One of our goals is to investigate how compartment-specific concentration changes of ROS modulate the activity of the HIFα family proteins and expression of their target genes.
Another goal is to unravel the mechanisms by which CIN85 interferes with HIF degradation and investigate whether or not it interferes with PHD function. So far, it is unknown how these molecules interact and which domains would be involved.
Further work will include investigations on USP28 functions and its role in cancer and angiogenesis.
Last updated: 19.1.2017