Palaute ja tiedustelut

oulun.yliopisto(at)oulu.fi
puh. (08) 553 1011
faksi (08) 553 4112
PL 8000
90014 Oulun yliopisto

University of Oulu
DEPARTMENT OF MEDICAL BIOCHEMISTRY AND MOLECULAR BIOLOGY

Professor Johanna Myllyharju, Ph.D.

Selected publications

  1. Myllyharju, J.& Kivirikko, K.I.: Characterization of the iron- and 2-oxoglutarate-binding sites of human prolyl 4-hydroxylase. EMBO J. 16: 1173-1180, 1997.
  2. Vuorela, A., Myllyharju, J., Nissi, R., Pihlajaniemi, T. & Kivirikko, K.I.: Assembly of human prolyl 4-hydroxylase and type III collagen in the yeast Pichia pastoris: formation of a stable enzyme tetramer requires coexpression with collagen and assembly of a stable collagen requires coexpression with prolyl 4-hydroxylase. EMBO J. 16: 6702-6712, 1997.
  3. Myllyharju, J. & Kivirikko, K.I.: Identification of a novel proline-rich peptide-binding domain in prolyl 4-hydroxylase. EMBO J. 18: 306-312, 1999.
  4. Hirsilä, M., Koivunen, P., Günzler, V., Kivirikko, K.I. & Myllyharju, J.: Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-induciple factor. J. Biol. Chem. 278: 30772-30780, 2003.
  5. Myllyharju, J. & Kivirikko, K.I.: Collagens, modifying enzymes and their mutations in humans, flies and worms. Trends Genet. 20: 33-43, 2004.
  6. Rautavuoma, K., Takaluoma, K., Sormunen, R., Myllyharju, J., Kivirikko, K.I. & Soininen, R.: Premature aggregation of type IV collagen and early lethality in lysyl hydroxylase 3 null mice. Proc. Natl. Acad. Sci. USA 101: 14120-14125, 2004.
  7. Pekkala, M., Hieta, R., Bergmann, U., Kivirikko, K.I., Wierenga, R.K. & Myllyharju, J.: The peptide-substrate-binding domain of collagen prolyl 4-hydroxylases is a tetratricopeptide repeat domain with functional aromatic residues. J. Biol. Chem. 279: 52255-52261, 2004.
  8. Hirsilä, M., Koivunen, P., Xu, L., Seeley, T., Kivirikko, K.I. & Myllyharju, J.: Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway. FASEB J. 19: 1308-1310, 2005.
  9. Keskiaho, K., Hieta, R., Sormunen, R. & Myllyharju, J.: Clamydomonas reinhardtii has multiple prolyl 4-hydroxylases, one of which is essential for proper cell wall assembly. Plant Cell 19, 256-269, 2007.
  10. Holster, T., Pakkanen, O., Soininen, R., Sormunen, R., Nokelainen, M., Kivirikko, K.I. & Myllyharju, J.: Loss of assembly of the main basement membrane collagen, type IV, but not fibril-forming collagens and embryonic death in collagen prolyl 4-hydroxylase I null mice. J. Biol. Chem. 282: 2512-2519, 2007.