Researchers
MD, PhD
PhD, Adjunct professor
Ph.D., Professor
Projects
the lack of oxygen (commonly termed hypoxia), the appearance of reactive oxygen species (ros) and excessive protein ... aim of our work to understand the mechanistic link between hypoxia-associated diseases, compartment-specific changes of ros levels and ...
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Projektin kuvaus The lack of oxygen (commonly termed hypoxia), the appearance of reactive oxygen species (ROS) and excessive protein ...
... and physiology, and several pathologies are associated with hypoxia or ecm abnormalities. we focus on the central enzymes regulating these ... 1) the prolyl 4-hydroxylases (p4hs) that control the hypoxia response pathway via determination of the oxygen-dependent fate of the ...
... 2+ and 2-oxoglutarate (2og). their affinity for o 2 varies. hypoxia-inducible factor (hif) prolyl 4-hydroxylases (hif-p4hs) are 2ogdds that ...
selected publications:
koivunen p & kietzmann t (2018) hypoxia-inducible factor prolyl 4-hydroxylases and metabolism. trends mol med ...
Other results
although hypoxia is speculated to play a role in development, firm data is lacking. ... mice, we should be able to integrate hypoxia to developmental control. this should also lead to opportunities for finding new modulators of the hypoxia response. when tumours grow they become hypoxic. we have found that ...
... of oulu has a strong position in the international hypoxia research community. karppinen and myllyharju have ongoing collaboration ...
william kaelin
. currently, there are approximately 50 hypoxia researchers working in the faculty of biochemistry and molecular ...
... mechanism that recognises a low oxygen level, or hypoxia, and starts a genetic programme to respond to it. the response to hypoxia involves hundreds of different genes that help cells survive in ...