Lehenkari - Publications and supervised doctoral dissertations

Selected publications:

  1. Salo, Jari, Lehenkari, Petri, Mulari, Mika, Metsikkö Kalervo and Väänänen H. Kalervo (1997) Osteoclasts remove bone resorption products by transcytosis. Science, 276:270-273
  2. Lehenkari, Petri, Horton, Michael (1999) Single integrin molecule adhesion forces in intact cells measured by atomic force microscopy Biochem Biophys Res Commun 16;259(3):645-50
  3. Lehenkari, Petri, Kellinsalmi, Maarit, Näpänkangas, Juha, Ylitalo, Kari, Mönkkönen, Jukka, Rogers, Michael, Azhayev, Alexander, Vaananen, Kalervo, Hassinen, Ilmo (2002) Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite. Mol Pharmacol, 61(5):1255-62.
  4. Lehenkari, Petri, Parikka, Vilhelmiina, Rautiala, Timo, Weckström, Matti, Dahllund, Johanna,. Härkönen, Pirkko and Väänänen, Kalervo (2003) The effects of Tamoxifen and Toremifene on bone cells involve changes in plasma membrane ion conductance J Bone Miner Res 318 (3): 473-81
  5. Leskelä HV, Risteli J, Niskanen S, Koivunen J, Ivaska KK, Lehenkari P (2003) Osteoblast recruitment from stem cells does not decrease by age at late adulthood. Biochem Biophys Res Commun. 2003 28;311(4):1008-13
  6. Parikka V, Väänänen A, Risteli J,  Salo T, Sorsa T, H., Väänänen K, Petri Lehenkari (2005) Collagen Synthesis And Degradation by Human Mesenchymal Stem Cell Derived Osteoblasts  Matrix Biology Sep;24(6):438-47.
  7. Kellinsalmi M, Leskelä HV, Mönkkönen J, Mönkkönen H, Parikka V, Hämäläinen M and Lehenkari P (2005) In vitro Comparison of Zoledronic Acid, Clodronate and Pamidronate in Rat Osteoclast and Human Stem Cell Derived Osteoblast Cultures rises a suspicion of the third mechanism of action of the potent N-BP zoledronic acid Basic and Clinical Pharmacology and Toxicology Dec;97(6):382-91
  8. Leskelä HV, Olkku A, Lehtonen S, Mahonen A, Koivunen J, Turpeinen M, Uusitalo J, Pelkonen O, Kangas L, Selander K, Lehenkari P (2006) Estrogen receptor alpha genotype confers interindividual variability of response to estrogen and testosterone in mesenchymal-stem-cell-derived osteoblasts. Bone. Nov;39(5):1026-34. Epub 2006 Jun 16
  9. Leskela HV, Satta J, Oiva J, Eriksen H, Juha R, Korkiamaki P, Ivaska KK, Soini Y, Lehenkari P. (2006) Calcification and cellularity in human aortic heart valve tissue determine the differentiation of bone-marrow-derived cells. J Mol Cell Cardiol. Oct;41(4):642-9.
  10. Kellinsalmi M, Parikka V, Risteli J, Hentunen T, Leskelä H-V, Lehtonen S, Selander K, Väänänen K, Lehenkari P (2007)  Inhibition of cyclooxygenase-2 inhibits osteoclast and osteoblast differentiation and favours adipocyte formation in vitro Eur J Pharmacol. Oct 31;572(2-3)
  11. Pietilä M, Lehtonen S, Närhi M, Aranko K, Hassinen IE,  Vepsäläinen A,  Nordström K and  Lehenkari P (2010) Mitochondrial function determines the viability and osteogenic potency of human mesenchymal stem cells. Tissue Engineering, Tissue Eng Part C Methods. 2010 Jun;16(3):435-45.
  12. Miettinen JA, Pietilä M, Salonen RJ, Ohlmeier S, Ylitalo K, Huikuri HV, Lehenkari P. (2011) Tumor necrosis factor alpha promotes the expression of immunosuppressive proteins and enhances the cell growth in a human bone marrow-derived stem cell culture. Exp Cell Res. 2011 Apr 1;317(6):791-801
  13. Pietilä M, Palomäki S, Lehtonen S, Ritamo I, Valmu L, Nystedt J, Laitinen S, Leskelä HV, Sormunen R, Pesälä J, Nordström K, Vepsäläinen A, Lehenkari P (2011)  Mitochondrial Function and Energy Metabolism in Umbilical Cord Blood- and Bone Marrow-Derived Mesenchymal Stem Cells. Stem Cells Dev. 2012 Mar 1;21(4):575-88
  14. Pietilä M, Lehtonen S, Tuovinen E, Lähteenmäki K, Laitinen S, Leskelä HV, Nätynki A, Pesälä J, Nordström K, Lehenkari P (2012) CD200 positive human mesenchymal stem cells suppress TNF-alpha secretion from CD200 receptor positive macrophage-like cells. PLoS One. 2012;7(2):e31671.
  15. Miettinen JA, Salonen RJ, Ylitalo K, Niemela M, Kervinen K, Saily M, Koistinen P, Savolainen ER, Makikallio TH, Huikuri HV, Lehenkari P (2012) The effect of bone marrow microenvironment on the functional properties of the therapeutic bone marrow-derived cells in patients with acute myocardial infarction. J Transl Med. 2012 Apr 2;10(1):66.
  16. Nystedt J, Anderson H, Tikkanen J, Pietilä M, Hirvonen T, Takalo R, Heiskanen A, Satomaa T, Natunen S, Lehtonen S, Hakkarainen T, Korhonen M, Laitinen S, Valmu L, Lehenkari P. Cell Surface Structures Influence Lung Clearance Rate of Systemically Infused Mesenchymal Stromal Cells. Stem Cells. 2013 Feb;31(2):317-26.
  17. Aho OM, Lehenkari P, Ristiniemi J, Lehtonen S, Risteli J, Leskelä HV The Mechanism of Action of Induced Membranes in Bone Repair J Bone Joint Surg Am. 2013;95:597-604
  18. Lehtonen ST, Mäkelä J, Ohlmeier S, Ylitalo K, Juvonen T, Anttila V, Lehenkari P Analysis of molecular changes after autologous cell therapy in swine myocardial infarction tissue can reveal novel targets for future therapy. (2012) J Tissue Eng Regen Med. 2012 May 2. doi: 10.1002/term.1502. [Epub ahead of print]
  19. Kerkelä E, Hakkarainen T, Mäkelä T, Raki M, Kambur O, Kilpinen L, Nikkilä J, Lehtonen S, RItamo I, Pernu R, Pietilä M, Takalo R, Juvonen T, Bergström K, Kalso E, Valmu L, Laitinen S, Lehenkari P, Nystedt J  Transient Proteolytic Modification of Mesenchymal Stromal Cells Increases Lung Clearance Rate and Targeting to Injured Tissue; 2013 Stem Cells Translational Medicine, in Press
  20. Palomäki S, Pietilä M, Laitinen S, Pesälä J, Sorumunen R, Lehenkari P, Koivunen P,  HIF-1a Is Upregulated in hMSCs;2013 Stem Cells, in Press

Supervised doctoral dissertations:

  1. Leskelä Hannu-Ville (2006) Human bone marrow stem cells – a novel aspect to bone remodelling and mesenchymal diseases
  2. Valkealahti Maarit (2008) The effects of bisphosphonates and COX-inhibitors on the bone remodeling unit
  3. Mäkelä Jussi (2011) Bone marrow-derived stem cell therapy in acute myocardial infarction. An experimental porcine model (co-supervision)
  4. Pietilä Mika (2012) Functionality of Human Mesenchymal Stem Cells: Assessing Energy Metabolism and Immunomodulative Capacity (co-supervision)

Last updated: 13.11.2018