoni G, Bertini E, Redonnet-Vernhet I, Wibrand F, Dionisi-Vici C, Uusimaa J, Vieira P, Osorio AN, McFarland R, Taylor RW, Holme E, Ostergaard E. Succinate-CoA ligase deficiency due to mutations in SUCLA2 and SUCLG1: phenotype and genotype correlations in 71 patients. J Inherit Metab Dis 39:243-52, 2016.

Diggle CP, Sukoff Rizzo SJ, Popiolek M, Hinttala R, Schülke JP, et al (incl Uusimaa J). Biallelic Mutations in PDE10A Lead to Loss of Striatal PDE10A and a Hyperkinetic Movement Disorder with Onset in Infancy. Am J Hum Genet 98:735-43, 2016.

Hautakangas MR, Hinttala R, Rantala H, Nieminen P, Uusimaa J, Hassinen IE. Evaluating clinical mitochondrial respiratory chain enzymes from biopsy specimens presenting skewed probability distribution of activity data. Mitochondrion 29:53-8, 2016

Lehtonen JM, Forsström S, Bottani E, Viscomi C, Baris OR, et al (incl Uusimaa J). FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders. Neurology 87:2290-2299, 2016.

Widgren P, Hurme A, Falck A, Keski-Filppula R, Remes AM, Moilanen J, Majamaa K, Kervinen M, Uusimaa J. Genetic aetiology of ophthalmological manifestations in children - a focus on mitochondrial disease-related symptoms. Acta Ophthalmol 94:83-91, 2016.

Project Vainio

Drelon C, Berthon A, Sahut-Barnola I, Mathieu M, Dumontet T, Rodriguez S, Batisse-Lignier M, Tabbal H, Tauveron I, Lefrançois-Martinez AM, Pointud JC, Gomez-Sanchez CE, Vainio S, Shan J, Sacco S, Schedl A, Stratakis CA, Martinez A, Val P. PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development. Nat Commun 7:12751, 2016. 

Halt KJ, Pärssinen HE, Junttila SM, Saarela U, Sims-Lucas S, Koivunen P, Myllyharju J, Quaggin S, Skovorodkin IN, Vainio SJ. CD146(+) cells are essential  for kidney vasculature development. Kidney Int 90:311-24, 2016.

Nagy II, Xu Q, Naillat F, Ali N, Miinalainen I, Samoylenko A, Vainio SJ. Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis. BMC Dev Biol. 16:30, 2016. 

Pietilä I, Prunskaite-Hyyryläinen R, Kaisto S, Tika E, van Eerde AM, Salo AM,  Garma L, Miinalainen I, Feitz WF, Bongers EM, Juffer A, Knoers NV, Renkema KY, Myllyharju J, Vainio SJ. Wnt5a Deficiency Leads to Anomalies in Ureteric Tree Development, Tubular Epithelial Cell Organization and Basement Membrane Integrity Pointing to a Role in Kidney Collecting Duct Patterning. PLoS One. 11:e0147171, 2016.

Prunskaite-Hyyryläinen R, Skovorodkin I, Xu Q, Miinalainen I, Shan J, Vainio SJ. Wnt4 coordinates directional cell migration and extension of the Müllerian duct essential for ontogenesis of the female reproductive tract. Hum Mol Genet. 25(6):1059-73, 2016.

Rak-Raszewska A, Vainio S. Nephrogenesis in organoids to develop novel drugs and progenitor cell based therapies. Eur J Pharmacol. 790:3-11, 2016. 

Vidal V, Sacco S, Rocha AS, da Silva F, Panzolini C, Dumontet T, Doan TM, Shan J, Rak-Raszewska A, Bird T, Vainio S, Martinez A, Schedl A. The adrenal capsule is a signaling center controlling cell renewal and zonation through Rspo3. Genes  Dev 30(12):1389-94, 2016.

Xu Q, Krause M, Samoylenko A, Vainio S. Wnt Signaling in Renal Cell Carcinoma. Cancers (Basel). 8(6), 2016.

Project Wei

Du M, Tillmans L, Gao J, Gao P, Yuan T, Dittmar RL, Song W, Yang Y, Sahr N, Wang T, Wei GH, Thibodeau SN, Wang L. Chromatin interactions and candidate genes at ten prostate cancer risk loci. Sci Rep. 6:23202, 2016.

Li J, Rodriguez JP, Niu F, Pu M, Wang J, Hung LW, Shao Q, Zhu Y, Ding W, Liu Y, Da Y, Yao Z, Yang J, Zhao Y, Wei GH, Cheng G, Liu ZJ, Ouyang S. Structural basis for DNA recognition by STAT6. Proc Natl Acad Sci U S A. 113(46):13015-13020, 2016.

Taipale M, Jakkula E, Kämäräinen OP, Gao P, Skarp S, Barral S, Kiviranta I, Kröger H, Ott J, Wei GH, Ala-Kokko L, Männikkö M. Targeted re-sequencing of linkage region on 2q21 identifies a novel functional variant for hip and knee osteoarthritis. Osteoarthritis Cartilage  24(4):655-63, 2016.

Tang X, Ma H, Han L, Zheng W, Lu YB, Chen XF, Liang ST, Wei GH, Zhang ZQ, Chen HZ, Liu DP. SIRT1 deacetylates  cardiac transcription factor Nkx2.5 and inhibits its transcriptional activity. Sci Rep 6:36576, 2016.

Whitington T, Gao P, Song W, Ross-Adams H, Lamb AD, Yang Y, Svezia I, Klevebring D, Mills IG, Karlsson R, Halim S, Dunning MJ, Egevad L, Warren AY, Neal DE, Grönberg H, Lindberg J, Wei GH, Wiklund F. Gene regulatory mechanisms underpinning prostate cancer susceptibility. Nat Genet 48(4):387-97, 2016.

Zhang K, Lee HM, Wei GH, Manninen A. Meta-analysis of gene expression and integrin-associated signaling pathways in papillary renal cell carcinoma subtypes. Oncotarget. 7(51):84178-84189, 2016.

Project Wierenga

Harijan RK, Mazet M, Kiema, TR, Bouyssou G, Alexson S, Bergmann U, Moreau P, Michels PAM, Bringaud F, Wierenga RK. The SCP2-thiolase-like protein (SLP) of Trypanosoma brucei is an enzyme involved in lipid metabolism. Proteins 84(8):1075-96, 2016.

Ithayaraja M, Janardan N, Wierenga RK, Savithri HS, Murthy MRN. Crystal structure of a thiolase from Escherichia coli at 1.8 Å resolution. Acta Crystallogr F Struct Biol Commun 72:534-544, 2016.

Krause M, Kiema TR, Neubauer P, Wierenga RK. Crystal structures of two monomeric TIM variants identified via a directed evolution protocol selecting for L-arabinose isomerase activity. Acta Crystallogr F Struct Biol Commun 72: 490-499, 2016.

Krause M, Wierenga RK. Towards new non-natural TIM-barrel enzymes using computational design and directed evolution approaches. In “Understanding enzymes: Function, Design, Engineering and Analysis”. Pan Stanford Publishing Pte. Ltd, Singapore, pp561-611, 2016.

Meriläinen G, Koski MK, Wierenga RK. The extended structure of the periplasmic region of CdsD, a structural protein of the type III secretion system of Chlamydia trachomatis. Protein Sci. 25: 987-998, 2016.

Richard JP, Amyes TL, Malabanan MM, Zhai X, Kim KJ, Reinhardt CJ, Wierenga RK, Drake EJ, Gulick AM. Structure-Function Studies on Hydrophobic Residues that Clamp a Basic Glutamate Side Chain During Catalysis by triosephosphate isomerase. Biochemistry 55:3036-3047, 2016.

Project Winqvist

Couch FJ, Kuchenbaecker KB, Michailidou K, Mendoza-Fandino GA, Nord S, et al (incl Winqvist R, Pylkäs K). Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Nat Commun 7:11375, 2016.

Darabi H, Beesley J, Droit A, Kar S, Nord S, et al (incl Winqvist R, Pylkäs K). Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGS). Sci Rep 6:32512, 2016.

Dunning AM, Michailidou K, Kuchenbaecker KB, Thompson D, French JD, et al (incl Winqvist R, Pylkäs K). Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170. Nat Genet 48:374-386, 2016.

Easton DF, Lesueur F, Decker B, Michailidou K, Li J, et al (incl Winqvist R, Pylkäs K). No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing. J Med Genet 53:298-309, 2016.

Ghoussaini M, French JD, Michailidou K, Nord S, Beesley J, et al (incl Winqvist R, Pylkäs K). Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation. Am J Hum Genet 99:903-911, 2016.

Guo Y, Warren Andersen S, Shu XO, Michailidou K, Bolla MK, et al (incl Winqvist R, Pylkäs K). Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent. PLoS Med 13:e1002105, 2016.

Hamdi Y, Soucy P, Adoue V, Michailidou K, Canisius S, et al (incl Winqvist R, Pylkäs K). Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21. Oncotarget 6;7(49):80140-80163, 2016.

Horne HN, Chung CC, Zhang H, Yu K, Prokunina-Olsson L, Michailidou K, et al (incl Winqvist R, Jukkola-Vuorinen A). Fine-Mapping of the 1p11.2 Breast Cancer Susceptibility Locus. PLoS One 11(8):e0160316, 2016.

Kar SP, Beesley J, Amin Al Olama A, Michailidou K, Tyrer J, et al (incl Winqvist R). Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types. Cancer Discov 6:1052-1067, 2016.

Kiiski JI, Fagerholm R, Tervasmäki A, Pelttari LM, Khan S, Jamshidi M, Mantere T, Pylkäs K, Bartek J, Bartkova J, Mannermaa A, Tengström M, Kosma VM, Winqvist R, Kallioniemi A, Aittomäki K, Blomqvist C, Nevanlinna H. FANCM c.5101C>T mutation associates with breast cancer survival and treatment outcome. Int J Cancer 139:2760-2770, 2016.

Lawrenson K, Kar S, McCue K, Kuchenbaeker K, Michailidou K, et al (incl Winqvist R, Pylkäs K). Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus. Nat Commun 7:12675, 2016.

Lei J, Rudolph A, Moysich KB, Behrens S, Goode EL, et al (incl Winqvist R, Grip M). Genetic variation in the immunosuppression pathway genes and breast cancer susceptibility: a pooled analysis of 42,510 cases and 40,577 controls from the Breast Cancer Association Consortium. Hum Genet 135:137-154, 2016.

Liu J, Lončar I, Collée JM, Bolla MK, Dennis J, et al (incl Winqvist R, Pylkäs K). rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk. Sci Rep 6:36874, 2016.

Mantere T, Winqvist R*, Kauppila S, Grip M, Jukkola-Vuorinen A, Tervasmäki A, Rapakko K, Pylkäs K* (shared senior authorship). Targeted Next-Generation Sequencing Identifies a Recurrent Mutation in MCPH1 Associating with Hereditary Breast Cancer Susceptibility. PLoS Genet 12:e1005816, 2016.

Meeks HD, Song H, Michailidou K, Bolla MK, Dennis J, et al (incl Winqvist R, Pylkäs K). BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers. J Natl Cancer Inst 108:djv315, 2016.

Muranen T, Blomqvist C, Dörk T, Jakubowska A, Heikkilä P, et al (incl Winqvist R, Pylkäs K). Patient survival and tumor characteristics associated with CHEK2:p.I157T - findings from the Breast Cancer Association Consortium. Breast Cancer Res 18:98, 2016.

Obermeier K, Sachsenweger J, Friedl TW, Pospiech H, Winqvist R*, Wiesmüller L* (shared senior authorship). Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients. Oncogene 35:3796-3806, 2016.

Pelttari LM, Khan S, Vuorela M, Kiiski JI, Vilske S, Nevanlinna V, Ranta S, Schleutker J, Winqvist R, et al (Vuorela M). RAD51B in Familial Breast Cancer. PLoS One 11:e0153788, 2016.

Petridis C, Brook MN, Shah V, Kohut K, Gorman P, et al (incl Winqvist R, Pylkäs K). Genetic predisposition to ductal carcinoma in situ of the breast. Breast Cancer Res 18:22, 2016.

Shi J, Zhang Y, Zheng W, Michailidou K, Ghoussaini M, Bolla MK, et al (incl Winqvist R). Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer. Int J Cancer 139:1303-1317, 2016.

Southey MC, Goldgar DE, Winqvist R, Pylkäs K, Couch F, et al. PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS. J Med Genet 53:800-811, 2016.

Wyszynski A, Hong CC, Lam K, Michailidou K, Lytle C, Yao S, et al (incl Winqvist R, Pylkäs K). An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression. Hum Mol Genet 25:3863-3876, 2016.

Zeng C, Guo X, Long J, Kuchenbaecker KB, Droit A, et al (incl Winqvist R). Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus. Breast Cancer Res 18:64, 2016.

Zhao Z, Wen W, Michailidou K, Bolla MK, Wang Q, et al (incl Winqvist R, Pylkäs K). Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry. Cancer Causes Control 27:679-693, 2016.

Last updated: 11.12.2017