Structural Biology of the Myelin Membrane
The myelin sheath enables the rapid transmission of nerve impulses in the vertebrate nervous system. The multilayered myelin membrane, tightly wrapped around axons, contains a number of specific proteins involved in myelin formation and neurological diseases. We are interested in the structure-function relationships in this unique but diverse set of proteins, in order to better understand the tight packing of the myelin membrane and the factors governing its function in nervous system development, function and disease. We also use these molecules as general models for protein–membrane interactions. Our work includes the recombinant production of myelin proteins and detailed elucidation of their structure and function by state-of-the-art biochemical, biophysical and structural biology methods.
Last updated: 12.6.2020