Selected publications

Lehtiö L, Jemth A-S, Collins R, Loseva O, Johansson A, Markova N, Hammarström M, Flores A, Holmberg-Schiavone L, Weigelt J, Helleday T, Schüler H, Karlberg T. (2009) Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3. J Med Chem 52:3108-3111

Lehtiö L, Collins R, van den Berg S, Johansson A, Dahlgren LG, Hammarström M, Helleday T, Holmberg-Schiavone L, Kalrberg T, Weigelt J. (2008) Zinc binding catalytic domain of human tankyrase 1. J. Mol. Biol. 379:136-145

Narwal, M., Fallarero, A., Vuorela, P. & Lehtiö, L. (2012a) Homogenous Screening Assay for Human Tankyrase. J. Biomol. Screen. 17:593-604

Narwal, M., Venkannagari, H. & Lehtiö, L. (2012b) Structural Basis of Selective Inhibition of Human Tankyrases. J. Med. Chem. 55:1360-1367.

Vilchez Larrea SC, Haikarainen T, Narwal M, Schlesinger M, Venkannagari H, Flawia MM, Fernandez Villamil SH, Lehtiö L. (2012) Inhibition of poly(ADP-ribose) polymerase interferes with Trypanosoma cruzi infection and proliferation of the parasite. PLoS One 7:e46063

Lehtiö, L., Chi, N-W. & Krauss, S. (2013) Tankyrases as Drug Targets. FEBS J. In press doi: 10.1111/febs.12320

Haikarainen, T., Venkannagari, H., Narwal, M., Obaji, E., Lee, H-W., Nkizinkiko, Y. & Lehtiö, L. (2013) Structural Basis and Selectivity of Tankyrase Inhibition by a Wnt Signaling Inhibitor WIKI4. PLoS ONE 8:e65404

Narwal, M., Haikarainen, T., Fallarero, A., Vuorela, P.M. &  Lehtiö, L. (2013) Screening and Structural Analysis of Flavones Inhibiting Tankyrases. J. Med. Chem.56:3507-3517

Venkannagari, H., Fallarero, A., Feijs, K.L.H, Lüscher, B. & Lehtiö, L. (2013) Activity-based assay for human mono-ADP-ribosyltransferases ARTD7/PARP15 and ARTD10/PARP10 aimed at screening and profiling inhibitors. Eur. J. Pharm. Sci. 49:148-156.
 

Last updated: 28.10.2016