Mia Monnius

MD Mia Monnius is working on her PhD in the research group of Professor Johanna Myllyharju since 2015. The aim is to investigate the role of oxygen sensors, HIF prolyl 4-hydroxylases, in (auto)inflammatory processes of central nervous system (CNS) and skin physiology. HIF prolyl 4-hydroxylases are key enzymes regulating hypoxia response. The hypoxia pathway is linked to immune system via a complex cross-talk. Hypoxia pathway induction under normoxia by silencing HIF prolyl 4-hydroxylases (HIF-P4Hs) leads to alterations in gene expression levels and in (patho)physiology. This is reported to affect the function of the immune system, amongst other manifestations in physiology. HIF-P4H inhibitors (HIF-PHIs) are under growing interest of investigating their suitability as treatment against a number of diseases.

Simultaneously, she is working as Attending Physician in Terveystalo, leading the clinical decision-making for the patients in the facilities under her care. The position requires providing a high level of knowledge, skill, and experience needed in caring for a medically complex population in a climate of high public expectations and stringent regulatory requirements.