Molecular mechanisms of parasite motility

Project description

Strategic research project of the University of Oulu
Focus institute: Biocenter Oulu
Faculty: Faculty of Biochemistry and Molecular Medicine (FBMM)

Our work is aimed at a mechanistic understanding of gliding motility, which malaria parasites and their relatives use for getting to and invading their host cells. We use a broad range of biochemical, biophysical and structural biology methods for creating a complete molecular picture of the parasite actin-myosin motor and the entire glideosome. We also want to understand the evolution of apicomplexan gliding motility and eukaryotic actin-myosin motors in a broader sense. Understanding the mechanistic differences in cell motility between parasites and humans may, furthermore, open up new avenues for treatment and/or prevention of malaria.