Although hypoxia is speculated to play a role in development, firm data is lacking. Using our nephrogenesis and MDCK models and our mutant HIF-proly-4-hydoroxylase mice, we should be able to integrate hypoxia to developmental control. This should also lead to opportunities for finding new modulators of the hypoxia response.
When tumours grow they become hypoxic. We have found that polarization of epithelial cells is disturbed in hypoxia and that inactivation of the hypoxia response pathway rescues polarization in hypoxia. We aim to address the synergies between hypoxia and other oncogenic factors using our mutant mice as well as the MDCK model.
Last updated: 12.6.2012