Our objective is to investigate activation of the hypoxia response pathway via HIF-P4H inhibition as a novel concept to treat hepatic, inflammatory and immunological diseases. Our second objective is to study the catalytic and inhibitory properties of KDMs, especially their potential to act as nuclear oxygen sensors and contribute to tumorigenesis. Our third objective is to unravel the role and function of P4H-TM.
The specific goals are:
To analyze the cross-talk between HIF hydroxylases and metabolism, inflammation and immunology
To characterize the kinetic and structural properties of selecetd KDMs and other less-studied 2OGDDs
To analyze the in vivo role of P4H-TM
Last updated: 5.2.2020