Minna Männikkö, Ph.D.

Genetic Susceptibility to Common Musculoskeletal Diseases

Project Leader: Docent Minna Männikkö, Ph.D.,
Institute of Health Sciences, Faculty of Medicine and Oulu Center for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of Oulu

mailing address:
P.O.Box 5000, FIN-90014 University of Oulu, Finland

street address:
Aapistie 5, University of Oulu, FIN-90220 Oulu, Finland
Tel. +358-(0)294 485751,
e-mail: minna.mannikko (at) oulu.fi


About the project

Degenerative musculoskeletal diseases such as osteoarthritis (OA) and osteoporosis (OP) are among the greatest reasons for disabilities among all medical conditions, particularly in the aging population. They cause considerable individual suffering and are a significant economic burden on public healthcare. Many of the underlying mechanisms driving disease progression are not fully understood, and yet this knowledge is essential for better diagnostics, prevention and treatment of the disease states. While these conditions can be secondary to various factors, in OA, for example, the majority of cases are considered primary and the proportion of heritability in OA can be as high as 65%. This project is aimed at improving the understanding of molecular pathways underlying common musculoskeletal diseases by identifying disease-associated genetic/epigenetic variants. The project is associated with the Centre for Life Course Epidemiology at the Institute of Health Sciences. Large population-based cohorts, the Northern Finland Birth Cohort (http://www.oulu.fi/nfbc/) and the Health 2000 Survey (http://www.terveys2000.fi/), are used to study the genetic, metabolic and environmental determinants of degenerative musculoskeletal diseases.

Project details

  1. Background and Significance
  2. Recent Progress
  3. Future Goals
  4. Publications 2014-
  5. Research Group Members

Last updated: 23.3.2016