Raisa Serpi

Raisa Serpi

PhD, Adjunct professor

Senior research fellow


I am a biology graduate, PhD and Adjunct Professor of molecular medicine. My main research interest is the ischemic and hypoxic tissue homeostasis and remodeling in cardiometabolic diseases. I have been focusing on the molecular mechanisms and signaling pathways of hypoxia response and tissue homeostasis and remodelling utilizing different genetic and experimental rodent models. In addition to tissue remodeling research, I have specialized in Disease Modeling (Pathology training programme in disease modeling) and phenotyping in Helmholz Center, Munich, Germany. Currently I am working as a senior research fellow with Professor Peppi Karppinen at the Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine and as a director of Northern Finland Biobank Borealis.

Research interests

  • Hypoxia response
  • Cardiometabolic diseases
  • Pathology


Research groups

  • Senior scientist, Hypoxia response

Selected publications

  • Renko, Outi; Tolonen, Anna-Maria; Rysä, Jaana; Magga, Johanna; Mustonen, Erja; Ruskoaho, Heikki; Serpi, Raisa (2018) SDF1 gradient associates with the distribution of c-Kit plus cardiac cells in the heart. - Scientific Reports 8, 1160 . https://www.nature.com/articles/s41598-018-19417-8.
  • Myllymäki, Mikko N. M.; Määttä, Jenni; Dimova, Elitsa Y.; Izzi, Valerio; Väisänen, Timo; Myllyharju, Johanna; Koivunen, Peppi; Serpi, Raisa (2017) Notch downregulation and extramedullary erythrocytosis in hypoxia-inducible factor prolyl 4-hydroxylase 2-deficient mice. - Molecular and cellular biology 37 (2), e00529-16 . http://dx.doi.org/10.1128/MCB.00529-16. [Original] [Self-archived]
  • Koivunen, P.; Serpi, R.; Dimova, E. (2016) Hypoxia-inducible factor prolyl 4-hydroxylase inhibition in cardiometabolic diseases. - Pharmacological research 114, 265-273 . [Original]
  • Rahtu-Korpela, Lea; Määttä, Jenni; Dimova, Elitsa Y.; Hörkkö, Sohvi; Gylling, Helena; Walkinshaw, Gail; Hakkola, Jukka; Kivirikko, Kari I.; Myllyharju, Johanna; Serpi, Raisa; Koivunen, Peppi (2016) Hypoxia-Inducible Factor Prolyl 4-Hydroxylase-2 Inhibition Protects Against Development of Atherosclerosis. - Arteriosclerosis, thrombosis, and vascular biology 36 (4), 608-617 . [Original]
  • Karsikas, Sara; Myllymäki, Mikko; Heikkilä, Minna; Sormunen, Raija; Kivirikko, Kari I.; Myllyharju, Johanna; Serpi, Raisa; Koivunen, Peppi (2016) HIF-P4H-2 deficiency protects against skeletal muscle ischemia-reperfusion injury. - Journal of molecular medicine 94 (3), 301-310 . [Original]
  • Tolonen, Anna-Maria; Magga, Johanna; Szabo, Zoltan; Viitala, Pirkko; Gao, Erhe; Moilanen, Anne-Mari; Ohukainen, Pauli; Vainio, Laura; Koch, Walter J.; Kerkelä, Risto; Ruskoaho, Heikki; Serpi, Raisa (2014) Inhibition of Let-7 microRNA attenuates myocardial remodeling and improves cardiac function postinfarction in mice. - Pharmacology Research & Perspectives 2 (4), e00056 . [Original]
  • Rahtu-Korpela, Lea; Karsikas, Sara; Hörkkö, Sohvi; Blanco Sequeiros, Roberto; Lammentausta, Eveliina; Mäkelä, Kari A; Herzig, Karl-Heinz; Walkinshaw, Gail; Kivirikko, Karl I; Myllyharju, Johanna; Serpi, Raisa; Koivunen, Peppi (2014) HIF Prolyl 4-hydroxylase-2 inhibition improves glucose and lipid metabolism and protects against obesity and metabolic dysfunction. - Diabetes 63 (10), 3324-3333

Research visits

  • Research fellow
    1.1.2011 to 31.12.2011

    Helmholtz Center Munich, Germany