Molecular Determinants of Metabolic Syndrome (Metsyn)

Markku Savolainen, M.D., Ph.D., Karl-Heinz Herzig, M.D., Ph.D and Marjo-Riitta Järvelin, M.D., Ph.D.

Project leaders
Prof. Markku Savolainen, M.D., Ph.D., Biocenter Oulu and Department of Internal Medicine, University of Oulu and Oulu University Hospital
Prof. Karl-Heinz Herzig, M.D., Ph.D., Biocenter Oulu and Department of Physiology, Institute of Biomedicine, University of Oulu and Oulu University Hospital
Prof. Marjo-Riitta Järvelin, M.D., M.Sc., Ph.D., Centre For Life-Course Health Research, Biocenter Oulu, Oulu University Hospital
Faculty of Medicine, University of Oulu

Mailing address:
P.O.Box 5000, FIN-90014 University of Oulu, Finland

Contact information:
e-mail: markku.savolainen (at), Tel. +358-(0)294 485101
e-mail: karl-heinz.herzig (at), Tel. +358-(0)294 485280
e-mail: m.jarvelin (at), Tel. +358-(0)294 485638

More information:
Web page of Group Herzig

Focus area spearhead project web page:

About the project

The project of the Savolainen, Herzig, Järvelin consortium involves teams in clinical sciences, medical physiology and life-course epidemiology and we investigate new molecular factors associated with metabolic syndrome (i.e. obesity, dyslipidaemia, high blood pressure and insulin resistance). We are focusing on unravelling the roles played by molecular factors in pro-inflammatory pathways and their potential as targets in therapeutic and preventive strategies. The consortium works in three main research areas: i) genetics and molecular determinants of atherosclerosis, ii) physiology of the inflammatory response as a path for inter-organ communication, and iii) life-course and molecular epidemiology of long-term metabolic health. We aim at defining intermediate and modifiable phenotypes and subgroups of the population to implement personalised medicine approaches. Following successful research into the genetics of common metabolic traits, the group is now developing approaches implementing exposomics, exomics and epigenomics.

Project details

  1. Background and Significance
  2. Recent Progress
  3. Future Goals
  4. Publications 2016-
  5. Doctoral Theses 2016
  6. Research Group Members
  7. National and International Activities

Last updated: 15.10.2018