Gonghong Wei, Ph.D.

Regulatory Genomics and Functional Cancer Genetics

Project leader
Gonghong Wei, Ph.D., Docent, Academy Research Fellow

Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine,
University of Oulu

Mailing address
P.O.Box 5000, FIN-90014 University of Oulu, Finland

Street address
Aapistie 5A, Biocenter Oulu, 4th floor, 90220 Oulu, Finland

Tel. +358-(0)294 486111,
e-mail: gonghong.wei (at) oulu.fi

About the project

Transcription factors (TFs) are a kind of sequence-specific DNA-binding proteins. The human genome contains approximately 1400 TFs contributing to complex gene regulation and accurate cell growth control. Aberrant expression of TFs is frequently observed in cancer of the breast and prostate, Ewing's sarcoma and leukemia. Charting gene regulatory networks driven by the TFs in cancer cells is a systematic way to discover novel mechanisms and clinical markers for cancer risk prediction and therapy. Here, we aim to uncover the cancerous roles of multiple TFs including key members of the ETS, HOX and Forkhead classes of DNA-binding proteins. Together with data from genome-wide association studies, we aim to explore how the cancer risk-associated single nucleotide polymorphisms (SNPs) alter TF–DNA binding at sites of clinically important enhancers and misregulation of the SNP-linked causative genes. We will validate key findings including risk SNPs, enhancers and genes that are potentially biomarkers and drug targets that could be used for cancer patient risk prediction, stratification and therapy.

Project details

  1. Background and Significance
  2. Recent Progress
  3. Future Goals
  4. Selected Publications
  5. Doctoral Theses 2016
  6. Research Group Members

Last updated: 24.4.2017