Janne Hukkanen

Professor, MD, PhD

Internal Medicine

48 peer reviewed publications in international journals. The publications have been cited 2950 times, of which the most cited publication accounts for 869 citations. The author has a h-index of 22.00. (Web of Science)

Biography

Janne Hukkanen is a Professor of Internal Medicine since 2019. After MD/PhD studies, he was a post-doctoral fellow in USA studying the clinical pharmacology of nicotine and learning to plan and perform investigator-initiated clinical drug studies. Subsequently, he has been involved in several industry-initiated clinical trials in the fields of diabetes, obesity and lipid disorders as well as investigator-initiated life-style modification trials.

The current research interests center on two topics: the metabolic actions of xenobiotic-sensing nuclear receptor PXR, and the development digital web-based health behavior change support system for subjects with obesity and metabolic syndrome. His group has shown that the activation of PXR leads to postprandial hyperglycemia, as well as hypertension and dyslipidemia in healthy volunteers. The aim is to show with translational approach combining epidemiological, clinical and preclinical research that PXR links the chemical environment and metabolic disturbations. His group is a partner in an EU project CoroPrevention aiming to develop interventions to improve the prognosis of the coronary heart disease, and a member of Biocenter Oulu.

Research interests

  • Xenobiotic-sensing nuclear receptors, especially PXR
  • Metabolic syndrome
  • Obesity
  • Regulation of cholesterol metabolism
  • Regulation of blood pressure
  • Endocrine disrupting chemicals

Databases

Research visits

  • Postdoctoral research fellow, University of California San Francisco (UCSF), USA, 2003 - 2004