Hallman & Rämet - Publications and supervised doctoral dissertations

Selected publications:

Genetics of complex perinatal diseases

  1. Rämet M, Haataja R, Marttila R, Floros J, Hallman M. Association between the surfactant protein A (SP-A) gene locus and respiratory-distress syndrome in the Finnish population.  Am J Hum Genet 66:1569-1579, 2000
  2. Marttila R, Haataja R, Guttentag S, Hallman M. Surfactant protein A and B genetic variants in respiratory distress syndrome in singletons and twins. Am J Respir Crit Care Med 168:1216-1222, 2003
  3. Rova M, Haataja R, Marttila R, Ollikainen V, Tammela O, Hallman M. Data mining and multiparameter analysis of lung surfactant protein genes in bronchopulmonary dysplasia. Hum Mol Genet 13:1095-1104, 2004
  4. Hadchouel A, Durrmeyer X, Bouzigon E, Incitti R, Huusko J, Jarreau PH, Lenclen R, Demenais F, Franco-Montoya ML, Layouni I, Patkai J, Bourbon J, Hallman M, Danan C, Delacourt C. Identification of SPOCK2 as a susceptibility gene for bronchopulmonary dysplasia. Am J Respir Crit Care Med 184:1164-1170, 2011
  5. Haataja R, Karjalainen MK, Luukkonen A, Teramo K, Puttonen H, Ojaniemi M, Varilo T, Chaudhari BP, Plunkett J, Murray JC, McCarroll SA, Peltonen L, Muglia LJ, Palotie A, Hallman M. Mapping a new spontaneous preterm birth susceptibility gene IGF1R using linkage, haplotype sharing and association analysis. PLoS Genet 7:e10001293, 2011
  6. Plunkett J, Doniger S, Orabona G, Morgan T, Haataja R, Hallman M, Puttonen H, Menon R, Kuczynski E, Norwitz E, Snegovskikh V, Palotie A, Peltonen L, Fellman F V, DeFranco EA, Chaudhari BP, McGregor TL, McElroy JJ, Oetjens MT, Teramo K, Borecki I, Fay J, Muglia L. An evolutionary genomic approach to identify genes involved in human birth timing. PLoS Genet 7:e10001365, 2011
  7. Karjalainen MK, Huusko JM, Ulvila J, Sotkasiira J, Luukkonen A, Teramo K, Plunkett J,  Anttila V, Palotie A, Haataja R, Muglia LJ, Hallman M. A potential novel spontaneous preterm birth gene, AR, Identified by linkage and association analysis of X chromosomal markers. PLOS ONE 7: e51378, 2012
  8. Karjalainen MK, Huusko JM, Tuohimaa A, Luukkonen A, Haataja R, Hallman M. A study of collectin genes in spontaneous preterm birth reveals an association with a common surfactant protein D gene polymorphism. Pediatr Res 71:93-99, 2012
  9. Salminen A, Vuolteenaho R, Paananen R, Ojaniemi M, Hallman M. Surfactant protein D modulates levels of IL-10 and TNF-α in intrauterine compartments during lipopolysaccharide-induced preterm birth. Cytokine 60:423-30, 2012
  10. McElroy JJ, Gutman CE, Shaffer CM, Busch TD, Puttonen H, Teramo K, Murray JC, Hallman M, Muglia LJ. Maternal coding variants in complement receptor 1 and spontaneous idiopathic preterm birth. Hum Genet 132:935-942, 2013
  11. Rämet M, Korppi M, Hallman M. Pattern recognition receptors and genetic risk for rsv infection: value for clinical decision-making? Pediatr Pulmonol 46:101-110, 2011
  12. Hallman M. Lung surfactant, respiratory failure, and genes. New Engl J Med 350:1278-1280, 2004

Cohorts and randomized therapeutic trials

  1. Kaukola T, Satyaraj E, Patel DD, Tchernev VT, Grimwade BG, Kingsmore SF, Koskela P, Tammela O, Vainionpää L, Pihko H, Äärimaa T, Hallman M. Cerebral palsy is characterized by protein mediators in cord serum. Ann Neurol 55:186-194, 2004
  2. Paananen R, Husa AK, Vuolteenaho R, Herva R, Kaukola T, Hallman M. Blood cytokines during the perinatal period in very preterm infants: Relationship of inflammatory response and bronchopulmonary dysplasia. J Pediatr 154:39-43.e3, 2009
  3. Aikio O, Metsola J, Vuolteenaho R, Perhomaa M, Hallman M. Transient defect in nitric oxide generation after rupture of fetal membranes and responsiveness to inhaled nitric oxide in very preterm infants with hypoxic respiratory failure. J Pediatr 161:397-403.e1, 2012
  4. Kaukola T, Kallankari H, Tuimala J, Olsén P, Tammela O, Kingsmore SF, Hallman M. Perinatal immunoproteins predict the risk of cerebral palsy in preterm children. Ann Med 45:57-65, 2013
  5. Peltoniemi OM, Kari MA, Tammela O, Lehtonen L, Marttila R, Halmesmäki E, Jouppila P, Hallman M for the Repeat Antenatal Betamethasone (RepeatBM) Study Group. Randomized trial on a single repeat dose of prenatal betamethasone treatment in imminent preterm birth. Pediatrics 119:290-298, 2007
  6. Mercier JC, Hummler H, Durrmeyer X, Sanchez-Luna M, Carnielli V, Field D, Greenough A, Van Overmeire B, Jonsson B, Hallman M, Baldassarre J; EUNO Study Group. Inhaled nitric oxide for prevention of bronchopulmonary dysplasia in premature babies (EUNO): a randomised controlled trial. Lancet  376(9738):346-354, 2010

Supervised doctoral dissertations by professor Hallman:

  1. Pitkänen, OM. Free oxygen radicals in tissue damage an experiment and clinical study based on measurement of ethane and pentane, University of Helsinki, 1992
  2. Bry, K. Cytokine interactions in prostaglandin production and preterm labor, University of Helsinki, 1993
  3. Eronen, M. Fetal and neonatal circulation during treatment of premature labor and in pregnancy induced hypertension. Neonatal morbidity and outcome, University of Helsinki, 1994
  4. Varsila, E. Free radicals reactions in the newborn infant: relationship to chronic lung disease, University of Helsinki , 1995
  5. Kari, A. Glucocorticoid therapy for prevention of mortality and morbidity in preterm infants. University of Helsinki, 1995
  6. Pelkonen, A. Bronchial lability in schoolchildren born very preterm. University of Helsinki,  2000
  7. Paananen, R. Characterization of surfactant proteins in porcine Eustachian tube. Acta Univ Oulu Ser D 644, 2001
  8. Haataja, R. The role of the surfactant protein A and B genes in heritable susceptibility to neonatal respiratory syndrome. Acta Univ Oulu Ser D 651, 2001
  9. Aikio, O. Pulmonary nitric oxide in preterm and term infants with respiratory failure. Acta Univ Oulu Ser D 651, 2002
  10. Väyrynen, O. Proinflammatory cytokines modify the expression of surfactant proteins. Study in perinatal rabbit lung. Acta Univ Oulu Ser D  735, 2003
  11. Marttila, R. Genetic and population study of  RDS in twin and singleton infants. Acta Univ Oulu Ser D 766, 2003
  12. Harju K. Toll-like receptors (TLR) 4 and 2 regulate the innate immune response. Study of endotoxin influence in mice. Acta Univ Oulu Ser D 783, 2004
  13. Mieskonen S. Outcome of very low birth weight infants at school age. University of Helsinki, 2005
  14. Rova, M. The significance of surfactant protein gene polymorhphisms in multifactorial infantile pulmonary diseases. Acta Univ Oul Ser D 834, 2005
  15. Rounioja, S. Experimental mouse model for fetal inflammatory response. Acta Univ Oulu Ser D 840, 2005
  16. Kaukola, T. Perinatal brain damage in very pretem infants. Prenatal inflammation and neurologic outcome in children born term and preterm. Acta Univ Oul Ser D 846, 2005
  17. Peltoniemi, O. Corticosteroid treatment in the perinatal period: Efficacy and safety of antenatal and neonatal corticosteroids in the prevention of acute and long-term morbidity and mortality in preterm infants. Acta Univ Oulu Ser D 927, 2007
  18. Liljeroos, M. Toll-like receptor 2 (TLR2) and TLR4 signaling in the innate response against bacterial components. Univ. Oulu Ser D 972, 2008
  19. Löfgren, J. Genetic polymorhphisms in collectins and Toll-like receptor 4 as factors influencing susceptibility to severe RVS infections and otitis media. Univ Oulu Ser D 1010, 2009
  20. Salminen, A. Surfactant proteins and cytokines in inflammation-induced preterm birth. Experimental mouse model and study on human tissues. Univ Oulu Ser D 1110, 2011
  21. Karjalainen, M. Genetic predisposition to spontaneous preterm birth. Approaches to identify susceptibility genes. Univ Oulu Ser D 1143, 2011

Supervised doctoral dissertations by Professor Rämet:

  1. Henna Myllymäki, H. Negative regulation of Drosophila immune response, University of Tampere, 2013
  2. Grönholm, J. Evolutionary conserved regulatory mechanisms of JAK/STAT signaling. University of Tampere, 2012 (Main Supervisor: Professor Olli Silvennoinen, University of Tampere, Finland)
  3. Kallio, J. Systems biological study of  Drosophila immune signaling. University of Tampere, 2011
  4. Kleino, A. The IMD pathway-mediated immune response in Drosophila, University of Tampere, 2010
  5. Löfgren, J. Genetic polymorphisms in Collectins and Toll-like receptor 4 as factors influencing the susceptibility to severe RSV infections and otitis media. University of Oulu, 2009 (Main Supervisor: Professor Mikko Hallman, University of Oulu)
  6. Ulvila, J. Functional genomic analysis of the Drosophila immune response.  Identification of genes essential for phagocytosis, viral defense and NF-?B signaling, 2008

 

 

Last updated: 13.11.2018