Lari Lehtiö

Lari Lehtiö

PhD, Professor

Principal Investigator
Structural Biology

Yhteensä 62 vertaisarvioitua julkaisua kansainvälisissä lehdissä. Julkaisujen yhteenlaskettu siteerausmäärä 1562, joista eniten siteerattu julkaisu 101. Julkaisujen h-indeksi on 23.00. (Web of Science)

Biografia

I am a Professor of Structural Biology as the Faculty of Biochemistry and Molecular Medicine and I act as a coordinator for Biocenter Oulu Structural Biology core facility. My research focuses on ADP-ribosylation and on structural studies of the enzymes involved in the post-translational signaling mechanism. We also develop small molecule inhibitors interfering with the signaling mechanism, which are often misregulated in especially cancer cells. Such small molecules can be used to validate drug targets and could potentially lead to new therapeutics. I teach on topics related to protein science, structural biology and drug discovery at the faculty. 

Tutkimusaiheet

  • ADP-ribosylation signaling
  • Structural Biology
  • Drug discovery

Tietokannat

Social media

Tieteelliset ansiot

Tutkimusryhmät

  • PI, Structural and Chemical Biology
  • Coordinator, Biocenter Oulu Structural Biology core facility

Valikoidut julkaisut

  • Obaji, E.; Haikarainen, T.; Lehtiö, L. (2018) Structural basis for DNA break recognition by ARTD2/PARP2. - Nucleic acids research 46 (22), 12154-12165 . [Original] [Self-archived]
  • Nkizinkiko, Yves; Desantis, Jenny; Koivunen, Jarkko; Haikarainen, Teemu; Murthy, Sudarshan; Sancineto, Luca; Massari, Serena; Ianni, Federica; Obaji, Ezeogo; Loza, Maria I.; Pihlajaniemi, Taina; Brea, Jose; Tabarrini, Oriana; Lehtio, Lari (2018) 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. - Scientific Reports 8, 1680 . [Original] [Self-archived]
  • Anumala, Upendra Rao; Waaler, Jo; Nkizinkiko, Yves; Ignatev, Alexander; Lazarow, Katina; Lindemann, Peter; Olsen, Petter Angell; Murthy, Sudarshan; Obaji, Ezeogo; Majouga, Alexander G.; Leonov, Sergey; von Kries, Jens Peter; Lehtiö, Lari; Krauss, Stefan; Nazaré, Marc (2017) Discovery of a novel series of tankyrase inhibitors by a hybridization approach. - Journal of medicinal chemistry 60 (24), 10013-10025 . [Original]
  • Nathubhai, Amit; Haikarainen, Teemu; Koivunen, Jarkko; Murthy, Sudarshan; Koumanov, Francoise; Lloyd, Matthew D.; Holman, Geoffrey D.; Pihlajaniemi, Taina; Tosh, David; Lehtiö, Lari; Threadgill, Michael D. (2017) Highly Potent and Isoform Selective Dual Site Binding Tankyrase/Wnt Signaling Inhibitors That Increase Cellular Glucose Uptake and Have Antiproliferative Activity. - Journal of medicinal chemistry 60 (2), 814-820 . http://dx.doi.org/10.1021/acs.jmedchem.6b01574. [Original] [Self-archived]
  • Haikarainen, Teemu; Maksimainen, Mirko M.; Obaji, Ezeogo; Lehtiö, Lari (2018) Development of an Inhibitor Screening Assay for Mono-ADP-Ribosyl Hydrolyzing Macrodomains Using AlphaScreen Technology. - SLAS Discovery 23 (3), 255-263 . [Original]
  • Zhang, Yuezhou; Jumppanen, Mikael; Maksimainen, Mirko M.; Auno, Samuli; Awol, Zulfa; Ghemtio, Leo; Venkannagari, Harikanth; Lehtiö, Lari; Yli-Kauhaluoma, Jari; Xhaard, Henri; Af Gennas, Gustav Boije (2018) Adenosine analogs bearing phosphate isosteres as human MDO1 ligands. - Bioorganic & Medicinal Chemistry 26 (8), 1588-1597 . [Original]
  • Obaji, Ezeogo; Haikarainen, Teemu; Lehtiö, Lari (2016) Characterization of the DNA dependent activation of human ARTD2/PARP2. - Scientific Reports 6, 34487 . [Original]
  • Venkannagari, Harikanth; Verheugd, Patricia; Koivunen, Jarkko; Haikarainen, Teemu; Obaji, Ezeogo; Ashok, Yashwanth; Narwal, Mohit; Pihlajaniemi, Taina; Lüscher, Bernhard; Lehtiö, Lari (2016) Small-Molecule Chemical Probe Rescues Cells from Mono-ADP-Ribosyltransferase ARTD10/PARP10-Induced Apoptosis and Sensitizes Cancer Cells to DNA Damage. - Cell chemical biology 23 (10), 1251-1260 . http://dx.doi.org/10.1016/j.chembiol.2016.08.012. [Original] [Self-archived]

Ohjauskokemus

PhD Ezeogo Obaji
  • ADP-ribosylation in DNA repair – structural studies of human ADP-ribosyltransferase 2 (2018)

PhD Yves Nkizinkiko
  • Structure-guided development of tankyrase Inhibitors (2018)

PhD Harikanth Venkannagari
  • Discovery of selective small molecule inhibitors towards human Diphtheria toxin-like mono ADP-ribosyltransferases (2016)

PhD Mohit Narwal
  • Selective inhibition of human tankyrases (2014)