Thesis defence in the University of Oulu

Doctoral Candidate

Master of science Eeva Sliz

Faculty and research unit

University of Oulu Graduate School, Faculty of Medicine, Center for Life Course Health Research

Field of study

Public health science

Date and time of the thesis defence

24.5.2019 12:00

Place of the thesis defence

Auditorium P117 (Aapistie 5B)

Topic of the dissertation

Genetics and molecular epidemiology of metabolic syndrome-related traits: Focus on metabolic profiling of lipid-lowering therapies and fatty liver, and the role of genetic factors in inflammatory load

Opponent

Professor Bertrand Cariou, University of Nantes

Custos

Professor Johannes Kettunen, University of Oulu

Novel insights into molecular mechanisms of metabolic syndrome

The present thesis focuses on the detailed molecular mechanisms of metabolic syndrome-related traits. The results indicate that PCSK9 inhibition is slightly less efficacious at lowering VLDL cholesterol than statins. The diversity in the molecular mechanisms of non-alcoholic fatty liver disease is highlighted by the observed discrepancies in the metabolic effects of its risk genotypes. The genetic associations with circulating markers of inflammation provide novel information on genetic mechanisms contributing to the inflammatory load.

The metabolic consequences of lipid-lowering medications and fatty liver were studied using genotype data and comprehensive blood analyses. Genome-wide tests were performed to identify genetic factors associating with inflammatory markers.

Metabolic syndrome is characterized by disturbances in multiple organ systems including cardiovascular, digestive, and immune systems. Dyslipidemia, fatty liver, and low-grade inflammation are features closely associated with the presence of metabolic syndrome. These metabolic risk factors predispose to cardiovascular disease, type 2 diabetes, and increased mortality.

Due to high prevalence and severe co-morbidities, metabolic syndrome constitutes a major burden for public health. Improved understanding of the detailed molecular mechanisms could provide novel strategies for the treatment and preferably prevention of the metabolic syndrome-related health issues.

Dissertation

Last updated: 17.5.2019