Biocenter Oulu Discovery of the Year 2020

The Biocenter Oulu Discovery of the Year 2020 Event was held on December 15, this time remotely.

Discovery of the year: 

*Kapiainen E, *Kihlström MK, Pietilä R, Kaakinen M, Ronkainen VP, Tu H, Heikkinen A, Devarajan R, Miinalainen I, Laitakari A, Ansarizadeh M, Zhang Q, Wei GH, Ruddock L, Pihlajaniemi T, Elamaa H, Eklund L.
The amino-terminal oligomerization domain of Angiopoietin-2 affects vascular remodeling, mammary gland tumor growth, and lung metastasis in mice.
Cancer Res. 2020 Oct 9:canres.1904.2019. doi: 10.1158/0008-5472.CAN-19-1904. Online ahead of print.
Presentation by Emmi Kapiainen (FBMM)

The other publications presented in the event were the following (not in the ranked order):

Hassani-Nezhad-Gashti F, Salonurmi T, Hautajärvi H, Rysä J, Hakkola J, Hukkanen J.
Pregnane X Receptor Activator Rifampin Increases Blood Pressure and Stimulates Plasma Renin Activity.
Clin Pharmacol Ther. 2020 Oct;108(4):856-865. doi: 10.1002/cpt.1871. Epub 2020 May 20.PMID: 32344455
Presentation by Fatemeh Hassani Nezhad Gashti (FMED)

Tolonen JP, Heikkilä M, Malinen M, Lee HM, Palvimo JJ, Wei GH, Myllyharju J. 
A long hypoxia-inducible factor 3 isoform 2 is a transcription activator that regulates erythropoietin.
Cell Mol Life Sci. 2020 Sep;77(18):3627-3642. doi: 10.1007/s00018-019-03387-9. 
Presentation by Jussi-Pekka Tolonen (FBMM)

Kuosmanen E, Kan V, Visuri A, Hosio S, Ferreira D (2020)
Let’s Draw: Detecting and Measuring Parkinson’s Disease on Smartphones
In Proc. The CHI Conference on Human Factors in Computing Systems (CHI ’20) 
DOI: https://doi.org/10.1145/3313831.3376864
Presentation by Elina Kuosmanen (ITEE Faculty of Information technology and electrical engineering)

Paavola J, Alakoski T, Ulvila J, Kilpiö T, Sirén J, Perttunen S, Narumanchi S, Wang H, Lin R, Porvari K, Junttila J, Huikuri H, Immonen K, Lakkisto P, Magga J, Tikkanen I, Kerkelä R.
Vezf1 regulates cardiac structure and contractile function.
eBioMedicine. 2020 Jan;51:102608. doi: 10.1016/j.ebiom.2019.102608. Epub 2020 Jan 3.PMID: 31911272
Presentation by Tarja Alakoski (FMED)

Laitakari A, Huttunen R, Kuvaja P, Hannuksela P, Szabo Z, Heikkilä M, Kerkelä R, Myllyharju J, Dimova EY, Serpi R, Koivunen P.
Systemic long-term inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 ameliorates aging-induced changes in mice without affecting their life span.
FASEB J. 2020 Apr;34(4):5590-5609. doi: 10.1096/fj.201902331R. Epub 2020 Feb 25.PMID: 32100354
Presentation by Anna Laitakari (FBMM)

Lin R, Rahtu-Korpela L, Magga J, Ulvila J, Swan J, Kemppi A, Pakanen L, Porvari K, Huikuri H, Junttila J, Kerkelä R.
miR-1468-3p Promotes Aging-Related Cardiac Fibrosis.
Mol Ther Nucleic Acids. 2020 Jun 5;20:589-605. doi: 10.1016/j.omtn.2020.04.001. Epub 2020 Apr 8.PMID: 32348937
Presentation by Ruizhu Lin (FMED)

The articles suggested by the BCO group leaders for the Discovery of the Year 2020 were evaluated and ranked by Professor Cecilia Sahlgren, Åbo Akademi University, Turku.

Last updated: 16.12.2020