Majamaa Kari

Northern Mitochondria

 

Research unit: Clinical Neuroscience

 

Group leader

Kari Majamaa, MD, DMSc, Professor of neurology

 

What do we do

The mechanisms involved in dopaminergic degeneration in Parkinson´s disease (PD) are not clearly understood. Identification of mutations in various genes has suggested that the pathogenesis of PD involves common mechanisms, such as endosomal protein sorting and recycling, synaptic transmission, mitochondrial maintenance and lysosome-mediated autophagy. Mitochondria are cell organelles that convert energy stored in organic molecules to ATP that can be used in a variety of cellular processes as an energy source. Mitochondrial Complex I activity has been found to be decreased in patients with PD and, interestingly, a toxin inducing parkinsonism in humans is a Complex I inhibitor. Identification of a clinically distinct form of PD with mitochondrial impairment would enable more precise definition of PD subtypes, targeted genetic testing, and provide new biomarkers associated with mitochondrial PD.

 

Our team

Post doc researchers

  • Kytövuori Laura, PhD
  • Kärppä Mikko, MD, PhD
  • Sipilä Jussi, MD, PhD, adjunct professor

PhD students

  • Heula Anna-Leena Heula, MD
  • Keränen Maija-Helena, MD
  • Kiiskilä Jukka, MD, MSc
  • Lipponen Joonas, MD
  • Marttila Maria, MD
  • Siitonen Ari, MD, MSc
  • Ylikotila Pauli, MD
  • Ylönen Susanna, MSc

Other staff

  • Heikkinen Anja, Laboratory technician

 

Where are we headed

We attempt to examine the role of mitochondrial aberration in patients with early-onset PD ascertained previously from the Finnish population as well as in patients with idiopathic PD ascertained from the population of North and East of Finland. Possible outcomes of this research would be more precise definition of PD subtypes, targeted genetic testing, and new biomarkers associated with mitochondrial PD.

 

Our main collaborators

Andrew Singleton, NIH
Mika Martikainen, University of Turku

 

How to find us

Research Unit of Clinical Neuroscience
Department of Neurology at Oulu University Hospital
Clinical Research Center
kari.majamaa[at]oulu.fi
 

Last updated: 9.7.2019