Project leader: Prof. Kalervo Hiltunen, M.D., Ph.D.
Faculty of Biochemistry and Molecular Medicine, University of Oulu
P.O.Box 3000, FIN-90014 University of Oulu, Finland
University of Oulu, Aapistie 7, FIN-90220 Oulu, Finland
Phone: +358-(0)294 481150,
e-mail: kalervo.hiltunen (at) oulu.fi
For more information, see Kalervo Hiltunen's home page at FBMM.
The proposed work is basic research in lipid biology and biochemistry with a tight link to biomedical topics of broad interest. The research is focused on (i) polyunsaturated fatty acids (PUFAs) and regulation of metabolism, (ii) mitochondrial fatty acid synthesis (mtFAS) and respiration, and (iii) the functional role of peroxisomal membrane protein 2 (Pxmp2). The subprojects require deep understanding of lipid and protein biochemistry, and they address the regulatory interplay between cells and intracellular organelles and metabolic compartmentalization in a physiological context. Typically we use mice and yeast as model organisms with perturbations in peroxisomal and mitochondrial lipid metabolism to address particular biological questions.