Selected Publications

Monteuuis G.*, Miścicka A.*, Świrski M., Zenad L., Niemitalo O., Wrobel L, Alam J., Chacinska A., Kastaniotis A.J.* and Joanna Kufel J*. (2019). Non-canonical translation initiation in yeast generates a cryptic pool of mitochondrial proteins. Nucleic Acids Res. 47(11): 5777-5791      * equally contributing first/senior authors

Nair R.R., Koivisto H., Jokivarsi K., Miinalainen I.J., Autio K.J., Manninen A., Poutiainen P., Tanila H., Hiltunen J.K., Kastaniotis A.J. (2018). Impaired mitochondrial fatty acid synthesis leads to neurodegeneration in mice. J. Neurosci. 2018 Sep 28. pii: 3514-17.

Monteuuis G.M., Suomi F, Kerätär J.M. and Kastaniotis A.J. (2017). A conserved mammalian mitochondrial isoform of acetyl-CoA carboxylase ACC1 provides the malonyl-CoA essential for mitochondrial biogenesis in tandem with ACSF3. Biochem. J. 474 (22): 3783-3797

Nair R.R., Kerätär J.M., Autio K.J., Masud A.J., Finnilä M.A.J., Autio-Harmainen H.I., Miinalainen I.J., Nieminen P.A., Hiltunen J.K., Kastaniotis A.J. (2017). Genetic modifications of Mecr reveal a role for mitochondrial 2-enoyl-CoA/ACP reductase in placental development in mice. Hum. Mol. Genet. 26(11):2104-2117

Heimer G., Kerätär J.M., Riley L.G., Balasubramaniam S., Pietikäinen L.P., Hiltunen J.K., Eyal E., Marek-Yagel D., Hamada J., Gregory A. ,Rogers C., Hogarth P., Nance M., Shalva N, Veber A, Tzadok M, Elpeleg O,University of Washington Center for Mendelian Genomics,   Tonduti D., Renaldo F, Kraoua I, Panteghini C., Valletta L., Garavaglia B, Cowley M.J., Gayevskiy V., Roscioli T., Silberstein J.M., Nissenkorn A, Raas-Rothschild A., Tiranti V, Anikster Y., Christodoulou J.*, Kastaniotis A.J.*, Ben-Zeev B.*, and Hayflick S.J.* (2016). MECR mutations cause childhood onset dystonia and optic atrophy - a mitochondrial fatty acid synthesis disorder. Am. J. Hum. Genet. 2016 Dec 1;99(6):1229-1244

Suomi F., Menger K.E., Monteuuis G., Naumann U., Kursu V.A., Shvetsova A., Kastaniotis A.J. (2014). Expression and evolution of the non-canonically translated yeast mitochondrial acetyl-CoA carboxylase Hfa1p. PLoS One. 11;9(12):e114738

Venkatesan R., Sah-Teli S.K., Awoniyi L.O., Jiang G., Prus P., Kastaniotis A.J., Hiltunen J.K., Wierenga R.K., Chen Z. (2014). Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase. Nat. Commun. 5:4805.

Kursu V.A.S., Pietikäinen L.P., Fontanesi F., Aaltonen M.J., Suomi F., Remya Raghavan Nair R., Schonauer M.S., Dieckmann C.L., Barrientos A., Hiltunen J.K. and Kastaniotis A.J. (2013). Defects in Mitochondrial Fatty Acid Synthesis Result in Failure of Multiple Aspects of Mitochondrial Biogenesis in Saccharomyces cerevisiae. Mol Microbiol. 2013 Nov;90(4):824-40.

Ramakrishnan S., Docampo M.D., Macrae J.I., Pujol F.M., Brooks C.F., van Dooren G.G., Hiltunen J.K., Kastaniotis A.J., McConville M.J., Striepen B.(2012). Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii. J. Biol. Chem. 10;287(7):4957-71.

Hiltunen J.K., Autio K.J., Schonauer M.S., Kursu V.A., Dieckmann C.L., Kastaniotis A.J. (2010). Mitochondrial fatty acid synthesis and respiration. Biochem Biophys Acta 1797(6-7):1195-202

Chen Z., Kastaniotis A.J., Miinalainen I.J., Rajaram V., Wierenga R.K., Hiltunen J.K. (2009). 17{beta}-Hydroxysteroid dehydrogenase type 8 and carbonyl reductase type 4 assemble as a ketoacyl reductase of human mitochondrial FAS. FASEB J. 23(11):3682-91

Schonauer M.S., Kastaniotis A.J., Kursu V.A., Hiltunen J.K., Dieckmann C.L. (2009). Lipoic acid synthesis and attachment in yeast mitochondria. J. Biol. Chem. 28;284(35):23234-42.

Schonauer M.S., Kastaniotis A.J., Hiltunen J.K., Dieckmann C.L. (2008). Intersection of RNA Processing and the Type II Fatty Acid Synthesis Pathway in Yeast Mitochondria. Mol. Cell. Biol. 28(21):6646-57.

Gurvitz A., Hiltunen J.K., Kastaniotis A.J. (2008). Function of heterologous Mycobacterium tuberculosis InhA, a type 2 fatty acid synthase enzyme involved in extending C20 fatty acids to C60-to-C90 mycolic acids, during de novo lipoic acid synthesis in Saccharomyces cerevisiae. Appl. Environ. Microbiol.74(16):5078-85

Haeuptle M.A., Pujol F.M., Neupert C., Winchester B., Kastaniotis A.J., Aebi M., Hennet T.(2008). Human RFT1 deficiency leads to a disorder of N-linked glycosylation. Am. J. Hum. Genet. 82(3):600-6

Autio K.J.*, Kastaniotis A.J.*, Pospiech H., Miinalainen I.J., Schonauer M.S., Dieckmann C.L. and Hiltunen J.K. (2008). An ancient genetic link between vertebrate mitochondrial fatty acid synthesis and RNA processing. FASEB. J. 22(2):569-78 *equal contribution

Kastaniotis A.J., Autio K.J., Sormunen R.T, and Hiltunen J.K. (2004). Htd2p/Yhr067p is a yeast 3-hydroxyacyl-ACP dehydratase essential for mitochondrial function and Morphology. Mol. Microbiol. 53(5):1407-21


 


 

Last updated: 21.8.2019