Anne Remes

Anne Remes

Professor, MD, PhD

Professor, Dean

121 peer reviewed publications in international journals. The publications have been cited 5434 times, of which the most cited publication accounts for 2089 citations. The author has a h-index of 26.00. (Scopus)

Biography

I have a broad expertise in clinical and translational research as well as molecular genetics in early onset dementias especially in frontotemporal dementia (FTD).  My most important scientific observations have been the first line identification of C9orf72 expansion as the major genetic cause of FTD and obtaining pluripotent stem cells from familial Alzheimer’s disease.

I have research groups in Universities of Oulu and Eastern Finland. We aim to identify and characterize novel diagnostic tools, imaging methods (including functional MRI), biomarkers and etiological factors as well as the underlying pathogenesis of FTD using patient derived pluripotent stem cells (hiPSC). Our research focuses also on psychiatric manifestations of FTD, cognitive decline in psychiatric disorders and in ethical and patient/caregiver aspects of early onset dementias. I am the founder and a partner of  Finnish FTD Research Network (FinFTD) - "a network for researchers and research groups investigating or interested in frontotemporal lobar degeneration, including frontotemporal dementia (FTD), and related disorders".

Research interests

  • Fontotemporal dementia
  • Alzheimer's disease
  • Cognitive decline
  • Rare dementias
  • Genetics
  • Biomarker
  • Brain imaging
  • Translational research
  • Stem cells
  • Multiple Sclerosis

Databases

Social media

Research groups

  • http://www.uef.fi/en/web/finftd

Selected publications

  • Renton AE; Majounie E; Waite A; Simón-Sánchez J; Rollinson S; Gibbs JR; Schymick JC; Laaksovirta H; van Swieten JC; Myllykangas L; Kalimo H; Paetau A; Abramzon Y; Remes AM; Kaganovich A; Scholz SW; Duckworth J; Ding J; Harmer DW; Hernandez DG (2011) A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. - Neuron 72 (2), 257-268
  • Israel MA; Yuan SH; Bardy C; Reyna SM; Mu Y; Herrera C; Hefferan MP; Van Gorp S; Nazor KL; Boscolo FS; Carson CT; Laurent LC; Marsala M; Gage FH; Remes AM; Koo EH; Goldstein LS (2012) Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. - Nature 482 (7384), 216-220 . [Original]
  • Katisko, Kasper; Solje, Eino; Koivisto, Anne M.; Krüger, Johanna; Kinnunen, Tuure; Hartikainen, Päivi; Helisalmi, Seppo; Korhonen, Ville; Herukka, Sanna-Kaisa; Haapasalo, Annakaisa; Remes, Anne M. (2018) Prevalence of immunological diseases in a Finnish frontotemporal lobar degeneration cohort with the C9orf72 repeat expansion carriers and non-carriers. - Journal of neuroimmunology 321, 29-35 . [Original]
  • Tuovinen, Timo; Rytty, Riikka; Moilanen, Virpi; Abou Elseoud, Ahmed; Veijola, Juha; Remes, Anne M.; Kiviniemi, Vesa J. (2017) The Effect of Gray Matter ICA and Coefficient of Variation Mapping of BOLD Data on the Detection of Functional Connectivity Changes in Alzheimer's Disease and bvFTD. - Frontiers in human neuroscience 10, 680 . [Original] [Self-archived]
  • Bruun, M.; Koikkalainen, J.; Rhodius-Meester, H.F.M.; Baroni, M.; Gjerum, L.; van Gils, M.; Soininen, H.; Remes, A.M.; Hartikainen, P.; Waldemar, G.; Mecocci, P.; Barkhof, F.; Pijnenburg, Y.; van der Flier, W.M.; Hasselbalch, S.G.; Lötjönen, J.; Frederiksen, K.S. (2019) Detecting frontotemporal dementia syndromes using MRI biomarkers. - Neuroimage. clinical 22, 101711 . [Original] [Self-archived]