Ala-Kokko Tero

Intensive Care Medicine Research Group

 

Research unit: Surgery, Anesthesia and Intensive Care

 

Group leader

Professor Tero Ala-Kokko (MD, PhD, EDICM), the Chief of Intensive Care Medicine at Oulu University Hospital

 

What do we do

The incidence of sepsis requiring intensive care is increasing with high one year mortality of 41 % in Finland as well as in other countries, despite the advances in antimicrobial and organ supportive therapies. According to our findings adequate fibrinogenic response seems to be crucial to successful healing of sepsis related organ damage as the markers of extracellular matrix remodelling correlate with disease severity and mortality. Methods for early detection of sepsis are crucial for survival. According to our findings characterization of leucocyte surface molecules may provide new diagnostic tools for early detection of sepsis. Our studies may have a major impact on the diagnostics and treatment of severe sepsis which is an increasing health problem worldwide with high costs, mortality and long term morbidity. Studies on pathophysiology will bring new ideas for the diagnostics and treatment of this population. Modulation of inflammation and organ healing is hypothesized to be in the center of future treatments.

In post out of hospital cardiac arrest patients a new prognostic tool for neurological prognostication is under development. We have shown that the diagnostic value of EEG signal analysis based on responses to so called propofol-stress well categorizes patients according to their neurological outcome. In the future if proved valid it will be tested also in patients with other types of encephalopathy such as septic encephalopathy as a prognostic tool of neurological recovery.

Health related quality of life is an important patient centered outcome. Long term outcome of physical and psychological factors, functional outcome and socioeconomic wellbeing after critical illness ultimately determine the success of intensive care and its cost effectiveness. National registries together with our electronic clinical information system, hospital information system and cohort 66 registries all provide a unique data base environment for studies looking at intensive care resource use and patient centered outcomes. The results can be used for planning healthcare provision and when deciding healthcare resource allocation at national and international level.

 

Our team

  • Koskenkari Juha, Docent
  • Laurila Jouko, Docent
  • Liisanantti Janne, Docent
  • Syrjälä Hannu, Docent

Post doc researchers

  • Jansson Miia
  • Karhu Jaana
  • Kortelainen Jukka

PhD students

  • Erikson Kristo
  • Hoikka Marko
  • Jaurila Henna
  • Kyösti Elina
  • Niittyvuopio Miikka
  • Pohjola Mari

The division of intensive care will provide a study nurse, clinical patient material and care of the study patients as well partly funding from the hospital EVO grants and the services of a medical biostatistician.

 

Where are we headed

Sepsis research will be even more translational and still focus on understanding the pathophysiology to find new diagnostic tools and treatment options. Registry and cohort studies as well as quality of life studies will focus on healthcare process improvement.

 

Our main collaborators

FINNICU national study consortium
The research team is a multidisciplinary team covering critical care, infectious disease, surgery, pathology, nursing, radiology and clinical chemistry.
 

How to find us

Division of Intensive Care Medicine, Oulu University Hospital, Oulu, Finland,
PO BOX 22, 90029 OUH 
tel: +(358)83153675
tero.alakokko[at]oulu.fi

Last updated: 9.7.2019