Prof. Lloyd Ruddock

About the project

There are hundreds of types of protein post-translational modification (PTM), which alter protein structure, function, stability, etc. In eukaryotes, two of the most common PTMs occur in the endoplasmic reticulum; disulfide bond formation and N-glycosylation. Disulfide bond formation is a complex, essential, multi-factorial process, which is often the rate limiting step in protein folding. The major limitation in expansion of protein based therapeutics and analytics is protein production on an industrial scale, especially the generation of homogenous disulfide bonded proteins. The same limitation severely inhibits academic studies into a very wide range of biological processes and associated disease states.

Project details

  1. Background and significance
  2. Recent progress
  3. Future goals
  4. Selected publications
  5. Research group members
  6. National and International significance

Last updated: 14.5.2020