Publications 2009

Coordinator Eskelinen:

Wang C, Kovanen V, Raudasoja P, Eskelinen S, Pospiech H, Myllylä R. The glycosyltransferase activities of lysyl hydroxylase 3 (LH3) in the extracellular space are important for cell growth and viability.J Cell Mol Med 13:508-521, 2009.

Project Hiltunen:

Chen Z-J, Kastaniotis AJ, Miinalainen IJ, Rajaram V, Wierenga RK, Hiltunen JK. 17beta-hydroxysteroid dehydrogenase type 8 and carbonyl reductase type 4 assemble as a ketoacyl reductase of human mitochondrial FAS . FASEB J 23:3682-3691, 2009.

Antonenkov VD, Mindfhoff S, Grunau S, Erdmann R, Hiltunen JK. An involvement of yeast peroxisomal channels in transmembrane transfer of glyoxylate cycle intermediates . Int J Biochem Cell B 41:2546-2554, 2009.

Schonauer MS, Kastaniotis AJ, Kursu VAS, Hiltunen JK, Dieckmannn CL. Lipoic acid synthesis and attachment in yeast mitochondria. J Biol Chem 284:23234-23242, 2009.

Gurvitz A , Suomi F , Rottenstener H , Hiltunen JK , Dawes IW. Avoiding unscheduled transcription in shared promoters: Saccharomyces cerevisiae Sum1p represses the divergent gene pair SPS18-SPS19 through a midsporulation element (MSE). FEMS Yeast Res 9:821-831, 2009.

Song W-Q, Qin Y-M, Saito M, Shirai T, Pujol FM, Kastaniotis AJ, Hiltunen JK, Zhu Y-X. Characterization of two cotton cDNAs encoding trans-2-enoyl-CoA reductase reveals a putative novel NADPH-binding motif. J Exp Bot 60:1839-1848, 2009.

Chen Z-J, Leskinen H, Liimatta E, Sormunen RT, Miinalainen IJ, Hassinen IE, Hiltunen JK. Myocardial overexpression of Mecr, a gene of mitochondrial FAS II leads to cardiac dysfunction in mouse. PloS One 4:e5589, 2009.

Miinalainen IJ, Schmitz W, Huotari A, Autio KJ, Soininen R, Ver Loren van Themaat E, Baes M, Herzig K-H, Conzelmann E, Hiltunen JK. Mitochondrial 2,4-dienoyl-CoA reductase deficiency in mice results in severe hypoglycemia with stress intolerance and unimpaired ketogenesis. PLoS Genet 5:e1000543, 2009.

Rokka A, Antonenkov VD, Soininen R, Immonen HL, Pirilä PL, Bergmann U, Sormunen RT, Weckström M, Benz R, Hiltunen JK. Pxmp2 is a channel-forming protein in mammalian peroxisomal membrane. PloS One 4:e5090, 2009.

Grunau S, Mindthoff S, Rottensteiner H, Sormunen RT, Hiltunen JK, Erdmann R, Antonenkov VD. Channel-forming activities of peroxisomal membrane proteins from the yeast Saccharomyces cerevisiae. FEBS J 276:1698-1708, 2009.

Gurvitz A, Hiltunen JK, Kastaniotis AJ. Heterologous expression of mycobacterial proteins in Saccharomyces cerevisiae reveals two physiologically functional 3-hydroxyacyl-thioester dehydratases, HtdX and HtdY, in addition to HadABC and HtdZ. J Bacteriol 191:2683-2690, 2009.

Hiltunen JK, Schonauer MS, Autio KJ, Mittelmeier TM, Kastaniotis AJ, Dieckmann CL. Mitochondrial FAS type II: More than just fatty acids. J Biol Chem 284:9011-9015, 2009.

Junior Investigator Jaakola:

Jaakola V-P and Stevens RC. G protein-coupled receptor structures. Handbook of Cell Signaling, 2nd Edition, Bradshaw RA and Dennis EA, Eds., Oxford: Academic Pres, pp. 129-138, 2009.

Biocomputing Coordinator Juffer:

Sharma S and Juffer AH. Hydrolysis of phosphohistidine in water and in prostatic acid phosphatase. Chem Commun 6385-6387, 2009.

Fukamizo T, Miyake R, Tamura A, Ohnuma T, Skriver K, Pursiainen NV, Juffer AH. A flexible loop controlling the enzymatic activity and specificity in a glycosyl hydrolase family 19 endochitinase from barley seeds (Hordeum vulgare L.). Biochim Biophys Acta 1794:1159-1167, 2009.

Donnini S, Villa A, Groenhof G, Mark AE, Wierenga RK, Juffer AH. Inclusion of ionization states of ligands in affinity calculations. Proteins 76:138-150, 2009.

Project Kesäniemi:

Haukkamaa L, Moilanen L, Kattainen A, Luoto R, Kähönen M, Leinonen M, Jula A, Kesäniemi YA, Kaaja R. Pre-eclampsia is a risk factor of carotid artery atherosclerosis. Cerebrovasc Dis 27:599-607, 2009.

Hietaniemi M, Jokela M, Rantala M, Ukkola O, Vuoristo JT, Ilves M, Rysä J, Kesäniemi YA. The effect of a short-term hypocaloric diet on liver gene expression and metabolic risk factors in obese women. Nutr Metab Cardiovas 19:177-183, 2009.

Hietaniemi M, Malo E, Jokela M, Santaniemi M, Ukkola O, Kesäniemi YA. The effect of energy restriction during pregnancy on obesity-related peptide hormones in rat offspring. Peptides 30:705-709, 2009.

Järvenpää J, Vuoristo JT, Santaniemi M, Ukkola O, Savolainen E-R, Jääskeläinen M, Tapanainen J, Kesäniemi A, Ryynänen M. Adiponectin induced placental cell apoptosis could be mediated via the ADIPOR1-receptor in pre-eclampsia with IUGR. J Perinat Med 37:257-262, 2009.

Kangas-Kontio T, Tapanainen JM, Huikuri H, Savolainen E-R, Päivänsalo M, Kauma H, Kesäniemi YA, Savolainen MJ, Kakko S. Variation in the vascular endothelial growth factor gene, carotid intima-media thickness and the risk of acute myocardial infarction. Scand J Clin Lab Inv 69:335-343, 2009.

Kastarinen H, Hörkkö S, Kauma H, Karjalainen A, Savolainen MJ, Kesäniemi YA. Low-density lipoprotein clearance in patients with chronic renal failure. Nephrol Dial Transpl 24:2131-2135, 2009.

K astarinen H, Kesäniemi YA, Ukkola O. Leptin and lipid metabolism in chronic kidney failure. Scand J Clin Lab Inv 69:401-408, 2009.

Kastarinen H, Ukkola O, Kesäniemi YA. Glomerular filtration rate is related to carotid intima-media thickness in middle-aged adults. Nephrol Dial Transpl 24:2767-2772, 2009.

Kellokoski E, Kummu O, Serpi R, Lehenkari P, Ukkola O, Kesäniemi YA, Hörkkö S. Ghrelin vaccination decreases plasma MCP-1 level in LDLR (-/-)- mice. Peptides 30:2292-2300, 2009.

Kellokoski E, Kunnari A, Jokela M, Mäkelä S, Kesäniemi YA, Hörkkö S. Ghrelin and obestatin modulate early atherogenic processes on cells: enhancement of monocyte adhesion and oxidized low-density lipoprotein binding. Metabolism 58:1572-1580, 2009.

Kunnari A, Savolainen E-R, Ukkola O, Kesäniemi YA, Jokela M. The expression of human resistin in different leucocyte lineages is modulated by LPS and TNFalpha. Regul Peptides 157:57-63, 2009.

Leskelä P, Ukkola O, Vartiainen J, Rönnemaa T, Kaprio J, Bouchard C, Kesäniemi YA. Fasting plasma total ghrelin concentrations in monozygotic twins discordant for obesity. Metabolism 58:174-179, 2009.

Ling H, Waterworth DM, Stirnadel HA, Pollin TI, Barter PJ, Kesäniemi YA et al. Genome-wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS study. Obesity 17:737-744, 2009.

Luotola K, Pääkkönen R, Alanne M, Lanki T, Moilanen L, Surakka I et al. (including Kesäniemi YA). Association of variation in the interleukin-1 gene family with diabetes and glucose homeostasis. J Clin Endocr Metab 94:4575-4583, 2009.

Niemi J, Mäkinen V-P, Heikkonen J, Tenkanen L, Hiltunen Y, Hannuksela ML, Jauhiainen M, Forsblom C, Taskinen M-R, Kesäniemi YA, Savolainen MS, Kaski K, Groop P-H, Kovanen PT, Ala-Korpela M. Estimation of VLDL, IDL, LDL, HDL 2 , apoA-I and apoB from the Friedewald inputs – apoB and IDL, but not LDL, are associated with mortality in type 1 diabetes. Ann Med 41:451-461. 2009.

Richards JB, Waterworth D, O’Rahilly S, Hivert M-F, Loos RJF, Perry JRB et al. (including Kesäniemi YA). A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PloS Genetics 12:e1000768, 2009.

Riikola A, Sipilä K, Kähönen M, Jula A, Nieminen MS, Moilanen L, Kesäniemi YA, Lehtimäki T, Hulkkonen J. Interleukin-6 promoter polymorphism and cardiovascular risk factors: The Health 2000 Survey. Atherosclerosis 207:466-470, 2009.

Sipilä K, Moilanen L, Nieminen T, Reunanen A, Jula A, Salomaa V et al. (including Kesäniemi YA). Metabolic syndrome and carotid intima media thickness in the Health 2000 Survey. Atherosclerosis 204:276-281, 2009.

Sämpi M , Ukkola O, Päivänsalo M, Kesäniemi YA, Hörkkö S. Early atherosclerosis and IgG 2 to bacteria are associated with FcgammaRIIa genotype in non-smokers. Eur J Clin Invest 39:517-526, 2009.

Ukkola O. Gastric bypass and glucose metabolism. Intern Med J 39:502-505, 2009.

Ukkola O . Ghrelin and metabolic disorders. Curr Protein Pept Sci 10:2-7, 2009.

Ukkola O, Kunnari A, Jokela M, Päivänsalo M, Kesäniemi YA. ApoE phenotype is associated with inflammatory markers in middle-aged subjects. Inflamm Res 58:54-59, 2009.

Ukkola O, Vasunta R-L, Kesäniemi YA. Non-dipping pattern in ambulatory blood pressure monitoring is associated with metabolic abnormalities in a random sample of middle-aged subjects. Hypertens Res 32:1022-1027, 2009.

Project Myllyharju:

Hyry M, Lantto J, Myllyharju J. Missense mutations that cause Bruck syndrome affect enzymatic activity, folding and oligomerization of lysyl hydroxylase 2. J Biol Chem 284:30917-30924, 2009.

Koski MK, Hieta R, Hirsilä M, Rönkä A, Myllyharju J, Wierenga RK. The crystal structure of an algal prolyl 4-hydroxylase complexed with a proline-rich peptide reveals a novel buried tripeptide binding motif. J Biol Chem 284:25290-25301, 2009.

Ovchinnikova O, Robertson A-KL, Wågsäter D, Folco EJ, Hyry M, Myllyharju J, Eriksson P, Libby P, Hansson GK. T-cell activation leads to reduced collagen maturation in atherosclerotic plaques of Apoe -/- mice. Am J Pathol 174:693-700, 2009.

Pischon N, Mäki JM, Weisshaupt P, Heng N, Palamakumbura AH, N’Guessan P, Ding A, Radlanski R, Renz H, Bronckers TALJJ, Myllyharju J, Kielbassa AM, Kleber BM, Bernimoulin J-P, Trackman PC. Lysyl oxidase (Lox) gene deficiency affects osteoblastic phenotype. Calcif Tissue Int 85:119-126, 2009.

Wilkins SE, Hyvärinen J, Chicher J, Gorman JJ, Peet DJ, Bilton RL, Koivunen P. Differences in hydroxylation and binding of Notch and HIF-1alpha demonstrate substrate selectivity for factor inhibiting HIF-1 (FIH-1). Int J Biochem Cell B 41:1563-1571, 2009.

Mäki JM. Lysyl oxidases in mammalian development and certain pathological conditions. Histol Histopathol 24:651-660, 2009. (Invited review).

MyllyharjuJ. HIF prolyl 4-hydroxylases and their potential as drug targets. Curr Pharm Design 15:3878-3885, 2009. (Invited review).

Project Männikkö:

Karasugi T, Semba K, Hirose Y, Kelempisioti A, Nakajima M, Miyake A, Furuichi T, Kawaguchi Y, Mikami Y, Chiba K, Kamata M, Ozaki K, Takahashi A, Mäkelä P, Karppinen J, Kimura T, Kubo T, Toyama Y, Yamamura K, Männikkö M, Mizuta H, Ikegawa S. Association of the tag SNPs in the human SKT gene (KIAA1217) with lumbar disc herniation. J Bone Miner Res 24:1537-1543, 2009.

Solovieva S, Kämäräinen O-P, Hirvonen A, Hämäläinen S, Laitala M, Vehmas T, Luoma K, Näkki A, Riihimäki H, Ala-Kokko L, Männikkö M, Leino-Arjas P. Association between interleukin 1 gene cluster polymorphisms and bilateral distal interphalangeal osteoarthritis. J Rheumatol 36:1977-1986, 2009.

Bioprocess Engineering Coordinator Neubauer:

Other Publications from the Biocenter Project:

György Z, Jaakola L, Neubauer P, Hohtola A. Isolation and genotype-dependent, organ-specific expression analysis of a Rhodiola rosea cDNA encoding tyrosine decarboxylase. J Plant Physiol 166:1581-1586, 2009.

Taskila S, Neubauer P, Tuomola M, Breitenstein A, Kronlöf J, Hillukkala T. Improved enrichment cultivation of beer spoiling lactic acid bacteria by continuous glucose addition to the culture. J Inst Brew 115:177-182, 2009.

Project Pamilo/Savolainen:

Biocenter Publications:

Palmé AE, Pyhäjärvi T, Wachowiak W, Savolainen O. Selection on nuclear genes in a Pinus phylogeny. Mol Biol Evol 26:893-905, 2009.

Shimizu-Inatsugi R, Lihová J, Iwanaga H, Kudoh H, Marhold K, Savolainen O, Watanabe K, Yakubov VV, Shimizu KK. The allopolyploid Arabidopsis kamchatica originated from multiple individuals of A. lyrata and A. halleri. Mol Ecol 18:4024-4048, 2009.

Viljakainen L, Evans JD, Hasselmann M, Rueppell O, Tingek S, Pamilo P. Rapid evolution of immune proteins in social insects. Mol Biol Evol 26:1791-1801, 2009.

Other Publications from the Biocenter Project:

Leinonen PH, Sandring S, Quilot B, Clauss MJ, Mitchell-Olds T, Ågren J, Savolainen O. Local adaptation in European populations of Arabidopsis lyrata (Brassicaceae) Am J Bot 96:1129-1137, 2009.

Project Pihlajaniemi:

Biocenter Publications:

Limaye N, Wouters V, Uebelhoer M, Tuominen M, Wirkkala R, Mulliken JB, Eklund L, Boon LM, Vikkula M. Somatic mutations in the angiopoietin-receptor TIE2 can cause both solitary and multiple sporadic venous malformations. Nat Genet 41:118-124, 2009.

Suzuki O, Kague E, Bagatini K, Tu H, Heljasvaara R, Carvalhaes L, Gava E, de Oliveira G, Godoi P, Oliva G, Kitten G, Pihlajaniemi T, Passos-Bueno M-R. Novel pathogenic mutations and skin biopsy analysis in Knobloch syndrome. Mol Vis 15:801-809, 2009.

Richter AG, McKeown S, Rathinam S, Harper L, Rajesh P, McAuley DF, Heljasvaara R, Thickett DR. Soluble endostatin is a novel inhibitor of epithelial repair in idiopathic pulmonary fibrosis. Thorax 64:156-161, 2009.

Huilaja L, Hurskainen T, Autio-Harmainen H, Sormunen R, Tu H, Hofmann SC, Pihlajaniemi T, Bruckner-Tuderman L, Tasanen K. Glycine substitution mutations cause intracellular accumulation of collagen XVII and affect its post-translational modifications. J Invest Dermatol 129:2302-2306, 2009.

Thulin Å, Ringvall M, Dimberg A, Kårehed K, Väisänen T, Väisänen M-R, Hamad O, Wang J, Bjerkvig R, Nilsson B, Pihlajaniemi T, Åkerud H, Pietras K, Jahnen-Dechent W, Siegbahn A, Olsson A-K. Activated platelets provide a functional microenvironment for the antiangiogenic fragment of histidine-rich glycoprotein. Mol Cancer Res 7:1792-1802, 2009 .

Sipola A, Seppinen L, Pihlajaniemi T, Tuukkanen J. Endostatin affects osteoblast behavior in vitro, but collagen XVIII/endostatin is not essential for skeletal development in vivo. Calcif Tissue Int 85:412-420, 2009.

Tuominen M, Vikkula M, Eklund L. Somatic mutations in TIE2 cause venous malformations. Somaattiset geenivirheet TIE2-reseptorissa aiheuttavat laskimoepämuodostumia. Duodecim. Finnish Medical Society Journal, article in Finnish. 25:391-392, 2009.

Other Publications from the Biocenter Project:

Perkins GD, Nathani N, Richter AG, Park D, Shyamsundar M, Heljasvaara R, Pihlajaniemi T, Manji M, Tunnicliffe W, McAuley D, Gao F, Thickett DR. Type XVIII collagen degradation products in acute lung injury. Crit Care 13:R52, 2009.

Project Ruskoaho:

Biocenter Publications:

Aydin J, Andersson DC, Hänninen SL, Wredenberg A, Tavi P, Park CB, Larsson N-G, Bruton JD, Westerblad H. Increased mitochondrial Ca 2+ and decreased sarcoplasmic reticulum Ca 2+ in mitochondrial myopathy. Hum Mol Genet 18:278-288, 2009.

Chen Z-J, Leskinen H, Liimatta E, Sormunen RT, Miinalainen IJ, Hassinen IE, Hiltunen JK. Myocardial overexpression of Mecr, a gene of mitochondrial FAS II leads to cardiac dysfunction in mouse. PLoS One 4:e5589, 2009.

Hietaniemi M, Jokela M, Rantala M, Ukkola O, Vuoristo JT, Ilves M, Rysä J, Kesäniemi YA. The effect of a short-term hypocaloric diet on liver gene expression and metabolic risk factors in obese women. Nutr Metab Cardiovas 19:177-183, 2009.

Kastarinen H, Hörkkö S, Kauma H, Karjalainen A, Savolainen MJ, Kesäniemi YA. Low-density lipoprotein clearance in patients with chronic renal failure. Nephrol Dial Transpl 24:2131-2135, 2009.

Kellokoski E, Kummu O, Serpi R, Lehenkari P, Ukkola O, Kesäniemi YA, Hörkkö S. Ghrelin vaccination decreases plasma MCP-1 level in LDLR(-/-)-mice. Peptides 30:2292-2300, 2009.

Kellokoski E, Kunnari A, Jokela M, Mäkelä S, Kesäniemi YA, Hörkkö S. Ghrelin and obestatin modulate early atherogenic processes on cells: enhancement of monocyte adhesion and oxidized low-density lipoprotein binding. Metabolism 58:1572-1580, 2009.

Kerola T, Nieminen T, Hartikainen S, Sulkava R, Vuolteenaho O, Kettunen R. High-density lipoprotein is superior to B-type natriuretic peptide as a marker of systolic dysfunction in an elderly general population. Scand J Clin Lab Inv 69:865-872, 2009.

Koivumäki JT, Takalo J, Korhonen T, Tavi P, Weckström M. Modelling sarcoplasmic reticulum calcium ATPase and its regulation in cardiac myocytes. Phil Trans R Soc A 367:2181-2202, 2009.

Koivumäki JT, Korhonen T, Takalo J, Weckström M, Tavi P. Regulation of excitation-contraction coupling in mouse cardiac myocytes: integrative analysis with mathematical modelling. BMC Physiol 9:16, 2009.

Korhonen T, Hänninen SL, Tavi P. Model of excitation-contraction coupling of rat neonatal ventricular myocytes. Biophys J 96:1189-1209, 2009.

Kurl S, Ala-Kopsala M, Ruskoaho H, Mäkikallio T, Nyyssönen K, Vuolteenaho O, Sivenius J, Salonen JT, Laukkanen JA. Plasma N-terminal fragments of natriuretic peptides predict the risk of stroke and atrial fibrillation in men. Heart 95:1067-1071, 2009.

Liesmaa I, Leskinen HK, Kokkonen JO, Ruskoaho H, Kovanen PT, Lindstedt KA. Hypoxia-induced expression of bradykinin type-2 receptors in endothelial cells triggers NO production, cell migration, and angiogenesis. J Cell Physiol 221:359-366, 2009.

Majalahti T, Tokola H, Ruskoaho H, Vuolteenaho O. Characterization of promoter elements required for cardiac chamber-specific expression. Mol Cell Endocrinol 307:50-56, 2009.

Mustonen E, Pohjolainen V, Aro J, Pikkarainen S, Leskinen H, Ruskoaho H, Rysä J. Upregulation of cardiac matrix Gla protein expression in response to hypertrophic stimuli. Blood Press 18:286-293, 2009.

Peltonen T, Taskinen P, Näpänkangas J, Leskinen H, Ohtonen P, Soini Y, Juvonen T, Satta J, Vuolteenaho O, Ruskoaho H. Increase in tissue endothelin-1 and ETA receptor levels in human aortic valve stenosis. Eur Heart J 30:242-249, 2009.

Serpi R, Tolonen A-M, Tenhunen O, Pieviläinen O, Kubin A-M, Vaskivuo T, Soini Y, Kerkelä R, Leskinen H, Ruskoaho H. Divergent effects of losartan and metoprolol cardiac remodeling, c-kit+ cells, proliferation and apoptosis in the left ventricle after myocardial infarction. Clin Transl Sci 2:422-430, 2009.

Sämpi M, Ukkola O, Päivänsalo M, Kesäniemi YA, Hörkkö S. Early atherosclerosis and IgG2 to bacteria are associated with FcgammaRIIa genotype in non-smokers. Eur J Clin Invest 39:517-526, 2009.

Peltonen T, Näpänkangas J, Vuolteenaho O, Ohtonen P, Soini Y, Juvonen T, Satta J, Ruskoaho H, Taskinen P. Apelin and its receptor APJ in human aortic valve stenosis. Heart Valve Dis 18:644-652, 2009.

Other Publications from the Biocenter Project:

Chou M-Y, Fogelstrand L, Hartvigsen K, Hansen LF, Woelkers D, Shaw PX, Choi J, Perkmann T, Bäckhed F, Miller YI, Hörkkö S, Corr M, Witztum JL, Binder CJ. Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans. J Clin Invest 119:1335-1349, 2009.

Kankaanpää J, Turunen SP, Moilanen V, Hörkkö S, Remes AM. Cerebrospinal fluid antibodies to oxidized LDL are increased in Alzheimer’s disease. Neurobiol Dis 33:467-472, 2009.

Ruohonen ST , Savontaus E, Rinne P, Rosmaninho-Salgado J, Cavadas C, Ruskoaho H, Koulu M, Pesonen U. Stress-induced hypertension and increased sympathetic activity in mice overexpressing neuropeptide Y in noradrenergic neurons. Neuroendocrinology 89:351-360, 2009.

Turpeinen AK, Vanninen E, Magga J, Tuomainen P, Kuusisto J, Sipola P, Punnonen K, Vuolteenaho O, Peuhkurinen K. Cardiac sympathetic activity is associated with inflammation and neurohumoral activation in patients with idiopathic dilated cardiomyopathy. Clin Physiol Funct Imaging 29:414-419, 2009.

Zhou J, Shao Z, Kerkelä R, Ichijo H, Muslin AJ, Pombo C, Force T. Serine 58 of 14-3-3zeta is a molecular switch regulating ASK1 and oxidant stress-induced cell death. Mol Cell Biol 29:4167-4176, 2009.

Project Savolainen:

Biocenter Publications:

Ala-Korpela M, Soininen P, Savolainen MJ. Letter by Ala-Korpela et al Regarding Article, "Lipoprotein Particle Profiles by Nuclear Magnetic Resonance Compared With Standard Lipids and Apolipoproteins in Predicting Incident Cardiovascular Disease in Women" . Circulation 120:e149, 2009.

Bonnefond A, Vaxillaire M, Labrune Y, Lecoeur C, Chèvre J-C, Bouatia-Naji N et al. (Kaakinen M, Järvelin M-R). Genetic variant in HK1 is associated with a proanemic state and A1C but not other glycemic control-related traits. Diabetes 58:2687-2697, 2009.

Bouatia-Naji N, Bonnefond A, Cavalcanti-Proença C, Sparsø T, Holmkvist J, Marchand M et al. (Hartikainen A-L, Ruokonen A, Järvelin M-R).A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet 41:89-94, 2009.

Chambers JC, Zhang W, Li Y, Sehmi J, Wass MN, Zabaneh D et al. (Ruokonen A, Järvelin M-R). Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels. Nat Genet 41:1170-1172, 2009.

Chambers JC, Zhang W, Zabaneh D, Sehmi J, Jain P, McCarthy MI et al. (Ruokonen A, Järvelin M-R). Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians. Diabetes 58:2703-2708, 2009.

Elliott P, Chambers JC, Zhang W, Clarke R, Hopewell JC, Peden JF et al. (Ruokonen A, Järvelin M-R). Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA 302:37-48, 2009.

Heinonen MV, Laaksonen DE, Karhu T, Karhunen L, Laitinen T, Kainulainen S, Rissanen A, Niskanen L, Herzig KH. Effect of diet-induced weight loss on plasma apelin and cytokine levels in individuals with the metabolic syndrome. Nutr Metab Cardiovas 19:626-633, 2009.

Heid IM, Huth C, Loos RJ, Kronenberg F, Adamkova V, Anand SS et al. (Järvelin M-R, Kaakinen M). Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: Does heterogeneity of estimates relate to study design? PLoS Genet 5:e1000694, 2009.

Juvonen KR, Purhonen A-K, Salmenkallio-Marttila M, Lähteenmäki L, Laaksonen DE, Herzig K-H, Uusitupa MIJ, Poutanen KS, Karhunen LJ. Viscosity of oat bran-enriched beverages influences gastrointestinal hormonal responses in healthy humans. J Nutr 139:461-466, 2009.

Kangas-Kontio T, Tapanainen JM, Huikuri H, Savolainen E-R, Päivänsalo M, Kauma H, Kesäniemi YA, Savolainen MJ, Kakko S. Variation in the vascular endothelial growth factor gene, carotid intima-media thickness and the risk of acute myocardial infarction. Scand J Clin Lab Inv 69:335-343, 2009.

Kangas-Kontio T, Vavuli S, Kakko SJ, Penna J, Savolainen ER, Savolainen MJ, Liinamaa MJ. Polymorphism of the manganese superoxide dismutase gene but not of vascular endothelial growth factor gene is a risk factor for diabetic retinopathy. Brit J Ophthalmol 93:1401-1406, 2009.

Liisanantti MK and Savolainen MJ. Phosphatidylethanol mediates its effects on the vascular endothelial growth factor via HDL receptor in endothelial cells. Alcohol Clin Exp Res 33:283-288, 2009.

Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L et al. (Ruokonen A, Järvelin M-R). Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet 5:e1000508, 2009.

Lähdesmäki K, Plihtari R, Soininen P, Hurt-Camejo E, Ala-Korpela M, Öörni K, Kovanen PT. Phospholipase A 2 –modified LDL particles retain the generated hydrolytic products and are more atherogenic at acidic pH. Atherosclerosis 207:352-359, 2009.

Meyre D, Delplanque J, Chèvre J-C, Lecoeur C, Lobbens S, Gallina S et al. (Hartikainen A-L, Järvelin M-R). Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet 41:157-159, 2009.

Mäkinen V-P, Forsblom C, Thorn LM, Wadén J, Kaski K, Ala-Korpela M, Groop P-H. Network of vascular diseases, death and biochemical characteristics in a set of 4,197 patients with type 1 diabetes (The FinnDiane Study). Cardiovasc Diabetol 8:54, 2009.

Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L et al. (Hartikainen A-L, Pouta A, Järvelin M-R). Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet 41:666-676, 2009.

Niemi J, Mäkinen V-P, Heikkonen J, Tenkanen L, Hiltunen Y, Hannuksela ML, Jauhiainen M, Forsblom C, Taskinen M-R, Kesäniemi YA, Savolainen MJ, Kaski K, Groop P-H, Kovanen PT, Ala-Korpela M. Estimation of VLDL, IDL, LDL, HDL 2, apoA-I and apoB from the Friedewald inputs – apoB and IDL, but not LDL, are associated with mortality in type 1 diabetes. Ann Med 41:451-461, 2009.

Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G et al. (Kaakinen M, Pouta A, Järvelin M-R). Variants in the melatonin receptor 1B gene (MTNR1B) influence fasting glucose levels. Nat Genet 41:77-81, 2009.

Rung J, Cauchi S, Albrechtsen A, Shen L, Rocheleau G, Cavalcanti-Proença C et al. (Järvelin M-R, Laitinen J, Pouta A, Ruokonen A). Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet 41:1110-1115, 2009.

Sabatti C, Service SK, Hartikainen A-L, Pouta A, Ripatti S, Brodsky J et al. (Kaakinen M, Sovio U, Ruokonen A, Laitinen J, Järvelin M-R). Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet 41:35-46, 2009.

Soininen P, Kangas AJ, Würtz P, Tukiainen T, Tynkkynen T, Laatikainen R, Järvelin M-R, Kähönen M, Lehtimäki T, Viikari J, Raitakari OT, Savolainen MJ, Ala-Korpela M. High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism. Analyst 134:1781-1785, 2009.

Sparso T, Bonnefond A, Andersson E, Bouatia-Naji N, Holmkvist J, Wegner L et al. (Järvelin M-R). G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans. Diabetes 58:1450-1456, 2009.

Sovio U, Bennett AJ, Millwood IY, Molitor J, O'Reilly PF, Timpson NJ et al. (Kaakinen M, Järvelin M-R). Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the Northern Finland Birth Cohort 1966. PLoS Genet 5:e1000409, 2009.

Vääräsmäki M, Pouta A, Elliot P, Tapanainen P, Sovio U, Ruokonen A, Hartikainen A-L, McCarthy MI, Järvelin M-R. Adolescent manifestations of metabolic syndrome among children born to women with gestational diabetes in a general-population birth cohort. Am J Epidemiol 169:1209-1215, 2009.

Cauchi S, Stutzmann F, Cavalcanti-Proença C, Durand E, Pouta A, Hartikainen A-L et al. (Järvelin M-R). Combined effects of MC4R and FTO common genetic variants on obesity in European general populations. J Mol Med 87:537-546, 2009.

Hintikka J, Lehto SM, Niskanen L, Huotari A, Herzig K-H, Koivumaa-Honkanen H et al. Unemployment and ill health: a connection through inflammation? BMC Public Health 9:410, 2009.

Kilpeläinen M, Riikonen J, Vlasova MA, Huotari A, Lehto VP, Salonen J, Herzig KH, Järvinen K. In vivo delivery of a peptide, ghrelin antagonist, with mesoporous silicon microparticles. J Control Release 137:166-170, 2009.

Steubesand N, Kiehne K, Brunke G, Pahl R, Reiss K, Herzig K-H et al. The expression of the beta-defensins hBD-2 and hBD-3 is differentially regulated by NF-kappaB and MAPK/AP-1 pathways in an in vitro model of Candida esophagitis. BMC Immunology 10:36, 2009.

Other Publications from the Biocenter Project:

Bengtsson MW, Mäkelä K, Herzig K-H, Flemström G. Short food deprivation inhibits orexin receptor 1 expression and orexin-A induced intracellular calcium signaling in acutely isolated duodenal enterocytes. Am J Physiol-Gastr L 296:G651-G658, 2009.

Aulchenko YS, Ripatti S, Lindqvist I, Boomsma D, Heid IM, Pramstaller PP et al. (Järvelin M-R); the ENGAGE Consortium. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet 41:47-55, 2009.

Freathy RM, Bennett AJ, Ring SM, Shields B, Groves CJ, Timpson NJ, Weedon MN et al. (Järvelin M-R). Type 2 diabetes risk alleles are associated with reduced size at birth. Diabetes 58:1428-1433, 2009.

Liimatainen T, Hakumäki JM, Kauppinen RA, Ala-Korpela M. Monitoring of gliomas in vivo by diffusion MRI and 1H MRS during gene therapy-induced apoptosis: interrelationships between water diffusion and mobile lipids. NMR Biomed 22:272-279, 2009.

Stutzmann F, Cauchi S, Durand E, Calvacanti-Proença C, Pigeyre M, Hartikainen A-L et al. (Järvelin M-R). Common genetic variation near MC4R is associated with eating behaviour patterns in European populations. Int J Obesity 33:373-378, 2009.

Transgenic Facility Coordinator Soininen:

Miinalainen IJ, Schmitz W, Huotari A, Autio KJ, Soininen R, Ver Loren van Themaat E, Baes M, Herzig K-H, Conzelmann E, Hiltunen JK. Mitochondrial 2,4-dienoyl-CoA reductase deficiency in mice results in severe hypoglycemia with stress intolerance and unimpaired ketogenesis. PLoS Genet 5:e1000543, 2009.

Rokka A, Antonenkov VD, Soininen R, Immonen HL, Pirilä PL, Bergmann U, Sormunen RT, Weckström M, Benz R, Hiltunen JK. Pxmp2 is a channel-forming protein in mammalian peroxisomal membrane. PLoS One 4:e5090, 2009.

EM Microscopy Coordinator Sormunen:

Risteli M, Ruotsalainen H, Salo AM, Sormunen R, Sipilä L, Baker NL, Lamandé SR, Vimpari-Kauppinen L, Myllylä R. Reduction of lysyl hydroxylase 3 causes deleterious changes in the deposition and organization of extracellular matrix. J Biol Chem 284:28204-28211, 2009.

Chen Z-J, Leskinen H, Liimatta E, Sormunen RT, Miinalainen IJ, Hassinen IE, Hiltunen JK. Myocardial overexpression of Mecr, a gene of mitochondrial FAS II leads to cardiac dysfunction in mouse. PLoS One 4:e5589, 2009.

Bolszak M, Anttonen A-K, Komulainen T, Hinttala R, Pakanen S, Sormunen R, Herva R, Lehesjoki A-E, Majamaa K, Rantala H, Uusimaa J. Digenic mutations in severe myoclonic epilepsy of infancy. Epilepsy Res 85:300-304, 2009.

Rokka A, Antonenkov VD, Soininen R, Immonen HL, Pirilä PL, Bergmann U, Sormunen RT, Weckström M, Benz R, Hiltunen JK. Pxmp2 is a channel-forming protein in Mammalian peroxisomal membrane. PLoS One 4:e5090, 2009.

Joenväärä S, Mattila P, Renkonen J, Mäkitie A, Toppila-Salmi S, Lehtonen M, Salmi P, Lehti S, Mäkinen J, Sormunen R, Paavonen T, Renkonen R. Caveolar transport through nasal epithelium of birch pollen allergen Bet v 1 in allergic patients. J Allergy Clin Immun 124:135-142.e1-21, 2009.

Huilaja L, Hurskainen T, Autio-Harmainen H, Sormunen R, Tu H, Hofmann SC, Pihlajaniemi T, Bruckner-Tuderman L, Tasanen K. Glycine substitution mutations cause intracellular accumulation of collagen XVII and affect its post-translational modifications. J Invest Dermatol 129:2302-2306, 2009.

Grunau S, Mindthoff S, Rottensteiner H, Sormunen RT, Hiltunen JK, Erdmann R, Antonenkov VD. Channel-forming activities of peroxisomal membrane proteins from the yeast Saccharomyces cerevisiae. FEBS J 276:1698-1708, 2009.

Kaarteenaho-Wiik R, Pääkkö P, Sormunen R. Ultrastructural features of lung fibroblast differentiation into myofibroblasts. Ultrastruct Pathol 33:6-15, 2009.

Renkonen J, Mattila P, Lehti S, Mäkinen J, Sormunen R, Tervo T, Paavonen T, Renkonen R. Birch pollen allergen Bet v 1 binds to and is transported through conjunctival epithelium in allergic patients. Allergy 64:868-875, 2009.

Project Vainio:

Shan J, Jokela T, Peltoketo H, Vainio S. Generation of an allele to inactivate Wnt4 gene function conditionally in the mouse. Genesis 47:782-788, 2009.

Railo A, Pajunen A, Itäranta P, Naillat F, Vuoristo J, Kilpeläinen P, Vainio S. Genomic response to Wnt signalling is highly context-dependent--evidence from DNA microarray and chromatin immunoprecipitation screens of Wnt/TCF targets. Exp Cell Res 315:2690-2704, 2009.

Itäranta P, Viiri K, Kaartinen V, Vainio S. Lumbo-sacral neural crest derivatives fate mapped with the aid of Wnt-1 promoter integrate but are not essential to kidney development. Differentiation 77:199-208, 2009.

Sabaneyeva EV, Derkacheva ME, Benken KA, Fokin SI, Vainio S, Skovorodkin IN. Actin-based mechanism of Holospora obtusa trafficking in Paramecium caudatum. Protist 160:205-219, 2009.

Project Weckström/Vähäsöyrinki:

Biocenter Publications:

Koivumäki JT, Korhonen T, Takalo J, Weckström M, Tavi P. Regulation of excitation-contraction coupling in mouse cardiac myocytes: integrative analysis with mathematical modelling. BMC Physiol 9:16, 2009.

Koivumäki JT, Takalo J, Korhonen T, Tavi P, Weckström M. Modelling sarcoplasmic reticulum calcium ATPase and its regulation in cardiac myocytes. Phil Trans R Soc A 367:2181-2202, 2009.

Koivumäki JT, Takalo J, Korhonen T, Weckström M, Tavi P. Calcium dependent release and its regulation in cardiac myocytes: mathematical model of the RyR channel. IFMBE Proc 25:669-672, 2009.

Rokka A, Antonenkov VD, Soininen R, Immonen HL, Pirilä PL, Bergmann U, Sormunen RT, Weckström M, Benz R, Hiltunen JK. Pxmp2 is a channel-forming protein in mammalian peroxisomal membrane. PLoS One 4:e5090, 2009.

Vähäsöyrinki M, Tuukkanen T, Sorvoja H, Pudas M. A minimally invasive displacement sensor for measuring brain micromotion in 3D with nanometer scale resolution. J Neurosci Meth 180:290-295, 2009.

Other Publications from the Biocenter Project:

Niemelä PS, Hyvönen MT, Vattulainen I. Atom-scale molecular interactions in lipid raft mixtures Biochim Biophys Acta 1788:122-135, 2009.

Koivuniemi A, Heikelä M, Kovanen PT, Vattulainen I, Hyvönen MT. Atomistic simulations of phosphatidylcholines and cholesteryl esters in high-density lipoprotein-sized lipid droplet and trilayer: clues to cholesteryl ester transport and storage. Biophys J 96:4099-4108, 2009.

Project Wierenga:

Donnini S, Villa A, Groenhof G, Mark AE, Wierenga RK, Juffer AH. Inclusion of ionization states of ligands in affinity calculations. Proteins 76:138-150, 2009.

Chen Z-J, Kastaniotis AJ, Miinalainen IJ, Rajaram V, Wierenga RK, Hiltunen JK. 17beta-hydroxysteroid dehydrogenase type 8 and carbonyl reductase type 4 assemble as a ketoacyl reductase of human mitochondrial FAS . FASEB J 23:3682-3691, 2009.

Koski MK, Hieta R, Hirsilä M, Rönkä A, Myllyharju J, Wierenga RK. The crystal structure of an algal prolyl 4-hydroxylase complexed with a proline-rich peptide reveals a novel buried tripeptide binding motif. J Biol Chem 284:25290-25301, 2009.

Meriläinen G, Poikela V, Kursula P, Wierenga RK. The thiolase reaction mechanism: the importance of Asn316 and His348 for stabilizing the enolate intermediate in the Claisen condensation. Biochemistry 48:11011-11025, 2009.

Pihko P, Rapakko S, Wierenga RK. Oxyanion holes and their mimics. In “Hydrogen Bonding in Organic Synthesis”, Editor: Pihko P, Wiley-VCH Verlag, Weinheim, Germany, pp 43-71, 2009.

Project Winqvist:

Nikkilä J, Coleman KA, Morrissey D, Pylkäs K, Erkko H, Messick TE, Karppinen S-M, Amelina A, Winqvist R, Greenberg RA. Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function. Oncogene 28:1843-1852, 2009.

Kaufman B, Laitman Y, Gronwald J, Winqvist R, Irmejs A, Lubinski J, Pylkäs K, Gardovskis J, Miklasevics E, Friedman E. Haplotypes of the I157T CHEK2 germline mutation in ethnically diverse populations. Fam Cancer 8:473-478, 2009.

Haanpää M, Reiman M, Nikkilä J, Erkko H, Pylkäs K, Winqvist R. Mutation analysis of the AATF gene in breast cancer families. BMC Cancer 9:457-461, 2009.

Last updated: 18.11.2016