Selected Publications

Most recent:

The dimeric structure of wild-type human glycosyltransferase B4GalT1.
Harrus D, Khoder-Agha F, Peltoniemi M, Hassinen A, Ruddock L, Kellokumpu S, Glumoff T.
PLoS One. (2018) Oct 23;13(10):e0205571. doi: 10.1371/journal.pone.0205571.

Crystal structures of eukaryote glycosyltransferases reveal biologically relevant enzyme homooligomers.
Harrus D, Kellokumpu S, Glumoff T. (2018) Cell Mol Life Sci., Mar;75(5):833-848. doi: 10.1007/s00018-017-2659-x.

Assembly of B4GALT1/ST6GAL1 heteromers in the Golgi membranes involves lateral interactions via highly charged surface domains
Fawzi Khoder-Agha, Deborah Harrus, Guillaume Brysbaert, Mark F. Lensink, Anne Harduin-Lepers, Tuomo Glumoff & Sakari Kellokumpu
J. Biol. Chem. (2019) Aug 8. pii: jbc.RA119.009539 [Epub ahead of print]

N-acetylglucosaminyltransferases and nucleotide sugar transporters form multi-enzyme-multi-transporter assemblies in golgi membranes in vivo
Fawzi Khoder-Agha, Paulina Sosicka, Maria Escriva Conde, Antti Hassinen, Tuomo Glumoff, Marius Olczak & Sakari Kellokumpu
Cell. Mol. Life Sci. 76 (2019), 1821-1832.

A Golgi-associated redox switch regulates catalytic activation and cooperative functioning of ST6Gal-I with B4GalT-I
Antti Hassinen, Fawzi Khoder-Agha, Elham Khosrowabadi, Daniela Mennerich, Deborah Harrus, Maxence Noel, Elitsa Y. Dimova, Tuomo Glumoff, Anne Harduin-Lepers, Thomas Kietzmann & Sakari Kellokumpu
Redox Biol. (2019 ) Jun;24:101182.

Abnormal Golgi pH Homeostasis in Cancer Cells Impairs Apical Targeting of Carcinoembryonic Antigen by Inhibiting Its Glycosyl-Phosphatidylinositol Anchor-Mediated Association with Lipid Rafts.
Kokkonen N, Khosrowabadi E, Hassinen A, Harrus D, Glumoff T, Kietzmann T, Kellokumpu S.
Antioxid Redox Signal., (2019) Jan 1;30(1):5-21. doi: 10.1089/ars.2017.7389.

17β-hydroxysteroid dehydrogenases as acyl thioester metabolizing enzymes
J. Kalervo Hiltunen, Alexander J. Kastaniotis, Kaija J. Autio, Gianguy Jiang, Zhijun Chen & Tuomo Glumoff
Mol. Cell. Endocrinol. 489 (2019), 107-118. REVIEW.

Browning of white fat: agents and implications for beige adipose tissue to type 2 diabetes
Anna Kaisanlahti & Tuomo Glumoff
J. Physiol. Biochem. 75 (2019), 1-10. REVIEW.

S. Kellokumpu, A. Hassinen & T. Glumoff (2015). Glycosyltransferase complexes in eukaryotes: long-known, prevalent but still unrecognized. Cell Mol. Life Sci. 2015 Oct 17.

A. Hassinen & S. Kellokumpu (2014). Organizational interplay of Golgi N-glycosyltransferases involves organelle microenvironment-dependent transitions between enzyme homo- and heteromers. J. Biol. Chem. 289(39):26937-48.

2013 and earlier (key papers only):

M.L. Mehtälä, T.J. Haataja, C.E. Blanchet, J.K. Hiltunen, D.I. Svergun & T. Glumoff (2013). Quaternary structure of human, Drosophila melanogaster and Caenorhabditis elegans MFE-2 in solution from synchrotron small-angle X-ray scattering. FEBS Lett. 587: 305-310

M.L. Mehtälä, M.F. Lensink, L.P. Pietikäinen, J.K. Hiltunen & T. Glumoff (2013). On the molecular basis of D-bifunctional protein deficiency type III. PLOS ONE 8: e53688

A. Rivinoja, A. Hassinen, F. Pujol and S. Kellokumpu (2012). Golgi pH. Its Regulation and Roles in Human Disease. Review. Ann. Med., 44, No 6: 542–554

A. Hassinen, F.M. Pujol, N. Kokkonen, C. Pieters, M. Kihlström, K. Korhonen and S. Kellokumpu (2011). Functional organization of the Golgi Glycosylation pathways Involves pH-dependent
Complex Formation That Is Impaired in Cancer Cells. J. Biol. Chem. 286, No 44: 38329–8340

T.J.K. Haataja, M.K. Koski, J.K. Hiltunen & T. Glumoff (2011). Peroxisomal multifunctional enzyme type 2 from the fruitfly: dehydrogenase and hydratase act as separate entities, as revealed by structure and kinetics. Biochem. J. 435: 771–781.

A. Hassinen, A. Kauppila and S. Kellokumpu (2010). Golgi N-Glycosyltransferases Form Both Homo- and Heterodimeric Enzyme Complexes in Live Cells. J. Biol. Chem. 285, No 23: 17771–17777

Antti Rivinoja, Antti Hassinen, Nina Kokkonen, Annika Kauppila, and Sakari Kellokumpu (2009). Elevated Golgi pH Impairs Terminal N-Glycosylation by Inducing Mislocalization of Golgi Glycosyltransferases. J. Cell. Physiol. 220: 144–154

A. Rivinoja, N. Kokkonen, I. Kellokumpu and S. Kellokumpu (2006). Elevated Golgi pH in Breast and Colorectal Cancer Cells Correlates with the Expression of Oncofetal Carbohydrate T-antigen. J. Cell Physiol., 208:167–174

M.S. Ylianttila, N. Pursiainen, A.M. Haapalainen, A. Juffer, Y. Pourier, J.K. Hiltunen & T. Glumoff (2006). Crystal structure of yeast peroxisomal multifunctional enzyme: structural basis for substrate specificity of (3R)-hydroxyacyl-CoA dehydrogenase units. J. Mol. Biol. 358: 1286-1295.

S. Ferdinandusse, M.S. Ylianttila, J. Gloerich, M.K. Koski, W. Oostheim, H.R. Waterham, J.K. Hiltunen, R.J.A. Wanders & T. Glumoff (2006). Mutational spectrum of D-Bifunctional protein deficiency and structure-based genotype-phenotype analysis. Am. J. Hum. Genet. 78: 112-124.

N. Kokkonen, A. Rivinoja, A. Kauppila, M. Suokas, I. Kellokumpu, S. Kellokumpu (2004). Defective acidification of intracellular organelles results in increased secretion of cathepsin D in cancer cells. J. Biol Chem. 279: 39982-8

M. Kristian Koski, Antti M. Haapalainen, J. Kalervo Hiltunen & Tuomo Glumoff (2004). A two-domain structure of one subunit explains unique features of eukaryotic hydratase 2. J. Biol. Chem. 279: 24666-24672.

A.M. Haapalainen, M.K. Koski, Y-M. Qin, J.K. Hiltunen & T. Glumoff (2003). Binary structure of the two-domain (3R)-hydroxyacyl-CoA dehydrogenase from rat peroxisomal multifunctional enzyme type 2 at 2.38 Å resolution. Structure 11: 87-97.


Viimeksi päivitetty: 14.1.2020