Lari Lehtiö

Lari Lehtiö

PhD, Docent

Principal Investigator
Structural Biology

53 peer reviewed publications in international journals. The publications have been cited 1069 times, of which the most cited publication accounts for 81 citations. The author has a h-index of 20.00. (Web of Science)

Research interests

  • ADP-ribosylation signaling
  • Structural Biology
  • Drug discovery

Databases

Scientific merits

  • University Researcher (Associate professor), University of Oulu, FInland, 2017-
  • Docent, University of Helsinki, Finland, 2012
  • PhD, University of Helsinki, Finland, 2006

Research groups

  • PI, Structural and Chemical Biology
  • Coordinator, Biocenter Oulu Protein Crystallography core facility

Selected publications

  • Nkizinkiko, Yves; Desantis, Jenny; Koivunen, Jarkko; Haikarainen, Teemu; Murthy, Sudarshan; Sancineto, Luca; Massari, Serena; Ianni, Federica; Obaji, Ezeogo; Loza, Maria I.; Pihlajaniemi, Taina; Brea, Jose; Tabarrini, Oriana; Lehtio, Lari (2018) 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. - Scientific Reports 8, 1680 . http://doi.org/10.1038/s41598-018-19872-3.
  • Anumala, Upendra Rao; Waaler, Jo; Nkizinkiko, Yves; Ignatev, Alexander; Lazarow, Katina; Lindemann, Peter; Olsen, Petter Angell; Murthy, Sudarshan; Obaji, Ezeogo; Majouga, Alexander G.; Leonov, Sergey; von Kries, Jens Peter; Lehtiö, Lari; Krauss, Stefan; Nazaré, Marc (2017) Discovery of a novel series of tankyrase inhibitors by a hybridization approach. - Journal of medicinal chemistry 60 (24), 10013-10025 . [Original]
  • Nathubhai, Amit; Haikarainen, Teemu; Koivunen, Jarkko; Murthy, Sudarshan; Koumanov, Francoise; Lloyd, Matthew D.; Holman, Geoffrey D.; Pihlajaniemi, Taina; Tosh, David; Lehtiö, Lari; Threadgill, Michael D. (2017) Highly Potent and Isoform Selective Dual Site Binding Tankyrase/Wnt Signaling Inhibitors That Increase Cellular Glucose Uptake and Have Antiproliferative Activity. - Journal of medicinal chemistry 60 (2), 814-820 . http://dx.doi.org/10.1021/acs.jmedchem.6b01574. [Original] [Self-archived]
  • Haikarainen, Teemu; Maksimainen, Mirko M.; Obaji, Ezeogo; Lehtiö, Lari (2018) Development of an Inhibitor Screening Assay for Mono-ADP-Ribosyl Hydrolyzing Macrodomains Using AlphaScreen Technology. - SLAS Discovery 23 (3), 255-263 . [Original]
  • Zhang, Yuezhou; Jumppanen, Mikael; Maksimainen, Mirko M.; Auno, Samuli; Awol, Zulfa; Ghemtio, Leo; Venkannagari, Harikanth; Lehtiö, Lari; Yli-Kauhaluoma, Jari; Xhaard, Henri; Af Gennas, Gustav Boije (2018) Adenosine analogs bearing phosphate isosteres as human MDO1 ligands. - Bioorganic & Medicinal Chemistry 26 (8), 1588-1597 . [Original]
  • Obaji, Ezeogo; Haikarainen, Teemu; Lehtiö, Lari (2016) Characterization of the DNA dependent activation of human ARTD2/PARP2. - Scientific Reports 6, 34487 . [Original]
  • Venkannagari, Harikanth; Verheugd, Patricia; Koivunen, Jarkko; Haikarainen, Teemu; Obaji, Ezeogo; Ashok, Yashwanth; Narwal, Mohit; Pihlajaniemi, Taina; Lüscher, Bernhard; Lehtiö, Lari (2016) Small-Molecule Chemical Probe Rescues Cells from Mono-ADP-Ribosyltransferase ARTD10/PARP10-Induced Apoptosis and Sensitizes Cancer Cells to DNA Damage. - Cell chemical biology 23 (10), 1251-1260 . http://dx.doi.org/10.1016/j.chembiol.2016.08.012. [Original] [Self-archived]

Thesis supervisions

PhD Yves Nkizinkiko
  • Structure-guided development of tankyrase Inhibitors (2018)

PhD Harikanth Venkannagari
  • Discovery of selective small molecule inhibitors towards human Diphtheria toxin-like mono ADP-ribosyltransferases (2016)

PhD Mohit Narwal
  • Selective inhibition of human tankyrases (2014)