Project leader: Prof. Kalervo Hiltunen, M.D., Ph.D.
Faculty of Biochemistry and Molecular Medicine, University of Oulu
P.O.Box 3000, FIN-90014 University of Oulu, Finland
University of Oulu, Aapistie 7A, FIN-90220 Oulu, Finland
Phone: +358-(0)294 481150,
e-mail: kalervo.hiltunen (at) oulu.fi
For more information, see Kalervo Hiltunen's home page at FBMM.
Cell organelles are key players in the maintenance of physiological homeostasis of cells and organs. The scope of how we gather information on metabolic control mechanisms in a cellular setting has undergone a major revision in recent years. Our project is a continuation of long-term basic research on cellular lipid biochemistry and biology with a tight link to biomedical topics of broad interest: (i) polyunsaturated fatty acids (PUFAs), mitochondria and regulation of metabolism, (ii) mitochondrial fatty acid synthesis (mtFAS) and respiration, and (iii) Pxmp2 family proteins as channel-forming proteins.
The subprojects require a deep understanding of lipid and protein biochemistry, and they address the regulatory interplay between cells and intracellular organelles and metabolic compartmentalization in a physiological context. Different model organisms (yeasts, mice, rats and humans) and technical approaches (e.g. protein chemistry, molecular genetics, molecular biology, membrane electrophysiology and structural biology) will be used to address particular biological questions.