Professor Johanna Myllyharju is an expert on the key enzymes regulating hypoxia response and extracellular matrix synthesis. Oxygen and extracellular matrix homeostasis is vital for normal functioning of cells and tissues, and disturbances in this balance are associated with many common diseases. Therefore, detailed information on these enzymes is essential for understanding their molecular mechanisms and biological effects in detail. This has already paved the way towards pharmacologic interventions, exemplified by a longterm industrial collaboration to develop enzyme inhibitors as drugs (in phase 3 clinical trials) that activate the hypoxia response to treat severe anemia of chronic kidney diseases.
For own research: Academy of Finland Academy Project 2016-2020, Academy of Finland Center of Excellence 2012-2017, Jane and Aatos Erkko Foundation 2015-2019, Sigrid Juselius Foundation 2017-2020, FibroGen Inc. 2002-
For research infrastructure: EU Infrafrontier2020, Academy of Finland FIRI2015 - Biocenter Finland, FIRI2018 - Infrarontier FI, FIRI 2016 - Biocenter Finland
University of Ulm, Germany