Conserved Collagens in Cell–Matrix Homeostasis
 

Project leader: Prof. Taina Pihlajaniemi, M.D., Ph.D., Professor and Chairman of Medical Biochemistry and Molecular Biology Collagen Research Unit, Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine, Faculty of Medicine, University of Oulu

mailing address:
P.O. Box 5000
FIN-90014 University of Oulu, FINLAND

street address:
Aapistie 5A, FIN-90220 Oulu, FINLAND
Tel. +358-(0)294 485800,
Fax +358-8-537 5811,
e-mail: taina.pihlajaniemi (at) oulu.fi

About the project

The extracellular matrix (ECM) is crucial in controlling cell differentiation and function in multicellular animals. It is continually remodelled and synthesised by cells in response to environmental factors such as physical force, hypoxia, trauma and infection. Collagens play a dominant structural role in maintaining the integrity of tissues. Collagens are also critical for tissue morphogenesis and homeostasis by binding growth factors and cellular receptors. We investigate the roles of collagens in the pericellular environment in supporting cell growth and differentiation. We also elucidate mechanisms whereby vascular endothelial cells interact with the underlying ECM and how such interactions lead to vascular anomalies. The project is part of the Finnish Centre of Excellence Programme funded by the Academy of Finland (Centre of Excellence Grant 2012 - 2017, 251314)
 

Project details
 

1. Background and Significance
2. Recent Progress
3. Future Goals
4. Publications 2011-
5. Doctoral Theses 2011
6. Research Group Members
7. National and International Activities