Publications 2012

Coordinator Eskelinen:

Wang C, Ristiluoma M-M, Salo AM, Eskelinen S, Myllylä R. Lysyl hydroxylase 3 is secreted from cells by two pathways. J Cell Physiol 227:668-675, 2012.

Project Hiltunen:

Ramakrishnan S, Docampo MD, MacRae JI, Pujol FM, Brooks CF, van Dooren GG, Hiltunen JK, Kastaniotis AJ, McConville MJ, Striepen B. Apicoplast and endoplastic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii. J Biol Chem 287:4957-4971, 2012.

Ytting CK, Fuglsang AT, Hiltunen JK, Kastaniotis AJ, Özalp VC, Junker Nielsen L, Olsen LF. Measurements of intracellular ATP provide new insight into the regulation of glycolysis in the yeast Saccharomyces cerevisiae. Integr Biol 4:99-107, 2012.

Antonenkov VD and Hiltunen JK. Transfer of metabolites across the peroxisomal membrane. Biochim Biophys Acta 1822:1374-1386, 2012.

Sharma S, Bhaumik P, Schmitz W, Venkatesan R, Hiltunen JK, Conzelmann E, Juffer AH, Wierenga RK. The enolization chemistry of a thioester-dependent racemase: the 1.4 Å crystal structure of a reaction intermediate complex characterized by detailed QM/MM calculations. J Phys Chem B 116:3619-3629, 2012.

Gualdron-Lopez M, Vapola MH, Miinalainen IJ, Hiltunen JK, Michels PAM, Antonenkov VD. Channel-forming activities in the glycosomal fraction from the bloodstream form of Trypanosoma brucei. PLoS One 7:e34530, 2012.

Biocomputing Coordinator Juffer:

Sharma S, Bhaumik P, Schmitz W, Venkatesan R, Hiltunen JK, Conzelmann E, Juffer AH, Wierenga RK. The enolisation chemistry of a thioester-dependent racemase: the 1.4 Å crystal structure of a reaction intermediate complex characterized by detailed QM/MM calculations. J Phys Chem B 116:3619-3629, 2012.

Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Mol Cell Proteomics 11:1510-1522, 2012.

Project Kietzmann:

Flügel D, Görlach A, Kietzmann T. GSK-3beta regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1alpha. Blood 119:1292-1301, 2012.

Samoylenko A, Vynnytska-Myronovska B, Byts N, Kozlova N, Basaraba O, Pasichnyk G, Palyvoda K, Bobak Y, Barska M, Mayevska O, Rzhepetsky Y, Shuvayeva H, Lyzogubov V, Usenko V, Savran V, Volodko N, Buchman V, Kietzmann T, Drobot L. Increased levels of the HER1 adaptor protein Rukl/CIN85 contribute to breast cancer malignancy.  Carcinogenesis 33:1976-1984, 2012.

Project Kursula:

Myllykoski M, Baumgärtel P, Kursula P. Conformations of peptides derived from myelin-specific proteins in membrane-mimetic conditions probed by synchrotron radiation CD spectroscopy. Amino Acids 42:1467-1474, 2012.

Myllykoski M, Raasakka A, Han H, Kursula P. Myelin 2´,3´-cyclic nucleotide 3´-phosphodiesterase: Active-site ligand binding and molecular conformation. PLoS One 7:e32336, 2012.

Ignatev A, Bhargav SP, Vahokoski J, Kursula P, Kursula I. The lasso segment is required for functional dimerization of the Plasmodium formin 1 FH2 domain. PLoS One 7:e33586, 2012.

Chen W-Q, Heymann G, Kursula P, Rosner M, Hengstschläger M, Huppertz H, Lubec G. Effects of gigapascal level pressure on protein structure and function. J Phys Chem B 116:1100-1110, 2012.

Kuczera K and Kursula P. Interactions of calmodulin with death-associated protein kinase peptides: experimental and modeling studies. J Biomol Struct Dyn 30:45-61, 2012.

Lehtimäki M, Laulumaa S, Ruskamo S, Kursula P. Production and crystallization of a panel of structure-based mutants of the human myelin peripheral membrane protein P2. Acta Crystallogr F 68:1359-1362, 2012.

Myllykoski M, Itoh K, Kangas SM, Heape AM, Kang S-U, Lubec G, Kursula I, Kursula P. The N-terminal domain of the myelin enzyme 2´,3´-cyclic nucleotide 3´-phosphodiesterase: Direct molecular interaction with the calcium sensor calmodulin. J Neurochem 123:515-524, 2012.

Ruskamo S, Chukhlieb M, Vahokoski J, Bhargav SP, Liang F, Kursula I, Kursula P. Juxtanodin is an intrinsically disordered F-actin-binding protein. Sci Rep 2:899, 2012.

Junior Investigator Lehtiö:

Vilchez Larrea SC, Haikarainen T, Narwal M, Schlesinger M, Venkannagari H, Flawia MM, Fernandez Villamil SH, Lehtiö L. Inhibition of poly(ADP-ribose) polymerase interferes with Trypanosoma cruzi infection and proliferation of the parasite. PLoS One 7:e46063, 2012.

Narwal M, Fallarero A, Vuorela P, Lehtiö L. Homogenous screening assay for human tankyrase. J Biomol Screen 17:593-604, 2012.

Narwal M, Venkannagari H, Lehtiö L. Structural basis of selective inhibition of human tankyrases. J Med Chem 55:1360-1367, 2012.

Project Manninen:

Rilla K, Pasonen-Seppänen S, Kärnä R, Karjalainen HM, Törrönen K, Koistinen V, Tammi MI, Tammi RH, Teräväinen T, Manninen A. HAS3-induced accumulation of hyaluronan in 3D MDCK cultures results in mitotic spindle misorientation and disturbed organization of epithelium. Histochem Cell Biol 137:153-164, 2012.

Greciano PG, Moyano JV, Buschmann MM, Tang J, Lu Y, Rudnicki J, Manninen A, Matlin KS. Laminin 511 partners with laminin 332 to mediate directional migration of Madin-Darby canine kidney epithelial cells. Mol Biol Cell 23:121-136, 2012.

Veikkolainen V, Naillat F, Railo A, Chi L, Manninen A, Hohenstein P, Hastie N, Vainio S, Elenius K. ErbB4 modulates tubular cell polarity and lumen diameter during kidney development. J Am Soc Nephrol 23:112-122, 2012.

Project Myllyharju:

Biocenter Publications

Laitala A, Aro E, Walkinshaw G, Mäki JM, Rossi M, Heikkilä M, Savolainen E-R, Arend M, Kivirikko KI, Koivunen P*, Myllyharju J*. Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis. *Equal contribution. Blood 120:3336-3344, 2012.

Aro E, Khatri R, Gerard-O’Riley R, Mangiavini L, Myllyharju J*, Schipani E*. Hypoxia-inducible factor-1 (HIF-1) but not HIF-2 is essential for hypoxic induction of collagen prolyl 4-hydroxylases in primary newborn mouse epiphyseal growth plate chondrocytes. *Equal contribution. J Biol Chem 287:37134-37144, 2012.

Haghighi Poodeh S, Salonurmi T, Nagy I, Koivunen P, Vuoristo J, Räsänen J, Sormunen R, Vainio S, Savolainen MJ. Alcohol-induced premature permeability in mouse placenta-yolk sac barriers in vivo. Placenta 33:866-873, 2012.

Koivunen P, Lee S, Duncan CG, Lopez G, Lu G, Ramkissoon S, Losman JA, Joensuu P, Bergmann U, Gross S, Travins J, Weiss S, Looper R, Ligon KL, Verhaak RG, Yan H, Kaelin WG Jr. Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Nature 483:484-488, 2012.

Other Publications from the Biocenter Project

Taube E, Jokinen E, Koivunen P, Koivunen JP. A novel treatment strategy for EGFR mutant NSCLC with T790M-mediated acquired resistance. Int J Cancer 131:970-979, 2012.

Project Männikkö:

Korvala J, Jueppner H, Mäkitie O, Sochett E, Schnabel D, Mora S, Bartels CF, Warman ML, Deraska D, Cole WG, Hartikka H, Ala-Kokko L, Männikkö M. Mutations in LRP5 cause primary osteoporosis without features of OI by reducing Wnt signaling activity. BMC Med Genet 13:26, 2012.

Korvala J, Löija M, Mäkitie O, Sochett E, Jueppner H, Schnabel D, Mora S, Cole WG, Ala-Kokko L, Männikkö M. Rare variations in WNT3A and DKK1 may predispose carriers to primary osteoporosis. Eur J Med Genet 55:515-519, 2012.

Hietikko E, Kotimäki J, Okuloff A, Sorri M, Männikkö M. A replication study on proposed candidate genes in Meniere’s disease, and a review of the current status of genetic studies. Int J Audiol 51:841-845, 2012.

Eskola PJ, Kjaer P, Sorensen JS, Okuloff A, Wedderkopp N, Daavittila I, Ala-Kokko L, Männikkö M, Karppinen J. Gender difference in genetic association between IL1A variant and early lumbar disc degeneration: a three-year follow-up. Int J Mol Epidemiol Genet 3:195-204, 2012.

Eskola PJ, Lemmelä S, Kjaer P, Solovieva S, Männikkö M, Tommerup N, Lind-Thomsen A, Husgafvel-Pursiainen K, Cheung KMC, Chan D, Samartzis D, Karppinen J. Genetic association studies in lumbar disc degeneration: a systematic review. PloS One 7:e49995, 2012.

Project Pihlajaniemi:

Biocenter Publications:

Holopainen T, López-Alpuche V*, Zheng W*, Heljasvaara R, Jones D, He Y, Tvorogov D, D’Amico G, Wiener Z, Andersson LC, Pihlajaniemi T, Min W, Alitalo K. Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth. *Equal contribution. Cancer Res 72:3512-3521, 2012.

Heikkinen A, Tu H, Pihlajaniemi T. Collagen XIII: a type II transmembrane protein with relevance to musculoskeletal tissues, microvessels and inflammation. Int J Biochem Cell B 44:714-717, 2012.

Su J, Stenbjorn RS, Gorse K, Su K, Hauser KF, Ricard-Blum S, Pihlajaniemi T, Fox MA. Target-derived matricryptins organize cerebellar synapse formation through α3β1 integrins. Cell Rep 2:223-230, 2012.

Moncada-Pazos A, Obaya AJ, Llamazares M, Heljasvaara R, Suárez MF, Colado E, Noël A, Cal S, López-Otín C. ADAMTS-12 metalloprotease is necessary for normal inflammatory response. J Biol Chem 287:39554-39563, 2012.

Holopainen T, Saharinen P, D'Amico G, Lampinen A, Eklund L, Sormunen R, Anisimov A, Zarkada G, Lohela M, Heloterä H, Tammela T, Benjamin LE, Ylä-Herttuala S, Leow CC, Koh GY, Alitalo K. Effects of angiopoietin-2-blocking antibody on endothelial cell–cell junctions and lung metastasis. J Natl Cancer I 104:461-475, 2012.

Pietilä R, Nätynki M, Tammela T, Kangas J, Pulkki KH, Limaye N, Vikkula M, Koh GY, Saharinen P, Alitalo K, Eklund L. Ligand oligomerization state controls Tie2 receptor trafficking and angiopoietin-2-specific responses. J Cell Sci 125:2212-2223, 2012.

Aikio M, Alahuhta I, Nurmenniemi S, Suojanen J, Palovuori R, Teppo S, Sorsa T, López-Otín C, Pihlajaniemi T, Salo T, Heljasvaara R, Nyberg P. Arresten, a collagen-derived angiogenesis inhibitor, suppresses invasion of squamous cell carcinoma. PLoS One 7:e51044, 2012.

Buler M, Aatsinki SM, Izzi V, Hakkola J. Metformin reduces hepatic expression of SIRT3, the mitochondrial deacetylase controlling energy metabolism. PLoS One 7:e49863, 2012.

Other Publications from the Biocenter Project:

Zainul Z. Recent immunohistochemical approaches for predicting tumor recurrence in oral squamous cell carcinoma (OSCC): Actors beyond the scene. Int J Oral-Med Sci 10: 406-413, 2012.

Project Ruddock:

Ruddock LW. Low-molecular-weight oxidants involved in disulfide bond formation. Antioxid Redox Signal 16:1129-1138, 2012.

Project Savolainen, Herzig & Järvelin:

Biocenter Publications:

Ali Khan A, Rodriguez A, Sebert S, Kaakinen M, Cauchi S, Froguel P, Hartikainen AL, Pouta A, Järvelin M-R. The interplay of variants near LEKR and CCNL1 and social stress in relation to birth size. PLoS One 7:e38216, 2012.

Bader V, Tomppo L, Trossbach SV, Bradshaw NJ, Prikulis I, Leliveld SR, et al. (Veijola J, Järvelin M-R). Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits. Hum Mol Genet 21:4406-4418, 2012.

Banasiewicz T, Walkowiak J, Drzymała-Czyż S, Borejsza-Wysocki M, Majewski P, Biczysko M, Stojcev Z, Herzig KH, Drews M. Stricture of ileo-anal J pouch anastomosis increased the intensity of pouchitis in an experimental rat model. Med Sci Monit 18:BR409-413, 2012.

Boraska V, Jeroncic A, Colonna V, Southam L, Nyholt DR, William Rayner N, et al. (Järvelin M-R). Genome-wide meta-analysis of common variant differences between men and women. Hum Mol Genet 21:4805-4815, 2012.

Boutant M, Ramos OH, Lecoeur C, Vaillant E, Philippe J, Zhang P, et al. (Sebert S, Järvelin M-R). Glucose-dependent regulation of NR2F2 promoter and influence of SNP-rs3743462 on whole body insulin sensitivity. PLoS One 7:e35810, 2012.

Bradfield JP, Taal HR, Timpson NJ, Scherag A, Lecoeur C, Warrington NM, et al. (Pouta A, Hartikainen AL, Järvelin M-R). A genome-wide association meta-analysis identifies new childhood obesity loci. Nat Genet 44:526-531, 2012.

Congdon E, Service S, Wessman J, Seppänen JK, Schönauer S, Miettunen J, et al. (Koiranen M, Järvelin M-R, Veijola J). Early environment and neurobehavioral development predict adult temperament clusters. PLoS One 7:e38065, 2012.

Coviello AD, Haring R, Wellons M, Vaidya D, Lehtimäki T, Keildson S, et al. (Ruokonen A, Hartikainen AL, Pouta A, Martikainen H, Morin Papunen L, Järvelin M-R). A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple loci implicated in sex steroid hormone regulation. PLoS Genet 8:e1002805, 2012.

Creemers JW, Choquet H, Stijnen P, Vatin V, Pigeyre M, Beckers S, et al. (Järvelin M-R). Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity. Diabetes 61:383-390, 2012.

Elomaa AP, Niskanen L, Herzig KH, Viinamäki H, Hintikka J, Koivumaa-Honkanen H, et al. Elevated levels of serum IL-5 are associated with an increased likelihood of major depressive disorder. BMC Psychiatry 12:2, 2012.

Elomaa AP, Uimonen K, Niskanen L, Koivumaa-Honkanen H, Honkalampi K, Valkonen-Korhonen M, Herzig KH, Viinamäki H, Lehto SM. Lowered serum PAI-1 levels in adults with a history of alcohol abuse in the childhood home. Psychiatria Fennica 43:9-22, 2012.

Froguel P, Ndiaye NC, Bonnefond A, Bouatia-Naji N, Dechaume A, Siest G, et al. (Ruokonen A, Järvelin M-R). A Genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels. PLoS One 7:e32327, 2012.

Gaál EI, Salo P, Kristiansson K, Rehnström K, Kettunen J, Sarin AP, et al. (Järvelin M-R, Pouta A). Intracranial aneurysm risk locus 5q23.2 is associated with elevated systolic blood pressure. PLoS Genet 8:e1002563, 2012.

Haghighi Poodeh S, Salonurmi T, Nagy I, Koivunen P, Vuoristo J, Räsänen J, Sormunen R, Vainio S, Savolainen MJ. Alcohol-induced premature permeability in mouse placenta-yolk sac barriers in vivo. Placenta 33:866-873, 2012.

Huusko TJ, Santaniemi M, Kakko S, Taskinen P, Ukkola O, Kesäniemi YA, Savolainen MJ, Salonurmi T. Long telomeres in blood leukocytes are associated with a high risk of ascending aortic aneurysm. PloS One 7:e50828, 2012.

Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L, et al. (Pouta A, Järvelin M-R). Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature 483:350-354, 2012.

Ikram MA, Fornage M, Smith AV, Seshadri S, Schmidt R, Debette S, et al. (Hartikainen AL, Järvelin M-R, Huikari V, Sebert S). Common variants at 6q22 and 17q21 are associated with intracranial volume. Nat Genet 44:539-544, 2012.

Inouye M, Ripatti S, Kettunen J, Lyytikäinen LP, Oksala N, Laurila PP, et al. (Järvelin M-R, Ala-Korpela M). Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. PLoS Genet 8:e1002907, 2012.

Juvonen KR, Lille ME, Laaksonen DE, Mykkänen HM, Niskanen LK, Herzig KH, Poutanen KS, Karhunen LJ. Crosslinking with transglutaminase does not change metabolic effects of sodium caseinate in model beverage in healthy young individuals. Nutr J 11:35, 2012.

Kaakinen M, Ducci F, Sillanpää MJ, Läärä E, Järvelin M-R. Associations between variation in CHRNA5-CHRNA3-CHRNB4, body mass index and blood pressure in the Northern Finland Birth Cohort 1966. PLoS One 7:e46557, 2012.

Kaasalainen M, Mäkilä E, Riikonen J, Kovalainen M, Järvinen K, Herzig KH, Lehto VP, Salonen J. Effect of isotonic solutions and peptide adsorption on zeta potential of porous silicon nanoparticle drug delivery formulations. Int J Pharm 431:230-236, 2012.

Kantola T, Klintrup K, Väyrynen JP, Vornanen J, Bloigu R, Karhu T, Herzig KH, Näpänkangas J, Mäkelä J, Karttunen TJ, Tuomisto A, Mäkinen MJ. Stage-dependent alterations of the serum cytokine pattern in colorectal carcinoma. Br J Cancer 107:1729-1736, 2012.

Kettunen J, Tukiainen T, Sarin AP, Ortega-Alonso A, Tikkanen E, Lyytikäinen LP, et al. (Savolainen MJ, Järvelin M-R, Ala-Korpela M). Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat Genet 44:269-276, 2012.

Khalife N, Glover V, Hartikainen AL, Taanila A, Ebeling H, Järvelin M-R, Rodriguez A. Placental size is associated with mental health in children and adolescents. PLoS One 7:e40534, 2012.

Kovalainen M, Mönkäre J, Mäkilä E, Salonen J, Lehto VP, Herzig KH, Järvinen K. Mesoporous silicon (PSi) for sustained peptide delivery: effect of PSi microparticle surface chemistry on peptide YY3-36 release. Pharm Res 29:837-846, 2012.

Kristiansson K, Perola M, Tikkanen E, Kettunen J, Surakka I, et al. (Hartikainen AL, Ruokonen A, Pouta A, Ala-Korpela M, Järvelin M-R). Genome-wide screen for metabolic syndrome susceptibility loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. Circ Cardiovasc Genet 5:242-249, 2012.

Kuusisto SM, Peltola T, Laitinen M, Kumpula LS, Mäkinen VP, Salonurmi T, Hedberg P, Jauhiainen M, Savolainen MJ, Hannuksela ML, Ala-Korpela M. The interplay between lipoprotein phenotypes, adiponectin, and alcohol consumption. Ann Med 44:513-522, 2012.

Laitinen J, Jääskeläinen A, Hartikainen A-L, Sovio U, Vääräsmäki M, Pouta A, Kaakinen M, Järvelin M-R. Maternal weight gain during the first half of pregnancy and offspring obesity at 16 years: a prospective cohort study. BJOG 119:716-723, 2012.

Lajunen TK, Purhonen AK, Haapea M, Ruokonen A, Puukka K, Hartikainen AL, Savolainen MJ, Morin-Papunen L, Tapanainen JS, Franks S, Järvelin MR, Herzig KH. Full-length visfatin levels are associated with inflammation in women with polycystic ovary syndrome. Eur J Clin Invest 42:321-328, 2012.

Lehto SM, Elomaaa AP, Niskanen L, Herzig KH, Tolmunen T, Viinamäki H, et al. Serum adipokine levels in adults with a history of childhood maltreatment. Prog Neuropsychopharmacol Biol Psychiatry 37:217-221, 2012.

Manning AK, Hivert MF, Scott RA, Grimsby JL, Bouatia-Naji N, Chen H, et al. (Järvelin M-R, Keinanen-Kiukaanniemi S). A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet 44:659-669, 2012.

McQuillan R, Eklund N, Pirastu N, Kuningas M, McEvoy BP, Esko T, et al. (Kaakinen M, Pouta A, Hartikainen AL, Järvelin M-R). Evidence of inbreeding depression on human height. PLoS Genet 8:e1002655, 2012.

Meriläinen S, Mäkelä J, Alaoja Jensen H, Dahlbacka S, Lehtonen S, Karhu T, Herzig KH, et al. Portal vein cytokines in the early phase of acute experimental oedematous and necrotizing porcine pancreatitis. Scand J Gastroentero 47:1375-1385, 2012.

Morandi A, Meyre D, Lobbens S, Kleinman K, Kaakinen M, Rifas-Shiman SL, et al. (Pouta A, Hartikainen AL, Laitinen J, Ruokonen A, Järvelin MR). Estimation of newborn risk for child or adolescent obesity: lessons from longitudinal birth cohorts. PLoS One 7:e49919, 2012.

Mutt SJ, Karhu T, Lehtonen S, Lehenkari P, Carlberg C, Saarnio J, Sebert S, Hyppönen E, Järvelin M-R, Herzig KH. Inhibition of cytokine secretion from adipocytes by 1,25-dihydroxyvitamin D3 via the NF-κB pathway. FASEB J 26:4400-4407, 2012.

Mönkäre J, Hakala RA, Kovalainen M, Korhonen H, Herzig KH, Seppälä JV, Järvinen K. Photocrosslinked poly(ester anhydride)s for peptide delivery: Effect of oligomer hydrophobicity on PYY3-36 delivery. Eur J Pharm Biopharm 80:33-38, 2012.

Niinikoski H, Pahkala K, Ala-Korpela M, Viikari J, Rönnemaa T, Lagström H, Jokinen E, Jula A, Savolainen MJ, Simell O, Raitakari OT. Effect of repeated dietary counseling on serum lipoproteins from infancy to adulthood. Pediatrics 129:e704-e713, 2012.

Nissinen AE, Laitinen LM, Kakko S, Helander A, Savolainen MJ, Hörkkö S. Low plasma antibodies specific for phosphatidylethanol in alcohol abusers and patients with alcoholic pancreatitis. Addict Biol 17:1057-1067, 2012.

Paavola T, Kangas-Kontio T, Salonurmi T, Kuusisto S, Huusko T, Savolainen MJ, Kakko S. Plasma levels of antibodies against oxidized LDL are inherited but not associated with HDL-cholesterol level in families with early coronary heart disease. Atherosclerosis 224:123-128, 2012.

Palmer ND, McDonough CW, Hicks PJ, Roh BH, Wing MR, An SS, et al. (Hartikainen AL, Kaakinen M, Pouta A, Ruokonen A, Järvelin M-R). A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One 7:e29202, 2012.

Patel SP, Rodriguez A, Little MP, Elliott P, Pekkanen J, Hartikainen A-L, Pouta A, Laitinen J, Harju T, Canoy D, Järvelin M-R. Associations between pre-pregnancy obesity and asthma symptoms in adolescents. J Epidemiol Commun H 66:809-814, 2012.

Pekkanen J, Lampi J, Genuneit J, Hartikainen A-L, Järvelin M-R. Analyzing atopic and non-atopic asthma. Eur J Epidemiol 27:281-286, 2012.

Piltonen T, Puurunen J, Hedberg P, Ruokonen A, Mutt SJ, Herzig KH, Nissinen A, Morin-Papunen L, Tapanainen JS. Oral, transdermal and vaginal combined contraceptives induce an increase in markers of chronic inflammation and impair insulin sensitivity in young healthy normal-weight women: a randomized study. Hum Reprod 27:3046-3056, 2012.

Ramasamy A, Kuokkanen M, Vedantam S, Gajdos ZK, Couto Alves A, Lyon HN, et al. (Pouta A, Järvelin M-R). Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA. PLoS One 7:e44008, 2012.

Ruotsalainen H, Risteli M, Wang C, Wang Y, Karppinen M, Bergmann U, Kvist AP, Pospiech H, Herzig KH, Myllylä R. The activities of Lysyl Hydroxylase 3 (LH3) regulate the amount and oligomerization status of adiponectin. PLoS ONE 7:e50045, 2012.

Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, et al. (Keinänen-Kiukaanniemi SM, Pouta A, Järvelin M-R). Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet 44:991-1005, 2012.

Service SK, Verweij KJ, Lahti J, Congdon E, Ekelund J, Hintsanen M, et al. (Taanila A, Veijola J, Järvelin M-R). A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales. Transl Psychiatry 2:e116, 2012.

Taal HR, St Pourcain B, Thiering E, Das S, Mook-Kanamori DO, Warrington NM, et al. (Kaakinen M, Huikari V, Sebert S, Järvelin M-R, Hartikainen AL, Pouta A). Common variants at 12q15 and 12q24 are associated with infant head circumference. Nat Genet 44:532-538, 2012.

Takatalo J, Karppinen J, Niinimäki J, Taimela S, Mutanen P, Sequeiros RB, Näyhä S, Järvelin M-R, Kyllönen E, Tervonen O. Association of modic changes, Schmorl's nodes, spondylolytic defects, high intensity zone lesions, disc herniations, and radial tears with low back symptom severity among young Finnish adults. Spine 37:1231-1239, 2012.

Tiira AH, Paananen MV, Taimela SP, Zitting PJ, Järvelin M-R, Karppinen JI. Determinants of adolescent health care use for low back pain. Eur J Pain 16:1467-1476, 2012.

Tukiainen T, Jylänki P, Mäkinen V-P, Gröhn O, Hallikainen M, Soininen H, Kivipelto M, Kaski K, Groop P-H, Savolainen MJ, Pirttilä T, Soininen P, Ala-Korpela M. Mild cognitive impairment associates with concurrent decreases in serum cholesterol and cholesterol-related lipoprotein subclasses. J Nutr Health Aging 16:631-635, 2012.

Tukiainen T, Kettunen J, Kangas AJ, Lyytikäinen LP, Soininen P, Sarin AP, et al. (Savolainen MJ, Pouta A, Järvelin M-R, Ala-Korpela M). Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci. Hum Mol Genet 21:1444-1455, 2012.

Tyrrell J, Huikari V, Christie JT, Cavadino A, Bakker R, Brion MJ, et al. (Hartikainen AL, Kaakinen M, Sebert SP, Järvelin M-R). Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight. Hum Mol Genet 21:5344-5358, 2012.

van der Harst P, Zhang W, Mateo Leach I, Rendon A, Verweij N, Sehmi J, et al. (Hartikainen AL, Pouta A, Ruokonen A, Järvelin M-R). Seventy-five genetic loci influencing the human red blood cell. Nature 492:369-375, 2012.

Varis E, Savolainen MJ, Penna J, Liinamaa MJ. Alcohol consumption, but not physical activity or smoking, contribute to advanced forms of diabetic retinopathy: a case-control study. J Clinic Experiment Ophthalmol S:5, 2012.

Verweij KJH, Yang J, Lahti J, Veijola J, Hintsanen M, Pulkki-Råback L, et al. (Pouta A, Taanila A, Isohanni M, Miettunen J, Järvelin M-R). Maintenance of genetic variation in human personality: Testing evolutionary models by estimating heritability due to common causal variants and investigating the effect of distant inbreeding. Evolution 66:3238-3251, 2012.

Widén E, Silventoinen K, Sovio U, Ripatti S, Cousminer DL, Hartikainen AL, et al. (Laitinen J, Pouta A, Järvelin M-R). Pubertal timing and growth influences cardiometabolic risk factors in adult males and females. Diabetes Care 35:850-856, 2012.

Würtz P, Mäkinen VP, Soininen P, Kangas AJ, Tukiainen T, Kettunen J, et al. (Savolainen MJ, Järvelin M-R, Ala-Korpela M). Metabolic signatures of insulin resistance in 7,098 young adults. Diabetes 61:1372-1380, 2012.

Würtz P, Raiko JR, Magnussen CG, Soininen P, Kangas AJ, Tynkkynen T, et al. (Savolainen MJ, Ala-Korpela M). High-throughput quantification of circulating metabolites improves prediction of subclinical atherosclerosis. Eur Heart J 33:2307-2316, 2012.

Yang J, Loos RJ, Powell JE, Medland SE, Speliotes EK, Chasman DI, et al. (Pouta A, Kaakinen M, Huikuri HV, Järvelin M-R). FTO genotype is associated with phenotypic variability of body mass index. Nature 490:267-272, 2012.

Other Publications from the Biocenter Project:

Astrup A, Carraro R, Finer N, Harper A, Kunesova M, Lean ME, et al. (Savolainen MJ). Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide. Int J Obes (Lond) 36:843-854, 2012.

Enwald HPK, Niemelä RM, Keinänen-Kiukaanniemi S, Leppäluoto J, Jämsä T, Herzig KH, Oinas-Kukkonen H, Huotari ML. Human information behaviour and physiological measurements as a basis to tailor health information. An explorative study in a physical activity intervention among prediabetic individuals in Northern Finland. Health Info Libr J 29:131-140, 2012.

Hartz SM, Short SE, Saccone NL, Culverhouse R, Chen L, Schwantes-An TH, et al. (Kaakinen M, Järvelin M-R). Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. Arch Gen Psychiat 69:854-861, 2012.

Koskinen J, Magnussen CG, Würtz P, Soininen P, Kangas AJ, Viikari JSA et al. (Ala-Korpela M). Apolipoprotein B, oxidized low-density lipoprotein, and LDL particle size in predicting the incidence of metabolic syndrome: the Cardiovascular Risk in Young Finns study. Eur J Cardiovasc Prev Rehabil 19:1296-1303, 2012.

Männistö T, Hartikainen A-L, Vääräsmäki M, Bloigu A, Surcel HM, Pouta A, Järvelin M-R, Ruokonen A, Suvanto E. Smoking and early pregnancy thyroid hormone and anti-thyroid antibody levels in euthyroid mothers of the Northern Finland Birth Cohort 1986. Thyroid 22:944-950, 2012.

Transgenic Facility Coordinator Soininen:

Biocenter Publications:

Aikio O, Metsola J, Vuolteenaho R, Perhomaa M, Hallman M. Transient defect in nitric oxide generation after rupture of fetal membranes and responsiveness to inhaled nitric oxide in very preterm infants with hypoxic respiratory failure. J Pediatr 161:397-403, 2012.

Hurskainen T, Moilanen J, Sormunen R, Franzke C-W, Soininen R, Loeffek S, Huilaja L, Nuutinen M, Bruckner-Tuderman L, Autio-Harmainen H, Tasanen K. Transmembrane collagen XVII is a novel component of the glomerular filtration barrier. Cell Tissue Res 348:579-588, 2012.

Other Publications from the Biocenter Project:

Salminen A, Vuolteenaho R, Paananen R, Ojaniemi M, Hallman M. Surfactant protein D modulates levels of IL-10 and TNF-alpha in intrauterine compartments during lipopolysaccharide-induced preterm birth. Cytokine 60:423-430, 2012.

Moilanen A-M, Rysä J, Serpi R, Mustonen E, Szabò Z, Aro J, Näpänkangas J, Tenhunen O, Sutinen M, Salo T, Ruskoaho H. (Pro)renin receptor triggers distinct angiotensin II-independent extracellular matrix remodeling and deterioration of cardiac function. PLoS One 7:e41404, 2012.

Vainio L, Perjes A, Ryti N, Magga J, Alakoski T, Serpi R, Kaikkonen L, Piuhola J, Szokodi I, Ruskoaho H, Kerkelä R. Neuronostatin, a novel peptide encoded by somatostatin gene, regulates cardiac contractile function and cardiomyocyte survival. J Biol Chem 287:4572-4580, 2012.

Project Savolainen & Sillanpää

Kaakinen M, Ducci F, Sillanpää MJ, Läärä E, Järvelin M-R. Associations between variation in CHRNA5-CHRNA3-CHRNB4, body mass index and blood pressure in the Northern Finland Birth Cohort 1966. PLoS One 7:e46557, 2012.

Kujala ST and Savolainen O. Sequence variation patterns along a latitudinal cline in Scots pine (Pinus sylvestris): signs of clinal adaptation? Tree Genetics & Genomes 8:1451-1467, 2012.

Kärkkäinen HP and Sillanpää MJ. Robustness of Bayesian multilocus association models to cryptic relatedness. Ann Hum Genet 76:510-523, 2012.

Kärkkäinen HP and Sillanpää MJ. Back to basics for Bayesian model building in genomic selection. Genetics 191:969-987, 2012.

Li Z and Sillanpää MJ. Estimation of quantitative trait locus effects with epistasis by variational Bayes algorithms. Genetics 190:231-249, 2012.

Li Z and Sillanpää MJ. Overview of LASSO-related penalized regression methods for quantitative trait mapping and genomic selection. Theor Appl Genet 125:419-435, 2012.

Mackay J, Dean J, Plomion C, Peterson D, Canovas F, Pavy N et al. (Savolainen O). Towards decoding the conifer giga-genome. Plant Mol Biol 80:555-569, 2012.

Mathew B, Bauer AM, Koistinen P, Reetz TC, Leon J, Sillanpää MJ. Bayesian adaptive Markov chain Monte Carlo estimation of genetic parameters. Heredity 109:235-245, 2012.

Mutshinda CM, Noykova N, Sillanpää MJ. A hierarchical Bayesian approach to multi-trait clinical quantitative trait locus modeling. Front Genet 3:97, 2012.

Mutshinda CM and Sillanpää MJ. Swift block-updating EM and pseudo-EM procedures for Bayesian shrinkage analysis of quantitative trait loci. Theor Appl Genet 125:1575-1587, 2012.

Mutshinda CM and Sillanpää MJ. A decision rule for quantitative trait locus detection under the extended Bayesian LASSO model. Genetics 192:1483-1491, 2012.

Pyhäjärvi T, Aalto EA, Savolainen O. Time scales of divergence and speciation among natural populations and subspecies of Arabidopsis lyrata (Brassicaceae). Am J Bot 99:1314-1322, 2012.

Sillanpää MJ, Pikkuhookana P, Abrahamsson S, Knürr T, Fries A, Lerceteau E, Garcia-Gil M. Simultaneous estimation of multiple quantitative trait loci and growth curve parameters through hierarchical Bayesian modeling. Heredity 108:134-146, 2012.

EM Microscopy Coordinator Sormunen:

Pan P-W, Parkkila A-K, Autio S, Hilvo M, Sormunen R, Pastorekova S, Pastorek J, Haapasalo H, Parkkila S. Brain phenotype of carbonic anhydrase IX-deficient mice. Transgenic Res 21:163-176, 2012.

Hurskainen T, Moilanen J, Sormunen R, Franzke C-W, Soininen R, Loeffek S, Huilaja L, Nuutinen M, Bruckner-Tuderman L, Autio-Harmainen H, Tasanen K. Transmembrane collagen XVII is a novel component of the glomerular filtration barrier. Cell Tissue Res 348:579-588, 2012.

Holopainen T, Saharinen P, D'Amico G, Lampinen A, Eklund L, Sormunen R, Anisimov A, Zarkada G, Lohela M, Heloterä H, Tammela T, Benjamin LE, Ylä-Herttuala S, Leow CC, Koh GY, Alitalo K. Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis. J Natl Cancer Inst 104:461-475, 2012.

Pietilä M, Palomäki S, Lehtonen S, Ritamo I, Valmu L, Nystedt J, Laitinen S, Leskelä H-V, Sormunen R, Pesälä J, Nordström K, Vepsäläinen A, Lehenkari P. Mitochondrial function and energy metabolism in umbilical cord blood- and bone marrow-derived mesenchymal stem cells. Stem Cells Dev 21:575-588, 2012.

Paino A, Lohermaa E, Sormunen R, Tuominen H, Korhonen J, Pöllänen MT, Ihalin R. Interleukin-1beta is internalised by viable Aggregatibacter actinomycetemcomitans biofilm and locates to the outer edges of nucleoids. Cytokine 60:565-574, 2012.

Lämsä V, Levonen A-L, Sormunen R, Yamamoto M, Hakkola J. Heme and heme biosynthesis intermediates induce Heme oxygenase-1 and Cytochrome P450 2A5, enzymes with putative sequential roles in heme and bilirubin metabolism: Different requirement for transcription factor Nuclear factor erythroid-derived 2-like 2. Toxicol Sci 130:132-144, 2012.

Karvonen HM, Lehtonen ST, Sormunen RT, Harju TH, Lappi-Blanco E, Bloigu RS, Kaarteenaho RL. Myofibroblasts in interstitial lung diseases show diverse electron microscopic and invasive features. Lab Invest 92:1270-1284, 2012.

Tervaniemi MH, Siitonen HA, Söderhäll C, Minhas G, Vuola J, Tiala I, Sormunen R, Samuelsson L, Suomela S, Kere J, Elomaa O. Centrosomal localization of the psoriasis candidate gene product, CCHCR1, supports a role in cytoskeletal organization. PLoS One 7:e49920, 2012.

Haghighi Poodeh S, Salonurmi T, Nagy I, Koivunen P, Vuoristo J, Räsänen J, Sormunen R, Vainio S, Savolainen MJ. Alcohol-induced premature permeability in mouse placenta-yolk sac barriers in vivo. Placenta 33:866-873, 2012.

Gualdron-Lopez M, Vapola MH, Miinalainen IJ, Hiltunen JK, Michels PAM, Antonenkov VD. Channel-forming activities in the glycosomal fraction from the bloodstream form of Trypanosoma brucei. PLoS One 7:e34530, 2012.

Project Vainio:

Biocenter Publications:

Vainio S. How the developing mammalian kidney assembles its thousands of nephrons: Fgfs as stemness signals. Dev Cell 22:1125-1126, 2012.

Murugan S, Shan J, Kühl SJ, Tata A, Pietilä I, Kühl M, Vainio SJ. WT1 and Sox11 regulate synergistically the promoter of the Wnt4 gene that encodes a critical signal for nephrogenesis. Exp Cell Res 318:1134-1145, 2012.

Murugan S, Saarela U, Airenne K, Shan J, Skovorodkin I, Ylä-Herttuala S, Vainio SJ. Conditional expression of Lodavin, an avidin-tagged LDL receptor, for biotin-mediated applications in vivo. Genesis 50:693-699, 2012.

Haghighi Poodeh S, Salonurmi T, Nagy I, Koivunen P, Vuoristo J, Räsänen J, Sormunen R, Vainio S, Savolainen MJ. Alcohol-induced premature permeability in mouse placenta-yolk sac barriers in vivo. Placenta 33:866-873, 2012.

Veikkolainen V, Naillat F, Railo A, Chi L, Manninen A, Hohenstein P, Hastie N, Vainio S, Elenius K. ErbB4 modulates tubular cell polarity and lumen diameter during kidney development. J Am Soc Nephrol 23:112-122, 2012.

Other Publications from the Biocenter Project:

Halt K and Vainio S. In vitro induction of nephrogenesis in mouse metanephric mesenchyme with lithium introduction and ureteric bud recombination. Methods Mol Biol 886:23-30, 2012.

Project Wierenga:

Sharma S, Bhaumik P, Schmitz W, Venkatesan R, Hiltunen JK, Conzelmann E, Juffer AH, Wierenga RK. The enolization chemistry of a thioester-dependent racemase: the 1.4 Å crystal structure of a reaction intermediate complex characterized by detailed QM/MM calculations. J Phys Chem B 116:3619-3629, 2012.

Janardan N, Harijan RK, Wierenga RK, Murthy MRN. Crystal structure of a monomeric thiolase-like protein type 1 (TLP1) from Mycobacterium smegmatis. PLoS One 7:e41894, 2012.

Project Winqvist:

Hein R, Maranian M, Hopper JL, Kapuscinski MK (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M). Comparison of 6q25 breast cancer hits from Asian and European genome wide association studies in the Breast Cancer Association Consortium (BCAC). PLoS One. 7:e42380, 2012.

Warren H, Dudbridge F, Fletcher O, Orr N (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M). 9q31.2-rs865686 as a susceptibility locus for estrogen receptor-positive breast cancer: evidence from the Breast Cancer Association Consortium. Cancer Epidem Biomar 21:1783-1791, 2012.

Wishart GC, Bajdik CD, Dicks E, Provenzano E (incl. Winqvist R and Pylkäs K). PREDICT Plus: development and validation of a prognostic model for early breast cancer that includes HER2. Brit J Cancer 107:800-807, 2012.

Pylkäs K, Vuorela M, Otsukka M, Kallioniemi A, Jukkola-Vuorinen A, Winqvist R. Rare copy number variants observed in hereditary breast cancer cases disrupt genes in estrogen signaling and TP53 tumor suppression network. PLoS Genet 8:e1002734, 2012.

Fasching PA, Pharoah PD, Cox A, Nevanlinna H (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Kauppila S). The role of genetic breast cancer susceptibility variants as prognostic factors. Hum Mol Genet 21:3926-3939, 2012.

Lambrechts D, Truong T, Justenhoven C, Humphreys MK (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M). 11q13 is a susceptibility locus for hormone receptor positive breast cancer. Hum Mutat 33:1123-1132, 2012.

Solyom S, Aressy B, Pylkäs K, Patterson-Fortin J, Hartikainen JM, Kallioniemi A, Kauppila S, Nikkilä J, Kosma VM, Mannermaa A, Greenberg RA, Winqvist R. Breast cancer-associated Abraxas mutation disrupts nuclear localization and DNA damage response functions. Sci Transl Med 4:122ra23, 2012.

Stevens KN, Fredericksen Z, Vachon CM, Wang X (incl. Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Grip M). 19p13.1 is a triple-negative-specific breast cancer susceptibility locus. Cancer Res 72:1795-1803, 2012.

Ghoussaini M, Fletcher O, Michailidou K, Turnbull C (Winqvist R, Pylkäs K, Jukkola-Vuorinen A, Kauppila S). Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nat Genet 44:312-318, 2012.

Last updated: 18.11.2016