Thesis defence in the University of Oulu

Doctoral Candidate

MSc Ruizhu Lin

Faculty and research unit

University of Oulu Graduate School, Faculty of Medicine, Research unit of Biomedicine

Field of study

Medicine

Date and time of the thesis defence

4.3.2021 12:00

Place of the thesis defence

F202 of the Faculty of Medicine (Aapistie 5B). Remote access: https://oulu.zoom.us/j/6135300476

Topic of the dissertation

miRNAs in cardiac fibrosis and aging

Opponent

Professor Leon J. De Windt, Department of Cardiology, Maastricht University

Custos

Professor Risto Kerkelä, Research unit of Biomedicine, University of Oulu

Understanding the function of miRNAs in cardiac fibrosis and aging

Cardiac fibrosis is the excessive deposition of extracellular matrix, which stiffens the myocardium and predisposes individuals to heart failure, arrhythmias and sudden cardiac death (SCD). Cardiac aging has features of cardiac fibrosis and is associated with increased risk for cardiovascular diseases (CVDs). Small non-coding RNAs (microRNAs, i.e. miRNAs) play inextricable roles in regulating cardiac physiology and pathology, including cardiac fibrosis, and exhibit advantages of feasibility in detection of cardiac fibrosis at a stage before overt clinical symptoms. The aim of the present study was to identify miRNAs that hold potential in regulating and reflecting human cardiac fibrosis, and delineate their functions and effects in terms of cardiac fibrosis and aging.
This study sheds light on mechanisms of cardiac fibrosis and aging. The main finding further highlights and updates the list of miRNA candidates that have therapeutic and diagnostic potential for cardiac fibrosis.

Last updated: 25.2.2021