Publications 2010

Coordinator Eskelinen:

Eskelinen S. E-cadherin and beta-catenin: Dual roles in carcinogenesis. Acta medico-biotechnica 3:9-14, 2010.

Töyli M, Rosberg-Kulha L, Capra J, Vuoristo J, Eskelinen S. Different responses in transformation of MDCK cells in 2D and 3D culture by v-Src as revealed by microarray techniques, RT-PCR and functional assays. Lab Invest 90:915-928, 2010.

Project Hiltunen:

Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ. Mitochondrial fatty acid synthesis – an adopted set of enzymes making a pathway of major importance for the cellular metabolism. Prog Lipid Res 49:27-45, 2010.

Durrant JD, Amaro RE, Xie L, Urbaniak MD, Ferguson MAJ, Haapalainen A, Chen Z , Di Guilmi AM, Wunder F, Bourne PE, McCammon JA. A multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homology. PLoS Comput Biol 6:e1000648, 2010.

Antonenkov VD, Grunau S, Ohlmeier S, Hiltunen JK. Peroxisomes are oxidative organelles. Antioxid Redox Signal 13:525-537, 2010.

Kashiwayama Y, Tomohiro T, Narita K, Suzumura M, Glumoff T, Hiltunen JK, van Veldhoven PP, Hatanaka Y, Imanaka T. Identification of a substrate-binding site in a peroxisomal beta-oxidation enzyme by photoaffinity labeling with a novel palmitoyl derivative. J Biol Chem 285:26315-26325, 2010.

Ohlmeier S, Hiltunen JK, Bergmann U. Protein phosphorylation in mitochondria – a study on fermentative and respiratory growth of Saccharomyces cerevisiae. Electrophoresis 31:2869-2881, 2010.

Kasaragod P, Venkatesan R, Kiema TR, Hiltunen JK, Wierenga RK. Crystal strucutre of liganded rat peroxisomal multifunctional enzyme type 1: a flexible molecule with two interconnected active sites. J Biol Chem 285:24089-24098, 2010.

Hiltunen JK, Autio KJ, Schonauer MS, Kursu VAS, Dieckmann CL, Kastaniotis AJ. Mitochondrial fatty acid synthesis and respiration. Biochim Biophys Acta 1797:1195-1202, 2010.

Junior Investigator Jaakola:

Piirainen H, Ashok Y, Nanekar RT, Jaakola V-P. Structural features of adenosine receptors: From crystal to function. Biochim Biophys Acta, in press.

Jaakola V-P and Ijzerman AP. The crystallographic structure of the human adenosine A2A receptor in a high-affinity antagonist-bound state: implications for GPCR drug screening and design. Curr Opin Struc Biol 20:401-414, 2010.

Jaakola V-P, Lane JR, Lin JY, Katritch V, Ijzerman AP, Stevens RC. Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residues. J Biol Chem 285:13032-13044, 2010.

Katritch V, Jaakola V-P, Lane JR, Lin J, Ijzerman AP, Yeager M, Kufareva I, Stevens RC, Abagyan R. Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists. J Med Chem 53:1799-1809, 2010.

Biocomputing Coordinator Juffer:

Belinskaya DA, Juffer AH, Shestakova NN. The role of electrostatic interactions in the absorption of ligands to the active sites of cholinesterases, as indicated by molecular modeling data. Russ J Bioorganic Chem 36:185-190, 2010.

Project Kesäniemi:

Biocenter Publications:

Hietaniemi M, Santaniemi M, Malo E, Ukkola O, Kesäniemi YA, Jokela M: Gene expression profiles in fetal and neonatal rat offspring of energy-restricted dams. J Nutrigenet Nutrigenomics 2:173-183, 2009 (Epub 2010 Feb 9).

Sofat R, Hingorani AD, Smeeth L, Humphries SE, Talmud PJ, Cooper J et al. (including Kesäniemi YA). Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms. Circulation 121:52-62, 2010.

Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU et al. (including Kesäniemi YA). New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 42:105-116, 2010.

Liu JZ, Tozzi F, Waterworth DM, Pillai SG, Muglia P, Middleton L et al. (including Kesäniemi A). Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet 42:436-440, 2010.

Pääkkö T, Ukkola O, Ikäheimo M, Kesäniemi YA. Plasma adiponectin levels are associated with left ventricular hypertrophy in a random sample of middle-aged subjects. Ann Med 42:131-137, 2010.

Sämpi M, Veneskoski M, Ukkola O, Kesäniemi YA, Hörkkö S. High plasma immunoglobulin (Ig) A and low IgG antibody titers to oxidized low-density lipoprotein are associated with markers of glucose metabolism. J Clin Endocr Metab 95:2467-2475, 2010.

Holme I, Boman K, Brudi P, Egstrup K, Goehlke-Baerwolf C, Kesäniemi YA et al. Observed and predicted reduction of ischemic cardiovascular events in the Simvastatin and Ezetimibe in Aortic Stenosis Trial. Am J Cardiol 105:1802-1808, 2010.

Kastarinen H, Vasunta RL, Ukkola O, Kesäniemi YA. Glomerular filtration rate is related to dipping pattern in ambulatory blood pressure monitoring - a cross-sectional population-based study. J Hum Hypertens 24:247-253, 2010.

Vasunta RL, Kesäniemi YA, Ukkola O. Plasma adiponectin concentration is associated with ambulatory daytime systolic blood pressure but not with the dipping status. J Hum Hypertens 24:545-551, 2010.

Vartiainen J, Rajala U, Jokelainen J, Keinänen-Kiukaanniemi S, Kesäniemi YA, Ukkola O. Serum ghrelin and the prediction of the development of impaired glucose regulation and Type 2 diabetes in middle-aged subjects. J Endocrinol Invest 33:496-500, 2010.

Kesäniemi YA, Riddoch CJ, Reeder B, Blair SN, Sørensen TIA; a Consensus Panel for the Canadian Society for Exercise Physiology; Canadian Physical Activity Guidelines Consensus Statement: Advancing the future of physical activity guidelines in Canada: an independent expert panel interpretation of the evidence. Int J Behav Nutr Phys Act 7:41, 2010.

Waterworth DM, Ricketts SL, Song K, Chen L, Zhao JH, Ripatti S et al. (including Kesäniemi YA). Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscl Throm Vas 30:2264-2276, 2010.

Saukko M, Kesäniemi YA, Ukkola O. Leptin receptor Lys109Arg and Gln223Arg polymorphisms are associated with early atherosclerosis. Metab Syndr Relat Disord 8:425-430, 2010.

Gerdts E, Rossebø AB, Pedersen TR, Boman K, Brudi P, Chambers JB et al. (including Kesäniemi YA). Impact of baseline severity of aortic valve stenosis on effect of intensive lipid lowering therapy (from the SEAS Study). Am J Cardiol 106:1634-1639, 2010.

Pulkkinen L, Ukkola O, Kolehmainen M, Uusitupa M. Ghrelin in diabetes and metabolic syndrome. Int J Pept Vol 2010, Article ID 248948, 11 pages, 2010.

Other Publications from the Biocenter Project:

Burgess DC, Hunt D, Li L, Zannino D, Williamson E, Davis TM, Laakso M, Kesäniemi YA et al. Incidence and predictors of silent myocardial infarction in type 2 diabetes and the effect of fenofibrate: an analysis from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. Eur Heart J 31:92-99, 2010.

Project Manninen:

Other Publications from the Biocenter Project:

de Oliveira JT, de Matos AJ, Gomes J, Vilanova M, Hespanhol V, Manninen A, Rutteman G, Chammas R, F Gärtner, Soares Bernardes E. Coordinated expression of galectin-3 and galectin-3-binding sites in malignant mammary tumors: implications for tumor metastasis. Glycobiology 20:1341-1352, 2010.

Project Myllyharju:

Myllyharju J and Schipani E. Extracellular matrix genes as hypoxia-inducible targets. Cell Tissue Res 339:19-29, 2010. (Invited review).

Osmekhina E, Neubauer A, Klinzing K, Myllyharju J, Neubauer P. Sandwich ELISA for quantitative detection of human collagen prolyl 4-hydroxylase. Microb Cell Fact 9:48-58, 2010.

Vlad F, Tiainen P, Owen C, Spano T, Daher FB, Oualid F, Senol NO, Vlad D, Myllyharju J, Kalaitzis P. Characterization of two carnation petal prolyl 4 hydroxylases. Physiol Plant 140:199-207, 2010.

Hyvärinen J, Hassinen IE, Sormunen R, Mäki JM, Kivirikko KI, Koivunen P*, Myllyharju J*. Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury. *Equal contribution. J Biol Chem 285:13646-13657, 2010.

Pasanen A, Heikkilä M, Rautavuoma K, Hirsilä M, Kivirikko KI, Myllyharju J. Hypoxia-inducible factor (HIF)-3alpha is subject to extensive alternative splicing in human tissues and cancer cells and is regulated by HIF-1 but not HIF-2. Int J Biochem Cell Biol 42:1189-1200, 2010.

Hyvärinen J*, Parikka M*, Sormunen R, Rämet M, Tryggvason K, Kivirikko KI, Myllyharju J, Koivunen P. Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney function. *Equal contribution. J Biol Chem 285:42023-42032, 2010.

Project Männikkö:

Biocenter Publications:

Reimann F, Cox JJ, Belfer I, Diatchenko L, Zaykin DV, McHale DP et al. (including Karppinen J, Männikkö M, Kelempisioti A). Pain perception is altered by a nucleotide polymorphism in SCN9A. Proc Natl Acad Sci USA 107:5148-5153, 2010.

Roulet M, Välkkilä M, Chanut-Delalande H, Hämäläinen E-R, Kessler E, Ala-Kokko L, Männikkö M, Bonod-Bidaud C, Ruggiero F. The collagen V homotrimer [alpha1(V)]3 production is unexpectedly favored over the heterotrimer [alpha1(V)]2alpha2(V) in recombinant expression systems. J Biomed Biotechnol 2010:376927, 2010.

Eskola PJ, Kjaer P, Daavittila I, Solovieva S, Okuloff A, Sorensen JS, Wedderkopp N, Ala-Kokko L, Männikkö M, Karppinen J. Genetic risk factors of disc degeneration among 12-14-year-old Danish children: a population study. Int J Mol Epidemiol Genet 1:158-165, 2010.

Korvala J, Hartikka H, Pihlajamäki H, Solovieva S, Ruohola J-P, Sahi T, Barral S, Ott J, Ala-Kokko L, Männikkö M. Genetic predisposition to femoral neck stress fractures in military conscripts. BMC Genet 11:95, 2010.

Other Publications from the Biocenter Project:

Costigan M, Belfer I, Griffin RS, Dai F, Barrett LB, Coppola G et al. (including Karppinen J, Männikkö M, Kelempisioti A). Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1. Brain 133:2519-2527, 2010.

Project Pamilo/Savolainen:

Biocenter Publications:

Kulmuni J, Seifert B, Pamilo P. Segregation distortion causes large-scale differences between male and female genomes in hybrid ants. Proc Natl Acad Sci USA 107:7371-7376, 2010.

Kuparinen A, Savolainen O, Schurr F. Increased mortality can promote evolutionary adaptation of forest trees to climate change. For Ecol Manage 259:1003-1008, 2010.

Leinonen P, Remington D, Savolainen O. Local adaptation, phenotypic differentiation, and hybrid fitness in diverged natural populations of Arabidopsis lyrata. Evolution 65:90-107, 2010.

Lundemo S, Stenøien H, Savolainen O. Investigating the effects of topography and clonality on genetic structuring within a large Norwegian population of Arabidopsis lyrata. Ann Botan 106:243-254, 2010.

Seifert B, Kulmuni J, Pamilo P. Independent hybrid populations of Formica polyctena X rufa wood ants (Hymenoptera: Formicidae) abound under conditions of forest fragmentation. Evol Ecol 24:1219-1237, 2010.

Other Publications from the Biocenter Project:

Werren JH et al. (incl. Viljakainen L). Functional and evolutionary insights from the genomes of three parasitoid Nasonia species. Science 327:343-348, 2010.

Alström-Rapaport C, Leskinen E, Pamilo P. Seasonal variation in the mode of reproduction of Ulva intestinalis in a brackish water environment. Aquat Bot 93:244-249, 2010.

Bernasconi C, Pamilo P, Cherix D. Molecular markers allow sibling species identification in red wood ants (Formica rufa group). System Entomol 35:243-249, 2010.

Boomsma JJ and Pamilo P. Retrospective. Ross Crozier (1943-2009). Science 327:45, 2010.

Fleury M, Bernasconi C, Freitag A, Pamilo P, Cherix D. Behavioural species discrimination in red wood ants (Formica rufa group). eco.mont 2:13-20, 2010.

Fogelqvist J, Niittyvuopio A, Ågren J, Savolainen O, Lascoux M. Cryptic population genetic structure: the number of inferred clusters depends on sample size. Mol Ecol Resour 10:314-323, 2010.

Sirviö A and Pamilo P. Multiple endosymbionts in populations of the ant Formica cinerea. BMC Evol Biol 10:335, 2010.

Project Pihlajaniemi:

Bruckner-Tuderman L, von der Mark K, Pihlajaniemi T, Unsicker K. Cell interactions with the extracellular matrix. Cell Tissue Res 339:1-5, 2010.

Hurskainen M, Ruggiero F, Hägg P, Pihlajaniemi T, Huhtala P. Recombinant human collagen XV regulates cell adhesion and migration. J Biol Chem 285:5258-5265, 2010.

Latvanlehto A, Fox MA, Sormunen R, Tu H, Oikarainen T, Koski A, Naumenko N, Shakirzyanova A, Kallio M, Ilves M, Giniatullin R, Sanes JR, Pihlajaniemi T. Muscle-derived collagen XIII regulates maturation of the skeletal neuromuscular junction. J Neurosci 30:12230-12241, 2010.

Rasi K, Hurskainen M, Kallio M, Stavén S, Sormunen R, Heape AM, Avila RL, Kirschner D, Muona A, Tolonen U, Tanila H, Huhtala P, Soininen R, Pihlajaniemi T. Lack of collagen XV impairs peripheral nerve maturation and, when combined with laminin-411 deficiency, leads to basement membrane abnormalities and sensorimotor dysfunction. J Neurosci 30:14490-14501, 2010.

Dennis J, Meehan DT, Delimont D, Zallocchi M, Perry GA, O’Brien S, Tu H, Pihlajaniemi T, Cosgrove D. Collagen XIII induced in vascular endothelium mediates alpha1beta1 integrin-dependent transmigration of monocytes in renal fibrosis. Am J Pathol 177:2527-2540, 2010.

Rasi K, Piuhola J, Czabanka M, Sormunen R, Ilves M, Leskinen H, Rysä J, Kerkelä R, Janmey P, Heljasvaara R, Peuhkurinen K, Vuolteenaho O, Ruskoaho H, Vajkoczy P, Pihlajaniemi T, Eklund L. Collagen XV is necessary for modeling of the extracellular matrix and its deficiency predisposes to cardiomyopathy. Circ Res 107:1241-1252, 2010.

Rasi K, Pihlajaniemi T, Eklund L. Lack of collagen XV predisposes to cardiomyopathy. Tyypin XV kollageenin puutos altistaa kardiomyopatialle. Finnish Medical Society Journal, article in Finnish. Duodecim 126:2628, 2010.

Project Ruskoaho:

Biocenter Publications:

Ala-Kopsala M, Moilanen A-M, Rysä J, Ruskoaho H, Vuolteenaho O. Characterization of molecular forms of n-terminal b-type natriuretic peptide in vitro. Clin Chem 56:1822-1829, 2010.

Breuer T, Skoumal R, Horkay F, Merkely B, Ala-Kopsala M, Leppäluoto J, Vuolteenaho O, Ruskoaho H, Tóth M, Székely A. Strong relationship between NT-proXNP levels and cardiac output following cardiac surgery in neonates and infants. Acta Anaesth Scand 54:502-509, 2010.

Hänninen SL, Ronkainen JJ, Leskinen H, Tavi P. Mitochondrial uncoupling downregulates calsequestrin expression and reduces SR Ca2+ stores in cardiomyocytes. Cardiovasc Res 88:75-82, 2010.

Kerola T, Nieminen T, Hartikainen S, Sulkava R, Vuolteenaho O, Kettunen R. B-type natriuretic peptide as a predictor of declining cognitive function and dementia–a cohort study of an elderly general population with a 5-year follow-up. Ann Med 42:207-215, 2010.

Konyi A, Skoumal R, Kubin A-M, Füredi G, Perjes A, Farkasfalvi K, Sarszegi Z, Horkay F, Horvath IG, Toth M, Ruskoaho H, Szokodi I. Prolacting-releasing peptide regulates cardiac contractility. Regul Pept 159:9-13, 2010.

Korhonen T, Rapila R, Ronkainen V-P, Koivumäki JT, Tavi P. Local Ca2+ releases enable rapid heart rates in developing cardiomyocytes. J Physiol 588:1407-1417, 2010.

Luosujärvi H, Aro J, Tokola H, Leskinen H, Tenhunen O, Skoumal R, Szokodi I, Ruskoaho H, Rysä J. A novel p38 MAPK target dyxin is rapibly induced by mechanical load in the heart. Blood Press 19:54-63, 2010.

Mustonen E, Säkkinen H, Tokola H, Isopoussu E, Aro J, Leskinen H, Ruskoaho H, Rysä J. Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14 during cardiac remodelling in rats. Acta Physiol (Oxf) 199:11-22, 2010.

Mustonen E, Leskinen H, Aro J, Luodonpää M, Vuolteenaho O, Ruskoaho H, Rysä J. Metoprolol treatment lowers thrombospondin-4 expression in rats with myocardial infarction and left ventricular hypertrophy. Basic Clin Pharmacol Toxicol 107:709-717, 2010.

Nagy II, Railo A, Rapila R, Hast T, Sormunen R, Tavi P, Räsänen J, Vainio SJ. Wnt-11 signalling controls ventricular myocardium development by patterning N-cadherin and beta-catenin expression. Cardiovasc Res 85:100-109, 2010.

Ola A, Kerkelä R, Tokola H, Pikkarainen S, Skoumal R, Vuolteenaho O, Ruskoaho H. The mixed-lineage kinase 1-3 signalling pathway regulates stress response in cardiac myocytes via GATA-4 and AP-1 transcription factors. Brit J Pharmacol 159:717-725, 2010.

Rasi K, Piuhola J, Czabanka M, Sormunen R, Ilves M, Leskinen H, Rysä J, Kerkelä R, Janmey P, Heljasvaara R, Peuhkurinen K, Vuolteenaho O, Ruskoaho H, Vajkoczy P, Pihlajaniemi T, Elkund L. Collagen XV is necessary for modeling of the extracellular matrix and its deficiency predisposes to cardiomyopathy. Circ Res 107:1241-1252, 2010.

Rysä J, Tenhunen O, Serpi R, Soini Y, Nemer M, Leskinen H, Ruskoaho H. GATA-4 is an angiogenic survival factor of the infarcted heart. Circ Heart Fail 3:440-450, 2010.

Tavi P, Korhonen T, Hänninen SL, Bruton JD, Lööf S, Simon A, Westerblad H. Myogenic skeletal muscle satellite cells communicate by tunnelling nanotubes. J Cell Physiol 223:376-383, 2010.

Other Publications from the Biocenter Project:

Miettinen JA, Ylitalo K, Hedberg P, Jokelainen J, Kervinen K, Niemelä M, Säily M, Koistinen P, Savolainen E-R, Ukkonen H, Pietilä M, Airaksinen KE, Knuuti J, Vuolteenaho O, Mäkikallio TH, Huikuri HV. Determinants of functional recovery after myocardial infarction of patients treated with bone marrow-derived stem cells after thrombolytic therapy. Heart 96:362-367, 2010.

Zhou J, Lal H, Chen X, Shang X, Song J, Li Y, Kerkelä R, Doble BW, MacAulay K, DeCaul M, Koch WJ, Farber J, Woodgett J, Gao E, Force T. GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice. J Clin Invest 120:2280-2291, 2010.

Voipio H-M, Kasanen IH, Leskinen H, Mäkinen T, Nevalainen T. The effects of intra-cage aspen tube on cardiac morphology and gene expression. Lab Anim 44:184-191, 2010.

Project Savolainen:

Biocenter Publications:

Bouatia-Naji N, Bonnefond A, Baerenwald DA, Marchand M, Bugliani M, Marchetti P et al. (Järvelin MR). Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels. Diabetes 59:2662-2671, 2010.

Chambers JC, Zhang W, Lord GM, van der Harst P, Lawlor DA, Sehmi JS et al. (Pouta A, Ruokonen A, Järvelin MR). Genetic loci influencing kidney function and chronic kidney disease. Nat Genet 42:373-375, 2010.

Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU et al. (Lajunen T, Hartikainen AL, Kaakinen M, Kesäniemi YA, Ruokonen A, Järvelin MR). New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 42:105-116, 2010.

Fararouei M, Robertson C, Whittaker J, Sovio U, Ruokonen A, Pouta A, Hartikainen AL, Järvelin MR, Hyppönen E. Maternal Hb during pregnancy and offspring's educational achievement: a prospective cohort study over 30 years. Brit J Nutr 104:1363-1368, 2010.

Flemström G, Bengtsson MW, Mäkelä K, Herzig KH. Effects of short-term food deprivation on orexin-A-induced intestinal bicarbonate secretion in comparison with related secretagogues. Acta Physiol 198:373-380, 2010.

Freathy RM, Mook-Kanamori DO, Sovio U, Prokopenko I, Timpson NJ, Berry DJ et al. (Kaakinen M, Hartikainen AL, Laitinen J, Pouta A, Taanila A, Järvelin MR). Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nat Genet 42:430-435, 2010.

Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V et al. (Kaakinen M, Hartikainen AL, Laitinen J, Järvelin MR). Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet 42:949-960, 2010.

Herzig KH and Purhonen AK. Physiology and pathophysiology of hypocretins/orexins. Acta Physiol 198:199-200, 2010.

Huotari A, Lehto SM, Niskanen L, Herzig KH, Hintikka J, Koivumaa-Honkanen H, Tolmunen T, Honkalampi K, Kaikkonen N, Viinamäki H. Increased serum PAI-1 levels in subjects with metabolic syndrome and long-term adverse mental symptoms: a population-based study. Cardiovasc Psychiatry Neurol 2010:501349, 2010.

Inouye M, Kettunen J, Soininen P, Silander K, Ripatti S, Kumpula LS, Hämäläinen E, Jousilahti P, Kangas AJ, Männistö S, Savolainen MJ, Jula A, Leiviskä J, Palotie A, Salomaa V, Perola M, Ala-Korpela M, Peltonen L. Metabonomic, transcriptomic, and genomic variation of a population cohort. Mol Syst Biol 6:441, 2010.

Kaakinen M, Läärä E, Pouta A, Hartikainen AL, Laitinen J, Tammelin TH, Herzig KH, Sovio U, Bennett AJ, Peltonen L, McCarthy MI, Elliott P, De Stavola B, Järvelin MR. Life-course analysis of a fat mass and obesity-associated (FTO) gene variant and body mass index in the Northern Finland Birth Cohort 1966 using structural equation modeling. Am J Epidemiol 172:653-665, 2010.

Kangas-Kontio T, Huotari A, Ruotsalainen H, Herzig KH, Tamminen M, Ala-Korpela M, Savolainen MJ, Kakko S. Genetic and environmental determinants of total and high-molecular weight adiponectin in families with low HDL-cholesterol and early onset coronary heart disease. Atherosclerosis 210:479-485, 2010.

Kangas-Kontio T, Kakko S, Tamminen M, von Rohr P, Hoeschele I, Juvonen T, Kere J, Savolainen MJ. Genome scan for loci regulating HDL cholesterol levels in Finnish extended pedigrees with early coronary heart disease. Eur J Hum Genet 18:604-613, 2010.

Karhunen L, Juvonen KR, Flander SM, Liukkonen KH, Lähteenmäki L, Siloaho M, Laaksonen D, Herzig KH, Uusitupa MI, Poutanen K. A psyllium fiber-enriched meal strongly attenuates postprandial gastrointestinal peptide release in healthy young adults. J Nutr 140:737-744, 2010.

Keränen AM, Rasinaho E, Hakko H, Savolainen M, Lindeman S. Eating behavior in obese and overweight persons with and without anhedonia. Appetite 55:726-729, 2010.

Kettunen J, Silander K, Saarela O, Amin N, Müller M, Timpson N et al. (Laitinen J, Hartikainen AL, Pouta A, Järvelin MR). European lactase persistence genotype shows evidence of association with increase in body mass index. Hum Mol Genet 19:1129-1136, 2010.

Kumpula LS, Mäkelä SM, Mäkinen V-P, Karjalainen A, Liinamaa JM, Kaski K, Savolainen MJ, Hannuksela ML, Ala-Korpela M. Characterization of metabolic interrelationships and in silico phenotyping of lipoprotein particles using self-organizing maps. J Lipid Res 51:431-439, 2010.

Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F et al. (Junttila JM, Hartikainen AL, Koiranen M, Laitinen J, Pouta A, Huikuri HV, Järvelin MR). Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467:832-838, 2010.

Lehto SM, Huotari A, Niskanen L, Herzig KH, Tolmunen T, Viinamäki H, Koivumaa-Honkanen H, Honkalampi K, Sinikallio S, Ruotsalainen H, Hintikka J. Serum IL-7 and G-CSF in major depressive disorder. Prog Neuro-Psychoph 34:846-851, 2010.

Lehto SM, Huotari A, Niskanen L, Tolmunen T, Koivumaa-Honkanen H, Honkalampi K, Ruotsalainen H, Herzig KH, Viinamäki H, Hintikka J. Serum adiponectin and resistin levels in major depressive disorder. Acta Psychiatr Scand 121:209-215, 2010.

Lehto SM, Niskanen L, Herzig KH, Tolmunen T, Huotari A, Viinamäki H, Koivumaa-Honkanen H, Honkalampi K, Ruotsalainen H, Hintikka J. Serum chemokine levels in major depressive disorder. Psychoneuroendocrino 35:226-232, 2010.

Mäkelä KA, Wigren HK, Zant JC, Sakurai T, Alhonen L, Kostin A, Porkka-Heiskanen T, Herzig KH. Characterization of sleep-wake patterns in a novel transgenic mouse line overexpressing human prepro-orexin/hypocretin. Acta Physiol 198:237-249, 2010.

Mönkäre J, Hakala RA, Vlasova MA, Huotari A, Kilpeläinen M, Kiviniemi A, Meretoja V, Herzig KH, Korhonen H, Seppälä JV, Järvinen K. Biocompatible photocrosslinked poly(ester anhydride) based on functionalized poly(epsilon-caprolactone) prepolymer shows surface erosion controlled drug release in vitro and in vivo. J Control Release 146:349-355, 2010.

Perry JR, Weedon MN, Langenberg C, Jackson AU, Lyssenko V, Sparsø T et al. (Ruokonen A, Järvelin MR). Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. Hum Mol Genet 19:535-544, 2010.

Pillas D, Hoggart CJ, Evans DM, O'Reilly PF, Sipilä K, Lähdesmäki R, Millwood IY, Kaakinen M et al. (Pouta A, Hartikainen AL, Laitinen J, Järvelin MR). Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. PLoS Genet 6:e1000856, 2010.

Pirkola J, Pouta A, Bloigu A, Hartikainen AL, Laitinen J, Järvelin MR, Vääräsmäki M. Risks of overweight and abdominal obesity at age 16 years associated with prenatal exposures to maternal prepregnancy overweight and gestational diabetes mellitus. Diabetes Care 33:1115-1121, 2010.

Pirkola J, Pouta A, Bloigu A, Miettola S, Hartikainen AL, Järvelin MR, Vääräsmäki M. Prepregnancy overweight and gestational diabetes as determinants of subsequent diabetes and hypertension after 20-year follow-up. J Clin Endocr Metab 95:772-778, 2010.

Pirkola J, Vääräsmäki M, Ala-Korpela M, Bloigu A, Canoy D, Hartikainen A-L, Leinonen M, Miettola S, Paldanius M, Tammelin TH, Järvelin M-R, Pouta A. Low-grade, systemic inflammation in adolescents: Association with early-life factors, gender, and lifestyle. Am J Epidemiol 171:72-82, 2010.

Repapi E, Sayers I, Wain LV, Burton PR, Johnson T, Obeidat M et al. (Hartikainen AL, Pouta A, Järvelin MR). Genome-wide association study identifies five loci associated with lung function. Nat Genet 42:36-44, 2010.

Rodriguez A, Kaakinen M, Moilanen I, Taanila A, McGough JJ, Loo S, Järvelin MR. Mixed-handedness is linked to mental health problems in children and adolescents. Pediatrics 125:e340-e348, 2010.

Scherag A, Dina C, Hinney A, Vatin V, Scherag S, Vogel CI et al. (Järvelin MR, Hartikainen AL). Two new loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and German study groups. PLoS Genet 6:e1000916, 2010.

Sofat R, Hingorani AD, Smeeth L, Humphries SE, Talmud PJ, Cooper J et al. (Kakko S, Kauma H, Savolainen MJ, Kesäniemi YA). Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms. Circulation 121:52-62, 2010.

Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU et al. Research group in Oulu: Järvelin MR, Savolainen MJ, Huikuri H, Kaakinen M, Ruokonen A, Laitinen J. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 42:937-948, 2010.

Thorgeirsson TE, Gudbjartsson DF, Surakka I, Vink JM, Amin N, Geller F et al. (Hartikainen AL, Pouta A, Laitinen J, Isohanni M, Järvelin MR). Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet 42:448-453, 2010.

Vlasova M, Purhonen AK, Järvelin MR, Rodilla E, Pascual J, Herzig KH. Role of adipokines in obesity-associated hypertension. Acta Physiol 200:107-127, 2010.

Walkowiak J, Lisowska A, Blask-Osipa A, Drzymala-Czyz S, Sobkowiak P, Cichy W, Breborowicz A, Herzig KH, Radzikowski A. Acid steatocrit determination is not helpful in cystic fibrosis patients without or with mild steatorrhea. Pediatr Pulm 45:249-254, 2010.

Walters RG, Jacquemont S, Valsesia A, de Smith AJ, Martinet D, Andersson J et al. (Hartikainen AL, Järvelin MR). A new highly penetrant form of obesity due to deletions on chromosome 16p11.2. Nature 463:671-675, 2010.

Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, Berry D et al. (Pouta A, Hartikainen AL, Laitinen J, Järvelin MR). Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 376:180-188, 2010.

Waterworth DM, Ricketts SL, Song K, Chen L, Zhao JH, Ripatti S et al. (Kesäniemi YA, Järvelin MR, Ruokonen A). Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscl Throm Vas 30:2264-2276, 2010.

Transgenic Facility Coordinator Soininen:

Biocenter Publications:

Lu N, Carracedo S, Ranta J, Heuchel R, Soininen R, Gullberg D. The human alpha11 integrin promoter drives fibroblast-restricted expression in vivo and is regulated by TGF-beta1 in a Smad- and Sp1-dependent manner. Matrix Biol 29:166-176, 2010.

Rasi K, Hurskainen M, Kallio M, Stavén S, Sormunen R, Heape AM, Avila RL, Kirschner D, Muona A, Tolonen U, Tanila H, Huhtala P, Soininen R, Pihlajaniemi T. Lack of collagen XV impairs peripheral nerve maturation and, when combined with laminin-411 deficiency, leads to basement membrane abnormalities and sensorimotor dysfunction. J Neurosci 30:14490-14501, 2010.

Other Publications from the Biocenter Project:

Gawlik KI, Åkerlund M, Carmignac V, Elamaa H, Durbeej M. Distinct roles for laminin globular domains in laminin alpha1 chain mediated rescue of murine laminin alpha2 chain deficiency. PLos One 5:e11549, 2010.

Kallankari H, Kaukola T, Ojaniemi M, Herva R, Perhomaa M, Vuolteenaho R, Kingsmore SF, Hallman M. Chemokine CCL18 predicts intraventricular hemorrhage in very preterm infants. Ann Med 42:416-425, 2010.

EM Microscopy Coordinator Sormunen:

Nagy II, Railo A, Rapila R, Hast T, Sormunen R, Tavi P, Räsänen J, Vainio SJ. Wnt-11 signalling controls ventricular myocardium development by patterning N-cadherin and beta-catenin expression. Cardiovasc Res 85:100-109, 2010.

Hyvärinen J, Hassinen IE, Sormunen R, Mäki JM, Kivirikko KI, Koivunen P, Myllyharju J. Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury. J Biol Chem 285:13646-13657, 2010.

Kaarteenaho R, Sormunen R, Pääkkö P. Variable expression of tenascin-C, osteopontin and fibronectin in inflammatory myofibroblastic tumour of the lung. APMIS 118:91-100, 2010.

Hyvärinen J, Parikka M, Sormunen R, Rämet M, Tryggvason K, Kivirikko KI, Myllyharju J, Koivunen P. Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney function. J Biol Chem 285:42023-42032, 2010.

Naillat F, Prunskaite-Hyyryläinen R, Pietilä I, Sormunen R, Jokela T, Shan J, Vainio SJ. Wnt4/5a signalling coordinates cell adhesion and entry into meiosis during presumptive ovarian follicle development. Hum Mol Genet 19:1539-1550, 2010.

Latvanlehto A, Fox MA, Sormunen R, Tu H, Oikarainen T, Koski A et al. (Kallio M, Ilves M and Pihlajaniemi T). Muscle-derived collagen XIII regulates maturation of the skeletal neuromuscular junction. J Neurosci 30:12230-12241, 2010.

Rasi K, Hurskainen M, Kallio M, Stavén S, Sormunen R, Heape AM, Avila RL, Kirschner D, Muona A, Tolonen U, Tanila H, Huhtala P, Soininen R, Pihlajaniemi T. Lack of collagen XV impairs peripheral nerve maturation and, when combined with laminin-411 deficiency, leads to basement membrane abnormalities and sensorimotor dysfunction. J Neurosci 30:14490-14501, 2010.

Rasi K, Piuhola J, Czabanka M, Sormunen R, Ilves M, Leskinen H, Rysä J, Kerkelä R, Janmey P, Heljasvaara R, Peuhkurinen K, Vuolteenaho O, Ruskoaho H, Vajkoczy P, Pihlajaniemi T, Eklund L. Collagen XV is necessary for modeling of the extracellular matrix and its deficiency predisposes to cardiomyopathy. Circ Res 107:1241-1252, 2010.

Project Vainio:

Naillat F, Prunskaite-Hyyryläinen R, Pietilä I, Sormunen R, Jokela T, Shan J, Vainio SJ. Wnt4/5a signalling coordinates cell adhesion and entry into meiosis during presumptive ovarian follicle development. Hum Mol Genet 19:1539-1550, 2010.

Jääskeläinen M, Prunskaite-Hyyryläinen R, Naillat F, Parviainen H, Anttonen M, Heikinheimo M, Liakka A, Ola R, Vainio S, Vaskivuo TE, Tapanainen JS. WNT4 is expressed in human fetal and adult ovaries and its signaling contributes to ovarian cell survival. Mol Cell Endocrinol 317:106-111, 2010.

Shan J, Jokela T, Skovorodkin I, Vainio S. Mapping of the fate of cell lineages generated from cells that express the Wnt4 gene by time-lapse during kidney development. Differentiation 79:57-64, 2010.

Nagy II, Railo A, Rapila R, Hast T, Sormunen R, Tavi P, Räsänen J, Vainio SJ. Wnt-11 signalling controls ventricular myocardium development by patterning N-cadherin and beta-catenin expression. Cardiovasc Res 85:100-109, 2010.

Project Weckström/Vähäsöyrinki:

Biocenter Publications:

Aikio M, Takalo J, Lempeä M, Vähäsöyrinki M. Hemispherical projection lens for insect behavior analysis. Proc SPIE Vol. 7717:771711, 2010.

Stenlund L, Riski K, Seppä J, Pudas M, Vähäsöyrinki M, Tuhkanen V, Röning J. Traceable characterization of a bending millimetre scale cantilever for nanoforce sensing. Meas Sci Technol 21:075102:1-9, 2010.

Weckström M and Laughlin S. Extracellular potentials modify the transfer of information at photoreceptor output synapses in the blowfly compound eye. J Neurosci 30:9557-9566, 2010.

Other Publications from the Biocenter Project:

Cilpa G, Hyvönen MT, Koivuniemi A, Riekkola M-L. Atomistic insight into chondroitin-6-sulfate glycosaminoglycan chain through quantum mechanics calculations and molecular dynamics simulation. J Comput Chem 31:1670-1680, 2010.

Frolov RV, Ignatova II, Singh S. Mechanism of K(v)2.1 channel inhibition by a selective COX-2 inhibitor SC-791―modification of gating. Brain Res 1359:67-74, 2010.

Frolov RV, Bondarenko VE, Singh S. Mechanisms of Kv2.1 channel inhibition by celecoxib – modification of gating and channel block. Brit J Pharmacol 159:405-418, 2010.

Lähdesmäki K, Ollila OHS, Koivuniemi A, Kovanen PT, Hyvönen MT. Membrane simulations mimicking acidic pH reveal increased thickness and negative curvature in a bilayer consisting of lysophosphatidylcholines and free fatty acids. Biochim Biophys Acta 1798:938-946, 2010.

Vuorela T, Catte A, Niemelä PS, Hall A, Hyvönen MT, Marrink S-J, Karttunen M, Vattulainen I. Role of lipids in spheroidal high density lipoproteins. PLoS Comput Biol 6:e1000964, 2010.

Yetukuri L, Söderlund S, Koivuniemi A, Seppänen-Laakso T, Niemelä PS, Hyvönen M, Taskinen M-R, Vattulainen I, Jauhiainen M, Oresic M. Composition and lipid spatial distribution of HDL particles in subjects with low and high HDL-cholesterol. J Lipid Res 51:2341-2351, 2010.

Caruana CJ, Wasilewska-Radwanska M, Aurengo A, Dendy PP, Karenauskaite V, Malisan MR, Meijer JH, Mihov D, Mornstein V, Rokita E, Vano E, Weckström M, Wucherer M. A comprehensive SWOT audit of the role of the biomedical physicist in the education of healthcare professionals in Europe. Phys Medica 26:98-110, 2010.

Weckström M. Intracellular recording. Scholarpedia 5:2224, 2010.

Project Wierenga:

Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ. Mitochondrial fatty acid synthesis – An adopted set of enzymes making a pathway of major importance for the cellular metabolism. Prog Lipid Res 49:27-45, 2010.

Alahuhta M and Wierenga RK. Atomic resolution crystallography of a complex of triosephosphate isomerase with a reaction-intermediate analog: New insight in the proton transfer reaction mechanism. Proteins 78:1878-1888, 2010.

Salin M, Kapetaniou EG, Vaismaa M, Lajunen M, Casteleijn MG, Neubauer P, Salmon L, Wierenga RK. Crystallographic binding studies with an engineered monomeric variant of triosephosphate isomerase. Acta Crystallogr D 66:934-944, 2010.

Kasaragod P, Venkatesan R, Kiema TR, Hiltunen JK, Wierenga RK. Crystal structure of liganded rat peroxisomal multifunctional enzyme type I: A flexible molecule with two interconnected active sites. J Biol Chem 285:24089-24098, 2010.

Wierenga RK, Kapetaniou EG, Venkatesan R. Triosephosphate isomerase: a highly evolved biocatalyst. Cell Mol Life Sci 67:3961-3982, 2010.

Project Winqvist:

Biocenter Publications:

Rantakari P, Nikkilä J, Jokela H, Ola R, Pylkäs K, Lagerbohm H, Sainio K, Poutanen M, Winqvist R. Inactivation of Palb2 gene leads to mesoderm differentiation defect and early embryonic lethality in mice. Hum Mol Genet 19:3021-3029, 2010.

Solyom S, Patterson-Fortin J, Pylkäs K, Greenberg RA, Winqvist R. Mutation screening of the MERIT40 gene encoding a novel BRCA1 and RAP80 interacting protein in breast cancer families. Breast Cancer Res Tr 120:165-168, 2010.

Rio Frio T, Haanpää M, Pouchet C, Pylkäs K, Vuorela M, Tischkowitz M, Winqvist R, Foulkes WD (shared first and senior authorship). Mutation analysis of the gene encoding the PALB2-binding protein MRG15 in BRCA1/2-negative breast cancer families. J Hum Genet 55:842-843, 2010.

Karihtala P, Winqvist R, Bloigu R, Jukkola-Vuorinen A. Long-term observational follow-up study of breast cancer diagnosed in women ≤ 40 years old. Breast 19:456-461, 2010.

Solyom S, Pylkäs K, Winqvist R. Screening for large genomic rearrangements of the BRIP1 and CHK1 genes in Finnish breast cancer families. Fam Cancer 9:537-540, 2010.

Antoniou AC, Wang X, Fredericksen ZS, McGuffog L, Tarrell R, Sinilnikova OM, (incl. Winqvist R, Pylkäs K), Couch FJ. A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. Nat Genet 42:885-892, 2010.

Arason A, Gunnarsson H, Johannesdottir G, Jonasson K, Bendahl P-O, Gillanders EM, Agnarsson BA, Jönsson G, Pylkäs K, Mustonen A, Heikkinen T, Aittomäki K, Blomqvist C, Melin B, Johannsson OT, Møller P, Winqvist R, Nevanlinna H, Borg A, Barkardottir RB. Genome-wide search for breast cancer linkage in large Icelandic non-BRCA1/2 families. Breast Cancer Res 12:R50, 2010.

Last updated: 18.11.2016