Project leader: Gonghong Wei, Ph.D.
Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine, Faculty of Medicine, University of Oulu
P.O.Box 5000, FIN-90014 University of Oulu, Finland
Aapistie 5A, 90220 Oulu, Finland
Tel. +358-(0)294 486111,
Fax +358-8-537 6115,
e-mail: gonghong.wei (at) oulu.fi
The project will focus on the ETS (E-twenty-six) family of transcription factors, which are featured with highly conserved DNA-binding ETS-domains and similar DNA recognition properties. However, the ETS members always display distinct functions and frequently regulate different biological processes. Here, we aim to address, on a genome-wide scale, the mechanisms that confer the unique biological roles of the ETS transcription factors in normal and cancer development. How do the ETS members contribute to targeting specificity in a cell-type-specific manner? How can the ETS gene regulatory networks and hub genes orchestrate cell growth and link to complex diseases, such as cancer?