Molecular Determinants of Metabolic Syndrome
Strategic research project of the University of Oulu
Focus institute: Biocenter Oulu
Faculty: Faculty of Medicine (FMED)
The project of the Savolainen, Herzig, Järvelin consortium involves teams in clinical sciences, medical physiology and life-course epidemiology and we investigate new molecular factors associated with metabolic syndrome (i.e. obesity, dyslipidaemia, high blood pressure and insulin resistance). We are focusing on unravelling the roles played by molecular factors in pro-inflammatory pathways and their potential as targets in therapeutic and preventive strategies. The consortium works in three main research areas: i) genetics and molecular determinants of atherosclerosis, ii) physiology of the inflammatory response as a path for inter-organ communication, and iii) life-course and molecular epidemiology of long-term metabolic health. We aim at defining intermediate and modifiable phenotypes and subgroups of the population to implement personalised medicine approaches. Following successful research into the genetics of common metabolic traits, the group is now developing approaches implementing exposomics, exomics and epigenomics.