Lari Lehtiö, Ph.D.

Short CV


Structure, Function and Selective Inhibition of ADP-ribosyltransferases

Our main focus is on the development of selective inhibitors of enzymes of the human poly(ADP-ribose) polymerase family, recently renamed Diphtheria toxin-like ADP-ribosyltransferases. These enzymes regulate various signalling events through covalent protein modification – ADP-ribosylation. We develop assays suitable for high-throughput screening of inhibitors and use structural information for more rational design. Protein X-ray crystallography is our main tool used to rationalise structure-activity relationships of compounds and to gain understanding of the structure and function of these multidomain proteins.                                                                                                                      

Project details

  1. Background and Significance
  2. Recent Progress
  3. Future Goals
  4. Selected Publications
  5. Research Group Members
  6. National and International Activities

Last updated: 28.10.2016