Mika Rämet, MD, PhD

Professor in peadiatrics, Leader of PEDEGO Research Unit
Peadiatrics, Neonatology, Immunology, Infectious Diseases, Tuberculosis
Current Position: 
Professor in peadiatrics
Leader of PEDEGO Research Unit
Mailing Address: 
P.O.BOX 5000,
FIN-90014 University of Oulu
FINLAND

E-mail: mika.ramet (at) oulu.fi
Phone: +358 50433 6276
Street Address: 
Aapistie 5A
90220 Oulu
FINLAND

Biography:

Dr Mika Rämet, Professor of Peadiatrics, received his MD and Ph.D. degrees from the University of Oulu, Finland. Rämet worked as a research Fellow at the Harvard University, Boston from 1999 to 2002. After returning to Finland, he has received Specialist’s degree in Peadiatrics and Neonatology at the University of Tampere, Finland. He has led his independent research team since 2003.

Dr Rämet’s research centers on the basic mechanisms of immune response using primarily non-mammalian models such as the fruit fly, Drosophila melanogaster and zebrafish Danio rerio. He was the first to demonstrate the power of RNAi screening in cultured cells. Nowadays he uses model organisms to investigate host-microbe interactions primarily related to the most important paediatric pathogens. In addition, he has focused on identifying genetic alterations predisposing to the preterm birth and to the most important diseases related to prematurity (bronchopulmonary dysplasia, ans susceptibility to severe respiratory infections during neonatal period).

Dr Rämet has received several honours in recognition of his research including awards from the Society for Pediatric Research (Fellow Clinical Research Award), the Finnish Medical Association Duodecim (Young Investigator Prize given every second year to the most promising medical scientist in Finland), the Finnish Pediatric Association (Helena and Niilo Hallman Award given every second year to the internationally recognized young Pediatric scientist in Finland) and the Anders Jahre Prize for young scientist.

Currently, his research is funded by the Jane and Aatos Erkko Foundation, the Academy of Finland, Sigrid Juselius Foundation, Tampere Tuberculosis Foundation and Stiftelsen Alma och K. A. Snellman Foundation.

 

The most important research areas:

Spontaneous preterm delivery: susceptibility genes and timing of childbirth

Mechanisms, prevention and treatment of the most common neonatal diseases

Molecular mechanisms regulating innate immunity

Development of a new vaccine against tuberculosis

Pathophysiology of Mycobacterial infection

Pathophysiology of Streptococcal infection

 

Academic merits:

Panel member, Organism biology, Vetenskaprådet, Swedish Research Council

Chair, Finnish Society for Immunology

Member of the Board, Scandinavian Society for Immunology

Member, Research Council, University of Oulu

Member of the editorial board, Developmental and Comparative Immunology

Member of the editorial board, Scandinavian Journal of Immunology

 

10 most important publications

 

  1. Rämet M, Haataja R, Marttila R, Floros J & Hallman M. Association between the Surfactant protein A (SP-A) gene locus and Respiratory-Distress Syndrome in the Finnish population. American Journal of Human Genetics 2000;66:1569-1579. Citations 97
  2. Rämet M, Pearson A, Manfruelli P, Li X, Koziel H, Göbel V, Chung E, Krieger M & Ezekowitz RA. Drosophila scavenger receptor CI is a pattern recognition receptor for bacteria. Immunity 2001;15:1027-1038. Citations 159
  3. Rämet M, Lanot R, Zachery D & Manfruelli P. JNK signaling pathway is required for efficient wound healing in Drosophila. Developmental Biology 2002;241:145-56. Citations 150
  4. Rämet M, Manfruelli P, Pearson A, Mathey-Prevot B & Ezekowitz RA. Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli. Nature 2002;416:644-648. Citations 435
  5. Kleino A, Valanne S, Ulvila J, Kallio J, Myllymäki H, Enwald H, Stöven S, Poidevin M, Ueda R, Hultmark D, Lemaitre B & Rämet M. Inhibitor of apoptosis 2 and TAK1 binding protein are components of the Drosophila Imd pathway. EMBO Journal 2005;24:3423-3434. Citations 103
  6. Kocks C, Cho JH, Nehme N, Ulvila J, Pearson AM, Meister M, Strom C, Conto S, Hetru C, Stuart L, Stehle T, Hoffmann JA, Reichhart J-M, Ferrandon D, Rämet M & Ezekowitz RA. Eater, a novel transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila. Cell 2005;123:335-346. Citations 172
  7. Valanne S, Myllymäki H, Kallio J, Sshmid M, Kleino A, Murumägi A, Airaksinen L, Kotipelto T, Kaustio M, Ulvila J, Esfahani S, Engström Y, Silvennoinen O, Hultmark D, Parikka M & Rämet M. Genome-wide RNAi in Drosophila cells identifies G protein-coupled receptor kinase 2 as an evolutionary conserved regulator of the NF-kB signaling. Journal of Immunology, 2010, 184:6188-98. Citations 31
  8. Parikka M, Vuoksio M, Harjula SK, Halfpenny N, Oksanen K, Lahtinen MJ, Pajula E, Iivanainen A, Pesu M & Rämet M. Mycobacterium marinum causes a latent infection that can be reactivated by gamma irradiation in adult zebrafish. PLoS Pathogens, 2012, 8:e1002944. Citations 24
  9. Hammarén MM, Oksanen K, Nisula HM, Luukinen B, Pesu M, Rämet M & Parikka M. Adequate Th2 response associates with restricted bacterial growth in latent mycobacterial infection of zebrafish. PLoS Pathogens, 2014, 10:e1004190. Citations 4
  10. Vanha-aho LM, Anderl I, Hultmark D, Valanne S & Rämet M. Edin expression in the fat body is required for resistance against parasitoid wasps in Drosophila melanogaster. PLoS Pathogens, 2015, 11:e1004895. No citations yet

 

Member of the Research Group:

PEDEGO