Johanna Myllyharju, Ph.D.,Professor
Scientific Director of Biocenter Oulu
Key Enzymes in the Synthesis of Collagens and the Response of Cells to Hypoxia
Project leader: Prof. Johanna Myllyharju,
Ph.D.
Oulu Center for Cell-Matrix Research, Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine, Faculty of Medicine, University of Oulu
mailing address:
P.O. Box 5000, FIN-90014 University of Oulu, FINLAND
street address:
Aapistie 7, FIN-90220 Oulu, FINLAND
Tel. +358-(0)294 485740
Fax +358-8-537 5811
e-mail: johanna.myllyharju (at) oulu.fi
About the project
Collagen prolyl 4-hydroxylases (C-P4Hs), lysyl hydroxylases (LHs) and lysyl oxidases (LOs) have essential roles in collagen synthesis. A further P4H family (HIF-P4Hs) and an asparaginyl hydroxylase (FIH) regulate the stability and activity of the hypoxia-inducible transcription factors (HIFs), αβ dimers, that play a central role in oxygen homeostasis. To understand the functions of these enzymes and their potential as therapeutic targets in detail, we are utilizing a wide repertoire of methods ranging from analysis of the catalytic and inhibitory properties of the recombinant enzymes to cell biology and animal models. The project is part of the Finnish Centre of Excellence Programme funded by the Academy of Finland (Centre of Excellence Grant 2012 - 2017, 251314)
Project details
Biocenter Oulu
P.O.Box 5000
FI-90014 University of Oulu, Finland
Street Address: Aapistie 5A, FI-90220 Oulu, Finland