Publications 2011

Coordinator Eskelinen:

Ulvila J, Vanha-aho L-M, Kleino A, Vähä-Mäkilä M, Vuoksio M, Eskelinen S, Hultmark D, Kocks C, Hallman M, Parikka M, Rämet M. Cofilin regulator 14-3-3zeta is an evolutionarily conserved protein required for phagocytosis and microbial resistance. J Leucocyte Biol 89:649-659, 2011.

Project Hiltunen:

Haataja TJK, Koski MK, Hiltunen JK, Glumoff T. Peroxisomal multifunctional enzyme type 2 from fruitfly: dehydrogenase and hydratase act as separate entities, as revealed by structure and kinetics. Biochem J 435:771-781, 2011.

Junior Investigator Jaakola:

Lane JR, Jaakola V-P, Ijzerman AP. The structure of the adenosine receptors: Implications for drug discovery. Adv Pharmacol 61:1-40, 2011.

Piirainen H, Ashok Y, Nanekar RT, Jaakola V-P. Structural features of adenosine receptors: From crystal to function. Biochim Biophys Acta 1808:1233-1244, 2011.

Biocomputing Coordinator Juffer:

Heikkinen J, Risteli M, Lampela O, Alavesa P, Karppinen M, Juffer AH, Myllylä R. Dimerization of human lysyl hydroxylase 3 (LH3) is mediated by the amino acids 541-547. Matrix Biol 30:27-33, 2011.

Ohnuma T, Numata T, Osawa T, Mizuhara M, Lampela O, Juffer AH, Skriver K, Fukamizo T. A class V chitinase from Arabidopsis thaliana: gene responses, enzymatic properties, and crystallographic analysis. Planta 234:123-137, 2011.

Szeker K, Niemitalo O, Casteleijn MG, Juffer AH, Neubauer P. High-temperature cultivation and 5‘ mRNA optimization are key factors for the efficient overexpression of thermostable Deinococcus geothermalis purine nucleoside phosphorylase in Escherichia coli. J Biotechnol 156:268-274, 2011.

Project Kesäniemi/Ukkola:

Malo E, Ukkola O, Jokela M, Moilanen L, Kähönen M, Nieminen MS, Salomaa V, Jula A, Kesäniemi YA. Resistin is an indicator of the metabolic syndrome according to five different definitions in the Finnish Health 2000 survey. Metab Syndr Relat Disord 9:203-210, 2011.

Pisto P, Ukkola O, Santaniemi M, Kesäniemi YA. Plasma adiponectin - an independent indicator of liver fat accumulation. Metabolism 60:1515-1520, 2011.

Davis TM, Ting R, Best JD, Donoghoe MW, Drury PL, Sullivan DR et al. (including Kesäniemi YA). Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study. Diabetologia 54:280-290, 2011.

Jander N, Minners J, Holme I, Gerdts E, Boman K, Brudi P et al. (including Kesäniemi YA). Outcome of patients with low-gradient "severe" aortic stenosis and preserved ejection fraction. Circulation 123:887-895, 2011.

Luotola K, Pietilä A, Zeller T, Moilanen L, Kähönen M, Nieminen MS, Kesäniemi YA, Blankenberg S, Jula A, Perola M, Salomaa V for the Health 2000 and FINRISK97 studies. Associations between interleukin-1 (IL-1) gene variations or IL-1 receptor antagonist levels and the development of type 2 diabetes. J Intern Med 269:322-328, 2011.

Jylhävä J, Haarala A, Kähönen M, Lehtimäki T, Jula A, Moilanen L, Kesäniemi YA, Nieminen MS, Hurme M. Pentraxin 3 (PTX3) is associated with cardiovascular risk factors: the Health 2000 Survey. Clin Exp Immunol 164:211-217, 2011.

Arking DE, Junttila MJ, Goyette P, Huertas-Vazquez A, Eijgelsheim M, Blom MT et al. (including Kesäniemi YA). Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals. PLoS Genet 7:e1002158, 2011.

Kontunen P, Vuolteenaho K, Nieminen R, Lehtimäki L, Kautiainen H, Kesäniemi YA, Ukkola O, Kauppi M, Hakala M, Moilanen E. Resistin is linked to inflammation, and leptin to metabolic syndrome, in women with inflammatory arthritis. Scand J Rheumatol 40:256-262, 2011.

Lehto H-R, Lehto S, Havulinna AS, Ketonen M, Lehtonen A, Kesäniemi YA, Airaksinen KJ, Salomaa V. Sex differences in short- and long-term case-fatality of myocardial infarction. Eur J Epidemiol 26:851-861, 2011.

Ukkola OH, Puurunen V-P, Piira O-P, Niva JT, Lepojärvi ES, Tulppo MP, Huikuri HV. High serum fasting peptide YY (3-36) is associated with obesity-associated insulin resistance and type 2 diabetes. Regul Peptides 170:38-42, 2011.

Ukkola O. Ghrelin in type 2 diabetes mellitus and metabolic syndrome. Mol Cell Endocrinol 340:26-28, 2011.

Ukkola O. Genetic variants of ghrelin in metabolic disorders. Peptides 32:2319-2322, 2011.

Project Manninen:

Myllymäki SM, Teräväinen TP, Manninen A. Two distinct integrin-mediated mechanisms contribute to apical lumen formation in epithelial cells. PLoS One 6:e19453, 2011.

Moilanen A-M, Rysä J, Mustonen E, Serpi R, Aro J, Tokola H, Leskinen H, Manninen A, Levijoki J, Vuolteenaho O, Ruskoaho H. Intramyocardial BNP gene delivery improves cardiac function through distinct context-dependent mechanisms. Circ Heart Fail 4:483-495, 2011.

de Oliveira JT, de Matos AJ, Santos AL, Pinto R, Gomes J, Hespanhol V, Chammas R, Manninen A, Bernardes ES, Reis CA, Rutteman G, Gärtner F. Sialylation regulates galectin-3/ligand interplay during mammary tumour progression - a case of targeted uncloaking. Int J Dev Biol 55:823-834, 2011.

Project Myllyharju:

Xu H, Raynal N, Stathopoulos S, Myllyharju J, Farndale RW, Leitinger B. Collagen binding specificity of the discoidin domain receptors: Binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1. Matrix Biol 30:16-26, 2011.

Sato S, Trackman PC, Mäki JM, Myllyharju J, Kirsch KH, Sonenshein GE. The Ras signaling inhibitor LOX-PP interacts with Hsp70 and c-Raf to reduce Erk activation and transformed phenotype of breast cancer cells. Mol Cell Biol 31:2683-2695, 2011.

Lucero HA, Mäki JM, Kagan HM. Activation of cellular chemotactic responses to chemokines coupled with oxidation of plasma membrane proteins by lysyl oxidase. J Neural Transm 118:1091-1099, 2011.

Luo X, Liu Y, Kubicek S, Myllyharju J, Tumber A, Ng S, Che KH, Podoll J, Heightman TD, Oppermann U, Schreiber SL, Wang X. A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases. J Am Chem Soc 133:9451-9456, 2011.

Mordechai S*, Gradstein L*, Pasanen A, Ofir R, El Amour K, Levy J, Belfair N, Lifshitz T, Joshua S, Narkis G, Elbedour K, Myllyharju J, Birk OS. High myopia caused by a mutation in LEPREL1, encoding prolyl 3-hydroxylase 2. Am J Hum Genet 89:438-445, 2011. *Equal contribution.

Heikkilä M, Pasanen A, Kivirikko KI, Myllyharju J. Roles of the human hypoxia-inducible factor (HIF)-3alpha variants in the hypoxia response. Cell Mol Life Sci 68:3885-3901, 2011.

Project Männikkö:

Näkki A, Videman T, Kujala UM, Suhonen M, Männikkö M, Peltonen L, Battié MC, Kaprio J, Saarela J. Candidate gene association study of magnetic resonance imaging-based hip osteoarthritis (OA): evidence for COL9A2 gene as a common predisposing factor for hip OA and lumbar disc degeneration. J Rheumatol 38:747-752, 2011.

Hietikko E, Kotimäki J, Kentala E, Klockars T, Sorri M, Männikkö M. Finnish familial Meniere disease is not linked to chromosome 12p12.3, and anticipation and cosegregation with migraine are not common findings. Genet Med 13:415-420, 2011.

Kelempisioti A, Eskola P, Okuloff A, Karjalainen U, Takatalo J, Daavittila I, Niinimäki J, Sequeiros RB, Tervonen O, Solovieva S, Kao PY, Song YQ, Cheung KM, Chan D, Ala-Kokko L, Järvelin MR, Karppinen J, Männikkö M. Genetic susceptibility of intervertebral disc degeneration among young Finnish adults. BMC Med Genet 12:153, 2011.

Project Pamilo/Savolainen:

Biocenter Publications:

Abbot P, Abe J, Alcock J, Alizon S, Alpedrinha JAC, Andersson M, (Pamilo P) et al. Inclusive fitness theory and eusociality. Nature 471:E1-E4, 2011.

Bernasconi C, Cherix D, Seifert B, Pamilo P. Molecular taxonomy of the Formica rufa group (red wood ants) (Hymenoptera: Formicidae): a new cryptic species in the Swiss Alps? Myrmecological News 14:37-47, 2011.

Leinonen P, Remington DL, Savolainen O. Local adaptation, phenotypic differentiation, and hybrid fitness in diverged natural populations of Arabdiopsis lyrata. Evolution 65:90-107, 2011.

Leppälä J and Savolainen O. Nuclear-cytoplasmic interactions reduce male fertility in hybrids of Arabidopsis lyrata subspecies. Evolution 65:2959-2972, 2011.

Pyhäjärvi T, Kujala S, Savolainen O. Revisiting protein heterozygosity in plants - nucleotide diversity in allozyme coding genes of conifer Pinus sylvestris. Tree Genetics & Genomes 7:385-397, 2011.

Savolainen O and Kuittinen H. Arabidopsis lyrata genetics. In: Genetics and genomics of the Brassicacea. R. Schmidt and I. Bancroft (eds). Plant Genetics and genomics: Crops and Models 9. Springer Verlag. 347-372, 2011.

Savolainen O, Kujala S, Sokol C, Pyhäjärvi T, Avia K, Knürr T, Kärkkäinen K, Hicks S. Adaptive potential of northernmost tree populations to climate change, with emphasis on Scots pine (Pinus sylvestris L.). J Hered 102:526-536, 2011.

Other Publications from the Biocenter Project:

Kremer A, Vinceti B, Alia R, Burczyk J, Cavers S, Degen B, (Savolainen O) et al. Forest ecosystem genomics and adaptation: EVOLTREE conference report. Tree Genetics & Genomes 7:869-875, 2011.

Pamilo P. Contributions by Ross Crozier on genetics and phylogeny of ants and other organisms. Obituary. Myrmecological News 15:V-XXI, 2011.

Savolainen O. Evolution. The genomic basis of local climatic adaptation. Science 334:49-50, 2011.

Sirviö A, Johnston JS, Wenseleers T, Pamilo P. A high recombination rate in eusocial Hymenoptera: evidence from the common wasp Vespula vulgaris. BMC Genet 12:95, 2011.

Sirviö A, Pamilo P, Johnson RA, Page RE, Gadau J. Origin and evolution of the dependent lineages in the genetic caste determination system of Pogonomyrmex ants. Evolution 65:869-884, 2011.

Smith CD, Zimin A, Holt C, Abouheif E, Benton R, Cash E, (Viljakainen L) et al. Draft genome of the globally widespread and invasive Argentine ant (Linepithema humile). Proc Natl Acad Sci USA 108:5673-5678, 2011.

Smith CR, Smith CD, Robertson HM, Helmkampf M, Zimin A, Yandell M, (Viljakainen L) et al. Draft genome of the red harvester ant, Pogonomyrmex barbatus. Proc Natl Acad Sci USA 108:5667-5672, 2011.

Suen G, Teiling C, Li L, Holt C, Abouheif E, Bornberg-Bauer E, (Viljakainen L) et al. The genome sequence of the leaf-cutter ant Atta cephalotes reveals insights into its obligate symbiotic lifestyle. PLoS Genet 7:e1002007, 2011.

Tay WT, Seppä P, Pamilo P. Colony kin structure, reproductive dominance and colony founding strategies in the ant Rhytidoponera sp. 12. Myrmecological News 15:65-76, 2011.

Wurm Y, Wang J, Riba-Grognuz O, Corona M, Nygaard S, Hunt BG, (Pamilo P) et al. The genome of the fire ant Solenopsis invicta. Proc Natl Acad Sci USA 108:5679-5684, 2011.

Project Pihlajaniemi:

Kinnunen AI, Sormunen R, Elamaa H, Seppinen L, Miller RT, Ninomiya Y, Janmey PA, Pihlajaniemi T. Lack of collagen XVIII long isoforms affects kidney podocytes, whereas the short form is needed in the proximal tubular basement membrane. J Biol Chem 286:7755-7764, 2011.

Farshchian M, Kivisaari A, Ala-aho R, Riihilä P, Kallajoki M, Grénman R, Peltonen J, Pihlajaniemi T, Heljasvaara R, Kähäri V-M. Serpin peptidase inhibitor clade A member 1 (SerpinA1) is a novel biomarker for progression of cutaneous squamous cell carcinoma. Am J Pathol 179:1110-1119, 2011.

Seppinen L and Pihlajaniemi T. The multiple functions of collagen XVIII in development and disease. Matrix Biol 30:83-92, 2011.

VEGF and angiopoietin signaling in tumor angiogenesis and metastasis. Saharinen P, Eklund L, Pulkki K, Bono P, Alitalo K. Trends Mol Med 17:347-362, 2011.

Heljasvaara R and Pihlajaniemi T. Experimental tumour models in mice. In: Mouse as a model organism – from animals to cells. Ed. Brakebusch C and Pihlajaniemi T. Springer-Verlag, 2011.

Brakebush C and Pihlajaniemi T. Mouse as a model organism – from animals to cells. Ed. Brakebusch C and Pihlajaniemi T. Springer-Verlag, 2011.

Project Ruskoaho:

Biocenter Publications:

Kerkelä R, Ilves M, Pikkarainen S, Tokola H, Ronkainen V-P, Majalahti T, Leppäluoto J, Vuolteenaho O, Ruskoaho H. Key roles of endothelin-1 and p38 MAPK in the regulation of atrial stretch response. Am J Physiol Regul Integr Comp Physiol 300:R140-R149, 2011.

Kerola T, Hiltunen M, Kettunen R, Hartikainen S, Sulkava R, Vuolteenaho O, Nieminen T. Mini-Mental State Examination score and B-type natriuretic peptide as predictors of cardiovascular and total mortality in an elderly general population. Ann Med 43:650-659, 2011.

Koivisto E, Karkkola L, Majalahti T, Aro J, Tokola H, Kerkelä R, Ruskoaho H. M-CAT element mediates mechanical stretch-activated transcription of B-type natriuretic peptide via ERK activation. Can J Physiol Pharm 89:539-550, 2011.

Koivisto E, Kaikkonen L, Tokola H, Pikkarainen S, Aro J, Pennanen H, Karvonen T, Rysä J, Kerkelä R, Ruskoaho H. Distinct regulation of B-type natriuretic peptide transcription by p38 MAPK isoforms. Mol Cell Endocrinol 338:18-27, 2011.

Kubin AM, Skoumal R, Tavi P, Kónyi A, Perjés A, Leskinen H, Ruskoaho H, Szokodi I. Role of reactive oxygen species in the regulation of cardiac contractility. J Mol Cell Cardiol 50:884-893, 2011.

Moilanen AM, Rysä J, Mustonen E, Serpi R, Aro J, Tokola H, Leskinen H, Manninen A, Levijoki J, Vuolteenaho O, Ruskoaho H. Intramyocardial BNP gene delivery improves cardiac function through distinct context-dependent mechanisms. Circ Heart Fail 4:483-495, 2011.

Peltonen T, Näpänkangas J, Ohtonen P, Aro J, Peltonen J, Soini Y, Juvonen T, Satta J, Ruskoaho H, Taskinen P. (Pro)renin receptors and angiotensin converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in human aortic valve stenosis. Atherosclerosis 216:35-43, 2011.

Peltonen T, Ohtonen P, Näpänkangas J, Ohukainen P, Ruskoaho H, Taskinen P. Statin treatment and gene expression of anti-atherogenic factor C-type natriuretic peptide system in stenotic aortic valves. J Heart Valve Dis 20:545-551, 2011.

Ronkainen JJ, Hänninen SL, Korhonen T, Koivumäki JT, Skoumal R, Rautio S, Ronkainen V-P, Tavi P. Ca2+-calmodulin-dependent protein kinase II represses cardiac transcription of the L-type calcium channel alpha(1C)-subunit gene (Cacna1c) by DREAM translocation. J Physiol 589:2669-2686, 2011.

Ronkainen V-P, Skoumal R, Tavi P. Hypoxia and HIF-1 suppress SERCA2a expression in embryonic cardiac myocytes through two interdependent hypoxia response elements. J Mol Cell Cardiol 50:1008-1016, 2011.

Serpi R, Tolonen AM, Huusko J, Rysä J, Tenhunen O, Ylä-Herttuala S, Ruskoaho H. Vascular endothelial growth factor-B gene transfer prevents angiotensin II-induced diastolic dysfunction via proliferation and capillary dilatation in rats. Cardiovasc Res 89:204-213, 2011.

Uusimaa P, Peuhkurinen S, Ylitalo A, Vuolteenaho O, Risteli J, Peuhkurinen K on behalf of the Anglo-Scandinavian Cardiac Outcomes Trial Investigators. Natriuretic peptides and collagen biomarkers in patients with medical treatment for hypertension. Acta Cardiol 66:21-27, 2011.

Other Publications from the Biocenter Project:

Kerkelä R, Boucher M, Zaka R, Gao E, Harris D, Piuhola J, Song J, Serpi R, Woulfe KC, Cheung JY, O'Leary E, Bonventre JV, Force T. Cytosolic phospholipase A(2)alpha protects against ischemia/reperfusion injury in the heart. Clin Transl Sci 4:236-242, 2011.

Koivumäki JT, Korhonen T, Tavi P. Impact of sarcoplasmic reticulum calcium release on calcium dynamics and action potential morphology in human atrial myocytes: a computational study. PLoS Comput Biol 7:e1001067, 2011.

Laatio L, Myllynen P, Serpi R, Rysä J, Ilves M, Lappi-Blanco E, Ruskoaho H, Vähäkangas K, Puistola U. BMP-4 expression has prognostic significance in advanced serous ovarian carcinoma and is affected by cisplatin in OVCAR-3 cells. Tumor Biol 32:985-995, 2011.

Miettinen JA, Ylitalo K, Hedberg P, Kervinen K, Niemelä M, Säily M, Koistinen P, Savolainen E-R, Ukkonen H, Pietilä M, Airaksinen KE, Knuuti J, Vuolteenaho O, Mäkikallio TH, Huikuri HV. Effects of intracoronary injection of autologous bone  marrow-derived stem cells on natriuretic peptides and inflammatory markers in patients with acute ST-elevation myocardial infarction. Clin Res Cardiol 100:317-325, 2011.

Partanen N, Husso M, Vuolteenaho O, Sipola P, Ruskoaho H, Peuhkurinen K, Magga J. N-terminal pro-atrial natriuretic peptide reflects cardiac remodelling in stage 1 hypertension. J Hum Hypertens 25:746-751, 2011.

Skoumal R, Tóth M, Serpi R, Rysä J, Leskinen H, Ulvila J, Saiho T, Aro J, Ruskoaho H, Szokodi I, Kerkelä R. Parthenolide inhibits STAT3 signaling and attenuates angiotensin II-induced left ventricular hypertrophy via modulation of fibroblast activity. J Mol Cell Cardiol 50:634-641, 2011.

Tavi P and Westerblad H. The role of in vivo Ca(2+) signals acting on Ca(2+) –calmodulin-dependent proteins for skeletal muscle plasticity. J Physiol 589:5021-5031, 2011.

Project Savolainen:

Biocenter Publications:

Ala-Korpela M, Kangas AJ, Inouye M. Genome-wide association studies and systems biology: Together at last. Trends Genet 27:493-498, 2011.

Ala-Korpela M, Salomaa V, Kvalheim OM. Special Issue Editorial: Clinical and epidemiological metabonomics. J Biomed Biotechnol 2011:843150, 2011.

Artigas MS, Loth DW, Wain LV, Gharib SA, Obeidat M, Tang W et al. (Pouta A, Hartikainen A-L, Järvelin M-R). Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet 43:1082-1090, 2011.

Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, et al (Hartikainen A-L, Pouta A, Ruokonen A, Savolainen MJ, Ala-Korpela M, Järvelin M-R). Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet 43:1131-1138, 2011.

Choquet H, Labrune Y, De Graeve F, Hinney A, Hebebrand J, Scherag A et al. (Järvelin MR). Lack of association of CD36 SNPs with early onset obesity: A meta-analysis in 9,973 European subjects. Obesity 19:833-839, 2011.

Dehghan A, Dupuis J, Barbalic M, Bis JC, Eiriksdottir G, Lu C et al. (Ruokonen A, Pouta A, Järvelin M-R). Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation 123:731-738, 2011.

Desrivières S, Lourdusamy A, Müller C, Ducci F, Wong CP, Kaakinen M et al. (Pouta A, Hartikainen AL, Isohanni M, Järvelin MR). Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents. Addict Biol 16:510-513, 2011.

Ducci F, Kaakinen M, Pouta A, Hartikainen AL, Veijola J, Isohanni M, Charoen P, Coin L, Hoggart C, Ekelund J, Peltonen L, Freimer N, Elliott P, Schumann G, Järvelin MR. TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood. Biol Psychiat 69:650-660, 2011.

Flemström G, Mäkelä K, Purhonen AK, Sjöblom M, Jedstedt G, Walkowiak J, Herzig KH. Apelin stimulation of duodenal bicarbonate secretion: feeding-dependent and mediated via apelin-induced release of enteric cholecystokinin. Acta Physiol (Oxf) 201:141-150, 2011.

Gieger C, Radhakrishnan A, Cvejic A, Tang W, Porcu E, Pistis G et al. (Hartikainen AL, Pouta A, Ruokonen A, Zitting P, Järvelin MR). New gene functions in megakaryopoiesis and platelet formation. Nature 480:201-208, 2011.

Haas BE, Weissglas-Volkov D, Aguilar-Salinas CA, Nikkola E, Vergnes L, Cruz-Bautista I et al. (Ala-Korpela M). Evidence of how rs7575840 influences apolipoprotein B-containing lipid particles. Arterioscl Throm Vas 31:1201-1207, 2011.

Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V et al. (Kaakinen M, Hartikainen A-L, Herzig KH, Laitinen J, Pouta A, Zitting P, Järvelin M-R). Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet 43:1164, 2011.

Herzig KH, Purhonen AK, Räsänen KM, Idziak J, Juvonen P, Phillips R, Walkowiak J. Fecal pancreatic elastase-1 levels in older individuals without known gastrointestinal diseases or diabetes mellitus. BMC Geriatr 11:4, 2011.

Holmer-Jensen J, Karhu T, Mortensen LS, Pedersen SB, Herzig KH, Hermansen K. Differential effects of dietary protein sources on postprandial low-grade inflammation after a single high fat meal in obese non-diabetic subjects. Nutr J 10:115, 2011.

Ilves I, Paajanen HE, Herzig KH, Fagerström A, Miettinen PJ. Changing incidence of acute appendicitis and nonspecific abdominal pain between 1987 and 2007 in Finland. World J Surg 35:731-738, 2011.

The International Consortium for Blood Pressure Genome-Wide Association Studies, Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD et al. (Laitinen J, Zitting P, Ala-Korpela M, Hartikainen A-L, Järvelin MR). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 478:103-109, 2011.

Jacquemont S, Reymond A, Zufferey F, Harewood L, Walters RG, Kutalik Z et al. (Järvelin M-R, Hartikainen A-L). Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus. Nature 478:97-102, 2011.

Juvonen KR, Karhunen LJ, Vuori E, Lille ME, Karhu T, Jurado-Acosta A et al. (Herzig KH). Structure modification of a milk protein-based model food affects postprandial intestinal peptide release and fullness in healthy young men. Brit J Nutr 106:1890-1898, 2011.

Juvonen KR, Salmenkallio-Marttila M, Lyly M, Liukkonen KH, Lähteenmäki L, Laaksonen DE, Uusitupa MI, Herzig KH, Poutanen KS, Karhunen LJ. Semisolid meal enriched in oat bran decreases plasma glucose and insulin levels, but does not change gastrointestinal peptide responses or short-term appetite in healthy subjects. Nutr Metab Cardiovas 21:748-756, 2011.

Jääskeläinen A, Pussinen J, Nuutinen O, Schwab U, Pirkola J, Kolehmainen M, Järvelin M-R, Laitinen J. Intergenerational transmission of overweight among Finnish adolescents and their parents: a 16-year follow-up study. Int J Obes (Lond) 35:1289-1294, 2011.

Kelempisioti A, Eskola PJ, Okuloff A, Karjalainen U, Takatalo J, Daavittila I et al. (Niinimäki J, Sequeiros RB, Tervonen O, Järvelin MR, Karppinen J, Männikkö M). Genetic susceptibility of intervertebral disc degeneration among young Finnish adults. BMC Med Genet 12:153, 2011.

Khan AA, Rodriguez A, Kaakinen M, Pouta A, Hartikainen AL, Järvelin MR. Does in utero exposure to synthetic glucocorticoids influence birthweight, head circumference and birth length? A systematic review of current evidence in humans. Paediatr Perinat Ep 25:20-36, 2011.

Kilpeläinen M, Mönkäre J, Vlasova MA, Riikonen J, Lehto VP, Salonen J, Järvinen K, Herzig KH. Nanostructured porous silicon microparticles enable sustained peptide (Melanotan II) delivery. Eur J Pharm Biopharm 77:20-25, 2011.

Kilpeläinen TO, Qi L, Brage S, Sharp SJ, Sonestedt E, Demerath E et al. (Kaakinen M, Tammelin TH, Järvelin MR). Physical activity attenuates the influence of FTO variants on obesity risk: A meta-analysis of 218,166 adults and 19,268 children. PLoS Med 8:e1001116, 2011.

Kraja AT, Vaidya D, Pankow JS, Goodarzi MO, Assimes TI, Kullo IJ et al. (Hartikainen A-L, Järvelin M-R). A bivariate genome-wide approach to metabolic syndrome: STAMPEED Consortium. Diabetes 60:1329-1339, 2011.

Kumar V, Butcher SJ, Öörni K, Engelhardt P, Heikkonen J, Kaski K, Ala-Korpela M, Kovanen PT. Three-dimensional cryoEM reconstruction of native LDL particles to 16Å resolution at physiological body temperature. PLoS One 6:e18841, 2011.

Lajunen T, Bloigu A, Paldanius M, Pouta A, Laitinen J, Ruokonen A, Hartikainen AL, Savolainen M, Herzig KH, Leinonen M, Saikku P, Järvelin MR. The association of body mass index, waist and hip circumference, and waist-hip ratio with Chlamydia pneumoniae IgG antibodies and high-sensitive C-reactive protein at 31 years of age in Northern Finland Birth Cohort 1966. Int J Obes (Lond) 35:1470-1478, 2011.

Lampi J, Canoy D, Jarvis D, Hartikainen A-L, Keski-Nisula L, Järvelin M-R et al. Farming environment and prevalence of atopy at age 31: prospective birth cohort study in Finland. Clin Exp Allergy 41:987-993, 2011.

Liukkonen T, Räsänen P, Jokelainen J, Leinonen M, Järvelin M-R, Meyer-Rochow VB, Timonen M. The association between anxiety and C-reactive protein (CRP) levels: Results from the Northern Finland 1966 Birth Cohort Study. Eur Psychiat 26:363-369, 2011.

Miettunen J, Veijola J, Isohanni M, Paunio T, Freimer N, Jääskeläinen E et al. (Taanila A, Järvelin M-R). Identifying schizophrenia and other psychoses with psychological scales in the general population. J Nerv Ment Dis 199:230-238, 2011.

Mook-Kanamori DO, Durmus B, Sovio U, Hofman A, Raat H, Steegers EA et al. (Järvelin M-R). Fetal and infant growth and the risk of obesity during early childhood: the Generation R Study. Eur J Endocrinol 165:623-630, 2011.

Myhrstad MC, Narverud I, Telle-Hansen VH, Karhu T, Bødtker Lund D, Herzig KH et al. Effect of the fat composition of a single high-fat meal on inflammatory markers in healthy young women. Brit J Nutr 106:1826-1835, 2011.

Obeidat M, Wain LV, Shrine N, Kalsheker N, Artigas MS, Repapi E et al. (Hartikainen A-L, Pouta A, Järvelin M-R). A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample. PLoS One 6:e19382, 2011.

Pietiläinen OPH, Rehnström K, Jakkula E, Service SK, Congdon E, Tilgmann C et al. (Hartikainen A-L, Taanila A, Heikura U, Järvelin M-R, Isohanni M). Phenotype mining in CNV carriers from a population cohort. Hum Mol Genet 20:2686-2695, 2011.

Schumann G, Coin LJ, Lourdusamy A, Charoen P, Berger KH, Stacey D et al. (Hartikainen A-L, Isohanni MK, Laitinen J, Pouta A, Järvelin M-R). Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. Proc Natl Acad Sci USA 108:7119-7124, 2011.

Sovio U, Mook-Kanamori DO, Warrington NM, Lawrence R, Briollais L, Palmer CN et al. (Kaakinen M, Laitinen J, Pouta A, Järvelin M-R). Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: The complex nature of genetic association through growth and development. PLoS Genet 7:e1001307, 2011.

Stančáková A, Paananen J, Soininen P, Kangas AJ, Bonnycastle LL, Morken MA et al. (Ala-Korpela M). Effects of 34 risk loci for type 2 diabetes or hyperglycemia on lipoprotein subclasses and their composition in 6,580 nondiabetic Finnish men. Diabetes 60:1608-1616, 2011.

Surakka I, Isaacs A, Karssen LC, Laurila PP, Middelberg RP, Tikkanen E et al. (Ala-Korpela M, Järvelin M-R). A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol. PLoS Genet 7:e1002333, 2011.

Tauriainen E, Luostarinen M, Martonen E, Finckenberg P, Kovalainen M, Huotari A, Herzig KH, Lecklin A, Mervaala E. Distinct effects of calorie restriction and resveratrol on diet-induced obesity and fatty liver formation. J Nutr Metab 2011:525094, 2011.

Valcárcel B, Würtz P, Seich Al Basatena NK, Tukiainen T, Kangas AJ et al. (Järvelin M-R, Ala-Korpela M). A differential network approach to exploring differences between biological states: An application to prediabetes. PLoS One 6:e24702, 2011.

Vanhala M, Kumpula LS, Soininen P, Kangas AJ, Ala-Korpela M, Kautiainen H, Mäntyselkä P, Saltevo J. High serum adiponectin is associated with favorable lipoprotein subclass profile in 6.4-year follow-up. Eur J Endocrinol 164:549-552, 2011.

Wain LV, Verwoert GC, O'Reilly PF, Shi G, Johnson T, Johnson AD et al. (Laitinen J, Pouta A, Zitting P, Järvelin M-R). Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet 43:1005-1011, 2011.

Würtz P, Soininen P, Kangas AJ, Mäkinen V-P, Groop P-H, Savolainen MJ, Juonala M, Viikari JS, Kähönen M, Lehtimäki T, Raitakari OT, Ala-Korpela M. Characterization of systemic metabolic phenotypes associated with subclinical atherosclerosis. Mol Biosyst 7:385-393, 2011.

Other Publications from the Biocenter Project:

Jin HT, Lämsä T, Nordback PH, Hyvönen MT, Räty S, Nordback I, Herzig KH, Alhonen L, Sand J. Polyamine catabolism in relation to trypsin activation and apoptosis in experimental acute pancreatitis. Pancreatology 11:83-91, 2011.

Keränen A-M, Strengell K, Savolainen MJ, Laitinen JH. Effect of weight loss intervention on the association between eating behaviour measured by TFEQ-18 and dietary intake in adults. Appetite 56:156-162, 2011.

Komulainen T, Keränen A-M, Rasinaho E, Hakko H, Savolainen MJ, Kujari M-L, Reponen A, Lindeman S. Quitting a weight loss program is associated with anhedonia: preliminary findings of the Lifestyle Intervention Treatment Evaluation Study in northern Finland. Int J Circumpolar Health 70:72-78, 2011.

Liu M, Rogers L, Cheng Q, Shao Y, Fernandez-Beros ME, Hirschhorn JN, Lyon HN et al. (Hartikainen A-L, Järvelin M-R). Genetic variants of TSLP and asthma in an admixed urban population. PLoS One 6:e25099, 2011.

Veneskoski M, Turunen SP, Kummu O, Nissinen A, Rannikko S, Levonen AL, Hörkkö S. Specific recognition of malondialdehyde and malondialdehyde acetaldehyde adducts on oxidized LDL and apoptotic cells by complement anaphylatoxin C3a. Free Radical Bio Med 51:834-843, 2011.

Transgenic Facility Coordinator Soininen:

Kinnunen AI, Sormunen R, Elamaa H, Seppinen L, Miller RT, Ninomiya Y, Janmey PA, Pihlajaniemi T. Lack of collagen XVIII long isoforms affects kidney podocytes, whereas the short form is needed in the proximal tubular basement membrane. J Biol Chem 286:7755-7764, 2011.

Salminen A, Vuolteenaho R, Paananen R, Ojaniemi M, Hallman M. Surfactant protein A modulates the lipopolysaccharide-induced inflammatory response related to preterm birth. Cytokine 56:442-449, 2011.

EM Microscopy Coordinator Sormunen:

Kinnunen AI, Sormunen R, Elamaa H, Seppinen L, Miller RT, Ninomiya Y, Janmey PA, Pihlajaniemi T. Lack of collagen XVIII long isoforms affects kidney podocytes, whereas the short form is needed in the proximal tubular basement membrane. J Biol Chem 286:7755-7764, 2011.

Pan PW, Parkkila AK, Autio S, Hilvo M, Sormunen R, Pastorekova S, Pastorek J, Haapasalo H, Parkkila S. Brain phenotype of carbonic anhydrase IX-deficient mice. Transgenic Res 21:163-176, 2011.

Sarajärvi T, Tuusa JT, Haapasalo A, Lackman JJ, Sormunen R, Helisalmi S, Roehr JT, Parrado AR, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Petäjä-Repo UE, Hiltunen M. Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking. Mol Cell Biol 31:2326-2340, 2011.

Project Vainio:

Biocenter Publications:

Pietilä I, Ellwanger K, Railo A, Jokela T, Barrantes Idel B, Shan J, Niehrs C, Vainio SJ. Secreted Wnt antagonist Dickkopf-1 controls kidney papilla development coordinated by Wnt-7b signalling. Dev Biol 353:50-60, 2011.

Chi L, Saarela U, Railo A, Prunskaite-Hyyryläinen R, Skovorodkin I, Anthony S, Katsu K, Liu Y, Shan J, Salgueiro AM, Belo JA, Davies J, Yokouchi Y, Vainio SJ. A secreted BMP antagonist, Cer1, fine tunes the spatial organization of the ureteric bud tree during mouse kidney development. PLoS One 6:e27676, 2011.

Xiao Z, Patrakka J, Nukui M, Chi L, Niu D, Betsholtz C, Pikkarainan T, Vainio S, Tryggvason K. Deficiency in Crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice. Dev Dynam 240:2646-2656, 2011.

Heinonen KM, Vanegas JR, Brochu S, Shan J, Vainio SJ, Perreault C. Wnt4 regulates thymic cellularity through the expansion of thymic epithelial cells and early thymic progenitors. Blood 118:5163-5173, 2011.

Renkema KY, Winyard PJ, Skovorodkin IN, Levtchenko E, Hindryckx A, Jeanpierre C, Weber S, Salomon R, Antignac C, Vainio S, Schedl A, Schaefer F, Knoers NV, Bongers EM; for the EUCAKUT consortium. Novel perspectives for investigating congenital anomalies of the kidney and urinary tract (CAKUT). Nephrol Dial Transpl 26(12):3843-3851, 2011.

Other Publications from the Biocenter Project:

Weyer K, Storm T, Shan J, Vainio S, Kozyraki R, Verroust PJ, Christensen EI, Nielsen R. Mouse model of proximal tubule endocytic dysfunction. Nephrol Dial Transpl 26:3446-3451, 2011.

Project Weckström/Vähäsöyrinki:

Biocenter Publications:

Takalo J, Ignatova I, Weckström M, Vähäsöyrinki M. A novel estimator for the rate of information transfer by continuous signals. PLoS One 6:e18792, 2011.

Fink M, Niederer SA, Cherry EM, Fenton FH, Koivumäki JT, Seemann G, Thul R, Zhang H, Sachse FB, Beard D, Crampin EJ, Smith NP. Cardiac cell modelling: Observations from the heart of the cardiac physiome project. Prog Biophys Mol Bio 104:2-21, 2011.

Piironen A, Weckström M, Vähäsöyrinki M. Ultrasmall and customizable multichannel electrodes for extracellular recordings, J Neurophysiol 105:1416-1421, 2011.

Other Publications from the Biocenter Project:

Cilpa G, Koivuniemi A, Hyvönen MT, Riekkola M-L. A molecular dynamics approach for the association of apolipoproteinB-100 and chondroitin-6-sulfate. J Phys Chem B 115:4818-4825, 2011.

Frolov RV, Ignatova II, Singh S. Inhibition of hERG potassium channels by celecoxib and its mechanism PLoS One 6:e26344, 2011.

Murtola T, Vuorela TA, Hyvönen MT, Marrink S-J, Karttunen M, Vattulainen I. Low density lipoprotein: structure, dynamics, and interactions of apoB-100 with lipids. Soft Matter 7:8135-8141, 2011.

Project Wierenga:

Papai I, Hamza A, Pihko PM, Wierenga RK. Stereoelectronic requirements for optimal hydrogen-bond-catalyzed enolization. Chemistry 17:2859-2866, 2011.

Janardan N, Paul A, Harijan RK, Wierenga RK, Murthy MRN. Cloning, expression, purification and preliminary X-ray diffraction studies of a putative Mycobacterium smegmatis thiolase. Acta Crystallogr F 67:817-820, 2011.

Venkatesan R, Alahuhta M, Pihko PM, Wierenga RK. High resolution crystal structures of triosephosphate isomerase complexed with its suicide inhibitors: The conformational flexibility of the catalytic glutamate in its closed, liganded active site. Protein Sci 20:1387-1397, 2011.

Mazet M, Harijan RK, Kiema T, Haapalainen AM, Morand P, Morales J, Bringaud F, Wierenga RK, Michels PAM. The characterization and evolutionary relationships of a trypanosomal thiolase. Int J Parasitol 41:1273-1283, 2011.

Project Winqvist:

Biocenter Publications:

Solyom S, Winqvist R, Nikkilä J, Rapakko K, Hirvikoski P, Kokkonen H, Pylkäs K. Screening for large genomic rearrangements in the FANCA gene reveals extensive deletion in a Finnish breast cancer family. Cancer Lett 302:113-118, 2011.

Tischkowitz M and Winqvist R. Using mouse models to investigate the biological and physiological consequences of defects in the Fanconi anemia/breast cancer DNA repair signalling pathway. J Pathol 224:301-305, 2011.

Vuorela M, Pylkäs K, Hartikainen JM, Sundfeldt K, Lindblom A, von Wachenfeldt Wäppling A, Haanpää M, Puistola U, Rosengren A, Anttila M, Kosma VM, Mannermaa A, Winqvist R. Further evidence for the contribution of the RAD51C gene in hereditary breast and ovarian cancer susceptibility. Breast Cancer Res Tr 130:1003-1010, 2011.

Vuorela M, Pylkäs K, Winqvist R. Mutation screening of the RNF8, UBC13 and MMS2 genes in Northern Finnish breast cancer families. BMC Med Genet 12:98, 2011.

Milne RL, Goode EL, Garcia-Closas M, Wang Q, Chenevix-Trench G, Easton DF et al. (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M). Confirmation of 5p12 as a susceptibility locus for progesterone-receptor–positive, lower grade breast cancer. Cancer Epidemiol Biomarkers Prev 20:2222-2231, 2011.

Figueroa JD, Garcia-Closas M, Humphreys M, Titus-Ernstoff L, Easton D, Spurdle AB et al. (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M). Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium. Hum Mol Genet 20:4693-4706, 2011.

Stevens KN, Vachon CM, Lee AM, Nevanlinna H, Wang X, Couch FJ et al. (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A). Common breast cancer susceptibility loci are associated with triple-negative breast cancer. Cancer Res 71:6240-6249, 2011.

Stevens KN, Garcia-Closas M, Fredericksen Z, Ziogas A, Couch FJ, Easton DF et al. (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M). Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk. Brit J Cancer 105:1934-1939, 2011.

Haiman CA, Chen GK, Vachon CM, Kraft P, Henderson BE, Couch FJ et al. (incl. Winqvist R, Pylkäs K). A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. Nat Genet 43:1210-1214, 2011.

Other Publications from the Biocenter Project:

Yang XR, Chang-Claude J, Goode EL, Pharoah P, Sherman ME, Garcia-Closas M et al. (incl. Pylkäs K, Jukkola-Vuorinen A, Mononen K, Grip M, Hirvikoski P, Winqvist R). Associations of breast cancer risk factors with tumor subtypes: A pooled analysis from the breast cancer association consortium studies. J Natl Cancer I 103:250-263, 2011.

Last updated: 18.11.2016