MSc Ruizhu Lin
Faculty and research unit
University of Oulu Graduate School, Faculty of Medicine, Research unit of Biomedicine
Field of study
Date and time of the thesis defence
Place of the thesis defence
F202 of the Faculty of Medicine (Aapistie 5B). Remote access: https://oulu.zoom.us/j/6135300476
Topic of the dissertation
miRNAs in cardiac fibrosis and aging
Professor Leon J. De Windt, Department of Cardiology, Maastricht University
Professor Risto Kerkelä, Research unit of Biomedicine, University of Oulu
Understanding the function of miRNAs in cardiac fibrosis and aging
Cardiac fibrosis is the excessive deposition of extracellular matrix, which stiffens the myocardium and predisposes individuals to heart failure, arrhythmias and sudden cardiac death (SCD). Cardiac aging has features of cardiac fibrosis and is associated with increased risk for cardiovascular diseases (CVDs). Small non-coding RNAs (microRNAs, i.e. miRNAs) play inextricable roles in regulating cardiac physiology and pathology, including cardiac fibrosis, and exhibit advantages of feasibility in detection of cardiac fibrosis at a stage before overt clinical symptoms. The aim of the present study was to identify miRNAs that hold potential in regulating and reflecting human cardiac fibrosis, and delineate their functions and effects in terms of cardiac fibrosis and aging.
This study sheds light on mechanisms of cardiac fibrosis and aging. The main finding further highlights and updates the list of miRNA candidates that have therapeutic and diagnostic potential for cardiac fibrosis.
Last updated: 25.2.2021