The most efficient tool for studying light propagation in biological tissues in different optical experimental arrangements is the Monte Carlo (MC) method. It is based on calculation of trajectories of a large number of photons randomly propagating in a scattering medium with subsequent statistical analysis of the obtained data. This method is able to account for different scattering phase functions as well as for the multilayered structure of the considered medium and various configurations of source and detector units.
Our team has a wide experience in MC simulations. We have developed our own MC-based algorithm of light propagation in multilayered media containing structural inhomogeneities and implemented it on a multiprocessor platform with parallel architecture using MPI (Message Passing Interface) technology. The developed program was used for simulation of a number of techniques, in particular, OCT and DOCT signals, signals of diffuse reflectance with spatial and temporal resolution, alteration of tissue optical properties with nanoparticles.
Typical photon trajectories in three-layer medium. Upper and bottom layers are transparent (glass), middle layer is scattering (μs = 15 mm-1, g = 0.7). The probing radiation is shown with an arrow.
2D spatially-resolved diffuse reflectance from a scattering medium with a cylindrical nonhomogeneity mimicking a blood vessel in skin embedded at the depth of 1 mm.
Experimental and simulated attenuation curves for sunscreens. Experiment: o/w emulsion (L'Oreal, France) with UV-TITAN M160 (Kemira, Finland). Simulations: 100-nm TiO2 particles with volume fraction 0.2% in 20-μm layer of transparent medium (n = 1.4).
J. Kalkman, A.V. Bykov, D.J. Faber, T.G. van Leeuwen, “Multiple and dependent scattering effects in Doppler optical coherence tomography”, Optics Express 18(4), 3883-3892 (2010). [PDF]
A.V. Bykov, M.Yu. Kirillin, A.V. Priezzhev, “Monte Carlo simulation of an optical coherence Doppler tomograph signal: the effect of the concentration of particles in a flow on the reconstructed velocity profile”, Quantum Electron. 35 (2), 135-139 (2005). [PDF]
M. Kirillin, I. Meglionski, V. Kuzmin, E. Sergeeva, R. Myllylä. "Simulation of optical coherence tomography images by Monte Carlo modeling based on polarization vector approach," Opt. Express 18, 21714-21724 (2010). [PDF]
M.Yu. Kirillin, A.V. Bykov, A.V. Priezzhev, R. Myllylä, "Application of time gating in the measurement of glucose level in a three-layer biotissue model by using ultrashort laser pulses", Quantum Electron. 38(5), 486-490 (2008). [PDF]
A.V. Bykov, M.Yu. Kirillin, A.V. Priezzhev, R. Myllylä, "Simulations of a spatially resolved reflectometry signal from a highly scattering three-layer medium applied to the problem of glucose sensing in human skin", Quantum Electron. 36(12), 1125-1130 (2006). [PDF]
A.V. Bykov, M.Yu. Kirillin, A.V. Priezzhev, “Monte Carlo simulation of light propagation in human tissues and noninvasive glucose sensing”. In: “Handbook of Optical Sensing of Glucose in Biological Fluids and Tissues”, V.V. Tuchin – editor, Taylor & Francis group, London, 744 pages (2008). [PDF]
A.V. Bykov, A.V. Priezzhev, R. Myllylä, “Spatial resolved diffuse reflection as a tool for determination of size and embedding depth of blood vessels”. Proc. SPIE 6629, 66291P (2007). [PDF]
A.P. Popov, A.V. Zvyagin, J. Lademann, M.S. Roberts, W. Sanchez, A.V. Priezzhev, R. Myllylä, “Designing light-protective skin nanotechnology products”, J. Biomed. Nanotech. 6(5), 432-451 (2010). [PDF]
A.P. Popov, A.V. Priezzhev, J. Lademann, R. Myllylä, "Nanoparticles as sunscreen compound: risks and benefits". In: "Handbook of Photonics for Biomedical Science", V.V. Tuchin – editor, Taylor & Francis group, 868 pages, London (2010). [PDF]
A.P. Popov, A.V. Priezzhev, J. Lademann, R. Myllylä, “Biophysical mechanisms of modification of skin optical properties in the UV wavelength range with nanoparticles”, J. Appl. Phys. 105(10), 102035 (2009). [PDF]
A.P. Popov, A.V. Priezzhev, J. Lademann, R. Myllylä, “Effect of multiple scattering of light by titanium dioxide nanoparticles implanted into a superficial skin layer on radiation transmission in different wavelength ranges”, Quantum. Electron. 37(1), 17-21 (2007). [PDF]
A.P. Popov, A.V. Priezzhev, J. Lademann, R. Myllylä, "Effect of size of TiO2 nanoparticles embedded into stratum corneum on ultraviolet-A and ultraviolet-B sun-blocking properties of the skin”, J. Biomed. Opt. 10(6), 064037 (2005). [PDF]
A.P. Popov, A.V. Priezzhev, J. Lademann, R. Myllylä, “TiO2 nanoparticles as an effective UV-B radiation skin-protective compound in sunscreens”, J. Phys. D: Appl. Phys. 38 (15), 2564-2570 (2005). [PDF]
Last updated: 9.9.2016