Personalized Medicine: unique treatment for unique patient

Personalized medicine recognizes that each patient is unique and special. This notion has changed the concept of treatment strategies for various diseases from “one treatment fits to all patients” to “every patient requires customized, tailored prevention and treatment”. Current generation of scientists has thus witnessed the development and implementation of precision medicine. Significant development in individualized treatment, patient care and disease prevention is expected to take place during the next decade.

Personalized medicine is also the current topic of the 16th Science Day of the Campus of Kontinkangas that is organized on February 19th 2019 jointly with the Faculty of Medicine and the Faculty of Biochemistry and Molecular Medicine at the University of Oulu.  Four specialists from the University of Oulu and Oulu University hospital tell how they see the personalized medicine in their field of expertise now and in 2030.

  

Markus Mäkinen, professor, Faculty of Medicine, University of Oulu and Oulu University Hospital:

Personalized medicine is a central part of daily practice of a pathologist, doctor who gives diagnoses based on cells and tissues. We assess whether a patient is eligible to a targeted treatment; examples include RAS gene mutations in intestinal cancers, BRAF gene analysis in malignant melanoma, and PD-L1 gene in lung cancer. This is because only subset of patients benefits of new targeted treatments today.

In 2030, pathologists are still in the picture guaranteeing the quality of personalized medicine that then is available for masses in developed countries. The use of genomic data is integrated to the treatment decisions, thanks to the development of artificial intelligence, and to the expanded understanding of complex cellular and intercellular interactions that are linked to various diseases. There will be an ongoing shift towards real-time mobile preventive medicine: portable or implanted devices connected to AI-assisted platforms monitor patients at risk of developing serious illnesses like chronic colitis, lung fibrosis or hereditary cancer. In 2030, these achievements will allow us to cure patients nowadays deemed incurable, and treatments will produce less side effects because illnesses are detected early. This technical and methodological development will change the way we teach our students.

 

Professor Seppo Vainio, Biocenter Oulu, Director of Borealis Biobank of Northern Finland, Faculty of Biochemistry and Molecular Medicine, University of Oulu:

Personalized medicine will offer to us medical treatment that suits best to you based on your inheritance since the genome impacts the efficacy of therapies. Adult human primary cells retain their capability of pluripotency and after induction back to this stage, they can be reprogrammed and differentiated to other cell types. These specialized cells can then be utilized for personalized drug screens and cell therapies.

Given this personalized medicine is advanced via so called pharmacogenomic research and therefore genome databases and stem cell biobanks are needed. The Finnish biobank legislation offers the grounds for personalized medicine, but much research is still needed to make personalized medicine a reality. In summary, the concrete way that you can advance personalized medicine in the Finnish health care setting is to support the biobanks and the associated research. This will provide concrete grounds to advance medicine and the health care system to serve you better with your special needs during your life cycle.

 

Jussi Koivunen, Medical doctor, Faculty of Medicine, University of Oulu and Oulu University Hospital:

Personalized medicine is already standard-of-care approach in oncology today. In many tumor types, numerous genetic alterations/gene expressions are routinely analyzed in tumors to help in selecting the best treatment approach for a patient.

What I predict to happen in next coming 10 years, is that the number of analyzed genetic/gene expression alterations is growing and it is likely that even whole tumor and normal genome is analyzed before treatment choice.  Other growing field is the genetic monitoring of disease during treatment course using tumor shed DNA fragments and modifying therapy accordingly. Electronic follow up of patients with e-questionnaires and wearable electronics that can be coupled to AI approaches will increase and enable accurate and timely feedback to patient and care unit. This offers ways to enhance patient follow-up and personalized care. 

  

Kalervo Hiltunen, Professor (emeritus), Faculty of Biochemistry and Molecular Medicine, University of Oulu:

In addition to currently utilized personalized medicine in oncology, common infections and small injuries will be treated case-by-case by medical professionals during the coming years. Automatization, development of analytical methods and tools of bioinformatics will allow faster collection of more information from smaller sample volumes in a customer friendly manner. In addition, due to increased understanding on pathophysiology of diseases, decision making will be based on individual molecular profiles and genetic make-up of patients instead of averaging responses across large cohorts. Combining metabolite profile and life style with genetic background helps disease risk assessment, prevention or counselling to delay development of the disease state. The novel information leads to precise categorizing subgroups of diseases and ultimately to optimal care based on state-of-art. In vitro screening of malignant cell lines for drug sensitivity is already now in practice for tailoring drug therapy in cancers. Pharmacogenomics will give tools to predict which medical treatment will be safe and effective for individual patient and help to define an individual’s risk based on their genetic and life style backgrounds. 

  

Interviews by:  

Anne Tuomisto, PhD, University of Oulu &  Renata Prunskaite-Hyyryläinen, PhD, University of Oulu 

Last updated: 11.2.2019

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AM HERBALIST DR OSE ODIAGBE, I Cure Different Types Of Human Infections And Diseases Using Natural Roots And Herbs. I’m also a professional spell caster and my major areas of concentration are Sexually transmitted infections (STI), also referred to as sexually transmitted diseases (STDs) e.g; Herpes 1&2, HPV, Diabetes 1&2, Hepatitis B, HIV and venereal diseases (VD)” contact me on my website; droseodiagbeherbalcenter.wordpress.com

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AM HERBALIST DR OSE ODIAGBE, I Cure Different Types Of Human Infections And Diseases Using Natural Roots And Herbs. I’m also a professional spell caster and my major areas of concentration are Sexually transmitted infections (STI), also referred to as sexually transmitted diseases (STDs) e.g; Herpes 1&2, HPV, Diabetes 1&2, Hepatitis B, HIV and venereal diseases (VD)” contact me on my website; droseodiagbeherbalcenter.wordpress.com

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Herpes is a serious and recurring disease which can't be cured through drugs or injections by the American doctors but the best way to deal with Herpes is by taking natural herbs medicine for it, I have read about DR EDIDIA the great herbalist doctor who cure me from herpes with his powerful herbal medicine. i contacted him to know how he can help me and he told me never to worry that he will help me with the natural herbs from God! after 2 days of contacting him, he told me that the cure has been ready and he sent it to me via UPS SPEED POST and it got to me after 3 days! i used the medicine as he instructed me (MORNING and EVENING) and i was cured! its really like a dream but i am so happy! for the people suffering from the following diseases, Cancer, hypothyroidism, Herpes, COPD, HIV, Arthritis, Hpv, Infections,Liver Disease, Autoimmune Diseases, Parkinson's disease,Lupus and more should contact him for his herbal medicine because i am a living testimony and i was cured of herpes and his medicine is legit. i sent him what he requested and he sent me his medicine which i took for 3 good weeks and today am out here with negative result. when i went for test i was so happy after going through his medication. you can reach him through his email dredidiaherbalhome@gmail.com or call whatsapp number:+2349074505296 he will help you out. here is the Dr website http://dredidiaherbalhome.weebly.com/ https://dr-edidia-herbal-home.business.site/ https://naturaltreatmentherpes.blogspot.com/ I,m rosesharon and you can get intouch with me via rosesharon915@gmail.com also view website to know him.

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hello everyone i am Shravan Chakrapani from India but base in USA /Texas i want to share a testimony of how Dr.HARRY herbal mixture cream saves me from shame and disgrace, my penis was a big problem to me as the size was really so embarrassing,and i was also having weak erection problem. I can't make love to my wife and my penis was just too small imagine a full grown up man like me having 2.5 inches penis and to worsen it i don't last in sex i cant even last two minutes it was really a thing of shame to me. My wife was really tired of me because my sex life was very poor,she never enjoyed sex,i was always thinking and searching for solutions everywhere until saw a testimony of how DR HARRY herbal mixture cream have been helping people regarding their sex life, so i decided to give him a try and visited his website https://drharryherbaltempl.wixsite.com/solutiontemple and he told me what to do and he sent me the herbal mixture cream and i used it for some weeks to my greatest surprise in less than 3 weeks of taking the herbs my penis grow to 8 inches i couldn't believe my eyes and as i speak now my penis is now 10.5 inches and i do not have weak erection again. I can make love to my wife longer in bed. And my marriage is now stable,my wife now enjoy sex with me very well in bed. you can contact him on his email drharrysolution@gmail.com website https://drharryherbaltempl.wixsite.com/solutiontemple or call and whatsapp him through +2349036417079 . .he also specialize on the following things {1}HIV/AIDS {2}DIABETES {3}EPILEPSY {4} BLOOD CANCER {5} HPV {6} ALS {7} HEPATITIS {8}LOVE SPELL {9} SICKLE AND ANNAEMIA {10}Cardiovascular disease {11}heart disease and stroke {12} Chronic diseases Contact him and be free for ever....

Hello everyone i Am Ben Mark and i am from USA i am here to give my testimony about an herbal doctor called Dr,Akioya I was heartbroken because i had very small penis,not nice to satisfy a woman, i have been in so many relationship, but cut off because of my situation, i have used so many product which doctors prescribe for me, but could not offer me the help i searched for. i saw some few comments on the internet about this specialist called Dr,Akioya and decided to email him on his email i saw on the internet,(drakioya17spellhome@gmail.com ) so I decided to give his herbal product a try. i emailed him and he got back to me, he gave me some comforting words with his herbal product for Penis Enlargement, Within three weeks of me use it, i began to feel the enlargement, " and now it just 4 weeks of using his products my penis is about 8 inches longer, and i had to settle thing out with my ex girlfriend , i was surprised when she said that she is satisfied with my performance in bed and i now have a large penis.thanks to DR Akioya for is herbal product. you can also reach him with emsil drakioya17spellhome@gmail.com though is..number WHATASPP him today on this number [ +2348105257464 ] you can checkout is website; http://drakioyaherbalcenter.home.blog https://drakioyaherbalhome.blogspot.com/

I was suffering from hiv/aids my pcv which is my blood level was very high, i was worried about my cd4count and viral load.. i heard about the power of Dr LOSA healing medicine i apply for it and the doctor gave me the medicine and spiritual healing prayers to say and told me that the power of the healing drugs can cure my hiv/aids and he also told me to for get about the pcv, cd4 and viral load.. i really used the medicine and i was cure from hiv/aids i urge you all to get the DR healing medicine, you reach the great man that produce the healing medicine through his email address at: dr.losaherbalhome@gmail.com or Whatsapp him on +2349056464736 his there for you DOCTOR LOSA CAN AS WELL CURE THE FOLLOWING DISEASE:- 1. HIV/AIDS 2. HERPES 3. CANCER 4. ALS 5. Hepatitis 6 Diabetes 7 LOVE SPELL 8 IF YOU NEED YOUR EX LOVER BACK TO LOVE YOU AGAIN.

Hello my name is Jenna i want to share my amazing experience with the greatest spell caster Priest Ade my husband was cheating on me and when i found out we had a fight which lead to him filling for a divorce i cried and fell sick when i was searching about love quotes online i saw people talking about him and his great work whose case was similar to mine they left his contact info i contacted him and he told me not to worry that after 24hrs he will cancel the divorce and be back to me after i did everything he asked me to do to my greatest surprise the next day evening it was my husband he knelt down begging me to accept him back,thank you once again Priest Ade you are indeed a blessing to me he can also help you contact ancientspiritspellcast@yahoo.com or ancientspiritspellcast@gmail.com https://ancientspiritspellcast12.wordpress.com Blog: https://ancientspirit1.blogspot.com Website http://ancientspiritspellcast.website2.me WhatsApp +2347059715465 .

How to have your husband back home with your kids again I'm a lady with 2 kids i am from India, my husband leave me and his 2 kids for about 10 months i go through a lot of pain i do all i could to make him returned to me and to his kids but nothing works out. it was really a stressful period to me because i could dint go through the heartbreak. i was told to get a love spell doctor contacted to help me out which i did i was lucky to get DR.PEPOKO Contact who was able to help me out, he cast up a love spell that brought back my husband to me and to his kids thanks so much DR. PEPOKO I really appreciate what you have done for me. here he his contact if you may required for it by solving your relationship email. Pepokospiritemple@gmail.com call whatssap +2348156148821 Here is also Dr. PEPOKO website you can visit it yourself www.pepokospiritemple.blogspot.com Here is my details also if you wish to contact me personal::: mathewlauren7@gmail.com

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