Intracellular redox compartments in Hypoxia-signalling and associated diseases
A limited supply of oxygen (hypoxia) has profound effects on both cellular and whole body function and contributes to the pathogenesis of diabetes mellitus, atherosclerosis, thrombosis, pulmonary hypertension and tumorigenesis. The hypoxia-inducible factor-1alpha(HIF-1alpha) plays a key role in the response to hypoxia. In addition to hypoxia, HIF-1alpha also responds to growth and coagulation factors and hormones by using reactive oxygen species (ROS) generated by various enzymes in different cellular compartments. Therefore, it is the overall aim of the project to understand the mechanistic link between hormone-regulated metabolism, compartment-specific changes of ROS and modulation of HIF-1alpha expression and degradation in vivo and in vitro.
Last updated: 28/10/2016