Master of Science Shivaprakash Jagalur Mutt
Faculty and research unit
University of Oulu Graduate School, Faculty of Medicine, Research Unit of Biomedicine
Field of study
Date and time of the thesis defence
Place of the thesis defence
Topic of the dissertation
Vitamin D and metabolic health. Effects on molecular pathways of adipocyte inflammation and insulin resistance
Professor Anastassios G. Pittas, Tufts Medical Center
Professor Karl-Heinz Herzig, Research Unit of Biomedicine, Faculty of Medicine
Vitamin D and metabolic health
Vitamin D is an essential micronutrient, playing a vital role in the regulation of calcium homeostasis and bone metabolism. The pandemic vitamin D deficiency has been associated with an increasing risk for several metabolic diseases.
In this dissertation, we found that vitamin D inhibited the inflammatory signalling pathways in adipose tissue. Vitamin D deficiency status induced the insulin resistance in lean and obese mice and subsequent vitamin D re-supplementation improved the insulin sensitivity and ameliorated the liver inflammation and oxidative stress in vitamin D deficient lean but not obese mice.
The low vitamin D status in elderly subjects born and living at latitude 65° North were associated with a higher incidence of the metabolic syndrome.
In conclusion, vitamin D has an important role in modulating the molecular pathways involved in adipose tissue inflammation and insulin resistance in hepatic tissue. Adequate levels of vitamin D are necessary for the regulation of metabolic pathways to maintain body homeostasis. The generated data provide novel insights into the cellular mechanisms of vitamin D and represent a basis for oral vitamin D supplementation in the prevention of metabolic diseases.Dissertation
Last updated: 12.6.2020