Sakari Kellokumpu, Adj.Prof., Ph.D and Tuomo Glumoff, Adj. Prof. and Ph.D

Short CV

Short CV

Molecular Mechanisms of Glycosylation and Glycosylation-Associated Human Diseases

Glycosylation is one of the most common modification of cellular proteins and lipids, and a major source of biological diversity between cells, tissues, organisms, species and the different kingdoms and domains of life. Glycosylation is also critical for many basic cellular functions that range from protein folding and transport to cell signaling and motility, immunological defense, fertilization, and the development/maintenance of multicellular organisms. Their importance is highlighted by the existence of several glycosylation-associated human disease states such as congenital diseases of glycosylation (CDGs), inflammation, diabetes and cancer. All of these diseases are characterized by expressing aberrant oligosaccharide chains (glycans), which e.g. cancers play an important role in cancer cell invasion and metastasis – the major cause of death in cancer patients. Our main aim is to understand how the cellular glycosylation machinery, consisting of dozens of functionally distinct glycosylation enzymes, functions and is regulated at the cellular and molecular level to allow faithful synthesis of a vast number of different glycan structures. An important part of our studies is also to unravel the molecular defects that hinder normal glycosylation in diseased cells, especially those that relate to cancer-associated glycosylation abnormalities. In the studies, we utilize modern molecular, cellular and structural biology approaches. The project has been funded mainly by The Academy of Finland and The University of Oulu.

Project Details

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Last updated: 28.10.2016