Integromic Study of ETS Gene Regulatory Networks in Normal and Cancer Development
 

Project leader: Gonghong Wei, Ph.D.
Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine, Faculty of Medicine, University of Oulu

mailing address:
P.O.Box 5000, FIN-90014 University of Oulu, Finland

street address:
Aapistie 5A, 90220 Oulu, Finland
Tel. +358-(0)294 486111,
Fax +358-8-537 6115,
e-mail: gonghong.wei (at) oulu.fi

About the project

The project will focus on the ETS (E-twenty-six) family of transcription factors, which are featured with highly conserved DNA-binding ETS-domains and similar DNA recognition properties. However, the ETS members always display distinct functions and frequently regulate different biological processes. Here, we aim to address, on a genome-wide scale, the mechanisms that confer the unique biological roles of the ETS transcription factors in normal and cancer development. How do the ETS members contribute to targeting specificity in a cell-type-specific manner? How can the ETS gene regulatory networks and hub genes orchestrate cell growth and link to complex diseases, such as cancer?
 

Project details
 

1. Background and Significance
2. Recent Progress
3. Future Goals
4. Selected Publications
5. Research Group Members
6. National and International Activities