Simo Ojanen

M.Sc.
University of Eastern Finland, Kuopio
University of Oulu, Oulu
simo.ojanen(at)uef.fi / simo.ojanen(at)oulu.fi


Present position

  • Ph.D. Student,Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu

Current research interests

  • Biomechanics of articular cartilage (AC) and chondrocytes
  • Early post-traumatic osteoarthritis (OA)
  • Progression of OA
  • Anterior cruciate ligament transection (ACLT)
  • AC structure and composition
  • µCT imaging of AC

Education

  • Master of Science, Applied Physics, University of Eastern Finland, 2014
  • Bachelor of Science, Physics, University of Eastern Finland, 2013

Biophysics of Bone and Cartilage-research group (University of Eastern Finland)

LinkedIn

ResearchGate

    Publications

    Published

    • Ojanen SP, Finnilä MAJ, Reunamo AE, Ronkainen AP, Mikkonen S, Herzog W, Saarakkala S, Korhonen RK, Site-specific glycosaminoglycan content is better maintained in the pericellular matrix than the extracellular matrix in early post-traumatic osteoarthritis. PLoS One. 2018;13(4):e0196203. doi:10.1371/journal.pone.0196203

    Sent for review

    • Ojanen SP, Finnilä MA, Mäkelä JT, Saarela K, Happonen E, Herzog W, Saarakkala S, Korhonen RK, Anterior cruciate ligament transection of rabbits alters composition, structure and biomechanics of articular cartilage and chondrocyte deformation 2 weeks post-surgery in a site-specific manner.
    • Prittinen J, Ylärinne J, Piltti J, Karhula S, Rieppo L, Ojanen SP, Korhonen RK, Saarakkala S, Lammi M, Qu C, Effect of centrifugal force on the development of articular neocartilage with bovine primary chondrocytes.
    • Afara IO, Sarin JK, Ojanen SP, Finnilä MAJ, Saarakkala S, Herzog W, Korhonen RK, Töyräs J, Machine learning classification of articular cartilage integrity based on near infrared (NIR) spectroscopy.

    Conference proceedings

    • Ojanen SP, Finnilä MAJ, Reunamo AE, Ronkainen AP, Herzog W, Saarakkala S, Korhonen RK, Site-specific Proteoglycan Content Is Better Maintained In The Pericellular Than Extracellular Matrix In Early Post-traumatic Osteoarthritis. 13th Science day of the Campus of Kontikangas – “Regulation of the Immune system – from bench to bedside”, February 2016, Oulu, Finland.
    • Podium presentation: Ojanen SP, Finnilä MAJ, Reunamo AE, Ronkainen AP, Herzog W, Saarakkala S, Korhonen RK, Site-specific Proteoglycan Content Is Better Maintained In The Pericellular Than Extracellular Matrix In Early Post-traumatic Osteoarthritis. Osteoarthritis and Cartilage 24:S17-S18 · April 2016, Amsterdam, the Netherlands.
    • Ojanen SP, Finnilä MAJ, Saarela K, Happonen E, Herzog W, Saarakkala S, Korhonen RK, Site-specific Changes In Deformation Of Articular Cartilage Chondrocytes At Very Early Stage Of Post-traumatic OA. Transactions of the Orthopaedic Research Society, San Diego, USA, 2017.
    • Casula V, Kajabi AW, Ojanen S, Finnilä M, Korhonen R, Herzog W, Saarakkala S, Nissi M, Nieminen MT, Multiparametric MRI assessment reveals early cartilage degeneration at 2 and 8 weeks after anterior cruciate ligament transection in a rabbit model. Proc. Intl. Soc. Magn. Reson. Med. 25 (5490), Honolulu, Hawaii, USA, 2017.
    • Podium presentation: Finnilä MAJ, Ojanen S, Saarakkala S, Hewitt C, Herzog W, Nieminen P, Hart DA, Korhonen RK, Increased cartilage remodelling and impaired chondrocyte mechanotransduction in early post-traumatic osteoarthritis. Osteoarthritis and Cartilage, 25:S67-S68, Las Vegas, USA, April 2017.
    • Podium presentation: Ojanen SP, Finnilä MAJ, Mäkelä J, Saarela K, Happonen E, Herzog W, Saarakkala S, Korhonen RK, Site-specific Changes Of Articular Cartilage Biomechanics and Chondrocytes Deformation in Early OA. 23rd Congress of the European Society of Biomechanics, July 2.-5., 2017, Seville, Spain.
    • Ojanen SP, Finnilä MAJ, Saarela K, Mäkelä J, Herzog W, Saarakkala S, Korhonen RK, ACLT of Rabbits Alters PG Content and Cartilage Biomechanics Two Weeks Post-surgery. 15th Science day of the Campus of Kontikangas, February 2018, Oulu, Finland.
    • Ojanen SP, Finnilä MAJ, Saarela K, Mäkelä J, Herzog W, Saarakkala S, Korhonen RK, ACL transection of rabbits alter FCD content, tissue modulus and cell deformation mostly in the lateral femoral condyle cartilage 2 weeks post-surgery. Transactions of the Orthopaedic Research Society, New Orleans, USA, 2018.
    • Ojanen SP, Finnilä MAJ, Saarela K, Herzog W, Saarakkala S, Korhonen RK, Time-dependent changes of FCD content during the progression of osteoarthritis in rabbits. Transactions of the Orthopaedic Research Society, New Orleans, USA, 2018.
    • Afara IO, Sarin JK, Ojanen SP, Finnilä MAJ, Herzog W, Saarakkala S, Korhonen RK, Töyräs J, Deep Learning Classification of Cartilage Integrity Using Near Infrared Spectroscopy. Microscopy Histopathology and Analytics, April 2018.
    • Kajabi AW, Casula V, Ojanen S, Finnilä M, Korhonen R, Herzog W, Saarakkala S, Nissi MJ and Nieminen MT, T1ρ dispersion assessment of articular cartilage in a rabbit ACL transection model. Proc. Intl. Soc. Magn. Reson. Med 26, 2018.

    Acknowledged for technical support

    • Puhakka PH, te Moller NCR, Afara IO, Mäkelä JTA, Tiitu V, Korhonen RK, Brommer H, Virén T, Jurvelin JS, Töyräs J, Estimation of articular cartilage properties using multivariate analysis of optical coherence tomography signal, Osteoarthritis and Cartilage, 2015.
    • Puhakka PH, te Moller NCR, Tanska P, Saarakkala S, Tiitu V, Korhonen RK, Brommer H, Virén T, Jurvelin JS and Töyräs J, Optical coherence tomography enables accurate equine cartilage thickness measurement for determination of speed of sound, Acta Orthopaedica, 2016.
    • Mononen ME, Tanska P, Isaksson H, Korhonen RK, New Algorithm for Simulation of Proteoglycan Loss and Collagen Degeneration in the Knee Joint: Data from the Osteoarthritis Initiative, Journal of Orthopaedic Research, 2018:36(6).

    Last updated: 8.7.2019